Open Medicine最新文献

{"title":"Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study.","authors":"Li Chen, Ying Yi, Yun Zhu","doi":"10.1515/med-2025-1240","DOIUrl":"10.1515/med-2025-1240","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the potential causal relationship between immune cell and the risk of ulcerative colitis (UC), and to explore whether serum metabolites may mediate this association, thereby suggesting potential biomarkers or therapeutic targets.</p><p><strong>Methods: </strong>We conducted a Mendelian randomization (MR) analysis using summary statistics from genome-wide association studies to evaluate both the direct effects and potential mediating roles of 731 immune cells and 1,400 serum metabolites in relation to UC. Instrumental variables were rigorously selected based on genome-wide significance and linkage disequilibrium thresholds. The primary analytical method was inverse variance weighted, supplemented by MR-Egger regression and weighted median methods to ensure robustness. Cochran's <i>Q</i> test, MR-Egger intercept, and leave-one-out analysis were employed to evaluate heterogeneity and pleiotropy. Mediation MR analysis was conducted to examine potential metabolite-mediated pathways.</p><p><strong>Results: </strong>We identified a statistically significant positive causal effect of CD39⁺ CD4⁺ T cell on UC risk (OR = 1.05, 95% CI = 1.03-1.08, <i>beta_all</i> = 0.05). Sensitivity analyses confirmed the robustness of this association, and reverse MR analysis indicated no causal effect of UC on CD39⁺ CD4⁺ T cell, suggesting a unidirectional relationship. Mediation analysis further revealed that succinyl carnitine (C4DC) partially mediated the effect of CD39⁺ CD4⁺ T cell on UC, with a mediation proportion of 3.3%.</p><p><strong>Conclusion: </strong>Our findings suggest that CD39⁺ CD4⁺ T cell may increase the risk of UC, potentially by modulating the levels of succinyl carnitine (C4DC). These results indicate a potential immunometabolic pathway in UC pathogenesis and highlight CD39⁺ CD4⁺ T cell and C4DC as promising targets for further research. However, additional experimental validation is required to confirm these findings and assess their clinical relevance.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251240"},"PeriodicalIF":1.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings.","authors":"Vesna G Marjanovic, Ivana Z Budic, Maja D Zecevic, Marija M Stevic, Dusica M Simic","doi":"10.1515/med-2025-1244","DOIUrl":"10.1515/med-2025-1244","url":null,"abstract":"<p><strong>Background: </strong>Intra-abdominal hypertension (IAH)/abdominal compartment syndrome (ACS) is one of the rarer clinical entities in the pediatric population, carrying a high degree of morbidity and mortality. The focus of this review is on assessing pathophysiological changes of organ systems in pediatric patients with risk factors for the occurrence of IAH/ACS based on the evaluation of diagnostic modalities and therapeutic strategies.</p><p><strong>Methodology: </strong>A comprehensive literature search of indexed databases was performed, aiming to identify, review, and evaluate published articles on IAH/ACS. The search was focused on studies examining pathophysiology, risk factors, diagnostic approaches, and management strategies.</p><p><strong>Results: </strong>The main risk factors encompass diminished abdominal wall compliance, increased intraluminal and abdominal contents, and capillary leak/fluid resuscitation. Diagnostic tools include clinical and imaging findings, intra-abdominal pressure (IAP) monitoring, and parameters of tissue perfusion. Therapeutic strategies involve non-surgical and surgical management of IAH/ACS in pediatric patients.</p><p><strong>Conclusion: </strong>Timely and continuous evaluation of IAP and parameters of tissue perfusion is crucial for the early diagnosis of IAH/ACS and implementing non-surgical procedures, reducing the need for surgical procedures. Future research should focus on the usefulness of advanced non-invasive monitoring technologies and the identification of predictors of increased IAP in the early implementation of personalized therapeutic strategies.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251244"},"PeriodicalIF":1.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation.","authors":"Yingbiao Wu, Can Jin, Luoning Zhu, Xiaogang Zhang, Xinpeng Cong, Budian Xing, Zhongping Ning","doi":"10.1515/med-2025-1223","DOIUrl":"10.1515/med-2025-1223","url":null,"abstract":"<p><p>Atherosclerosis (AS) is initiated by the activation of the endothelial cells, which is followed by a series of events that trigger the narrowing of blood vessels and the activation of inflammation. This study aimed to investigate <i>in vitro</i> the roles and underlying mechanisms of curdione in AS. Human umbilical vein endothelial cells (HUVECs) were stimulated with oxidized low-density lipoprotein (ox-LDL) and then treated with curdione, after which the growth of the HUVECs and the related mechanisms were determined. HUVECs with ERBB4 overexpression were constructed to explore the role of ERBB4 in curdione-mediated AS. The interaction among ERBB4, methylation, and curdione was confirmed by chromatin immunoprecipitation (ChIP)-quantitative PCR (qPCR) and dual luciferase reporter gene assays. Both curdione and ERBB4 overexpression individually and significantly enhanced viability and proliferation while suppressing apoptosis of the ox-LDL-induced HUVECs, and the combination of curdione and ERBB4 overexpression had better effects. Compared with the ox-LDL-induced HUVECs, both curdione and ERBB4 overexpression individually decreased the levels of IL-6, IL-1β, and IL-8 (<i>P</i> < 0.05). They also upregulated Bax, caspase-3, E-cadherin, and F-actin while downregulating Bcl-2 and VEGF (<i>P</i> < 0.05). Additionally, the ERBB4 bound to the DNMT1 gene, and the curdione participated in AS via the ERBB4 gene. The study demonstrated that either curdione or ERBB4 overexpression individually may ameliorate AS development by inhibiting apoptosis, inflammation, and the EndMT of HUVECs. In addition, curdione may protect the vascular endothelial cells and AS by regulating the DNMT1-mediated ERBB4 promoter methylation.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251223"},"PeriodicalIF":1.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis.","authors":"Yilin Wang, Xianhe Liang, Haitao Zhang, Jinhua Hao, Min Wei","doi":"10.1515/med-2024-1108","DOIUrl":"10.1515/med-2024-1108","url":null,"abstract":"<p><strong>Objective: </strong>To compare the diagnostic effects of computed tomography (CT) and bronchoscopy guided biopsy on pulmonary nodules.</p><p><strong>Methods: </strong>\"Subject words + free words\" were used to search four literature databases including Pubmed, Embase, Cochrane Library, and Web of Science. The subject words were CT, bronchoscope-guided biopsy, pulmonary nodules, and diagnosis. The search is up to August 25, 2023. The retrieved literature was screened, and the literature with duplicate, review, incomplete data or article content and inconsistent with our research was deleted. Revman 5.4 was used for bias analysis of the literatures included in the analysis, and forest map, funnel map, and ROC curve were drawn to compare the accuracy, specificity, and sensitivity of the two diagnostic methods.</p><p><strong>Results: </strong>A total of 2,622 articles were retrieved, and 8 articles were included in the study after screening. Bias analysis and funnel plot showed that eight included articles had higher quality and smaller bias. The sensitivity and specificity of the forest map were both 95% CI, and the sensitivity of CT diagnosis was better than that of bronchoscopy diagnosis, with similar specificity between the two groups. The funnel plot shows some heterogeneity in the literature on pulmonary nodules. The ROC curve shows that CT diagnosis is significantly superior to bronchoscopy diagnosis, with diagnostic accuracy approaching 100%.</p><p><strong>Conclusion: </strong>CT has significant advantages in detecting and diagnosing pulmonary nodules, as it can detect nodules in various parts of the lungs. However, bronchoscopy has significant advantages in diagnosing small pulmonary nodules.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241108"},"PeriodicalIF":1.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study.","authors":"Yiming Yao, Shiqiang Zhou, Yumin Fang, Wenxing Zeng, Shaofeng Zhan","doi":"10.1515/med-2025-1177","DOIUrl":"10.1515/med-2025-1177","url":null,"abstract":"<p><strong>Background: </strong>Previous research has indicated a possible association between asthma and ankylosing spondylitis (AS).</p><p><strong>Methods: </strong>We pinpointed single nucleotide polymorphisms linked to various forms of asthma and AS, employing them as instrumental variables for a bidirectional two-sample Mendelian randomization (TSMR) analysis. Our TSMR analysis focused on European populations to minimize racial confounding. Multivariate adjustments for body mass index (BMI), smoking, and alcohol use were performed to control for confounders. Colocalization analysis was used to validate MR findings and explore genetic links between asthma and AS.</p><p><strong>Results: </strong>Individuals with asthma and eosinophilic asthma exhibited a relatively higher risk of AS (asthma: OR 1.31, 95% CI 1.07-1.62, <i>P</i> = 0.008; eosinophilic asthma: OR 1.24, 95% CI 1.005-1.544, <i>P</i> = 0.044). Allergic asthma, childhood-onset asthma, and obesity-related asthma showed no causal relationship with AS (allergic asthma: IVW <i>P</i> = 0.27; childhood-onset asthma: IVW <i>P</i> = 0.66; obesity-related asthma: IVW <i>P</i> = 0.53). After adjusting for cigarette smoking, alcohol consumption, and BMI, the results supported a direct causal effect of asthma on the increased risk of AS onset (IVW <i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>This study revealed that a positive causal connection between asthma, specifically eosinophilic asthma, and AS.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251177"},"PeriodicalIF":1.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations of health literacy with individuals' understanding and use of medications in Southern Taiwan.","authors":"Pin-Tzu Chen, Min-Li Chen, Li-Chun Chang, Chin-Ho Kuo, Yu-Hsiang Kuan","doi":"10.1515/med-2025-1203","DOIUrl":"10.1515/med-2025-1203","url":null,"abstract":"<p><strong>Background: </strong>Investigated the relationship between health literacy and treatment adherence and compliance due to incorrect medication use resulting from low health literacy in southern Taiwan.</p><p><strong>Methods: </strong>A cross-sectional study in Chiayi, Taiwan (Sep-Nov 2013) used randomized sampling to survey 300 adults. Health literacy was assessed via the test of functional health literacy in adults, and medication knowledge/behavior was assessed via a validated questionnaire (KR-20 = 0.83). Data were analyzed using SPSS (chi-square, <i>t</i>-tests, ANOVA, Pearson's correlation, <i>P</i> < 0.05).</p><p><strong>Results: </strong>It was found that 97.9% of the respondents had adequate health literacy. Age negatively correlated with health literacy (<i>r</i> = -0.395; <i>P</i> < 0.0001) and positively with medication knowledge (<i>r</i> = 0.121; <i>P</i> = 0.038). Women exhibited higher health literacy and medication knowledge than men. Higher education levels and living with health professionals were associated with better health literacy. Patients with chronic diseases had lower health literacy than those without (mean scores: 31.5 vs 32.7). Significant correlations were observed between health literacy and treatment adherence and compliance and use.</p><p><strong>Conclusions: </strong>Targeted health literacy interventions are required across different ages, genders, and education levels to improve medication use and health outcomes. Future research should examine the long-term effects of these interventions.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251203"},"PeriodicalIF":1.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of serum calprotectin with outcome of acute cerebral infarction.","authors":"HaiYan Li, KaiMeng Zhao, WenWen Yu","doi":"10.1515/med-2025-1207","DOIUrl":"10.1515/med-2025-1207","url":null,"abstract":"<p><strong>Objective: </strong>This study was to investigate the correlation between serum calprotectin (Cal) and the severity and outcome of patients with acute cerebral infarction (ACI).</p><p><strong>Methods: </strong>Clinical data and serum Cal data were collected from 160 ACI patients and 60 healthy individuals. ACI patients were grouped according to their prognosis. Clinical data, biochemical indicators, and Cal levels were measured. Correlations between serum Cal and National Institute of Health stroke scale (NIHSS) scores, Glasgow Coma Scale (GCS) scores, and hematocrit (HCT) were analyzed.</p><p><strong>Results: </strong>In ACI patients, elevated serum Cal levels were observed. These levels were positively correlated with NIHSS scores and inversely correlated with GCS scores and HCT. The receiver operating characteristic curve showed that serum Cal had an area under the curve of 0.770 for predicting poor outcomes, with a diagnostic cutoff of 18.01 mg/L. Serum Cal levels over 18.01 mg/L were independently related to poor prognosis for ACI and were identified as an independent risk factor for adverse outcomes.</p><p><strong>Conclusion: </strong>Serum Cal shows high expression in patients with ACI. Serum Cal has a good predictive value for the outcome of ACI.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251207"},"PeriodicalIF":1.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital.","authors":"Dae-Hwan Lee, Bong-Sik Woo, Jong-Hyeon Lim, Jin-Ook Choi, Yong-Hwa Park","doi":"10.1515/med-2025-1212","DOIUrl":"10.1515/med-2025-1212","url":null,"abstract":"<p><strong>Background and aim: </strong>Stroke patients with low levels of walking independence often experience persistent deficits in gait and balance, which significantly limit their functional mobility and quality of life. Robotic-assist gait training (RAGT) has emerged as a promising intervention to promote motor recovery and improve postural control in this patients. While previous studies have demonstrated the benefits of RAGT, few have directly compared the effects of fixed end-effector type and mobile robotic gait devices in patients with severely impaired ambulation. This study aimed to investigate and compare the effects of these two robotic gait training on balance and lower extremities motor recovery in stroke patients classified as functional ambulation category 0 to 2.</p><p><strong>Methods: </strong>Twenty-eight stroke patients were randomly assigned to either end-effector or mobile robot groups, undergoing 12 weeks of therapy with one daily robotic session and seven conventional physical therapy sessions per week. Outcomes were measured using the Berg Balance Scale (BBS) and Fugl-Meyer Assessment for Lower Extremity (FMA-LE), with subcategory analysis for reflex activities, volitional movement within synergies, volitional movement mixing synergies, volitional movement with little or no synergy, normal reflex activity, and coordination/speed.</p><p><strong>Results: </strong>Both groups showed significant improvements in BBS and FMA-LE, with the mobile robot group showing greater gains. Both groups improved in walking independence, though no significant difference was found between them. Subcategory analysis showed improvements in reflex activities and coordination/speed in both groups, but volitional movement within synergies and volitional movement with little or no synergy improved only in the mobile robot group. Correlation analysis revealed significant relationships between FAC and BBS, and BBS and reflex activities. Volitional movement within synergies and volitional movement mixing synergies had high correlations with motor recovery.</p><p><strong>Conclusion: </strong>Both robotic methods effectively improved balance and motor recovery, with mobile robots showing greater potential for enhancing functional autonomy.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251212"},"PeriodicalIF":1.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review.","authors":"Ensiyeh Jenabi, Hoda Arabzadeh, Sara Abdoli, Salman Khazaei","doi":"10.1515/med-2025-1217","DOIUrl":"10.1515/med-2025-1217","url":null,"abstract":"<p><strong>Background: </strong>There is no umbrella review on maternal risk factors associated with intrauterine growth retardation (IUGR). Therefore, we assessed an umbrella review on maternal risk factors during pregnancy for IUGR.</p><p><strong>Methods: </strong>We searched three prominent international databases: PubMed, Scopus, Web of Science, and Cochrane Library. We focused on meta-analyses that examined maternal factors during pregnancy associated with IUGR. The comparison was based on the odds ratio (OR) or related risk ratios reported in the included studies, heterogeneity <i>I</i> ², 95% prediction interval, small-study effects, excess significance biases, and sensitive analysis.</p><p><strong>Results: </strong>Four risk factors for IUGR include placenta previa with an OR of 1.19, placenta abruption with an OR of 2.06, epilepsy in pregnancy with an OR of 1.28, and hepatitis C virus (HCV) infection with an OR of 1.53 were categorized as having suggestive evidence (Class III). Celiac disease with an OR of 2.48 and mullerian anomaly with an OR of 1.93 were considered risk factors with weak evidence (Class IV).</p><p><strong>Conclusion: </strong>Four risk factors for IUGR including placenta previa, placenta abruption, epilepsy in pregnancy, and HCV infection were categorized as having suggestive evidence (Class III). Celiac disease and Mullerian anomaly were considered risk factors with weak evidence (Class IV).</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251217"},"PeriodicalIF":1.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery.","authors":"Jiaoyan Lian, Fang Zhang, Haoyu Chen","doi":"10.1515/med-2025-1204","DOIUrl":"10.1515/med-2025-1204","url":null,"abstract":"<p><strong>Objective: </strong>This work investigated intraoperative nutritional risk and nutritional support for children with congenital diabetes.</p><p><strong>Materials and methods: </strong>A total of 60 cases of children with congenital diabetes were assigned into two groups: the intravenous group (<i>n</i> = 30) and the oral group (<i>n</i> = 30). Medications were administered based on the actual conditions of patients. After surgery, the relationship between intraoperative nutritional risk score and glucose changes was studied.</p><p><strong>Results: </strong>All patients had normal liver and kidney function. In the intravenous group, 26 cases had sufficient calorie intake. The numbers of cases with normal nutrition, malnutrition, and severe malnutrition were 7, 12, and 11, respectively. The incidences of infection, delayed wound healing (DWH), difficult glucose control (DGC), and respiratory system complications were 3, 6, 12, and 1, respectively. In the oral group, 21 cases had sufficient calorie intake. Numbers of cases with normal nutrition, malnutrition, and severe malnutrition were 8, 9, and 13, respectively. The incidences of infection, DWH, and DGC were 2, 6, and 9, respectively. Fasting blood glucose <6.5 mmol/L and body mass index <17.3 were independent risk factors affecting nutritional support.</p><p><strong>Conclusion: </strong>Nutritional risk assessment and support during surgery for children with congenital diabetes were crucial for appropriate support.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251204"},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}