Open Medicine最新文献

{"title":"Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus.","authors":"GuangZhi Li, Dongmei Zhang","doi":"10.1515/med-2024-1124","DOIUrl":"10.1515/med-2024-1124","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and β-cell dysfunction. A hallmark of T2DM pathology is the accumulation of toxic amyloid polypeptides in and around pancreatic islet cells, leading to the progressive loss of β-cell populations. Human islet amyloid polypeptide (hIAPP), also known as amylin, is a 37-amino acid peptide hormone primarily produced by pancreatic β-cells. hIAPP aggregation and amyloid formation are strongly correlated with β-cell death and disease severity in T2DM patients.</p><p><strong>Objectives: </strong>This article aims to review the current research progress on the correlation between hIAPP and T2DM, focusing on the molecular mechanisms and potential therapeutic strategies.</p><p><strong>Methods: </strong>We conducted a comprehensive literature review covering recent studies on the molecular structure, physiological function, and pathological mechanisms of hIAPP. Key areas include biosynthesis, monomer structure, and the formation of hIAPP fiber structures. Additionally, we examined the mechanisms of hIAPP-induced β-cell death, including oxidative stress (OS), endoplasmic reticulum stress (ERS), impaired cell membrane and mitochondrial functions, and inflammatory factors.</p><p><strong>Results: </strong>Our review highlights the critical role of hIAPP in the pathogenesis of T2DM. Specifically, we found that hIAPP biosynthesis and monomer structure contribute to its physiological functions, while hIAPP aggregation forms toxic amyloid fibers, contributing to β-cell dysfunction. OS, ERS, impaired cell membrane and mitochondrial functions, and inflammatory factors play significant roles in hIAPP-induced β-cell death. There is a strong correlation between hIAPP aggregation and the severity of T2DM, and potential therapeutic approaches using small molecule inhibitors to prevent hIAPP aggregation and fibrosis are discussed.</p><p><strong>Conclusion: </strong>Understanding the molecular mechanisms of hIAPP in T2DM provides insights into potential therapeutic targets and preventive strategies. Future research should focus on developing more effective treatments targeting hIAPP aggregation and its downstream effects.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241124"},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients.","authors":"Mian Wang, JiHong Lian, Bin Kuang, ChaoHui Zhang, MingHui Zhang","doi":"10.1515/med-2025-1149","DOIUrl":"10.1515/med-2025-1149","url":null,"abstract":"<p><strong>Objective: </strong>This study was to investigate the relationship between serum superoxide dismutase (SOD) and malondialdehyde (MDA) and arteriovenous fistula (AVF) maturation in maintenance hemodialysis (MHD) patients.</p><p><strong>Methods: </strong>A total of 120 MHD patients were divided into a maturation group (72 patients) and a maturation failure group (48 patients). General information and ultrasound data were collected and venous blood was drawn for routine blood tests. General data and serum SOD and MDA were compared. Independent variables with statistically significant (<i>P</i> < 0.05) differences in univariate analysis were included in multivariate logistic regression. Serum SOD and MDA in predicting maturation failure of AVF were analyzed using receiver operating characteristic curves.</p><p><strong>Results: </strong>The internal diameter of the cephalic vein, internal diameter of the cephalic vein after tourniquet binding, internal diameter of the radial artery, and serum SOD level were lower and serum MDA level was higher in the maturation failure group. Reduced SOD and elevated MDA were independent risk factors for maturation failure of AVF. The area under the curve (AUC) for serum SOD and MDA was 0.68 each. When combined, their AUC for predicting AVF maturation failure was 0.79.</p><p><strong>Conclusion: </strong>Reduced serum SOD and increased MDA are risk factors affecting AVF maturation in MHD patients.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251149"},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between epithelial-mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma.","authors":"Xiaoju Wang, Yuxin Zhang, Yiqing Wang, Lei Shi, Caiqin Yuan, Wei Yin, Yaoshu Teng, Jing Li, Yanjiao Mao","doi":"10.1515/med-2024-1074","DOIUrl":"https://doi.org/10.1515/med-2024-1074","url":null,"abstract":"<p><strong>Background: </strong>Epithelial-mesenchymal transition (EMT) and circulating tumor cells (CTCs) are key prognostic factors in nasopharyngeal carcinoma (NPC). However, the role of EMT status in CTCs for predicting outcomes in advanced NPC treated with radiotherapy after induction chemotherapy remains unclear.</p><p><strong>Methods: </strong>A total of 143 CTC tests from 95 advanced/metastatic NPC patients were analyzed before, during, and after radiotherapy, with a 60-month follow-up. CTC count, matrix metalloproteinase 2 (MMP2)) protein expression, and EMT subtypes were examined.</p><p><strong>Results: </strong>During radiotherapy, CTC counts increase but decrease afterward. Patients with higher pre-radiotherapy tumor-node-metastasis (TNM) stages have lower total and M-subtype CTC counts. Higher T and TNM stages during radiotherapy correlate with increased EMT-state CTCs, especially hybrid CTCs. EA/IgG-positive patients have a higher number of hybrid CTCs and E-type (epithelial + hybrid) CTCs, while EBV-EA-negative patients have more mesenchymal CTCs. A higher post-radiotherapy CTC count predicts relapse, and the positive rate of MMP2 expression on hybrid and epithelial CTCs is higher than that on mesenchymal CTCs.</p><p><strong>Conclusion: </strong>EMT status, particularly in hybrid CTCs, is a potential prognostic marker for relapse in advanced NPC after radiotherapy.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241074"},"PeriodicalIF":1.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Commiphora gileadensis</i> ameliorate infertility and erectile dysfunction in diabetic male mice.","authors":"Ayman Saeed Alhazmi","doi":"10.1515/med-2025-1166","DOIUrl":"https://doi.org/10.1515/med-2025-1166","url":null,"abstract":"<p><strong>Background: </strong>The <i>Commiphora gileadensis</i> (<i>C. gileadensis</i>) is a tree belonging to the genus <i>Commiphora.</i> Aim of the study: This study investigates the effect of <i>C. gileadensis</i> on erectile dysfunction and infertility in male mice.</p><p><strong>Methods: </strong>Fifty male BALB/c mice are divided into five groups: control, untreated diabetic, diabetic <i>C. gileadensis</i> sap-treated, methanol extract-treated, and acetone extract-treated. All groups were assessed for body weight, testicular weight, serum follicle-stimulating hormone, luteinizing hormone, testosterone, prolactin, nitric oxide, adropin, endothelin levels, semen analysis, CD4⁺, CD8⁺, CD25⁺, and testicular nitric oxide synthase (NOS) immunoreactivity.</p><p><strong>Outcome: </strong><i>C. gileade</i>nsis maintains sexual integrity and infertility in mice.</p><p><strong>Results: </strong>Diabetic groups treated with <i>C. gileadensis</i> had significantly higher body weight than the untreated group. Furthermore, the diabetic group treated with <i>C. gileadensis</i> sap had significantly increased testicular weight than the untreated groups. Diabetic groups treated with <i>C. gileadensis</i> had significantly greater testosterone levels than the untreated groups. Additionally, these groups exhibit considerably higher nitric oxide and adropin levels than the untreated diabetic group. Endothelin levels were considerably lower in diabetic groups treated with <i>C. gileadensis</i> than in the untreated group. Semen analysis shows that the diabetic group treated with <i>C. gileadensis</i> sap had considerably more sperm count than the untreated group (<i>P</i> < 0.05). CD4⁺, CD8⁺, CD4⁺, CD25⁺, and CD8⁺ CD25⁺ were reduced significantly in diabetic mice treated with <i>C. gileadnesis</i>. In addition, the NOS immunoreactivity is greater in diabetic <i>C. gileadensis</i> treated groups than in the untreated group.</p><p><strong>Clinical implications: </strong><i>C. gileadensis</i> induces mice erectile function and fertility.</p><p><strong>Strength and limitations: </strong>The study does not use laser Doppler flowmetry for the measurement of erectile dysfunction.</p><p><strong>Conclusion: </strong><i>C. gileadensis</i> ameliorates infertility and erectile dysfunction in diabetic mice.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251166"},"PeriodicalIF":1.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Kolb's experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients.","authors":"Yue Xu, Jingzheng Lu, Xinting Yu, Heguo Ding","doi":"10.1515/med-2025-1157","DOIUrl":"10.1515/med-2025-1157","url":null,"abstract":"<p><strong>Background: </strong>Family caregiving for dementia patients is a challenging task, with profound effects on caregivers' physical and mental well-being. The purpose of this study was to explore the impact of Kolb's experiential learning theory on the caregiving burden and psychological status of caregivers for dementia patients.</p><p><strong>Methods: </strong>This study enrolled 110 caregivers of nursing dementia patients. These caregivers were divided into two groups: a control group (<i>n</i> = 55) and an intervention group (<i>n</i> = 55). The control group received routine care, while the intervention group received nursing based on Kolb's experiential learning theory in addition to routine care. Changes in caregiving burden and psychological status were compared between the two groups before and after the intervention.</p><p><strong>Result: </strong>The results showed that after the intervention, the intervention group's caregivers had significantly lower scores on the caregiver burden inventory dimensions and total score compared to the control group (<i>P</i> < 0.05). Additionally, the intervention group's self-assessment scores on the self-rating anxiety scale and self-rating depression scale were also lower than those of the control group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Kolb's experiential learning theory has a positive impact on alleviating the caregiving burden and reducing anxiety and depression among family caregivers of dementia patients.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251157"},"PeriodicalIF":1.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery.","authors":"QiaoXian Tian, JiaYao Ma, YaHua Wu, LingYun Wang, WenJiao Yang","doi":"10.1515/med-2024-1101","DOIUrl":"10.1515/med-2024-1101","url":null,"abstract":"<p><strong>Objective: </strong>This study analyzed the prognosis of patients with high-grade squamous intraepithelial lesion (HSIL) after loop electrosurgical excision procedure (LEEP) and elucidated the predictive value of neutrophil-to-lymphocyte ratio (NLR) and margin condition in relation to prognostic recurrence.</p><p><strong>Methods: </strong>A total of 209 patients were included, with 46 cases in the recurrence/residual group, 156 cases in the no recurrence/residual group, and 7 cases lost to follow-up. General information, past history and comorbid underlying diseases, laboratory tests, and other relevant clinical information were compared between the two groups. The ROC curves were plotted to assess the diagnostic values of NLR, platelet-to-lymphocyte ratio (PLR), and lymphocytes. Log-rank test was conducted to plot the Kaplan Meier curves to assess the occurrence of recurrence/residual. Risk factors for the occurrence of recurrence/residual in patients during follow-up were analyzed.</p><p><strong>Results: </strong>Patients with high-risk human papillomavirus (HR-HPV) infection, positive margins, and higher PLR and NLR had a higher risk of recurrence/residual at follow-up. HR-HPV infection, positive margins, and higher levels of PLR and NLR showed significant hazard ratios. High NLR, positive margins, and HR-HPV infection resulted in poor prognosis and the occurrence of recurrence or residual.</p><p><strong>Conclusion: </strong>NLR levels and positive margins may be markers for predicting HSIL recurrence/residual lesions after LEEP.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241101"},"PeriodicalIF":1.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis.","authors":"Peng Zhou, Jie Yu, Bingmei Yan","doi":"10.1515/med-2024-1135","DOIUrl":"10.1515/med-2024-1135","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the serum levels of interleukin (IL)-17A in patients with traumatic bowel rupture and its clinical significance, particularly its correlation with inflammatory cytokines, preoperative severity, and postoperative prognosis.</p><p><strong>Methods: </strong>A total of 104 patients with traumatic bowel rupture admitted to Ruian People's Hospital between February 2021 and June 2024 were included in this prospective observational study. All patients underwent standard surgical treatment for traumatic bowel rupture at our hospital. Serum levels of IL-17A, IL-6, tumor necrosis factor-alpha, and C-reactive protein were measured at various time points using enzyme-linked immunosorbent assay. Clinical data and demographics were collected. Patients were followed up for 3 months post-discharge.</p><p><strong>Results: </strong>The study found significantly higher levels of IL-17A and IL-6 in patients with an injury severity score (ISS) of ≥16 compared to those with an ISS of <16 (<i>p</i> < 0.05). Serum IL-17A levels were particularly elevated in patients with poor prognosis (<i>p</i> < 0.05). Of particular importance, receiver operating characteristic curve analysis demonstrated that serum IL-17A levels at 72 h post-surgery had predictive value for poor prognosis, with an area under the curve of 0.773, a cutoff value of 41.75 pg/mL, a sensitivity of 62.2%, and a specificity of 83.6%. Logistic regression analysis identified elevated IL-17 levels at 72 h post-surgery as a significant risk factor for poor prognosis (odds ratio = 1.273, 95% confidence interval: 1.115-1.453, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>In summary, our study highlights the significant potential of serum IL-17A as a biomarker for predicting poor prognosis in patients with traumatic bowel rupture post-surgery, suggesting its utility in clinical assessment and potential as a therapeutic target.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241135"},"PeriodicalIF":1.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial.","authors":"Min Tang, Seidu A Richard, Chaofeng Fan, Zhen Luo, Wei Zhu, Qian He, Zhigang Lan, Lijuan Duan","doi":"10.1515/med-2025-1139","DOIUrl":"10.1515/med-2025-1139","url":null,"abstract":"<p><strong>Introduction: </strong>Transsphenoidal endoscopic pituitary (TEP) tumor resection is performed through the nose via the sphenoid sinus to remove tumors from the pituitary gland. Also, enhanced recovery after surgery (ERAS) was adapted to reduce physical and physiological traumatic stress response of surgical patients.</p><p><strong>Methods: </strong>A total of 174 patients who underwent TEP tumor resection in our department from August 2021 to June 2022 were randomly divided into non-ERAS group and ERAS group. The main primary observational indicator was postoperative self-care ability parameters such as early urethral catheters' removal and postoperative food intake. Also, secondary indicators such as postoperative complications, average length of hospital stay (LOS), and total hospital cost were compared.</p><p><strong>Results: </strong>The overall self-care ability of the ERAS group was higher than that of the non-ERAS group 24 h after surgery (35 points vs 20 points, <i>p</i> < 0.001). Also, food intake on the first day after surgery was higher than that of the non-ERAS group (<i>p</i> < 0.001). Furthermore, the average LOS in the ERAS group was lower than that of the non-ERAS group (4 days vs 7 days, <i>p</i> < 0.01). Additionally, the average hospitalization cost in the ERAS group was lower than that of the non-ERAS group (32, 886 RMB vs 48, 125 RMB, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>ERAS nursing strategy promoted early recovery of self-care, shorten the average LOS, and reduce hospitalization costs without increasing the incidence of postoperative complications.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251139"},"PeriodicalIF":1.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women.","authors":"Chao Chen, Huai-Ming Zhang, Lei Shen, Hua-Ping He, Zhen-Yu Ma, Yu-Qin Zhu, Zhao-Hui Geng, Yan-Xia Qin","doi":"10.1515/med-2025-1164","DOIUrl":"10.1515/med-2025-1164","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine the impact of stability-focused core muscle strength training coupled with respiratory techniques on diminishing the inter-recti distance (IRD) among postpartum women.</p><p><strong>Methods: </strong>A total of 106 women diagnosed with diastasis recti abdominis within 42 days following delivery were 1:1 randomly allocated into a control group (<i>n</i> = 53) and an intervention group (<i>n</i> = 53). Both groups underwent standard postpartum follow-up care and independently pursued self-directed rehabilitation exercises. Additionally, the intervention group commenced a 6-week program of core muscle strength stability-oriented breathing training 42 days postpartum. Measurements of IRD were taken both pre- and post-intervention.</p><p><strong>Results: </strong>Prior to the intervention, no statistically significant difference in IRD was observed between the two groups (<i>P</i> > 0.05). Subsequent to the intervention, notable reductions in IRD measurements were evident above, at the level of, and below the umbilicus in both groups compared to baseline measurements (intervention group: <i>P</i> < 0.001 at all measured points; control group: <i>P</i> = 0.035 above the umbilicus, <i>P</i> < 0.001 at the level of, and below the umbilicus). However, the intervention group exhibited a more pronounced decrease in IRD at all measured points when compared to the control group, demonstrating statistical significance with <i>P</i> = 0.000.</p><p><strong>Conclusion: </strong>Core muscle strength stability-oriented breathing training demonstrates efficacy in reducing IRD among postpartum women.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251164"},"PeriodicalIF":1.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific associations of sex hormone binding globulin and risk of bladder cancer.","authors":"Junyong Ou, Hai Bi, Haobin Zhou, Zhanyi Zhang, Peichen Duan, Haoming Yin, Zezhen Zhou, Zhixin Xie, Xiaojun Tian, Jianfei Ye, Shudong Zhang","doi":"10.1515/med-2025-1163","DOIUrl":"10.1515/med-2025-1163","url":null,"abstract":"<p><strong>Background: </strong>Males have a three times higher risk of a diagnosis of bladder cancer (Bca) than females. Sex hormone-binding globulin (SHBG) may be associated with Bca risk. However, the sex-specific role of SHBG in Bca remains unclear. In this study, we aimed to determine the role of SHBG in Bca.</p><p><strong>Methods: </strong>A sex-specific univariable Mendelian randomization (MR) analysis involving 369,426 men and 395,375 women was conducted to assess the causal relationship between SHBG and testosterone and Bca risk. Sensitivity analyses and multivariable MR were conducted to confirm the robustness of our results. Linkage disequilibrium score regression assessed the genetic correlation between these diseases influenced by heredity.</p><p><strong>Results: </strong>Univariable MR results showed that one-SD elevated SHBG was related to a low risk of Bca in males (OR: 0.60, 95% CI: 0.39-0.93; <i>p</i> = 0.022) but had no benefit in females. Genetically predicted BT was positively associated with Bca risk in males (OR: 1.59; 95% CI: 1.06-2.40; <i>p</i>  =  0.027). In multivariable MR, higher SHBG levels were not related to male Bca risk after controlling for BT.</p><p><strong>Conclusions: </strong>Our findings do not provide evidence to support a causal relationship between SHBG and Bca risk in males although an association was observed in the univariable analysis. Further research is needed to identify the underlying pathways.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251163"},"PeriodicalIF":1.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}