The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review.

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2025-06-27 eCollection Date: 2025-01-01 DOI:10.1515/med-2025-1217

Ensiyeh Jenabi, Hoda Arabzadeh, Sara Abdoli, Salman Khazaei

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引用次数: 0

Abstract

Background: There is no umbrella review on maternal risk factors associated with intrauterine growth retardation (IUGR). Therefore, we assessed an umbrella review on maternal risk factors during pregnancy for IUGR.

Methods: We searched three prominent international databases: PubMed, Scopus, Web of Science, and Cochrane Library. We focused on meta-analyses that examined maternal factors during pregnancy associated with IUGR. The comparison was based on the odds ratio (OR) or related risk ratios reported in the included studies, heterogeneity I ², 95% prediction interval, small-study effects, excess significance biases, and sensitive analysis.

Results: Four risk factors for IUGR include placenta previa with an OR of 1.19, placenta abruption with an OR of 2.06, epilepsy in pregnancy with an OR of 1.28, and hepatitis C virus (HCV) infection with an OR of 1.53 were categorized as having suggestive evidence (Class III). Celiac disease with an OR of 2.48 and mullerian anomaly with an OR of 1.93 were considered risk factors with weak evidence (Class IV).

Conclusion: Four risk factors for IUGR including placenta previa, placenta abruption, epilepsy in pregnancy, and HCV infection were categorized as having suggestive evidence (Class III). Celiac disease and Mullerian anomaly were considered risk factors with weak evidence (Class IV).

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妊娠期间母体因素对宫内发育迟缓的影响：综述。

背景：目前尚无与宫内生长迟缓（IUGR）相关的母体危险因素的综述。因此，我们对IUGR孕妇妊娠期间的危险因素进行了综合评估。方法：检索PubMed、Scopus、Web of Science、Cochrane Library三个国际知名数据库。我们关注于检查妊娠期间与IUGR相关的母体因素的荟萃分析。比较基于纳入研究中报告的优势比（OR）或相关风险比、异质性i2、95%预测区间、小研究效应、过度显著性偏差和敏感分析。结果：IUGR的4个危险因素包括前置胎盘（OR为1.19）、胎盘早剥（OR为2.06）、妊娠期癫痫（OR为1.28）和丙型肝炎病毒（HCV）感染（OR为1.53）被归为具有提示证据（III类）。乳糜泻OR为2.48，缪勒管异常OR为1.93被认为是证据不足的危险因素（IV类）。结论：IUGR的4个危险因素包括前置胎盘、胎盘早剥、妊娠期癫痫和HCV感染被列为具有提示证据（III类）。乳糜泻和缪勒管异常被认为是证据不足的危险因素（IV类）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.