{"title":"Association of Periodontal Disease and Tooth Loss with Cancer in Korean Adults: A Nationwide Cross-Sectional Study.","authors":"Eun-Seo Jung, Hae-Young Kim","doi":"10.3290/j.ohpd.c_2151","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The precise mechanisms underlying cancer development remain unclear, and limited research has been con-ducted on the association between periodontal health and cancer in the Korean population. The aim of this study was to evaluate the relationship between periodontal status and tooth loss with the cancer risk among Korean adults by using data from the Korea National Health and Nutrition Examination Survey (2010-2018).</p><p><strong>Materials and methods: </strong>This cross-sectional study included 13,616 adults aged ≥ 19 years who participated in health surveys and oral examinations. Logistic regression analysis was conducted to evaluate the associations of periodontal status (com-munity periodontal index [CPI]) and tooth loss with cancer. We adjusted the model for demographic, health-related, and oral health-related factors in a stepwise fashion to minimise confounding variables.</p><p><strong>Results: </strong>Participants with a CPI score of 3-4 (indicating periodontitis) had slightly higher odds of having cancer in minimally adjusted models than those with a CPI score of 0, but this association was not significant after full adjustment. Conversely, individuals with eight or more missing teeth showed consistently higher odds of having cancer than those with no missing teeth across all models, even after adjusting for confounders (adjusted odds ratio: 1.23; 95% CI: 1.11-1.73).</p><p><strong>Conclusion: </strong>The findings suggest that tooth loss may be a stronger indicator of cancer risk than periodontal disease. Further studies with longitudinal designs are needed to clarify the causal relationships between oral health and cancer development.</p>","PeriodicalId":19696,"journal":{"name":"Oral health & preventive dentistry","volume":"23 ","pages":"383-389"},"PeriodicalIF":1.4000,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329577/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral health & preventive dentistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3290/j.ohpd.c_2151","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
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Abstract
Purpose: The precise mechanisms underlying cancer development remain unclear, and limited research has been con-ducted on the association between periodontal health and cancer in the Korean population. The aim of this study was to evaluate the relationship between periodontal status and tooth loss with the cancer risk among Korean adults by using data from the Korea National Health and Nutrition Examination Survey (2010-2018).
Materials and methods: This cross-sectional study included 13,616 adults aged ≥ 19 years who participated in health surveys and oral examinations. Logistic regression analysis was conducted to evaluate the associations of periodontal status (com-munity periodontal index [CPI]) and tooth loss with cancer. We adjusted the model for demographic, health-related, and oral health-related factors in a stepwise fashion to minimise confounding variables.
Results: Participants with a CPI score of 3-4 (indicating periodontitis) had slightly higher odds of having cancer in minimally adjusted models than those with a CPI score of 0, but this association was not significant after full adjustment. Conversely, individuals with eight or more missing teeth showed consistently higher odds of having cancer than those with no missing teeth across all models, even after adjusting for confounders (adjusted odds ratio: 1.23; 95% CI: 1.11-1.73).
Conclusion: The findings suggest that tooth loss may be a stronger indicator of cancer risk than periodontal disease. Further studies with longitudinal designs are needed to clarify the causal relationships between oral health and cancer development.
期刊介绍：
Clinicians, general practitioners, teachers, researchers, and public health administrators will find this journal an indispensable source of essential, timely information about scientific progress in the fields of oral health and the prevention of caries, periodontal diseases, oral mucosal diseases, and dental trauma. Central topics, including oral hygiene, oral epidemiology, oral health promotion, and public health issues, are covered in peer-reviewed articles such as clinical and basic science research reports; reviews; invited focus articles, commentaries, and guest editorials; and symposium, workshop, and conference proceedings.
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