History of Oral Mucosal Lesions in Oral Squamous Cell Carcinoma Patients.

IF 1.4 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Oral health & preventive dentistry Pub Date : 2025-06-03 DOI:10.3290/j.ohpd.c_2028

Arvi Keinänen, Johanna Snäll, Jaana Hagström, Johanna Uittamo

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引用次数: 0

Abstract

Purpose: To evaluate the occurrence of previous mucosal dysplasia in patients with oral squamous cell carcinoma (OSCC) and to charaterise patient profile, types of previous oral mucosal lesions, and care-seeking in relation to earlier mucosal findings.

Materials and methods: Retrospective data of OSCC patients with a primary tumour were collected. The primary outcome variable was any history of oral mucosal findings; the secondary outcome variable was a history of previous oral mucosal dysplasia. The primary predictor variable was the mode of seeking treatment. Patient and tumour-related variables were compared between patients with and without anamnestic mucosal changes or findings.

Results: A total of 528 patients were included in the study. Of these patients, 169 (32.0%) had a history of an oral mucosal lesion. Oral mucosal dysplasia was detected in 34 patients (6.4%) before the OSCC diagnosis. Patients who had a history of heavy alcohol use were less likely to have a history of any mucosal lesions or dysplasia (adjusted odds ratio [aOR] 0.350, 95% confidence interval [CI] 0.215-0.571, p 0.001 and aOR 0.235, 95% CI 0.070-0.795, p = 0.020). Tumours were detected more often in conjunction with routine appointments in patients with a history of any mucosal lesions (aOR 2.671, 95% CI 1.704-4.187, p 0.001) and in those with previously detected dysplasia (aOR 6.195, 95% CI 3.004-12.774, p 0.001).

Conclusions: The results emphasise the importance of careful examination and close follow-up of findings in the oral mucosa.

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口腔鳞状细胞癌患者口腔黏膜病变史。

目的：评估口腔鳞状细胞癌（OSCC）患者既往粘膜发育不良的发生率，并描述患者的特征，既往口腔黏膜病变的类型，以及与早期粘膜发现相关的求医行为。材料与方法：回顾性收集伴有原发肿瘤的OSCC患者资料。主要结局变量是口腔黏膜的任何病史；次要结局变量是既往口腔黏膜发育不良史。主要预测变量是寻求治疗的方式。患者和肿瘤相关变量在有无遗忘性粘膜改变或发现的患者之间进行比较。结果：共纳入528例患者。其中169例（32.0%）有口腔黏膜病变史。口腔黏膜发育不良34例（6.4%）在OSCC诊断前被发现。有大量饮酒史的患者有任何粘膜病变或发育不良史的可能性较小（调整优势比[aOR] 0.350, 95%可信区间[CI] 0.215-0.571, p 0.001；调整优势比[aOR] 0.235, 95% CI 0.070-0.795, p = 0.020）。有任何粘膜病变史的患者（aOR为2.671,95% CI为1.704-4.187,p 0.001）和以前检测过不典型增生的患者（aOR为6.195,95% CI为3.004-12.774,p 0.001）在常规就诊时更常发现肿瘤。结论：本研究结果强调了口腔黏膜仔细检查和密切随访的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral health & preventive dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinicians, general practitioners, teachers, researchers, and public health administrators will find this journal an indispensable source of essential, timely information about scientific progress in the fields of oral health and the prevention of caries, periodontal diseases, oral mucosal diseases, and dental trauma. Central topics, including oral hygiene, oral epidemiology, oral health promotion, and public health issues, are covered in peer-reviewed articles such as clinical and basic science research reports; reviews; invited focus articles, commentaries, and guest editorials; and symposium, workshop, and conference proceedings.