Correlation of serum calprotectin with outcome of acute cerebral infarction.

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2025-07-08 eCollection Date: 2025-01-01 DOI:10.1515/med-2025-1207

HaiYan Li, KaiMeng Zhao, WenWen Yu

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引用次数: 0

Abstract

Objective: This study was to investigate the correlation between serum calprotectin (Cal) and the severity and outcome of patients with acute cerebral infarction (ACI).

Methods: Clinical data and serum Cal data were collected from 160 ACI patients and 60 healthy individuals. ACI patients were grouped according to their prognosis. Clinical data, biochemical indicators, and Cal levels were measured. Correlations between serum Cal and National Institute of Health stroke scale (NIHSS) scores, Glasgow Coma Scale (GCS) scores, and hematocrit (HCT) were analyzed.

Results: In ACI patients, elevated serum Cal levels were observed. These levels were positively correlated with NIHSS scores and inversely correlated with GCS scores and HCT. The receiver operating characteristic curve showed that serum Cal had an area under the curve of 0.770 for predicting poor outcomes, with a diagnostic cutoff of 18.01 mg/L. Serum Cal levels over 18.01 mg/L were independently related to poor prognosis for ACI and were identified as an independent risk factor for adverse outcomes.

Conclusion: Serum Cal shows high expression in patients with ACI. Serum Cal has a good predictive value for the outcome of ACI.

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血清钙保护蛋白与急性脑梗死预后的相关性。

目的：探讨血清钙保护蛋白（Cal）与急性脑梗死（ACI）患者严重程度及预后的关系。方法：收集160例ACI患者和60例正常人的临床资料和血清Cal资料。ACI患者根据预后进行分组。测量临床资料、生化指标和钙水平。分析血清钙与美国国立卫生研究院卒中量表（NIHSS）评分、格拉斯哥昏迷量表（GCS）评分和红细胞压积（HCT）之间的相关性。结果：ACI患者血清钙水平升高。这些水平与NIHSS评分呈正相关，与GCS评分和HCT呈负相关。受试者工作特征曲线显示，血清Cal预测不良预后的曲线下面积为0.770，诊断临界值为18.01 mg/L。血清钙水平超过18.01 mg/L与ACI预后不良独立相关，并被确定为不良结局的独立危险因素。结论：血清钙在ACI患者中呈高表达。血清钙对ACI预后有较好的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.