Oral health & preventive dentistry最新文献

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Oral and Periodontal Manifestations in Systemic Sclerosis: A Comprehensive Review of Pathophysiology, Clinical Features, and Management Strategies. 系统性硬化症的口腔和牙周表现:病理生理学、临床特征和治疗策略的综合综述。
IF 1.7 4区 医学
Oral health & preventive dentistry Pub Date : 2026-09-10 DOI: 10.3290/j.ohpd.c_2825
Rayan Meer
{"title":"Oral and Periodontal Manifestations in Systemic Sclerosis: A Comprehensive Review of Pathophysiology, Clinical Features, and Management Strategies.","authors":"Rayan Meer","doi":"10.3290/j.ohpd.c_2825","DOIUrl":"10.3290/j.ohpd.c_2825","url":null,"abstract":"<p><strong>Purpose: </strong>Systemic sclerosis is a connective tissue disorder that presents with various orofacial manifestations, which may influence oral health status and complicate dental management. This review sought to identify the oral and periodontal signs linked to systemic sclerosis, examine the specific oral health challenges faced by individuals with this condition, and outline their potential oral healthcare requirements.</p><p><strong>Materials and methods: </strong>A review of the available literature was undertaken to evaluate the reported oral and periodontal manifestations associated with systemic sclerosis and to assess their clinical implications.</p><p><strong>Results: </strong>Orofacial manifestations of systemic sclerosis include skin fibrosis, reduced mouth opening, dry mouth, and difficulty swallowing, as well as a potential increased risk of tooth decay, periodontal disease, and oral cancer. These oral and periodontal characteristics, along with their associated complications, improve the understanding and anticipation of oral healthcare requirements for affected patients.</p><p><strong>Conclusion: </strong>Recognition of the oral and periodontal features of systemic sclerosis emphasizes the importance of raising awareness among dental professionals to enhance treatment planning and improve the quality of dental care delivered to this patient population.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"859-863"},"PeriodicalIF":1.7,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Critical Genes for Recurrent Aphthous Ulcer by Transcriptome Data Analysis and Mendelian Randomization. 通过转录组数据分析和孟德尔随机化鉴定复发性阿弗顿溃疡的关键基因。
IF 1.7 4区 医学
Oral health & preventive dentistry Pub Date : 2026-09-09 DOI: 10.3290/j.ohpd.c_2799
Xingguo Fu, Haishan Zhang, Yaomei Li, Andi Li, Qiulin Liu, Xiaojuan Zeng
{"title":"Identification of Critical Genes for Recurrent Aphthous Ulcer by Transcriptome Data Analysis and Mendelian Randomization.","authors":"Xingguo Fu, Haishan Zhang, Yaomei Li, Andi Li, Qiulin Liu, Xiaojuan Zeng","doi":"10.3290/j.ohpd.c_2799","DOIUrl":"10.3290/j.ohpd.c_2799","url":null,"abstract":"<p><strong>Purpose: </strong>Recurrent aphthous ulcer (RAU) is a common oral mucosal disorder with a poorly understood etiology, significantly affecting patients' quality of life. This study aims to investigate critical genes linked to RAU and explore their biological mechanisms using transcriptomic data and Mendelian randomization (MR) analysis.</p><p><strong>Materials and methods: </strong>RAU-related gene expression data from the GEO database (GSE37265) were analyzed to identify differentially expressed genes (DEGs). A two-sample MR approach was used to assess the causal impact of expression quantitative trait loci (eQTL) on RAU. Critical genes were identified by intersecting DEGs with significant MR findings. GO and KEGG pathway enrichment analyses were performed, along with GSEA and immune cell infiltration analysis, to investigate the functions and mechanisms of these genes in RAU.</p><p><strong>Results: </strong>A total of 184 differentially expressed genes (DEGs) were identified, while 339 RAU-associated genes were screened through MR analysis. Cross-validation further identified 7 critical genes. Among these, CCR1, ERP27, HCK, MICB, and SLC2A3 showed protective associations with RAU risk, whereas CD177 and IFITM1 were positively associated with increased risk. Enrichment analysis revealed that these genes are involved in specific biological processes, including cell migration, immune response, and metabolic regulation, which are closely linked to RAU pathogenesis.</p><p><strong>Conclusion: </strong>This systematic study comprehensively investigates the critical causative genes underlying RAU, emphasizing the intricate relationships between immune regulation and metabolic disturbances in its pathology. These findings lay a solid foundation for the development of novel biomarkers and may inform future research on targeted therapeutic strategies for RAU.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"831-841"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Health Knowledge and Training of French Community Pharmacy Students. 法语社区药学专业学生口腔健康知识与培训。
IF 1.7 4区 医学
Oral health & preventive dentistry Pub Date : 2026-09-09 DOI: 10.3290/j.ohpd.c_2813
Lise Gentet, Lucile Barré, Alexia Marie-Cousin, Sylvie Jeanne, Sarah Dion, Solen Novello
{"title":"Oral Health Knowledge and Training of French Community Pharmacy Students.","authors":"Lise Gentet, Lucile Barré, Alexia Marie-Cousin, Sylvie Jeanne, Sarah Dion, Solen Novello","doi":"10.3290/j.ohpd.c_2813","DOIUrl":"10.3290/j.ohpd.c_2813","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the sixth-year community pharmacy French students' perception of their oral health education and knowledge.</p><p><strong>Methods and materials: </strong>An analytical cross-sectional study was conducted using a questionnaire sent by e-mail to sixth-year community pharmacy students of 20 faculties of pharmacy. Data were collected online, and descriptive data analyses were conducted.</p><p><strong>Results: </strong>A total of 318 students responded to the survey. The majority (n = 308) felt that courses in dentistry would be useful for their future practice. Two-thirds of students (n = 228) rated their perceived knowledge as 'insufficient' or 'non-existent'. More than half reported feeling uncomfortable when facing a patient presenting to the pharmacy with an oral health complaint or pathology. Overall, participants emphasised the importance of strengthening oral health training and improving communication between pharmacists and dentists. A collaboration between pharmacists and dentists could improve patient care, according to 298 students.</p><p><strong>Conclusion: </strong>The results showed that, although students reported some familiarity with oral health conditions, their perceived knowledge remained limited. Since the study assessed perceived knowledge rather than objectively measured competence, the findings should be interpreted with caution. These findings suggest that strengthening oral health education in pharmacy studies could help improve pharmacists' confidence in managing oral-health-related situations and appropriately referring patients when necessary.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"809-819"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluoride Toothpaste Market Surveillance in the Dominican Republic: Quality Gaps and Policy Implications. 多米尼加共和国含氟牙膏市场监测:质量差距和政策影响。
IF 1.7 4区 医学
Oral health & preventive dentistry Pub Date : 2026-09-09 DOI: 10.3290/j.ohpd.c_2783
Ninoska Abreu-Placeres, Luis Eduardo Garrido, Frank Lippert, Kim Rud Ekstrand, George Eckert, Guillermo Tamayo-Cabeza, Stefania Martignon, Esperanza Angeles Martinez-Mier
{"title":"Fluoride Toothpaste Market Surveillance in the Dominican Republic: Quality Gaps and Policy Implications.","authors":"Ninoska Abreu-Placeres, Luis Eduardo Garrido, Frank Lippert, Kim Rud Ekstrand, George Eckert, Guillermo Tamayo-Cabeza, Stefania Martignon, Esperanza Angeles Martinez-Mier","doi":"10.3290/j.ohpd.c_2783","DOIUrl":"10.3290/j.ohpd.c_2783","url":null,"abstract":"<p><strong>Purpose: </strong>The objective was to determine whether toothpastes marketed across the Dominican Republic provide fluoride levels that consistently meet internationally recommended benchmarks for caries prevention.</p><p><strong>Methods and materials: </strong>A total of 22 toothpaste products representing 11 brands were sampled from four of the country's most populated provinces. Six tubes per toothpaste were analysed using standardised fluoride measurement protocols. Total soluble fluoride (TSF) concentrations were evaluated against two internationally recognised benchmarks: ≥ 90% of labelled content and the 1000 ppm threshold for effective caries prevention. The proportion of toothpastes meeting these benchmarks was calculated, and Welch's ANOVAs assessed regional variability in TSF.</p><p><strong>Results: </strong>Results showed that while 68.2% of toothpastes met both fluoride benchmarks, 31.8% failed to do so by containing insufficient TSF relative to labelled content, falling below the 1000-ppm threshold, or both. Toothpastes with sodium monofluorophosphate (SMFP) exhibited the highest non-soluble fluoride levels, averaging up to 44.1%. Significant variability in TSF concentrations was observed across provinces, with Greater Santo Domingo consistently showing lower TSF levels than other regions. Locally manufactured toothpastes and products with incompatible abrasives demonstrated the greatest fluoride losses.</p><p><strong>Conclusions: </strong>Our findings provide market-wide surveillance evidence from a low- and middle-income country directly supporting WHO's Global Oral Health Action Plan (2023-2030). They highlight quality assurance gaps in fluoride toothpaste that undermine population-level caries prevention. These results underscore the global need for routine market monitoring, ISO-concordant standards, and fiscal policies to ensure effective, affordable fluoride toothpaste is reliably available worldwide.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"799-808"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of Signals for Smell and Taste Disorders Associated with Z-drugs: A Disproportionality Analysis of the FAERS Database. 与z -药物相关的嗅觉和味觉障碍信号的检测:FAERS数据库的歧化分析。
IF 1.7 4区 医学
Oral health & preventive dentistry Pub Date : 2026-09-09 DOI: 10.3290/j.ohpd.c_2791
Hui Yang, Youde Liang, Haijing Wang, Qiang Xu, Zhengwei Kou, Yuzhen Zou
{"title":"Detection of Signals for Smell and Taste Disorders Associated with Z-drugs: A Disproportionality Analysis of the FAERS Database.","authors":"Hui Yang, Youde Liang, Haijing Wang, Qiang Xu, Zhengwei Kou, Yuzhen Zou","doi":"10.3290/j.ohpd.c_2791","DOIUrl":"10.3290/j.ohpd.c_2791","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to detect and characterise signals of disproportionate reporting for smell and taste disorders associated with Z-drugs in the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS).</p><p><strong>Methods: </strong>Reports involving Z-drugs and smell/taste disorders were identified using the Standardised MedDRA Query (SMQ) 'Taste and smell disorders'. Disproportionality analyses were performed using the reporting odds ratio (ROR), proportional reporting ratio (PRR), empirical Bayes geometric mean (EBGM), and information component (IC). Sex-stratified, age-stratified, and time-to-onset (TTO) analyses were also conducted.</p><p><strong>Results: </strong>Among 32,853 reports involving Z-drugs, 3,480 were classified as smell- or taste-related adverse events. Eszopiclone accounted for 97.6% of these reports and demonstrated a strong disproportionality signal. Dysgeusia was the predominant adverse event, whereas parosmia and the preferred term 'taste disorder' generated additional positive signals. Signal strength was greatest among adults aged 18 to 45 years, and parosmia showed stronger disproportionality among women. Most events were reported within 30 days after treatment initiation.</p><p><strong>Conclusions: </strong>FAERS data indicate a strong association between eszopiclone and smell/taste disorders, particularly dysgeusia. Parosmia emerged as an additional signal warranting clinical attention. Further epidemiological and mechanistic studies are needed to clarify the underlying mechanisms and clinical significance of these findings.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"821-829"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Awareness, Knowledge, and Attitudes of Dentists in Türkiye Regarding the 2034 Phase-Out of Dental Amalgam Under the Minamata Convention: A Cross-Sectional Study. 根据《水俣公约》,日本牙医对2034年逐步淘汰牙科汞合金的认识、知识和态度:一项横断面研究。
IF 1.7 4区 医学
Oral health & preventive dentistry Pub Date : 2026-09-09 DOI: 10.3290/j.ohpd.c_2804
Ayşenur Altuğ Yıldırım, Sena Ayyıldız
{"title":"Awareness, Knowledge, and Attitudes of Dentists in Türkiye Regarding the 2034 Phase-Out of Dental Amalgam Under the Minamata Convention: A Cross-Sectional Study.","authors":"Ayşenur Altuğ Yıldırım, Sena Ayyıldız","doi":"10.3290/j.ohpd.c_2804","DOIUrl":"10.3290/j.ohpd.c_2804","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated Turkish dentists' knowledge of and attitudes toward the Minamata Convention, the 2025 amalgam phase-down decisions, and current dental amalgam use, and identified factors associated with knowledge and attitude scores across sociodemographic and professional subgroups.</p><p><strong>Materials and methods: </strong>A cross-sectional survey was conducted among 408 dentists practising in Türkiye between January and April 2026. The 26-item questionnaire assessed sociodemographic and professional characteristics, amalgam use frequency, perceived health and environmental risks, awareness of the Minamata Convention and the 2025 regulatory amendments, factual knowledge, and attitudes toward amalgam phase-down. Internal consistency was evaluated using Cronbach's alpha. Group comparisons were performed using independent-samples t-tests, Welch's ANOVA with Games-Howell post-hoc tests, and Pearson's correlation. Effect sizes were reported as Cohen's d and eta-squared.</p><p><strong>Results: </strong>Only 40.2% had heard of the Minamata Convention, and 21.1% were aware of the 2025 phase-down decisions. Knowledge and attitude scores were positively correlated (r = 0.242, p 0.001). Knowledge scores were significantly higher among academic staff, university-based practitioners, and those aware of the Convention (all p 0.001). Attitude scores were significantly higher among females (d = 0.61), non-users of amalgam, and those with Minamata awareness. Most participants (73.0%) never used amalgam, yet 79.9% perceived it as an environmental risk.</p><p><strong>Conclusions: </strong>Despite favorable attitudes toward amalgam reduction, knowledge of the Minamata Convention remains limited among Turkish dentists. Targeted educational programs are needed, particularly for general practitioners in private practice, to support the transition toward mercury-free restorative dentistry.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"849-858"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dental Anxiety Before Non-Surgical Periodontal Treatment: Evaluating the Interaction of Gender and Education Level. 牙周非手术治疗前的牙齿焦虑:性别与文化程度的相互作用评估。
IF 1.7 4区 医学
Oral health & preventive dentistry Pub Date : 2026-09-09 DOI: 10.3290/j.ohpd.c_2800
Tüba Bayat, Koray Cömert
{"title":"Dental Anxiety Before Non-Surgical Periodontal Treatment: Evaluating the Interaction of Gender and Education Level.","authors":"Tüba Bayat, Koray Cömert","doi":"10.3290/j.ohpd.c_2800","DOIUrl":"10.3290/j.ohpd.c_2800","url":null,"abstract":"<p><strong>Purpose: </strong>Dental anxiety is a multidimensional factor that influences treatment compliance and periodontal outcomes. This investigation evaluated how gender, educational level, and their combined interaction relate to dental anxiety in a sample of patients receiving initial non-surgical periodontal therapy (Phase I), minimizing potential confounding effects from procedural differences.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 200 volunteers (100 females, 100 males) who received Phase I periodontal therapy. The required sample size was estimated using G*Power analysis to achieve a statistical power of 95%. Dental anxiety was assessed using the Modified Dental Anxiety Scale (MDAS). Age homogeneity between genders was confirmed using the independent samples t-test. Data were analyzed using two-way ANOVA, the Games-Howell post-hoc test, and simple effects analysis. Effect sizes were determined via partial eta squared (partial η²).</p><p><strong>Results: </strong>No statistically significant difference in mean age was found between genders (p = 0.890). Two-way ANOVA revealed no statistically significant main effect for gender (p = 0.683) or educational level (p = 0.315). However, a statistically significant interaction effect with a large effect size was observed between gender and educational level (F(3,192) = 13.237; p 0.001; partial η2= 0.171). Simple effects analysis demonstrated that anxiety levels statistically significantly decreased as educational level increased in females (partial η² = 0.197), whereas in males, anxiety levels paradoxically increased with higher education (partial η² = 0.175).</p><p><strong>Conclusion: </strong>The impact of education on dental anxiety is not uniform but is statistically significantly modulated by gender. These findings emphasize the necessity of moving beyond standardized communication toward a customized, gender- and education-tailored chairside approach to optimize compliance during non-surgical periodontal therapy.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"843-847"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Various Types of Remineralizing Agents on the Remineralization of Mild and Moderate Defects Caused by Molar-Incisor Hypomineralization in Mexican Schoolchildren: A 12-month Follow-up Randomized Clinical Trial. 不同类型再矿化剂对墨西哥学童磨牙-门牙低矿化所致轻中度缺陷再矿化的影响:一项12个月随访随机临床试验
IF 1.7 4区 医学
Oral health & preventive dentistry Pub Date : 2026-09-08 DOI: 10.3290/j.ohpd.c_2796
Alvaro García Pérez, Danely Minelli Muñiz Alquisiras, Jacqueline Adelina Rodríguez Chávez, Hugo Marcelo Flores Ruíz, Karen Angelina Mora Navarrete
{"title":"Effect of Various Types of Remineralizing Agents on the Remineralization of Mild and Moderate Defects Caused by Molar-Incisor Hypomineralization in Mexican Schoolchildren: A 12-month Follow-up Randomized Clinical Trial.","authors":"Alvaro García Pérez, Danely Minelli Muñiz Alquisiras, Jacqueline Adelina Rodríguez Chávez, Hugo Marcelo Flores Ruíz, Karen Angelina Mora Navarrete","doi":"10.3290/j.ohpd.c_2796","DOIUrl":"10.3290/j.ohpd.c_2796","url":null,"abstract":"<p><strong>Purpose: </strong>Using Laser-Induced Fluorescence (LIF), this study aimed to evaluate the effect of three remineralizing agents on permanent molars and incisors with both mild and moderate Molar-Incisor Hypomineralization (MIH) in 8-to-12-year-old Mexican schoolchildren.</p><p><strong>Materials and methods: </strong>In this randomized clinical trial, 104 children were selected to participate and then divided randomly into four groups: Group I: control, Oral-B kids (toothpaste); Group II: Fluor Protector (varnish); Group III: Clinpro White Varnish; and Group IV: MI Paste (CCP-ACP). Both varnishes were applied once every four weeks for twelve months for each group. Remineralization was evaluated by LIF at intervals of 1, 3, 6, 9, and 12 months. Paired-sample t-tests and repeated-measures ANOVA were performed, while the Greenhouse-Geisser correction was used to evaluate sphericity.</p><p><strong>Results: </strong>The three test agents used increased the level of remineralization observed at the site of mild and moderate MIH defects over the course of twelve months (p0.001). A similar decrease in average LIF values was observed across the three treatment groups.</p><p><strong>Conclusions: </strong>The use of both fluoride varnishes and the CPP-ACP toothpaste was observed to promote the remineralization of both mild and moderate MIH defects.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"791-798"},"PeriodicalIF":1.7,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Potential Allergic Role of Mast Cells to Orthodontic Appliance in Orthodontic-Induced Gingival Enlargement. 正畸诱导的牙龈增大中肥大细胞对正畸矫治器的潜在过敏作用。
IF 1.7 4区 医学
Oral health & preventive dentistry Pub Date : 2026-09-04 DOI: 10.3290/j.ohpd.c_2801
Amal Ali Ibrahim, Omneya Emam Ahmed, Gihan A Balbola, Amany M Taha, Doaa Adel Habba, Basma Badr Hasaneen, Naglaa S El-Kilani
{"title":"The Potential Allergic Role of Mast Cells to Orthodontic Appliance in Orthodontic-Induced Gingival Enlargement.","authors":"Amal Ali Ibrahim, Omneya Emam Ahmed, Gihan A Balbola, Amany M Taha, Doaa Adel Habba, Basma Badr Hasaneen, Naglaa S El-Kilani","doi":"10.3290/j.ohpd.c_2801","DOIUrl":"10.3290/j.ohpd.c_2801","url":null,"abstract":"<p><strong>Background: </strong>Gingival mast cells (MCs) are strategically scattered throughout connective tissue and adhere to the endothelium to convert local impulses into systemic signals and attract additional immune effector cells. Numerous mediators, such as histamine, cytokines, and proteases, modulate these interaction pathways.</p><p><strong>Objectives: </strong>The purpose of this study was to determine and compare MC count in the gingival enlargement tissue of patients receiving orthodontic treatment versus patients having plaque-induced gingival enlargement without orthodontic treatment, utilising hematoxylin and eosin (H&E) staining, toluidine blue (TB), and CD117 (c-kit) immunohistochemistry (IHC) as a specific marker for MC identification.</p><p><strong>Methods and materials: </strong>This study involved 30 patients who were divided into three groups: Group 1 included 10 patients with clinically healthy gingival tissue that intentionally needed crown lengthening. Group 2 included 10 cases of plaque-induced gingival enlargement in individuals without orthodontic treatment. Group 3 included 10 cases of orthodontic gingival enlargement in individuals receiving orthodontic treatment. Patients received non-surgical periodontal therapy and oral hygiene instructions. After the plaque control phase, with a Gingival Index (GI) = 0 and no Bleeding on Probing (BoP), the gingiva was surgically treated. During the surgical procedure, the excised gingival margin was collected for histological examination with H&E, TB special stain, and c-kit to count the MCs.</p><p><strong>Results: </strong>The gingiva of patients in group 3 was characterised by more frequent epithelial changes (mild hyperplasia of the basal layer and spongiosis), a stronger degree of inflammation, including band-like inflammatory infiltrates and individual inflammatory cells, and a milder degree of fibrosis, compared to group 2. In addition, a significant increase in the number of MCs was observed in group 3 compared with groups 2 and 1. c-kit was a more specific marker for MCs than for TB.</p><p><strong>Conclusion: </strong>Orthodontic-induced gingival enlargement showed a significantly higher number of mast cells than plaque-induced gingival enlargement, and this involvement of MCs, particularly, may be associated with mast cell activation and degranulation. These findings may suggest an immunological role for MCs in the pathogenesis of orthodontically induced gingival enlargement.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"767-773"},"PeriodicalIF":1.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13584724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Subjective Oral Status and Oral Health Behaviours With a History of Systemic Disease Among Community-Dwelling Older Adults. 社区老年人主观口腔状况和口腔健康行为与全身性疾病史的关系
IF 1.7 4区 医学
Oral health & preventive dentistry Pub Date : 2026-09-04 DOI: 10.3290/j.ohpd.c_2807
Rumi Nishimura, Haruka Fukutani, Marin Ishigami, Maho Omoda, Mayuka Asaeda, Yukoh Muraki, Noriyasu Uchibori, Mariko Naito
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