Open Medicine最新文献_第3页

Eosinophil count combined with routine indicators enhances early risk prediction value for ARDS in ICU patients: a retrospective cohort study. 一项回顾性队列研究：嗜酸性粒细胞计数联合常规指标可提高ICU患者ARDS的早期风险预测价值。

IF 1.6 4区医学

Open Medicine Pub Date : 2026-03-18 eCollection Date: 2026-01-01 DOI: 10.1515/med-2026-1401

WeiNing Ma, Hua Gao, MingZhe Wen

{"title":"Eosinophil count combined with routine indicators enhances early risk prediction value for ARDS in ICU patients: a retrospective cohort study.","authors":"WeiNing Ma, Hua Gao, MingZhe Wen","doi":"10.1515/med-2026-1401","DOIUrl":"https://doi.org/10.1515/med-2026-1401","url":null,"abstract":"Objectives: This study aims to systematically evaluate the incremental value of admission eosinopenia EOS(-) in enhancing the predictive efficacy of early-stage acute respiratory distress syndrome (ARDS) risk models for ICU patients.Methods: This study employed a single-center retrospective cohort design, enrolling 482 adult ICU patients between 2020 and 2023. Using Cox proportional hazards regression, we constructed and compared three models: Model 1 (baseline clinical model) included age, pneumonia, sepsis, and SOFA score; Model 2 added lymphocytes and eosinophils to Model 1; Model 3 further adjusted for BMI and diabetes. Predictive performance was assessed using the C-index, net reclassification improvement (NRI), and integrated discrimination improvement (IDI), and validated internally.Results: C-statistics for Models 1, 2, and 3 were 0.683, 0.710, and 0.729, respectively. Model 3 demonstrated optimal performance (NRI=0.185, p=0.004), with an adjusted C-statistic of 0.695. Multivariate analysis identified age, pneumonia, and sepsis as independent ARDS risk factors, while EOS(-) showed non-independence. Results from competing risks analysis were consistent with the primary analysis conclusions.Conclusions: Although eosinopenia is not an independent predictor of ARDS, it provides incremental information for early risk stratification based on conventional clinical factors, thereby aiding in the identification of high-risk patients.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261401"},"PeriodicalIF":1.6,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing an innovative chimeric multi-epitope subunit vaccine against Staphylococcus intermedius using an immunoinformatics strategy via Multi-omics approaches. 利用多组学方法的免疫信息学策略开发一种新型嵌合多表位亚单位抗中间葡萄球菌疫苗。

IF 1.6 4区医学

Open Medicine Pub Date : 2026-03-18 eCollection Date: 2026-01-01 DOI: 10.1515/med-2025-1281

Muhammad Naveed, Furrmein Fatima, Sarmad Mahmood, Tariq Aziz, Nimra Hanif, Nausheen Nazir, Ashwag Shami, Maher S Alwethaynani, Fakhria A Al-Joufi, Bandar K Baothman, Sarah Almaghrabi, Majid Alhomrani

{"title":"Developing an innovative chimeric multi-epitope subunit vaccine against Staphylococcus intermedius using an immunoinformatics strategy via Multi-omics approaches.","authors":"Muhammad Naveed, Furrmein Fatima, Sarmad Mahmood, Tariq Aziz, Nimra Hanif, Nausheen Nazir, Ashwag Shami, Maher S Alwethaynani, Fakhria A Al-Joufi, Bandar K Baothman, Sarah Almaghrabi, Majid Alhomrani","doi":"10.1515/med-2025-1281","DOIUrl":"https://doi.org/10.1515/med-2025-1281","url":null,"abstract":"Background: Streptococcus intermedius is a major human pathogen associated with invasive diseases such as meningitis and endocarditis. These infections may lead to inflammation, fever, and cardiac damage. At present, no effective vaccine exists for prevention.Objectives: This study aimed to design a stable, non-allergenic, and antigenic chimeric multi-epitope vaccine against S. intermedius using Immunoinformatics approaches.Methods: Twelve B-cell, five helper T lymphocyte (HTL), and five cytotoxic T lymphocyte (CTL) epitopes were predicted using advanced immunoinformatics tools. These epitopes were assembled into a single vaccine candidate. The construct was evaluated in silico for its antigenicity, allergenicity, and physicochemical stability. A 3D structural model of the vaccine was generated and validated. Molecular docking and dynamics simulations were conducted to assess interactions between the vaccine and immune receptors: TLR4, TLR3, MHC-I, and MHC-II.Results: The final vaccine candidate demonstrated favorable antigenic and non-allergenic properties, along with high stability. Structural validation confirmed proper folding. Docking analyses revealed strong binding affinities between the vaccine and target immune receptors. Molecular dynamics simulations indicated stable complexes, supporting the construct's immunological compatibility.Conclusions: The designed chimeric multi-epitope vaccine shows strong potential to elicit an immune response against S. intermedius. These findings provide a foundation for further experimental validation through in vivo and clinical trials.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20251281"},"PeriodicalIF":1.6,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective analysis of adverse drug reaction patterns from the national monitoring system in a tertiary care hospital in China (2019-2024). 2019-2024年中国某三级医院国家监测系统药品不良反应模式回顾性分析

IF 1.6 4区医学

Open Medicine Pub Date : 2026-03-16 eCollection Date: 2026-01-01 DOI: 10.1515/med-2026-1393

Xiao-Lei Yuan, Xiao-Yu Fang, Feng Li, Feng-Jun Wang, Qian-Qian Ma, Jun-Tao Chen, Ya-Nan Wang

{"title":"Retrospective analysis of adverse drug reaction patterns from the national monitoring system in a tertiary care hospital in China (2019-2024).","authors":"Xiao-Lei Yuan, Xiao-Yu Fang, Feng Li, Feng-Jun Wang, Qian-Qian Ma, Jun-Tao Chen, Ya-Nan Wang","doi":"10.1515/med-2026-1393","DOIUrl":"https://doi.org/10.1515/med-2026-1393","url":null,"abstract":"Objectives: To characterize the patterns, risk factors, and reporting trends of adverse drug reactions (ADRs) in a tertiary care hospital in China to inform targeted medication safety interventions.Methods: A single-center, retrospective analysis was conducted on 5,564 ADR reports extracted from the National Adverse Drug Reaction Monitoring System (2019-2024). Reports were assessed for causality using the WHO-UMC criteria. Descriptive statistics and chi-squared tests were employed to analyze demographics, reporting trends, causative drugs, administration routes, and clinical outcomes.Results: The mean patient age was 62.4 years, with males slightly predominating (52.5 %). ADR reporting increased markedly over the study period, with pharmacists becoming the primary reporters (93.1 % in 2024). Intravenous infusion was the most common route (67.3 %). Antineoplastic agents were the predominant drug class implicated (34.2 %), followed by anti-infectives (10.8 %) and cardiovascular drugs (9.4 %). Statistically significant associations were found between ADR outcomes and both the type of ADR (new/serious vs. general, p<0.001) and the administration route (intravenous vs. oral, p<0.001). No significant association was observed between patient age and ADR outcomes (p=0.244).Conclusions: Antineoplastic drugs and intravenous administration are key ADR risk factors. Enhanced monitoring of high-risk medications and optimized infusion protocols are needed. Limitations include retrospective single-center design and reporting biases.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261393"},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The C-reactive protein-to-body mass index ratio predicts prognosis in patients with different types of heart failure. c反应蛋白与身体质量指数比值预测不同类型心力衰竭患者的预后。

IF 1.6 4区医学

Open Medicine Pub Date : 2026-03-16 eCollection Date: 2026-01-01 DOI: 10.1515/med-2026-1385

Tao Shi, Jianping Yang, Ningli Zhang, Dan Xu, Fazhi Yang, Sirui Yang, Lixing Chen

{"title":"The C-reactive protein-to-body mass index ratio predicts prognosis in patients with different types of heart failure.","authors":"Tao Shi, Jianping Yang, Ningli Zhang, Dan Xu, Fazhi Yang, Sirui Yang, Lixing Chen","doi":"10.1515/med-2026-1385","DOIUrl":"https://doi.org/10.1515/med-2026-1385","url":null,"abstract":"Objectives: The aim of this study was to explore the predictive value of the C-reactive protein-to-body mass index ratio (CBR) in the prognosis of all-cause mortality in patients with heart failure (HF) with different ejection fractions.Methods: We included 1196 HF patients from the First Affiliated Hospital of Kunming Medical University after exclusion criteria. Based on the optimal cut-off value from the ROC curves, patients were categorised into low CBR group and high CBR group. The predictive value of the CBR for the prognosis of all-cause mortality in patients with different types of HF was assessed using Kaplan-Meier curves, Cox proportional hazards analyses, cubic spline plots and ROC curves analyses.Results: Kaplan‒Meier analyses showed that the high CBR group had the highest cumulative incidence of all-cause mortality regardless of the type of HF patients. Multivariate Cox regression analysis revealed that the CBR was an independent predictor of prognosis for all-cause mortality in patients with all types of HF. The cubic spline plots showed a roughly positive association between the CBR and all-cause mortality. The ROC curves showed that for all types of HF patients, the area under the curve for the CBR was the largest relative to individual CRP and BMI.Conclusions: Regardless of the type of HF patients, the CBR can be a good predictor of prognosis for all-cause mortality in patients with a higher CBR associated with a higher risk of all-cause mortality.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261385"},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a machine learning algorithm model to predict intraoperative hypotension in elderly patients undergoing thoracic and abdominal surgeries. 开发一种机器学习算法模型来预测接受胸腹外科手术的老年患者术中低血压。

IF 1.6 4区医学

Open Medicine Pub Date : 2026-03-16 eCollection Date: 2026-01-01 DOI: 10.1515/med-2026-1381

Yifan An, Pengfei Liu, Lei Liu, Xiaoyun Hu, Hui Qiao, Weixuan Sheng

{"title":"Development of a machine learning algorithm model to predict intraoperative hypotension in elderly patients undergoing thoracic and abdominal surgeries.","authors":"Yifan An, Pengfei Liu, Lei Liu, Xiaoyun Hu, Hui Qiao, Weixuan Sheng","doi":"10.1515/med-2026-1381","DOIUrl":"https://doi.org/10.1515/med-2026-1381","url":null,"abstract":"Objectives: To develop and validate machine learning (ML) models for identifying key predictors and estimating the risk of intraoperative hypotension (IOH) in elderly patients undergoing general anesthesia.Methods: This secondary analysis included 1,720 elderly surgical patients from a randomized controlled trial. Data were split chronologically into training sets. Feature selection was performed using univariate analysis and the Boruta algorithm. Eight ML models - logistic regression, Bayesian model, K-nearest neighbor, support vector machine, neural network, classification and regression tree, extreme gradient boosting, and random forest - were developed with cross-validation, hyperparameter tuning, and random oversampling. Model performance was evaluated using ROC, PRC, calibration, and decision curve analyses, and interpretability was enhanced using SHapley Additive exPlanations (SHAP).Results: Key predictors included anesthesia protocol, Charlson comorbidity index, preoperative sodium, creatinine, BUN/creatinine ratio, intraoperative drug use (e.g., sevoflurane, lidocaine, morphine), preoperative MAP and MHR, surgical and anesthesia duration, and surgical site. The random forest model achieved the best performance (accuracy=0.9917; MCC=0.9832; AUC-ROC=0.9998; AUC-PRC=0.9998).Conclusions: A robust ML-based model was established to accurately predict IOH in elderly patients. These findings may support individualized anesthesia management and targeted preventive strategies to reduce IOH incidence.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261381"},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of vitamin D in improving antioxidant defense and blood rheology in a rat model of experimental diabetes mellitus. 维生素D改善实验性糖尿病大鼠模型抗氧化防御和血液流变学的治疗潜力。

IF 1.6 4区医学

Open Medicine Pub Date : 2026-03-12 eCollection Date: 2026-01-01 DOI: 10.1515/med-2026-1403

Nino Sakhanberidze, Manana Namoradze, Nino Charkviani, Maia Mantskava, Nana Momtselidze, Davit Delibashvili, Natia Gamkrelidze

{"title":"Therapeutic potential of vitamin D in improving antioxidant defense and blood rheology in a rat model of experimental diabetes mellitus.","authors":"Nino Sakhanberidze, Manana Namoradze, Nino Charkviani, Maia Mantskava, Nana Momtselidze, Davit Delibashvili, Natia Gamkrelidze","doi":"10.1515/med-2026-1403","DOIUrl":"10.1515/med-2026-1403","url":null,"abstract":"Objectives: To evaluate the preventive and corrective effects of vitamin D on antioxidant defense and blood rheology in rats with streptozotocin (STZ)-induced diabetes mellitus.Methods: Forty male rats (10 weeks old, ∼200 g) were randomly assigned to four groups: Group I - Intact controls; Group II - Diabetic rats (STZ only); Group III - Preventive (vitamin D for 14 days before STZ and continued throughout the experiment); Group IV - Therapeutic (vitamin D from day 3 post-STZ). DM was induced with streptozotocin (30 mg/kg), and vitamin D was administered orally at 300 IU/day, according to a previous dose-control experiment. Data from the 21st experimental day were evaluated. Blood samples collected at this point were used to determine catalase (CAT), superoxide dismutase (SOD), and blood rheological parameters.Results: Vitamin D supplementation enhanced antioxidant-related parameters and improved blood rheological indices, particularly when administered therapeutically.Conclusions: Vitamin D shows therapeutic potential in attenuating oxidative imbalance and improving blood rheology in streptozotocin-induced diabetes mellitus.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261403"},"PeriodicalIF":1.6,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-induced gingival overgrowth in renal transplants patients. 肾移植患者药物性牙龈过度生长。

IF 1.6 4区医学

Open Medicine Pub Date : 2026-03-12 eCollection Date: 2026-01-01 DOI: 10.1515/med-2025-1348

Sarah Monserrat Lomelí-Martínez, Melissa Martínez-Nieto, Ruth Rodríguez-Montaño, Mario Alberto Alarcón-Sánchez, Juan José Varela Hernández, Adrián Fernando Gutiérrez-Maldonado, Juan Carlos Gomez-Mireles, Christian Ramírez Sánchez, Erandis Dheni Torres-Sánchez

{"title":"Drug-induced gingival overgrowth in renal transplants patients.","authors":"Sarah Monserrat Lomelí-Martínez, Melissa Martínez-Nieto, Ruth Rodríguez-Montaño, Mario Alberto Alarcón-Sánchez, Juan José Varela Hernández, Adrián Fernando Gutiérrez-Maldonado, Juan Carlos Gomez-Mireles, Christian Ramírez Sánchez, Erandis Dheni Torres-Sánchez","doi":"10.1515/med-2025-1348","DOIUrl":"10.1515/med-2025-1348","url":null,"abstract":"Introduction: This narrative review describes the scientific evidence on drug-induced gingival overgrowth (DIGO) in kidney transplant patients treated with immunosuppressive agents, particularly Cyclosporine A, focusing on its prevalence, pathogenetic mechanisms, and clinical management strategies.Content: This study was conducted including PubMed, Scopus, and Web of Science, highlighting clinical studies and case reports.Summary: DIGO is an oral complication in transplant patients treated with cyclosporine A, and its frequency may increase when combined with calcium channel blockers. However, tacrolimus has shown a lower incidence of DIGO compared with Cyclosporine A, making it a favorable therapeutic alternative in immunosuppressive regimens for renal transplant patients. Mycophenolate mofetil, despite being less directly linked to DIGO, can exacerbate gingival changes when combined with other immunosuppressants by promoting inflammation and connective tissue remodeling. Sirolimus is associated with a lower risk of DIGO compared with calcineurin inhibitors; however, some isolated cases have been reported, particularly in patients previously exposed to Cyclosporine A or when used in combination with calcium channel blockers. Management strategies include proper oral hygiene, dose adjustment or medication substitution, and, in some cases surgical intervention.Outlook: The fundamental keys to reducing its incidence and severity are a personalized immunosuppressive regimen with a multidisciplinary approach.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20251348"},"PeriodicalIF":1.6,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nephroprotective effects of visnagin through modulation of macrophage polarization, oxidative stress, inflammation and apoptosis in renal I/R injury. visnagin通过调节肾I/R损伤中的巨噬细胞极化、氧化应激、炎症和凋亡发挥肾保护作用。

IF 1.6 4区医学

Open Medicine Pub Date : 2026-03-09 eCollection Date: 2026-01-01 DOI: 10.1515/med-2026-1399

Suleyman Sagir, Ugur Seker, Merve Pekince-Ozoner, Meral Yuksel, Gul Sahika Gokdemir, Seval Kaya, Mehmet Demir

{"title":"Nephroprotective effects of visnagin through modulation of macrophage polarization, oxidative stress, inflammation and apoptosis in renal I/R injury.","authors":"Suleyman Sagir, Ugur Seker, Merve Pekince-Ozoner, Meral Yuksel, Gul Sahika Gokdemir, Seval Kaya, Mehmet Demir","doi":"10.1515/med-2026-1399","DOIUrl":"https://doi.org/10.1515/med-2026-1399","url":null,"abstract":"Objectives: The study aimed to investigate the nephroprotective effects of visnagin on renal ischemia-reperfusion (I/R) injury and the role of M1/M2 macrophage polarization in this process.Methods: Forty-two adult rats were divided into six groups: Control, Visnagin30 mg/kg, Visnagin60 mg/kg, I/R, I/R + Visnagin30 mg/kg, I/R + Visnagin60 mg/kg (n=7). Bilateral renal ischemia was induced by clamping for 25 min, followed by 2 h of reperfusion. Visnagin or vehicle was administered to the animals intraperitoneally 2 h before reperfusion. At the end of the study, kidney samples were collected for analysis of oxidative stress, inflammatory cytokines, apoptotic protein expression, and M1/M2 macrophage polarization.Results: I/R injury increased malondialdehyde (MDA), chemiluminescence (CL), IL-1β, and IL-6 levels while decreasing glutathione (GSH) in renal tissue, indicating enhanced oxidative stress (p<0.001) and inflammation (p<0.05). Histopathological examination showed glomerular atrophy, tubular degeneration, and intertubular hemorrhage. Visnagin treatment at 60 mg/kg significantly reduced MDA, CL, and IL-1β levels, and increased GSH (p<0.05). Immunohistochemically, visnagin decreased Bax (p<0.001), caspase-3 (p<0.01), and TNF-α (p<0.01) expressions elevated by I/R injury. Furthermore, visnagin reversed I/R induced M1/M2 macrophage polarization (CD86↑, CD163↓), decreasing CD86 (p<0.05) and increasing CD163 immunodensity (p<0.05).Conclusions: Visnagin treatment (60 mg/kg) exerts promising nephroprotective effects in renal I/R injury by reducing oxidative stress, inflammation, apoptosis, and modulating M1/M2 macrophage polarization.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261399"},"PeriodicalIF":1.6,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12965831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the link between glycated serum protein and esophageal metrics in diabetic GERD patients. 探讨糖尿病性胃食管反流患者糖化血清蛋白与食管指标之间的关系。

IF 1.6 4区医学

Open Medicine Pub Date : 2026-03-09 eCollection Date: 2026-01-01 DOI: 10.1515/med-2025-1373

JingXia Wang, QiaoQiao Kong, Jing Chen, HePing Xia, MaoLin Han, ChuangZhou Xie, Ning You

{"title":"Exploring the link between glycated serum protein and esophageal metrics in diabetic GERD patients.","authors":"JingXia Wang, QiaoQiao Kong, Jing Chen, HePing Xia, MaoLin Han, ChuangZhou Xie, Ning You","doi":"10.1515/med-2025-1373","DOIUrl":"https://doi.org/10.1515/med-2025-1373","url":null,"abstract":"Objectives: This study assessed the relationship between glycated serum protein (GSP) and post-reflux swallow-induced peristaltic wave (PSPW) index and esophageal baseline impedance (BI) in patients with diabetes mellitus (DM) with gastroesophageal reflux disease (GERD).Methods: General clinical data of patients in the DM and DM/GERD groups were compared. Multifactorial Logistic regression analyses were performed to screen for independent factors on GERD in DM patients, and odds ratio (OR) was calculated. The risk of GERD was assessed using a spline regression model constructed on the basis of GSP, PSPW and BI. Predictive efficacy was analyzed using Receiver operating curve (ROC) curve analysis.Results: Statistically significant differences were found in TG, hs-CRP, GSP, PSPW, and BI between patients in the DM and DM/GERD groups. PSPW and BI (OR=0.99, p<0.01) were independent protective factors, and elevated GSP was an independent risk factor for the development of GERD. A linear relationship was validated between GSP and PSPW and BI and the prevalence risk of developing GERD in patients with DM, all with good predictive efficacy.Conclusions: GSP, PSPW, and BI show significant correlations with the onset and progression of GERD in patients and all demonstrate good predictive efficacy. However, due to the small size of the patient cohort, the generalizability of these findings requires further validation.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20251373"},"PeriodicalIF":1.6,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12965830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond muscle weakness: pathogenesis of sepsis-induced myopathy and its management. 超越肌肉无力：败血症引起的肌病的发病机制及其管理。

IF 1.6 4区医学

Open Medicine Pub Date : 2026-03-06 eCollection Date: 2026-01-01 DOI: 10.1515/med-2025-1342

Yukun Liu, Xuan Zhao, Zhikai Xu, Qinxin Liu, Yuchang Wang

{"title":"Beyond muscle weakness: pathogenesis of sepsis-induced myopathy and its management.","authors":"Yukun Liu, Xuan Zhao, Zhikai Xu, Qinxin Liu, Yuchang Wang","doi":"10.1515/med-2025-1342","DOIUrl":"10.1515/med-2025-1342","url":null,"abstract":"Background: Sepsis-induced myopathy (SIM)significantly contributes to long-term disability and mortality among sepsis survivors. A comprehensive understanding of both the molecular mechanisms and rehabilitation strategies is crucial for effective management.Methods: A review of pertinent studies was conducted, focusing on the molecular pathogenesis, therapeutic strategies, and rehabilitation interventions for SIM, with particular attention to clinical and translational advancements.Results: Current management strategies encompass infection control, modulation of inflammation, nutritional support, and structured rehabilitation programs, including early mobilization and physiotherapy. Emerging therapies that target inflammation, cellular protection, and regeneration - such as stem cell therapy and gene-editing techniques - demonstrate potential. Furthermore, advancements in personalized medicine, including genomics, transcriptomics, and individualized metabolic interventions, may further improve outcomes.Conclusions: Optimizing both mechanistic and rehabilitation strategies is essential for enhancing functional recovery and quality of life in patients with SIM. An integrated clinical and molecular approach presents the most promising path forward. Keywords: sepsis-induced myopathy, sepsis.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20251342"},"PeriodicalIF":1.6,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0