Open Medicine最新文献

{"title":"Plant polyphenols, terpenes, and terpenoids in oral health.","authors":"Vida Arzani, Mohsen Soleimani, Tilman Fritsch, Ursula M Jacob, Vittorio Calabrese, Ahmad Arzani","doi":"10.1515/med-2025-1183","DOIUrl":"https://doi.org/10.1515/med-2025-1183","url":null,"abstract":"<p><strong>Introduction: </strong>Herbal products are increasingly being used for their potential to promote oral health. Phytochemicals can act as scavengers of reactive or toxic chemicals, selective growth factors for beneficial oral bacteria, fermentation substrates for beneficial oral bacteria, and selective inhibitors of harmful oral microflora. Plant-derived secondary metabolites encompass a variety of natural products, including alkaloids, polyphenols (including flavonoids and tannins), terpenes, terpenoids, steroids, saponins, quinones, coumarins, glycosides, and carotenoids.</p><p><strong>Objectives: </strong>This review explores medicinal plant-based products for preventing and treating oral diseases, offering updated insights into the scientific basis for using herbs as active ingredients in oral health care. Hence, we focused on: (1) phenolic compounds, the most abundant and common phytochemicals and (2) terpenes and terpenoids, the most diverse and widely distributed group in the plant kingdom.</p><p><strong>Methods: </strong>Several databases were queried to acquire peer-reviewed studies focusing on the major phytochemical compositions - phenolic compounds, terpenes, and terpenoids - and their oral health benefits.</p><p><strong>Results: </strong>The review lists numerous medicinal herbs in various forms and applications for treating dental caries, gingivitis, and periodontitis.</p><p><strong>Conclusion: </strong>This review explores the evidence supporting the oral health-promoting effects of specific constituents in herbs with the potential for incorporation into pharmaceutical formulations.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251183"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study.","authors":"Xinhang Hu, Fenglei Yu, Muyun Peng, Zhi Yang, Yifan Ouyang, Zhe Zhang, Wangcheng Zhao, Xuyang Yi, Huali Hu, Xingchun Huang, Li Wang","doi":"10.1515/med-2025-1171","DOIUrl":"https://doi.org/10.1515/med-2025-1171","url":null,"abstract":"<p><strong>Purpose: </strong>Marginal zone lymphoma (MZL) is a rare subtype of non-Hodgkin lymphoma, and its diagnosis primarily relies on pathological biopsy. The study aims to investigate the causal relationships between 41 inflammatory cytokines and MZL using a two-sample bidirectional Mendelian randomization (MR) approach, providing new insights and methodologies for rapid differential diagnosis and treatment strategies.</p><p><strong>Methods: </strong>Causal associations between 41 inflammatory cytokines and MZL were examined using genetic variant data from two large-scale genome-wide association studies. The inverse variance weighting method was employed, and multiple sensitivity analyses, including MR-Egger, weighted median, simple model, and weighted model methods, were conducted to strengthen the robustness of the findings.</p><p><strong>Results: </strong>Elevated levels of MIG and IL-10 were associated with an increased risk of MZL (MIG: OR = 1.57, <i>p</i> = 0.035; IL-10: OR = 1.69, <i>p</i> = 0.021), while higher B-NGF levels exhibited a protective effect (OR = 0.46, <i>p</i> = 0.027). Reverse MR analysis revealed a negative correlation between MZL and IFN-γ levels (OR = 0.97, <i>p</i> = 0.015).</p><p><strong>Conclusions: </strong>MIG, IL-10, B-NGF, and IFN-γ are potential biomarkers and therapeutic targets for MZL. IFN-γ likely acts as a downstream molecule in MZL pathogenesis, offering novel insights into MZL-related research, clinical diagnosis, and treatment strategies.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251171"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"rSIG combined with NLR in the prognostic assessment of patients with multiple injuries.","authors":"Dan Wei, Xing Liu, Yanlai Gu, Qiuhong Fu, Hua Tang","doi":"10.1515/med-2025-1161","DOIUrl":"https://doi.org/10.1515/med-2025-1161","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the significance of the reverse shock index multiplied by the Glasgow Coma Scale score (rSIG) and the neutrophil-lymphocyte ratio (NLR) in the prediction of prognosis in patients with multiple injuries.</p><p><strong>Methods: </strong>The clinical data of 142 patients with multiple injuries admitted to the Emergency Department of Shenzhen Longhua District Central Hospital between January 2019 and December 2022 were retrospectively analyzed. Subjects were divided into the survival group (<i>n</i> = 102) and the deceased group (<i>n</i> = 40) based on their survival status at 28 days after injury. We subsequently analyzed the intergroup differences in blood test results, rSIG, and NLR, as well as the relationship between rSIG and NLR. The predictive value of rSIG, NLR, and both combined in determining the prognosis of patients with multiple injuries was explored by plotting the receiver operator characteristic (ROC) curve. Based on the optimal cut-point value of the ROC curves, subjects were divided into groups with rSIG ≤ 7.75 (22 patients) and rSIG > 7.75 (120 patients), as well as groups with NLR ≤ 10.36 (104 patients) and NLR > 10.36 (38 patients), and the 28-day mortality rate was compared between the groups.</p><p><strong>Results: </strong>A total of 142 patients were enrolled. The rSIG of the survival group (<i>n</i> = 102) was significantly greater (15.7 ± 4.8) than that of the deceased group (<i>n</i> = 40, 6.2 ± 2.9), (<i>t</i> = 14.307, <i>p</i> < 0.001). The NLR of the survival group was higher than that of the deceased group, but the difference was not statistically significant (<i>p</i> > 0.05). The area under the curve (AUC) of the ROC of NLR was significantly greater than that of rSIG (0.922 vs 0.54) (<i>Z</i> = -7.881, <i>p</i> < 0.001). The AUC for NLR was also statistically greater than that of the combination of rSIG and NLR (0.963 vs 0.54) (<i>Z</i> = -8.378, <i>p</i> < 0.001). The AUC of the combination of rSIG and NLR was significantly greater than that of rSIG (0.844 vs 0.540) (<i>Z</i> = 2.239, <i>p</i> = 0.025). The 28-day mortality rate of patients in the rSIG ≤ 7.75 group was also significantly greater than that of patients in the rSIG > 7.75 group (10.0%) (<i>p</i> < 0.05). Finally, the 28-day mortality rate in the group with an NLR ≤ 10.36 was lower than that in the group with an NLR > 10.36 (<i>p</i> < 0.05). Pearson correlation analysis showed that the correlation coefficient between rSIG and NLR was <i>r</i> = 0.13, which did not reach statistical significance (<i>p</i> = 0.12).</p><p><strong>Conclusion: </strong>NLR, rSIG, and the combination of the two are all valuable in predicting the prognosis of patients with multiple injuries (all AUC > 0.5). However, the predictive capacity of NLR was better than either rSIG alone or both combined. These findings may serve as references in guiding the treatment of patients with multiple injuries in clinical practice.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251161"},"PeriodicalIF":1.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction of \"miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway\".","authors":"Weidong Zhou, Peifei Li, Peihua Jin","doi":"10.1515/med-2025-9995","DOIUrl":"https://doi.org/10.1515/med-2025-9995","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1515/med-2021-0369.].</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20259995"},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and clinical significance of ITGA3 in breast cancer.","authors":"Huachun Song, Meihui Gao, Zheng Bao, Yong Yang, Yang Chen, Jing Hao","doi":"10.1515/med-2024-1113","DOIUrl":"10.1515/med-2024-1113","url":null,"abstract":"<p><strong>Background: </strong>Integrin subunit Alpha 3 is essential for cell adhesion and movement, but its role in breast cancer (BC) is unclear. This study evaluated ITGA3 expression in BC and its clinical significance.</p><p><strong>Methods: </strong>The Human Protein Atlas (HPA), UALCAN, and Kaplan-Meier plotter were used to analyze ITGA3 in BC. ITGA3 was evaluated using receiver operating characteristic curves. The cell counting kit-8 test was used to examine the role of ITGA3 in cell proliferation.</p><p><strong>Results: </strong>BC tissues' ITGA3 protein and mRNA levels were significantly lower than normal controls. ITGA3 was associated with better recurrence-free survival (RFS) and distant metastasis-free survival, especially in estrogen receptor (ER)-positive, Luminal B, and Luminal B subtypes. ITGA3 predicted RFS for 5 years and the response to chemotherapy. ITGA3 was associated with ER status but not age, tumor, node, metastasis stages, or tumor size. ITGA3 has a positive impact on BC cell growth.</p><p><strong>Conclusions: </strong>ITGA3 may be a predictive marker for BC and a therapeutic target. These findings need to be confirmed, and the molecular mechanisms of ITGA3 need to be clarified.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241113"},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy.","authors":"Fengxia Zhang, Xianhu Tang, Zhimei Zeng, Chunyu Cao, Caocui Yun, Yue Shen, Chaohong Nie, Ying Xiong, Mao Chulian, Yueheng Wu, Ruiquan Xu","doi":"10.1515/med-2025-1146","DOIUrl":"10.1515/med-2025-1146","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic kidney disease (DKD) represents serious diabetes-associated complications, and podocyte loss is an important histologic sign of DKD. The cellular and molecular profiles of podocytes in DKD have yet to be fully elucidated.</p><p><strong>Methods: </strong>This study analyzed kidney-related single-nucleus RNA-seq datasets (GSE131882, GSE121862, and GSE141115) and human diabetic kidney glomeruli transcriptome profiling (GSE30122). ARHGAP28 expression was validated by western blot and immunohistochemistry.</p><p><strong>Results: </strong>In human kidney tissues, 154 differentially expressed genes (DEGs) were identified in podocytes, which were enriched in biological processes related to nephron development and extracellular matrix-receptor interactions. Similarly, in the mouse kidney, 344 DEGs were found, clustering in pathways associated with renal development and signaling mechanisms like PI3K/Akt (phosphatidylinositol-3 kinase/protein kinase B) and PPAR (peroxisome proliferator-activated receptor). In diabetic human kidney glomeruli, 438 DEGs were identified, showing significant enrichment in pathways related to diabetic nephropathy. Venn analysis revealed 22 DEGs common across human and mouse podocytes and diabetic glomeruli, with ARHGAP28 being notably overexpressed in podocytes. The diabetic nephropathy model using db/db mice showed that ARHGAP28 expression was significantly upregulated in the kidney cortex and glomeruli. <i>In vitro</i> studies using a high-glucose podocyte model corroborated these findings.</p><p><strong>Conclusions: </strong>Collectively, this study provides an insight into the function and diagnosis of DKD and indicates that ARHGAP28 in podocytes is a potential biomarker of DKD.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251146"},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury.","authors":"Yang Cao, Yansong Liu, Yunlong Li, Junbo Zheng, Yue Wang, Hongliang Wang","doi":"10.1515/med-2025-1156","DOIUrl":"10.1515/med-2025-1156","url":null,"abstract":"<p><strong>Background: </strong>Sepsis is a prevalent and severe condition. However, research investigating the relationship between the immune microenvironment in sepsis-associated acute kidney injury (SA-AKI) through diagnostic models using RNA biomarkers remains limited. Therefore, this study developed a diagnostic model using gene expression data from the Gene Expression Omnibus (GEO) database, leveraging a sufficient sample size.</p><p><strong>Methods: </strong>We proposed a computational method to identify RNAs Rela and Stat3 constructing a diagnostic model using Least Absolute Shrinkage and Selection Operator regression algorithms. Gene expression data from the GEO, comprising five samples each of SA-AKI and sepsis, were analyzed.</p><p><strong>Results: </strong>Diagnostic models were developed for the datasets, followed by immune cell infiltration and correlation analyses. Experiments were conducted to test and confirm the high expression of Stat3 via Rela in AKI cells post-sepsis, leading to a worse prognosis.</p><p><strong>Conclusion: </strong>This study identified the significant roles of RNAs Rela and Stat3 in SA-AKI. The developed diagnostic model demonstrated improved accuracy in identifying SA-AKI, suggesting that these RNA markers may provide valuable insights into the pathophysiology of SA-AKI and enhance early diagnosis. These findings contribute to a better understanding of immune-related mechanisms underlying SA-AKI and may inform future therapeutic strategies.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251156"},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern \"A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma\".","authors":"","doi":"10.1515/med-2025-9996","DOIUrl":"https://doi.org/10.1515/med-2025-9996","url":null,"abstract":"","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20259996"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients.","authors":"Qingyun Li, Xinqiang Zhong, Tongxia Cui, Bairong Chen, Weiping Zhu","doi":"10.1515/med-2025-1155","DOIUrl":"10.1515/med-2025-1155","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a risk factor for cardiovascular disease. The present study aimed to explore the impact of ambulatory blood pressure load (BPL) on mitral regurgitation (MR) in continuous ambulatory peritoneal dialysis (CAPD) patients.</p><p><strong>Methods: </strong>A total of 215 CAPD patients hospitalized in the Department of Nephrology at the Fifth Affiliated Hospital of Sun Yat-sen University between November 2017 and June 2022 were included in the study. All subjects underwent 24-h ambulatory BP monitoring and an echocardiography examination. BPL and MR area (MRA) were calculated. Subjects were divided into high regurgitation group and non-high regurgitation group. General data were also collected. The effect of ambulatory BPL on MR in CAPD patients was analyzed using multiple linear regression.</p><p><strong>Results: </strong>Baseline data comparison revealed statistically significant differences in hemoglobin, serum β₂-microglobulin, NT-proBNP, left atrial diameter (LAD), left ventricular end-diastolic diameter (LVDD), LV ejection fraction (LVEF), LV fractional shortening (LVFS), and mitral valve calcification between the high and non-high regurgitation groups (<i>P</i> < 0.05). There was no statistically significant difference in other clinical characteristics. Correlation analysis showed correlations between MRA and 24-h systolic BPL (24h-SBPL), 24-h diastolic BPL (24h-DBPL), daytime systolic BPL (D-SBPL), daytime DBPL (D-DBPL), nighttime systolic BPL (N-SBPL), nighttime DBPL (N-DBPL), hemoglobin level, NT-proBNP level, LAD, LVDD, LVEF, and LVFS. Multiple linear regression analysis revealed that the effects of 24h-DBPL and D-DBPL on MRA were statistically significantly different (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>Ambulatory BPL, particularly 24h-DBPL and D-DBPL, significantly affected MR. Therefore, controlling BPL, especially DBPL, was essential for reducing the incidence of cardiovascular events and clinical mortality in CAPD patients.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251155"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study.","authors":"Liang Li, Jianjun Bian, Yuxuan Su, Chunchun Zhang","doi":"10.1515/med-2025-1151","DOIUrl":"10.1515/med-2025-1151","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to explore the efficacy and safety of azacitidine (AZA) in middle-aged and elderly patients with myelodysplastic syndrome (MDS).</p><p><strong>Methods: </strong>The clinical data of 59 middle-aged and elderly patients with middle- and high-risk MDS, who attended our hospital from April 2019 to January 2024, were retrospectively analyzed and were divided into an observation group (AZA) and a control group (conventional supportive treatment) according to the treatments, and the patients in the two groups were evaluated for their clinical efficacy and safety.</p><p><strong>Results: </strong>The overall response rate of the observation group was 66.67%. In terms of blood cells, the observation group's blood cell level after four courses of treatment was significantly higher than that of the control group (<i>P</i> < 0.05). In terms of lactate dehydrogenase (LDH), the level of LDH decrease after four courses of treatment in the observation group was significantly better than that in the control group (<i>P</i> < 0.05). The safety of both groups was good.</p><p><strong>Conclusions: </strong>AZA is safe and effective in the treatment of high risk MDS in middle and old age patients.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251151"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}