{"title":"RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation.","authors":"Shuo Chen, Mengxing Li, Jishi Wang","doi":"10.1515/med-2025-1168","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The objective of this research was to investigate the involvement of RAB39B in acute myeloid leukemia (AML) using bioinformatics analysis and <i>in vitro</i> experiments for validation.</p><p><strong>Methods: </strong>In this article, RNA sequencing data from The Cancer Genome Atlas and genotype-tissue expression were utilized to analyze the expression of RAB39BA and identify differentially expressed genes.</p><p><strong>Results: </strong>AML exhibited elevated expression of RAB39B in diverse tumor types. In laboratory experiments, it has been demonstrated that RAB39B exhibits a significant expression level in AML cell lines when compared to normal peripheral blood monocytes. Moreover, RAB39B is closely linked to the growth and programmed cell death of AML cells.</p><p><strong>Conclusion: </strong>In conclusion, RAB39B shows potential as a biomarker for the identification and prediction of AML, contributing to the growth and cell death processes in AML.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251168"},"PeriodicalIF":1.7000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964188/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/med-2025-1168","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The objective of this research was to investigate the involvement of RAB39B in acute myeloid leukemia (AML) using bioinformatics analysis and in vitro experiments for validation.
Methods: In this article, RNA sequencing data from The Cancer Genome Atlas and genotype-tissue expression were utilized to analyze the expression of RAB39BA and identify differentially expressed genes.
Results: AML exhibited elevated expression of RAB39B in diverse tumor types. In laboratory experiments, it has been demonstrated that RAB39B exhibits a significant expression level in AML cell lines when compared to normal peripheral blood monocytes. Moreover, RAB39B is closely linked to the growth and programmed cell death of AML cells.
Conclusion: In conclusion, RAB39B shows potential as a biomarker for the identification and prediction of AML, contributing to the growth and cell death processes in AML.
背景：本研究旨在通过生物信息学分析和体外实验验证 RAB39B 在急性髓性白血病（AML）中的参与：该研究旨在通过生物信息学分析和体外实验验证RAB39B参与急性髓性白血病（AML）的研究：本文利用癌症基因组图谱中的RNA测序数据和基因型-组织表达来分析RAB39BA的表达，并鉴定差异表达基因：结果：在不同的肿瘤类型中，急性髓细胞白血病表现出RAB39B的高表达。实验室实验证明，与正常外周血单核细胞相比，RAB39B 在 AML 细胞系中的表达水平明显升高。此外，RAB39B 与 AML 细胞的生长和程序性细胞死亡密切相关：总之，RAB39B具有作为识别和预测急性髓细胞性白血病的生物标志物的潜力，有助于急性髓细胞性白血病的生长和细胞死亡过程。
期刊介绍：
Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.
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