Oral health & preventive dentistry最新文献

{"title":"Natural Teeth Present and Quality of Life in Older Adults from Indigenous Communities in the Peruvian Amazon: A Cross-Sectional Study.","authors":"Yshoner Antonio Silva-Diaz, Cintya Elisabeth Odar-Rojas, Ruth Clarivel Vega-Rojas, José Luis Rodriguez Medina, Lenin Edwads Velez Rodríguez, Clelia Jima Chamiquit","doi":"10.3290/j.ohpd.c_2833","DOIUrl":"10.3290/j.ohpd.c_2833","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the association between the number of natural teeth and quality of life, and to identify the prevalence of edentulism among older adults in two indigenous communities in the Peruvian Amazon.</p><p><strong>Materials and methods: </strong>This was a cross-sectional observational study conducted in adults over 60 years of age from the communities of Imacita and Yamayakat. Quality of life was assessed using the WHOQOL-BREF questionnaire adapted for indigenous communities, and the number of natural teeth present was recorded using a dental chart.</p><p><strong>Results: </strong>A total of 54 participants from the Imacita community and 41 from Yamayakat were included. The prevalence of edentulism was higher in Yamayakat, n=18 (43.90%), compared to Imacita, n=14 (25.93%). The number of natural teeth present was significantly associated with satisfaction with general health (β = 1.85; 95% CI: 1.37-2.34; p0.001), perceived overall quality of life (β = 1.54; 95% CI: 1.14-1.95; p0.001), physical domain (β = 0.81; 95% CI: 0.51-1.10; p0.001), and social domain (β = 0.72; 95% CI: 0.26-1.18; p=0.002).</p><p><strong>Conclusions: </strong>An association was observed between the number of teeth present and the quality of life of older adults, while the prevalence of edentulism did not show significant differences between the two communities. These findings highlight the need to implement interventions aimed at preventing tooth loss among indigenous older adults.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"887-894"},"PeriodicalIF":1.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of 5-Aminolevulinic Acid Photodynamic Therapy in the Treatment of Oral Leukoplakia: A Prospective Study with Long-Term Follow-Up.","authors":"Jinjin Zhao, Yang Cai, YongXin Hu, Xun Wang, Hong Lu, Ting Liu","doi":"10.3290/j.ohpd.c_2827","DOIUrl":"10.3290/j.ohpd.c_2827","url":null,"abstract":"<p><strong>Purpose: </strong>To observe the clinical efficacy and influencing factors of 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) in treatment oral leukoplakia (OL), so as to provide therapeutic references for clinical application.</p><p><strong>Materials and methods: </strong>After optimizing the 5-ALA-PDT treatment process, 31 OL patients were locally treated with 5- ALA-PDT (wavelength, 635 nm; energy density, 100 J/cm2), with 3 sessions per course of treatment. Efficacy was evaluated one month post-treatment by assessing lesion changes. Additionally, the factors that might influence therapeutic efficacy were analyzed.</p><p><strong>Results: </strong>An overall response rate of 90.3 % was achieved in this study, including 19 patients with complete remission, 9 with partial remission, and 3 with stable disease.The patients were followed for a median of 15 months (95% CI: 9-20 months; range: 3-25 months), during which recurrence occurred in 3 patients and malignant transformation in 2 patients. The treatment effect appeared better for lesions on the ventral tongue than at other sites. Patients who experienced local symptoms such as pain or ulcers after 5-ALA-PDT showed a more favorable response than those without any postoperative reactions. Patients with heterogeneous oral leukoplakia and moderate epithelial dysplasia had a higher recurrence rate than those with homogeneous lesions, simple hyperplasia, or mild epithelial dysplasia, with the peak of recurrence registered at 1-6 months after treatment.</p><p><strong>Conclusion: </strong>5-ALA-PDT appears to be a promising treatment for OL. However, recurrence and malignant transformation remain concerns.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"955-964"},"PeriodicalIF":1.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Topical Fluorides in Preventing Dental Caries in Children and Adolescents: A Systematic Review and Meta-Analysis.","authors":"Meijia Shao, Qinfen Shen, Wenjun Zhao","doi":"10.3290/j.ohpd.c_2826","DOIUrl":"10.3290/j.ohpd.c_2826","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the effectiveness of topical fluoride treatments, including mouth rinses, toothpaste, gels, foams and varnish, in preventing dental caries in children and adolescents through a systematic review and meta-analysis. It primarily focuses on the impact of different intervention frequencies, durations, concentrations, and types of fluoride on the incidence of dental caries and on changes in decayed, missing and filled surfaces (DMFS) and the surface area of initial caries (SIC) indices.</p><p><strong>Methods and materials: </strong>Clinical intervention studies that met the inclusion criteria were identified through searches of PubMed, Embase, Web of Science, Cochrane Library, ScienceDirect, SinoMed, Chinese National Knowledge Infrastructure and Wanfang databases. The literature search was conducted on 2 June 2025 and covered publications between 1 January 2000 and 31 May 2025. Two independent reviewers performed literature screening, data extraction and risk-of-bias assessment. A meta-analysis was performed using fixed-effects or random-effects models. Subgroup analyses and narrative heterogeneity exploration were conducted according to fluoride concentration, intervention frequency, duration, age group and control type. Safety outcomes were narratively summarised.</p><p><strong>Results: </strong>The meta-analysis of 10 included clinical studies showed that topical fluoride significantly reduced caries incidence when the event was defined as development of dental caries (odds ratio [OR] = 0.27, 95% CI: 0.21-0.36, p 0.00001), prevented DMFS increment (weighted mean difference [WMD] = 0.35, 95% CI: 0.07-0.63, p = 0.01) and reduced SIC changes (WMD = -0.85, 95% CI: -1.66 to -0.05, p = 0.04). Subgroup analyses indicated superior outcomes with 0.2% fluoride, higher intervention frequency and longer duration. The 5% sodium fluoride varnish study was summarised separately because it used a professionally applied varnish and delayed-varnish control. Safety reporting was limited, and no serious fluoride-related adverse events were identified in the available reports. Formal meta-regression was not performed because the number of study-level estimates for DMFS and SIC was limited.</p><p><strong>Conclusion: </strong>Topical fluoride is highly effective in preventing dental caries in children and adolescents. The findings support sustained and appropriately supervised use of topical fluoride, while highlighting the need for standardised protocols and better long-term safety reporting.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"913-924"},"PeriodicalIF":1.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Casearia sylvestris Derivatives Inhibit Inflammation and Oxidative Activity and Promote Healing in Human Gingival Fibroblasts - An In Vitro Study.","authors":"Angélica Letícia Reis Pavanelli, Maria Eduarda Scordamaia Lopes, André Thiago Reis, Flávio Alexandre Carvalho, Sven Zalewski, André Gonzaga Dos Santos, Sigrun Eick, Joni Augusto Cirelli, Andressa Vilas Boas Nogueira, James Deschner","doi":"10.3290/j.ohpd.c_2831","DOIUrl":"10.3290/j.ohpd.c_2831","url":null,"abstract":"<p><strong>Purpose: </strong>New promising adjuvant approaches for managing periodontal inflammation are emerging. Casearia sylvestris, a medicinal plant rich in diterpenes, has demonstrated anti-inflammatory, antioxidant, and reparative properties. The present study aimed to investigate the anti-inflammatory, antiproteolytic, and pro-healing effects of C. sylvestris leaf derivatives: ethanolic extract (extract), diterpene-enriched fraction (F2), and isolated casearin J (Cas J) on human gingival fibroblasts (HGF).</p><p><strong>Methods and materials: </strong>HGF were exposed to Escherichia coli lipopolysaccharide (LPS) and treated with C. sylvestris derivatives. Transcription and protein levels of TNF-α, IL-8, MMP-1, and iNOS were assessed by real-time polymerase chain reaction (PCR) and ELISA, respectively. Nitric oxide (NO) levels were measured using the Griess reaction. NF-κB p65 nuclear translocation and ERK1 phosphorylation were analysed by immunofluorescence and immunoassay, respectively. Cell viability and scratch wound-healing assays were also performed.</p><p><strong>Results: </strong>E. coli LPS triggered a significant pro-inflammatory and proteolytic cellular response, characterised by increased TNF-α, IL-8, MMP-1, iNOS, and NO levels. Treatment with C. sylvestris derivatives significantly reduced the levels of these mediators, while also inhibiting NF-κB p65 translocation and ERK1 phosphorylation. All compounds were biocompatible and promoted cell migration and wound closure in vitro.</p><p><strong>Conclusion: </strong>These findings suggest that C. sylvestris leaf derivatives exert anti-inflammatory, antiproteolytic, and pro-healing effects, thus highlighting their potential as adjunctive phytotherapeutic agents for periodontal disease management.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"925-936"},"PeriodicalIF":1.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Hyaluronic Acid Versus Enamel Matrix Derivative in the Treatment of Intrabony Periodontal Defects: A Systematic Review and Meta-Analysis.","authors":"Théo Mahintach, Camille Bechina, Sofiya Galina, Assem Soueidan, Christian Verner, Xavier Struillou","doi":"10.3290/j.ohpd.c_2808","DOIUrl":"10.3290/j.ohpd.c_2808","url":null,"abstract":"<p><strong>Purpose: </strong>Evaluate the potential non-inferiority of hyaluronic acid (HA) when compared to enamel matrix derivative (EMD) for the surgical management of intrabony defects.</p><p><strong>Methods and materials: </strong>A systematic search was performed in PubMed, ScienceDirect, Scopus, Google Scholar, LILACS, following PRISMA guidelines. Weighted mean differences (WMD) and 95% confidence intervals (CI) between HA and EMD were estimated using a random-effect model for clinical attachment level (CAL gain, primary outcome), probing pocket depth (PPD), and gingival recession (REC). A non-inferiority margin of 0.5 mm was defined for CAL. In order to minimise bias, only randomised clinical studies (RCTs) were selected.</p><p><strong>Results: </strong>Across 117 articles, 3 RCTs were included. HA achieved clinical non-inferiority in CAL gain versus EMD (WMD = 0.51 mm, CI [-0.08; 1.11] at 12 months, WMD = 0.53 mm). Regarding PPD, the data do not support the non-inferiority hypothesis in comparison to EMD at 12 months (PPD: WMD = 0.71 mm, CI [-0.11; 1,54], I2=72.5%). For gingival recession, HA demonstrated clinical non-inferiority at 12 months (WMD = -0.4 mm, CI [-0.79; -0.01], I2 = 0).</p><p><strong>Conclusion: </strong>Within the limits, the present data indicate that HA could be an alternative to EMD in intrabony defects. Further RCTs are required to consolidate these preliminary results. Prospero registration number: CRD420261301986.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"865-875"},"PeriodicalIF":1.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13584719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral and Periodontal Manifestations in Systemic Sclerosis: A Comprehensive Review of Pathophysiology, Clinical Features, and Management Strategies.","authors":"Rayan Meer","doi":"10.3290/j.ohpd.c_2825","DOIUrl":"10.3290/j.ohpd.c_2825","url":null,"abstract":"<p><strong>Purpose: </strong>Systemic sclerosis is a connective tissue disorder that presents with various orofacial manifestations, which may influence oral health status and complicate dental management. This review sought to identify the oral and periodontal signs linked to systemic sclerosis, examine the specific oral health challenges faced by individuals with this condition, and outline their potential oral healthcare requirements.</p><p><strong>Materials and methods: </strong>A review of the available literature was undertaken to evaluate the reported oral and periodontal manifestations associated with systemic sclerosis and to assess their clinical implications.</p><p><strong>Results: </strong>Orofacial manifestations of systemic sclerosis include skin fibrosis, reduced mouth opening, dry mouth, and difficulty swallowing, as well as a potential increased risk of tooth decay, periodontal disease, and oral cancer. These oral and periodontal characteristics, along with their associated complications, improve the understanding and anticipation of oral healthcare requirements for affected patients.</p><p><strong>Conclusion: </strong>Recognition of the oral and periodontal features of systemic sclerosis emphasizes the importance of raising awareness among dental professionals to enhance treatment planning and improve the quality of dental care delivered to this patient population.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"859-863"},"PeriodicalIF":1.7,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Critical Genes for Recurrent Aphthous Ulcer by Transcriptome Data Analysis and Mendelian Randomization.","authors":"Xingguo Fu, Haishan Zhang, Yaomei Li, Andi Li, Qiulin Liu, Xiaojuan Zeng","doi":"10.3290/j.ohpd.c_2799","DOIUrl":"10.3290/j.ohpd.c_2799","url":null,"abstract":"<p><strong>Purpose: </strong>Recurrent aphthous ulcer (RAU) is a common oral mucosal disorder with a poorly understood etiology, significantly affecting patients' quality of life. This study aims to investigate critical genes linked to RAU and explore their biological mechanisms using transcriptomic data and Mendelian randomization (MR) analysis.</p><p><strong>Materials and methods: </strong>RAU-related gene expression data from the GEO database (GSE37265) were analyzed to identify differentially expressed genes (DEGs). A two-sample MR approach was used to assess the causal impact of expression quantitative trait loci (eQTL) on RAU. Critical genes were identified by intersecting DEGs with significant MR findings. GO and KEGG pathway enrichment analyses were performed, along with GSEA and immune cell infiltration analysis, to investigate the functions and mechanisms of these genes in RAU.</p><p><strong>Results: </strong>A total of 184 differentially expressed genes (DEGs) were identified, while 339 RAU-associated genes were screened through MR analysis. Cross-validation further identified 7 critical genes. Among these, CCR1, ERP27, HCK, MICB, and SLC2A3 showed protective associations with RAU risk, whereas CD177 and IFITM1 were positively associated with increased risk. Enrichment analysis revealed that these genes are involved in specific biological processes, including cell migration, immune response, and metabolic regulation, which are closely linked to RAU pathogenesis.</p><p><strong>Conclusion: </strong>This systematic study comprehensively investigates the critical causative genes underlying RAU, emphasizing the intricate relationships between immune regulation and metabolic disturbances in its pathology. These findings lay a solid foundation for the development of novel biomarkers and may inform future research on targeted therapeutic strategies for RAU.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"831-841"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health Knowledge and Training of French Community Pharmacy Students.","authors":"Lise Gentet, Lucile Barré, Alexia Marie-Cousin, Sylvie Jeanne, Sarah Dion, Solen Novello","doi":"10.3290/j.ohpd.c_2813","DOIUrl":"10.3290/j.ohpd.c_2813","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the sixth-year community pharmacy French students' perception of their oral health education and knowledge.</p><p><strong>Methods and materials: </strong>An analytical cross-sectional study was conducted using a questionnaire sent by e-mail to sixth-year community pharmacy students of 20 faculties of pharmacy. Data were collected online, and descriptive data analyses were conducted.</p><p><strong>Results: </strong>A total of 318 students responded to the survey. The majority (n = 308) felt that courses in dentistry would be useful for their future practice. Two-thirds of students (n = 228) rated their perceived knowledge as 'insufficient' or 'non-existent'. More than half reported feeling uncomfortable when facing a patient presenting to the pharmacy with an oral health complaint or pathology. Overall, participants emphasised the importance of strengthening oral health training and improving communication between pharmacists and dentists. A collaboration between pharmacists and dentists could improve patient care, according to 298 students.</p><p><strong>Conclusion: </strong>The results showed that, although students reported some familiarity with oral health conditions, their perceived knowledge remained limited. Since the study assessed perceived knowledge rather than objectively measured competence, the findings should be interpreted with caution. These findings suggest that strengthening oral health education in pharmacy studies could help improve pharmacists' confidence in managing oral-health-related situations and appropriately referring patients when necessary.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"809-819"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoride Toothpaste Market Surveillance in the Dominican Republic: Quality Gaps and Policy Implications.","authors":"Ninoska Abreu-Placeres, Luis Eduardo Garrido, Frank Lippert, Kim Rud Ekstrand, George Eckert, Guillermo Tamayo-Cabeza, Stefania Martignon, Esperanza Angeles Martinez-Mier","doi":"10.3290/j.ohpd.c_2783","DOIUrl":"10.3290/j.ohpd.c_2783","url":null,"abstract":"<p><strong>Purpose: </strong>The objective was to determine whether toothpastes marketed across the Dominican Republic provide fluoride levels that consistently meet internationally recommended benchmarks for caries prevention.</p><p><strong>Methods and materials: </strong>A total of 22 toothpaste products representing 11 brands were sampled from four of the country's most populated provinces. Six tubes per toothpaste were analysed using standardised fluoride measurement protocols. Total soluble fluoride (TSF) concentrations were evaluated against two internationally recognised benchmarks: ≥ 90% of labelled content and the 1000 ppm threshold for effective caries prevention. The proportion of toothpastes meeting these benchmarks was calculated, and Welch's ANOVAs assessed regional variability in TSF.</p><p><strong>Results: </strong>Results showed that while 68.2% of toothpastes met both fluoride benchmarks, 31.8% failed to do so by containing insufficient TSF relative to labelled content, falling below the 1000-ppm threshold, or both. Toothpastes with sodium monofluorophosphate (SMFP) exhibited the highest non-soluble fluoride levels, averaging up to 44.1%. Significant variability in TSF concentrations was observed across provinces, with Greater Santo Domingo consistently showing lower TSF levels than other regions. Locally manufactured toothpastes and products with incompatible abrasives demonstrated the greatest fluoride losses.</p><p><strong>Conclusions: </strong>Our findings provide market-wide surveillance evidence from a low- and middle-income country directly supporting WHO's Global Oral Health Action Plan (2023-2030). They highlight quality assurance gaps in fluoride toothpaste that undermine population-level caries prevention. These results underscore the global need for routine market monitoring, ISO-concordant standards, and fiscal policies to ensure effective, affordable fluoride toothpaste is reliably available worldwide.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"799-808"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Signals for Smell and Taste Disorders Associated with Z-drugs: A Disproportionality Analysis of the FAERS Database.","authors":"Hui Yang, Youde Liang, Haijing Wang, Qiang Xu, Zhengwei Kou, Yuzhen Zou","doi":"10.3290/j.ohpd.c_2791","DOIUrl":"10.3290/j.ohpd.c_2791","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to detect and characterise signals of disproportionate reporting for smell and taste disorders associated with Z-drugs in the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS).</p><p><strong>Methods: </strong>Reports involving Z-drugs and smell/taste disorders were identified using the Standardised MedDRA Query (SMQ) 'Taste and smell disorders'. Disproportionality analyses were performed using the reporting odds ratio (ROR), proportional reporting ratio (PRR), empirical Bayes geometric mean (EBGM), and information component (IC). Sex-stratified, age-stratified, and time-to-onset (TTO) analyses were also conducted.</p><p><strong>Results: </strong>Among 32,853 reports involving Z-drugs, 3,480 were classified as smell- or taste-related adverse events. Eszopiclone accounted for 97.6% of these reports and demonstrated a strong disproportionality signal. Dysgeusia was the predominant adverse event, whereas parosmia and the preferred term 'taste disorder' generated additional positive signals. Signal strength was greatest among adults aged 18 to 45 years, and parosmia showed stronger disproportionality among women. Most events were reported within 30 days after treatment initiation.</p><p><strong>Conclusions: </strong>FAERS data indicate a strong association between eszopiclone and smell/taste disorders, particularly dysgeusia. Parosmia emerged as an additional signal warranting clinical attention. Further epidemiological and mechanistic studies are needed to clarify the underlying mechanisms and clinical significance of these findings.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"24 ","pages":"821-829"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}