Oral health & preventive dentistry最新文献

{"title":"Association between Live Dietary Microbes and Root Caries: A Cross-Sectional Study with a Predictive Risk Model.","authors":"Donglei Wu, Zhengshen Lin, Peng Zhou, Hongxia You, Weixuan Chen, Yuyan Zheng","doi":"10.3290/j.ohpd.c_2532","DOIUrl":"10.3290/j.ohpd.c_2532","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between medium‑to‑high (MedHi) levels of live dietary microbe intake and the prevalence of root caries, and to develop a predictive model for estimating root caries risk.</p><p><strong>Methods and materials: </strong>This cross‑sectional study analysed data from participants in the National Health and Nutrition Examination Survey (NHANES) 2015-2020. Dietary intake was assessed using 24‑h dietary recalls, and root caries status was determined via standardised oral examinations. Univariate and multivariable logistic regression analyses were conducted to identify factors associated with root caries, including live dietary microbe intake. Participants were randomly divided into training and testing data sets. A least absolute shrinkage and selection operator (LASSO) regression was used to construct a predictive model, which was visualised using a nomogram and evaluated by receiver operating characteristic (ROC) curves and calibration plots.</p><p><strong>Results: </strong>Among 7,839 participants, MedHi live dietary microbe intake, age, education level, smoking status, dental floss frequency, and systemic conditions were significantly associated with root caries (P 0.05). The predictive model incorporating these variables demonstrated good discrimination and calibration in both the training and testing data sets.</p><p><strong>Conclusion: </strong>Higher intake of live dietary microbes was associated with a lower prevalence of root caries. Although the cross‑sectional design precludes causal inference, the findings suggest a potential link between dietary microbes and oral health. The proposed model may aid clinicians in identifying individuals at high risk and in developing targeted preventive strategies.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"145-154"},"PeriodicalIF":1.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12933191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics Identification and Functional Analysis of Key Genes of Nucleotide Metabolism in Oral Squamous Cell Carcinoma.","authors":"Feng Wei, Hong Fan","doi":"10.3290/j.ohpd.c_2470","DOIUrl":"10.3290/j.ohpd.c_2470","url":null,"abstract":"<p><strong>Purpose: </strong>Oral squamous cell carcinoma (OSCC) is a typical hypoxic and metabolically heterogeneous adult invasive oral malignant tumour. Nucleotide metabolism-related genes (NMRGs) have been identified as therapeutic targets for various cancers. This study aims to analyse the characteristics of NMRGs in OSCC and identify potential biomarkers.</p><p><strong>Materials and methods: </strong>Based on the the Cancer Genome Atlas (TCGA) and GEO data, differentially expressed genes (DEGs) in OSCC were screened and intersected with NMRGs to obtain DE-NMRGs. Key genes were selected through the protein interaction (PPI) network combined with MCC and MCODE algorithms, and receiver operating characteristic (ROC) and survival curves were drawn. Genes with an area under the curve (AUC) > 0.7 and statistically significant differences were selected as hub genes. Further analysis of the immune infiltration characteristics, gene set enrichment analysis (GSEA) enrichment, potential drug effects of hub genes, and construction of the ceRNA network were conducted.</p><p><strong>Results: </strong>Three hub genes related to nucleotide metabolism (ADA, NT5E, and TYMS) were identified, showing good diagnostic performance (AUC > 0.7). Immune analysis showed that cytotoxic lymphocytes, B lineage, and monocytic lineage had increased infiltration in OSCC (P 0.05). The ceRNA network showed that hsa-miR-30a-5p, hsa-miR-30b-5p interacted with NT5E, and hsa-miR-192-5p, hsa-miR-215-5p interacted with TYMS. Drug prediction suggested that denileukin difitox ontak, STREPTOZOCIN, and nitrogen mustard may be potential therapeutic drugs for OSCC.</p><p><strong>Conclusion: </strong>ADA, NT5E and TYMS can serve as potential diagnostic markers and therapeutic targets for OSCC. The study has reference value for early diagnosis and the development of individualised treatment strategies.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"119-136"},"PeriodicalIF":1.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Oral Hygiene Practices and Their Effectiveness: A Systematic Review of the Evidence.","authors":"Muhammad Shahzad, Habab Ali Ahmad, Sriram Ambadi, Shenita Peterson, Irene Yang","doi":"10.3290/j.ohpd.c_2475","DOIUrl":"10.3290/j.ohpd.c_2475","url":null,"abstract":"<p><strong>Purpose: </strong>Given the increasing interest in natural and sustainable oral hygiene options, this systematic review evaluates the efficacy of traditional oral hygiene practices, specifically miswak and oil pulling, in maintaining oral health compared with conventional practices, addressing the question: how do these practices affect plaque and gingival outcomes relative to toothbrushing and standard rinses? We hypothesized non-inferiority for short-term plaque/gingivitis control, with limited evidence for longer-term outcomes.</p><p><strong>Materials and methods: </strong>A systematic review was conducted following PRISMA guidelines. Comprehensive literature searches were performed in PubMed, Embase.com, Global Health (CABI), Scopus, and Web of Science up to April 2024 using predefined inclusion criteria, focusing on randomized controlled trials and quasi-experimental designs that evaluated traditional oral hygiene methods against conventional practices. Data extraction, quality assessment, and risk bias analysis were conducted independently by two reviewers. Preliminary pilot searches (targeted scoping) were undertaken to refine concepts, eligibility criteria, and keywords. No formal scoping review was registered.</p><p><strong>Results: </strong>Thirty-one studies met the inclusion criteria. Miswak statistically significantly reduced plaque accumulation and gingival inflammation, performing comparably to or better than conventional toothbrushes. Herbal dentifrices and mouthwashes containing neem, clove, turmeric, and ginger exhibited antimicrobial properties and were as effective as fluoridated products in reducing plaque and gingival inflammation. Oil pulling with sesame or coconut oil showed moderate reductions in microbial load and improved gingival health, though findings varied compared to chlorhexidine mouthwash. Indigenous methods, (e.g., finger brushing, twigs, charcoal) offered accessibility and sustainability benefits but lacked extensive clinical validation.</p><p><strong>Conclusion: </strong>Traditional oral hygiene practices may offer benefits similar to conventional methods. Nonetheless, methodological limitations and variability among studies necessitate cautious interpretation of these findings. Further thorough research is required to confirm their efficacy and integration into modern oral care.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"107-118"},"PeriodicalIF":1.4,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Immediate vs Delayed Dental Implants on Survival, Patient Satisfaction, and Quality of Life.","authors":"Yi Yang, Shuncheng Zhou, Yihui Ma, Xiang Wang, Jinfang Chen, Qingshan Dong","doi":"10.3290/j.ohpd.c_2438","DOIUrl":"10.3290/j.ohpd.c_2438","url":null,"abstract":"<p><strong>Purpose: </strong>This randomised controlled trial investigated whether immediate placement confers any advantage over delayed placement with respect to implant survival (primary outcome), peri-implant health, patient-reported satisfaction (VAS) and oral-health-related quality of life (OHIP-14).</p><p><strong>Methods and materials: </strong>This study included 220 patients with missing teeth, randomly divided into a control group (n = 110) and an observation group (n = 110) using a random number table (block = 10, concealed allocation). Baseline variables (age, sex, BMI, tooth site, aetiology and oral hygiene habits) showed no statistically significant between-group differences (all P > 0.05). The control group received delayed implants, while the observation group received immediate implants. Outcomes measured included implant survival rate, periodontal indexes (PD, mPLI, mSBI), aesthetic evaluation (PES, WES), quality of life (OHIP-14), and patient satisfaction (VAS). Attachment level in the satisfaction assessment refers to the perceived gingival margin position relative to the restoration, evaluated subjectively by patients using a visual analogue scale rather than clinical probing measurements.</p><p><strong>Results: </strong>At 1 year, implant survival rates were 95.45% (105/110) in the immediate group versus 92.73% (102/110) in the delayed group, with no statistically significant difference (χ2 = 0.736, P = 0.391). The observation group demonstrated significantly lower mean values compared to the control group for PD (3.16 ± 0.51 mm vs 3.39 ± 0.59 mm), mPLI (0.95 ± 0.38 vs 1.21 ± 0.54), and mSBI (0.85 ± 0.47 vs 1.01 ± 0.35) (all P 0.05). The PES total scores were significantly higher in the observation group than the control group (12.18 ± 1.13 vs 11.34 ± 1.30, P 0.001), as were WES total scores (7.78 ± 0.99 vs 7.23 ± 1.10, P 0.001). After 1 year of implantation, OHIP-14 total scores in the observation group were significantly lower than those in the control group (3.20 ± 1.33 vs 4.15 ± 1.23, P 0.001). The satisfaction scores for Attachment Level (8.12 ± 1.05 vs 7.45 ± 1.18), Colour (8.67 ± 0.89 vs 8.15 ± 1.12), and Chewing Function (8.89 ± 0.94 vs 8.23 ± 1.08) were significantly higher in the observation group than in the control group (all P 0.05).</p><p><strong>Conclusion: </strong>Based on the primary outcome of 1-year implant survival, there was no significant difference between immediate and delayed implantation. However, immediate implantation demonstrated superior secondary outcomes, including periodontal-related indexes, aesthetic effects, quality of life, and patient satisfaction. These findings suggest that immediate implantation may offer clinical advantages in early functional and aesthetic outcomes without compromising implant survival, providing patients with reduced treatment duration and improved peri-implant tissue preservation.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"77-88"},"PeriodicalIF":1.4,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12888209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Association Between Transferrin Saturation and Periodontitis: A Mendelian Randomization Study.","authors":"Jie Gao","doi":"10.3290/j.ohpd.c_2421","DOIUrl":"10.3290/j.ohpd.c_2421","url":null,"abstract":"<p><strong>Purpose: </strong>Iron deficiency anemia may influence the development of periodontitis bidirectionally. This study aimed to examine the causal association of iron deficiency anemia and iron status on the occurrence of periodontitis predicted through Mendelian randomization (MR) analysis.</p><p><strong>Materials and methods: </strong>This two-sample MR study used summary data from large-scale genome-wide association studies of iron deficiency anemia (obtained through the meta-analysis of two large datasets), iron status, and periodontitis. Analysis was conducted using inverse variance weighted (IVW) as the main analysis and with weighted median, weighted mode, and MR-Egger regression methods as complementary analyses. Sensitivity analyses were evaluated using Cochran's Q-test, MR-Egger regression, MR-PRESSO analysis, and leave-one-out analysis to assess the robustness and consistency of the results.</p><p><strong>Results: </strong>Genetic predictions indicated a statistically significant association between transferrin saturation as the exposure and periodontitis as the outcome (OR=1.23, 95%CI: 1.08-1.41, p=0.002). No causal associations were observed between the other exposures (iron deficiency anemia, serum iron, serum ferritin, and TIBC) (all p>0.05). Cochran's Q-test showed no statistically significant heterogeneity, and the MR-Egger regression results suggested that this analysis was not influenced by horizontal pleiotropy. The MR-PRESSO results indicated that there were no outliers.</p><p><strong>Conclusion: </strong>The results suggest the presence of a positive causal association between transferrin saturation and periodontitis, but not iron deficiency anemia, serum iron, serum ferritin, and TIBC as exposures. Hence, the findings provide genetic evidence that anemia may be a potential cause for periodontitis, suggesting that attention to and management of patients' systemic hematological status may be important in the prevention and comprehensive treatment of periodontal disease.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"94-105"},"PeriodicalIF":1.4,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12888854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Removable Space Maintainer Use on Oral-Health-Related Quality of Life in Children: A Cross-Sectional Study.","authors":"Fatma Saraç, Fatıma Nuran Kiran, Shokoufeh Ranjbarsisan, Feride Aktaş","doi":"10.3290/j.ohpd.c_2504","DOIUrl":"10.3290/j.ohpd.c_2504","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the oral-health-related quality of life (OHRQoL) of children aged 8-10 years using removable space maintainers (RSMs) and to compare their outcomes with caries-free healthy peers.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 51 children who had been using RSMs for at least six months and 51 systemically healthy and caries-free children as controls. All participants were aged 8-10 years. Demographic data were recorded, and the Child Perceptions Questionnaire (CPQ8-10) was administered. The regular use of RSM was determined based on statements from both children and parents. Group comparisons of CPQ8-10 scores were performed using the Mann-Whitney U test and the independent samples t-test, with the level of significance set at P 0.05.</p><p><strong>Results: </strong>Children using RSMs had significantly higher total CPQ8-10 scores (26.88 ± 11.94) compared to the control group (12.24 ± 7.31) (P 0.001). Additionally, RSM users demonstrated significantly higher scores in all subscales, including oral symptoms, functional limitations, emotional well-being, and social well-being (P 0.05), showing poorer OHRQoL. No significant differences were observed between regular and irregular RSM users in any CPQ8-10 domain (P > 0.05). Gender and age did not significantly affect total CPQ8-10 scores.</p><p><strong>Conclusion: </strong>The use of RSMs was associated with lower oral-health-related quality of life among children aged 8-10 years when compared with caries-free peers. RSM use could have exerted a deleterious effect on functional limitations, emotional and social well-being. Clinicians may need to consider psychosocial adaptation in addition to clinical indications when planning treatment with RSMs and provide supportive, child-centred approaches during follow-up.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"89-93"},"PeriodicalIF":1.4,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12892132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Study Based on Deep Learning to Explore the Effect of Triglyceride/Glucose Index on Periodontitis: An Analysis Based on the Large NHANES Database.","authors":"Hongliang Ning, Xiaowen Chen, Wenjie Song, Zixuan Liu, Ziyue Xu","doi":"10.3290/j.ohpd.c_2468","DOIUrl":"10.3290/j.ohpd.c_2468","url":null,"abstract":"<p><strong>Purpose: </strong>Periodontitis is a common chronic inflammatory disease closely associated with metabolic syndrome. The triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance. However, its relationship with periodontitis remains underexplored. This study aims to utilise the large national database (NHANES) and explore the predictive value of TyG index for periodontitis through a deep learning model, and to clarify its correlation.</p><p><strong>Materials and methods: </strong>This study utilised data from the National Health and Nutrition Examination Survey (NHANES), including participants with complete demographic, laboratory, and oral health data. TyG index was calculated and incorporated into a deep learning model. A neural network with multiple hidden layers was built using PyTorch framework and trained using binary cross-entropy loss and the Adam optimiser. Model performance in predicting periodontitis was evaluated by metrics including -ROC, accuracy, sensitivity, and specificity. Traditional logistic regression and SHapley Additive ex-Planations (SHAP) algorithms were applied to validate and interpret the model's predictive capacity and feature contributions.</p><p><strong>Results: </strong>2,834 participants were included. Baseline characteristics showed that individuals with periodontitis had significantly higher age, BMI, fasting glucose, and triglyceride levels compared to those without periodontitis (P 0.001). The deep learning model demonstrated good performance on the test set, with AUC-ROC of 0.7482 and an accuracy of 87.13%. Feature importance analysis revealed that TyG index was the most influential predictor in the model. Logistic regression analysis indicated a significant dose-response relationship between TyG index and risk of periodontitis. Although statistical significance decreased after full adjustment for confounders, trend analysis still supported the TyG index as a potential independent risk factor.</p><p><strong>Conclusion: </strong>The TyG index was significantly dose-dependent and correlated with the risk of periodontitis, and the deep learning model demonstrated excellent predictive performance. The TyG index may serve as a simple and low-cost biomarker for the risk stratification and early identification of periodontitis, providing new ideas for the interdisciplinary management of oral-metabolic diseases.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"61-76"},"PeriodicalIF":1.4,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12907751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-Dependent Anti-Erosive Effect of Green Tea Extract Modification of Rivella Beverage.","authors":"Nicolai Blatter, Blend Hamza, Florian J Wegehaupt","doi":"10.3290/j.ohpd.c_2430","DOIUrl":"10.3290/j.ohpd.c_2430","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the effect of adding increasing amounts of green tea extract (GTE) to a soft drink (Rivella) on dentin wear in an erosion-only model.</p><p><strong>Materials and methods: </strong>The study consists of two experiments: In the first experiment, a total of 60 bovine dentin samples from 4 groups (n=15) were immersed in four Rivella variants: red, blue, green, and yellow. The samples were subjected to 4 cycles (per cycle: 10 min in the specified solution followed by rinsing with deionised water for 5 sec then storage 60 min in artificial saliva). In the second experiment, a total of 120 bovine dentin samples from 8 groups (n=15) were immersed in Rivella red with modified GTE concentrations (0.0; 0.05, 0.2, 0.4, 0.8, 1.0 or 1.2%). The cycle procedure was the same as in the first experiment. The measured dentin loss corresponded to the vertical shift on the y-axis between the baseline and the final profile after the wear process in 2D. Erosive dentin wear was measured by a stylus profilometer (µm). Data were analyzed using ANOVA followed by post-hoc pairwise comparisons and the p-values were adjusted after Holm.</p><p><strong>Results: </strong>In experiment 1 the following dentin wear (mean ± SD) was observed: Rivella red: 2.7 ± 0.4 µm; Rivella blue: 3.1 ± 0.4 µm; Rivella green: 2.1 ± 0.4 µm; Rivella yellow: 2.1 ± 0.3 µm. While the first two differed significantly, the last two did not. In experiment 2 dentin wear (mean ± SD) was: Rivella+0% GTE: 3.6 ± 0.6) µm; Rivella+0.05% GTE: 3.6 ± 0.2) µm; Rivella+0.2% GTE: 3.4 ± 0.6) µm; Rivella+0.4% GTE: 3.1 ± 0.4) µm; Rivella+0.6% GTE: 2.6 ± 0.3) µm; Rivella+0.8% GTE: 2.6 ± 0.4) µm; Rivella+1.0% GTE: 2.2 ± 0.2) µm; Rivella+1.2% GTE: 2.1 ± 0.3) µm. A significant decrease in erosive wear with increasing amount of GTE was observed.</p><p><strong>Conclusion: </strong>When increasing the addition of green tea extract to the soft drink Rivella, an almost linearly increasing protection against erosion can be observed in vitro.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"43-49"},"PeriodicalIF":1.4,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12852984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146065568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Feasibility of Exosome-Enriched Platelet-rich Fibrin (PRF) for the Treatment of Gingival Recessions: A Case Series of 27 Patients.","authors":"Scott Froum, Nathan E Estrin, Paras Ahmad, Nima Farshidfar, Richard J Miron","doi":"10.3290/j.ohpd.c_2394","DOIUrl":"10.3290/j.ohpd.c_2394","url":null,"abstract":"<p><strong>Purpose: </strong>Given the emerging potential of bioactive, cell-free regenerative therapies, integrating exosomes into dental practice may provide a biologically driven, minimally invasive method to improve soft tissue healing and root coverage outcomes. Hence, this first case series aimed to clinically assess the efficacy and safety of exosome-enriched solid platelet-rich fibrin (Exos-solid-PRF) to treat gingival recessions.</p><p><strong>Materials and methods: </strong>Twenty-seven patients (125 teeth) treated between January 2023 and July 2024 using a minimally invasive vestibular access technique with Exos-solid-PRF and liquid-PRF were included. Autologous PRF was prepared via horizontal centrifugation and hydrated with exosomes before surgical application. Clinical parameters, such as attachment gain (AG), keratinized tissue (KT), recession depth (RD), and recession width (RW), were measured at baseline and at a 6-month follow-up.</p><p><strong>Results: </strong>According to the Cairo classification system for recession, out of 125 teeth, 23 (18.4%) were recession type 1 (RT1) and 102 (81.6%) were RT2. Statistically significant improvements were observed in AG (+0.46 ± 0.84mm), RD (-1.93 ± 1.05 mm), and RW (-1.43 ± 1.43mm), with a mean root coverage of 68% and complete root coverage in 34 teeth. RT1 cases demonstrated 86% coverage, and RT2 cases achieved 64%, exhibiting the regenerative potential of this novel therapy in treating both isolated and multiple adjacent gingival recessions, particularly in the esthetic zone.</p><p><strong>Conclusions: </strong>While the outcomes for RT1 defects are comparable to those of gold-standard CTG approaches, the modest improvements in RT2 defects reflect both the potential and the limitations of this novel method. Additional controlled studies, long-term follow-up, and mechanistic investigations are required to validate these outcomes and optimize the therapeutic application of exosomes in clinical periodontology.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"51-60"},"PeriodicalIF":1.4,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12852986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146065539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediation of Systemic Inflammation and Oxidative Stress Markers in the Association of Life's Crucial 9 with Periodontitis: Evidence from NHANES 2009-2014.","authors":"Ruoyao Zhang, Chong Han, Dijia Hu, Qiukai Chen, Jinguo Zheng, Toshinori Okinaga","doi":"10.3290/j.ohpd.c_2469","DOIUrl":"10.3290/j.ohpd.c_2469","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the cross-sectional association between LC9 and periodontitis using NHANES 2009-2014 data, while also investigating the roles of systemic inflammation and oxidative stress in this relationship.</p><p><strong>Materials and methods: </strong>LC9 was calculated based on the 8 components of LE8 and the depression score assessed by the Patient Health Questionnaire-9. Periodontitis was assessed according to the CDC-AAP definition. Multivariable logistic regression and restricted cubic spline (RCS) analyses were used to explore the relationship between LC9 and periodontitis. Exploratory mediation analyses were performed to examine the roles of systemic inflammation and oxidative stress markers.</p><p><strong>Results: </strong>A total of 7191 participants were enrolled, and 3540 had periodontitis. In the fully adjusted model, LC9 was inversely associated with the odds of periodontitis (OR per 10-point increase 0.85, 95% CI 0.80-0.90, p 0.0001). Compared to Q1, participants with LC9 at Q2, Q3, and Q4 had statistically significantly lower periodontitis prevalence (OR 0.78, 0.64, and 0.62, respectively; p for trend = 0.0001). Most LC9 component scores were inversely associated with periodontitis. RCS analysis showed that LC9 was linearly associated with the odds of periodontitis. Exploratory mediation analyses suggested that white blood cell count, neutrophil count, systemic immune-inflammation index, serum albumin, and uric acid may explain 32.53%, 24.05%, 3.64%, 10.70%, and 6.64% of this association, respectively. Stratified analysis showed that age, race, and marital status moderate the relationship between LC9 and periodontitis.</p><p><strong>Conclusion: </strong>LC9 was linearly and negatively associated with the odds of periodontitis; systemic inflammation and oxidative stress markers may partially explain this association. These findings suggest that LC9 may serve as a valuable, comprehensive tool for assessing the likelihood of developing periodontitis, emphasizing that improving overall cardiovascular and mental health may be associated with lower prevalence of periodontitis.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"27-41"},"PeriodicalIF":1.4,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12852985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146065581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}