Mediation of Systemic Inflammation Response Index in the Association of Healthy Eating Index-2020 in Patientis with Periodontitis.

IF 1.4 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Oral health & preventive dentistry Pub Date : 2025-04-15 DOI:10.3290/j.ohpd.c_1946

Jiajia Yang, Liqin Gong, Xinchen Zhu, Yueyan Wang, Chong Li

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引用次数: 0

Abstract

Purpose: To investigate the function of the Systemic Inflammation Response Index (SIRI) in the association of Healthy Eating Index (HEI) 2020 in patients with periodontitis risk.

Materials and methods: This study utilised data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2014, including participants's oral examination results, dietary records, and levels of inflammatory markers. The study employed HEI-2020 as the independent variable and periodontitis as the dependent variable, using weighted logistic regression analysis to examine the association between HEI-2020 and periodontitis. Additionally, restricted cubic splines (RCS) were employed to further explore the non-linear association between the two. Mediation analysis was conducted to investigate the role of SIRI in the association between HEI-2020 and periodontitis.

Results: 3829 (34.5%) of the 9569 patients were diagnosed with periodontitis. In the weighted logistics regression model, HEI-2020 and the risk of periodontitis showed a statistically significant negative association (OR: 0.99, 95% CI: 0.98-1.00, p 0.001). The findings of the RCS curve showed a linear correlation (pnon-linear=0.684) between the risk of periodontitis and HEI-2020. With a mediation proportion of 9.82% (p 0.001), the findings of the mediation study indicated that SIRI partially mediated the relationship between HEI-2020 and periodontitis.

Conclusion: HEI-2020 and periodontitis risk are statistically significantly negatively correlated, and SIRI is a major mediating factor in this relationship. The study results may help clinicians better understand how a healthy diet impacts the risk of periodontal disease and identify the mediating role of SIRI in this association. This knowledge can guide personalised dietary and inflammation management strategies, enhancing oral and overall health by preventing and managing periodontal issues effectively.

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牙周炎患者全身炎症反应指数在健康饮食指数-2020相关性中的中介作用

目的：探讨全身炎症反应指数（SIRI）与健康饮食指数（HEI） 2020在牙周炎风险患者中的关联作用。材料和方法：本研究利用了2009年至2014年国家健康和营养检查调查（NHANES）的数据，包括参与者的口腔检查结果、饮食记录和炎症标志物水平。本研究以HEI-2020为自变量，以牙周炎为因变量，采用加权logistic回归分析检验HEI-2020与牙周炎的相关性。此外，采用限制三次样条（RCS）进一步探讨两者之间的非线性关系。通过中介分析来探讨SIRI在HEI-2020与牙周炎之间的关联中的作用。结果：9569例患者中有3829例（34.5%）诊断为牙周炎。在加权logistic回归模型中，HEI-2020与牙周炎风险呈统计学显著负相关（OR: 0.99, 95% CI: 0.98-1.00, p 0.001）。RCS曲线结果显示牙周炎风险与HEI-2020呈线性相关（p非线性=0.684）。中介比例为9.82% (p 0.001)，表明SIRI在HEI-2020与牙周炎的关系中起到部分中介作用。结论：HEI-2020与牙周炎风险呈显著负相关，而SIRI是影响这一关系的主要中介因素。研究结果可能有助于临床医生更好地了解健康饮食如何影响牙周病的风险，并确定SIRI在这一关联中的中介作用。这些知识可以指导个性化的饮食和炎症管理策略，通过有效预防和管理牙周问题来增强口腔和整体健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral health & preventive dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinicians, general practitioners, teachers, researchers, and public health administrators will find this journal an indispensable source of essential, timely information about scientific progress in the fields of oral health and the prevention of caries, periodontal diseases, oral mucosal diseases, and dental trauma. Central topics, including oral hygiene, oral epidemiology, oral health promotion, and public health issues, are covered in peer-reviewed articles such as clinical and basic science research reports; reviews; invited focus articles, commentaries, and guest editorials; and symposium, workshop, and conference proceedings.