Orthodontics & Craniofacial Research最新文献

{"title":"Estimation of Mandibular Buccal Shelf Cortical Bone Thickness at Variable Sites, Heights and Angulations in Three Different Growth Patterns-A Cone Beam Computed Tomography Study.","authors":"Vishal Rohit, S Praveen, V P Latheef, P Muhammed Shibin, Shobha Sundareswaran, Prathapan Parayaruthottam, Nileena R Kumar, Baby Jisha","doi":"10.1111/ocr.70184","DOIUrl":"https://doi.org/10.1111/ocr.70184","url":null,"abstract":"<p><strong>Objectives: </strong>To compare mandibular buccal shelf cortical bone thickness in different skeletal growth patterns for temporary skeletal anchorage device placement using Cone Beam Computed Tomographic imaging (CBCT).</p><p><strong>Methods: </strong>Forty-two CBCT scans were selected and separated into three groups: Horizontal, normal and Vertical, based on cephalometric angular and linear measurements. Five sites were examined on left side of the mandible-Distal of first molar, Interdental between the first and second molar, Mesial, Middle and Distal of lower second molar. Buccal shelf cortical bone thickness (in mm) at 5 and 7 mm height from alveolar bone crest and at 70 and 80 degree angulation from the occlusal plane were measured in all the three groups.</p><p><strong>Results: </strong>Significant variance (p < 0.001) in thickness of cortical bone was seen among the three groups: higher in horizontal followed by vertical and normal groups and higher at 7 mm height from alveolar crest and 80° angulation distal to mandibular second molar in each group. Overall, the findings demonstrated a consistent trend of greater cortical bone thickness in females compared to males at several sites, particularly in the posterior mandibular region.</p><p><strong>Conclusion: </strong>Based on the results, placing a buccal shelf bone screw is safer and more stable in horizontal individual, compared to normal and vertical individual because of greater cortical engagement. At a site distal to 2nd molar, at a height of 7 mm from alveolar bone crest and angulating at 80° gives the best cortical bone engagement, which in turn increases the primary stability and decreases the chances of failure of buccal shelf implant. Across all growth patterns, posterior mandibular inter-radicular areas (7 M, 7 Mi, and 7D) exhibit greater variability in cortical bone thickness between genders with increased bone thickness in females compared to males.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Orthodontics: Part 3-Cautions, Limitations and Future Prospects.","authors":"Fatemeh Sohrabniya, Julian Woolley, Khuram Naveed, Ruben Pauwels, Peter Bangsgaard Stoustrup, Hossein Mohammad-Rahimi","doi":"10.1111/ocr.70180","DOIUrl":"https://doi.org/10.1111/ocr.70180","url":null,"abstract":"<p><p>Artificial intelligence (AI) is increasingly affecting orthodontic practice and research, yet its adoption requires a careful understanding of both its capabilities and its limitations. As the final part of a three-section review, this paper focuses on the practical cautions and constraints that accompany current AI developments in orthodontics. Topics such as data quality, educational preparedness and the ethical and legal responsibilities surrounding AI use are discussed as essential considerations for preventing errors, misuse and misinterpretation. Technical challenges, including model generalizability, transparency and interpretability, are elucidated in relation to their impact on clinical applicability. Finally, new trends and future directions in the evolution of AI within orthodontics and other fields are described. Together, these perspectives aim to provide a realistic and balanced perspective of how AI can be integrated responsibly into orthodontic care and research.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Changes in the Occlusal Contacts During Anterior Segmental Orthodontic Treatment With Clear Aligners in Adult Patients.","authors":"Ji-Hye Song, Ji-Hyun Lee, Sanghee Lee, Kee-Joon Lee, Jung-Yul Cha, Chooryung J Chung, Kyung-Ho Kim","doi":"10.1111/ocr.70182","DOIUrl":"https://doi.org/10.1111/ocr.70182","url":null,"abstract":"<p><strong>Objective: </strong>To compare ClinCheck-predicted and achieved maxillary occlusal contact areas immediately after an initial 14-aligner anterior segmental sequence without programmed posterior movement.</p><p><strong>Materials and methods: </strong>This retrospective study included 31 adult women treated with 14 maxillary and mandibular clear aligners. Bilateral first premolars through second molars were digitally locked. Predicted stage-14 models and intraoral scans obtained immediately after aligner 14 and before refinement were assessed at maximum intercuspation. Contact regions at 0.00-mm clearance were quantified with ImageJ. The primary outcome was the patient-level total posterior achieved-minus-predicted difference. Tooth-type differences were analysed using patient-clustered generalized estimating equations with Holm adjustment; bite-ramp comparisons were exploratory.</p><p><strong>Results: </strong>Predicted and achieved total posterior areas were 63.71 ± 36.56 and 30.30 ± 18.26 mm², respectively (mean difference, -33.41 mm²; 95% CI, -44.42 to -22.40; p < 0.001). After Holm adjustment, the achieved central-incisor area was 0.49 mm² greater than predicted (p = 0.003), whereas areas were smaller at the first premolars, second premolars, first molars, and second molars by 3.09, 5.44, 11.46, and 13.42 mm², respectively (adjusted p ≤ 0.016). Lateral-incisor and canine differences were not significant. Bite-ramp groups did not differ significantly.</p><p><strong>Conclusion: </strong>After 14 aligners, the achieved posterior contact area was substantially smaller than predicted despite no programmed posterior movement. This early discrepancy supports direct evaluation of posterior contacts before refinement.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Childhood Longitudinal Cephalograms Predict Adult Facial Soft-Tissue Dimensions? A Bayesian Modelling Study.","authors":"Sushant Pandey, Jamal Giri, Samikshya Sangroula, Avinash Chaudhary, Prabhat Ranjan Pokharel, Rajesh Gyawali","doi":"10.1111/ocr.70186","DOIUrl":"https://doi.org/10.1111/ocr.70186","url":null,"abstract":"<p><strong>Introduction: </strong>Predicting facial soft-tissue growth is essential for treatment planning and long-term outcome forecasting in orthodontics, orthognathic surgery and facial aesthetic surgery. This study evaluated whether longitudinal childhood cephalograms can predict adult facial soft-tissue dimensions using Bayesian growth models.</p><p><strong>Methods: </strong>Serial lateral cephalograms from four studies in the AAOF Craniofacial Growth Legacy Collection (Bolton-Brush, Denver, Iowa, Oregon) were analysed. The sample comprised 96 subjects (39 females, 57 males), over an age range of 6-29 years. Eight soft-tissue linear measurements were analysed: upper and lower facial heights, upper and lower lip lengths, upper and lower lip thicknesses and soft-tissue chin thickness at pogonion and menton. Population-level and individual-level Bayesian models were fitted for each variable. Predictive accuracy was assessed using five-fold cross-validation, with a childhood cutoff age of 14 years and prediction of withheld adult observations at age > 20 years. Predictive accuracy was quantified using the mean absolute error, bias and 95% prediction interval coverage.</p><p><strong>Results: </strong>Mean absolute error ranged from 0.73 mm (lower lip thickness) to 2.85 mm (lower facial height), with 95% prediction interval coverage of 94.1%-99.0%. Bias was close to zero for all variables. Residual standard deviation reduction from the individual-level model ranged from 3% (upper lip length) to 42% (lower lip length). Prediction accuracy was generally higher in females than males.</p><p><strong>Conclusion: </strong>Longitudinal childhood cephalometric records contain predictive information regarding adult facial soft-tissue dimensions beyond population-based growth standards. Prediction accuracy and inter-individual variation both differed by soft-tissue variable and sex.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Maxillary and Mandibular Transverse Dimensions on Digital Models and CBCT in Untreated Subjects With Normal Occlusion.","authors":"Leandra Garcia Jorge, Jedtanut Thussananutiyakul, Chenshuang Li, Jaime Guberman, Normand Boucher, Todd Welsh, Chun-Hsi Chung","doi":"10.1111/ocr.70183","DOIUrl":"https://doi.org/10.1111/ocr.70183","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the transverse dimension in adults with normal occlusion using cone-beam computed tomography (CBCT) and digital models, and to establish norms for maxillo-mandibular differentials.</p><p><strong>Material and methods: </strong>Twenty-four untreated adults with normal occlusion were selected. Inter-buccal and inter-lingual bone widths were measured on both the CBCT and digital models at the first molar. Measurements were taken 4 mm apical from the cementoenamel junction on CBCT and 4 mm apical to the free gingival margin on digital models. Maxillo-mandibular width differentials were calculated. The correlation between CBCT and digital model measurements was tested.</p><p><strong>Results: </strong>CBCT and digital models demonstrated strong correlations for all transverse measurements (r = 0.87-0.91). CBCT showed an average inter-lingual differential of 0.86 ± 3.80 mm and an inter-buccal differential of 1.09 ± 3.46 mm. Digital models showed -2.48 ± 2.79 mm and 0.89 ± 3.38 mm, respectively. Differential measurements between modalities were also strongly correlated for inter-lingual (r = 0.82) and inter-buccal (r = 0.84) differentials.</p><p><strong>Conclusions: </strong>CBCT- and digital model-derived transverse measurements in patients with normal occlusion were comparable and highly correlated; thus, they are suitable for diagnostic purposes.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthodontic and Oral Health Assessment in Children With Autism: A Comparative Study With Typically Developing Children.","authors":"Mevlüde Yüce Polat, Fethiye Kılıçaslan","doi":"10.1111/ocr.70181","DOIUrl":"https://doi.org/10.1111/ocr.70181","url":null,"abstract":"<p><strong>Objective: </strong>Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that may influence oral health and orthodontic characteristics due to associated behavioural, sensory, and motor challenges. This study aimed to compare orthodontic treatment need, Angle classification, and oral hygiene status between children with ASD and typically developing children.</p><p><strong>Materials and methods: </strong>This cross-sectional comparative study included 50 children aged 6-18 years with ASD and 43 age- and sex-matched typically developing children. Malocclusion and orthodontic treatment need were assessed using Angle classification and the Index of Complexity, Outcome, and Need (ICON), respectively. Oral hygiene was evaluated with the Simplified Oral Hygiene Index (OHI-S). Intra-rater reliability was assessed with the intraclass correlation coefficient (ICC = 0.96). Group differences were assessed using the Mann-Whitney U, chi-square, or Fisher's exact tests, as appropriate. Spearman's correlation and age- and sex-adjusted multivariable regression analyses were also performed.</p><p><strong>Results: </strong>ICON scores were significantly higher in children with ASD than in typically developing children (p = 0.024). Oral hygiene was significantly poorer in the ASD group (p < 0.001), whereas Angle classification did not differ significantly between the groups (p = 0.118). After adjustment for age and sex, ASD diagnosis remained significantly associated with higher ICON scores (adjusted B = 9.74, 95% CI: 2.95-16.53, p = 0.005) and greater odds of being classified in a poorer oral hygiene category (adjusted OR = 4.65, 95% CI: 2.05-10.56, p < 0.001). CARS scores were not significantly correlated with ICON scores (rho = -0.152, p = 0.291).</p><p><strong>Conclusion: </strong>Within the limitations of this study sample, children with ASD showed higher ICON scores and poorer oral hygiene status compared with typically developing children. These findings indicate an association between ASD status, orthodontic treatment need as assessed by ICON, and oral hygiene status in the study population. Further studies are needed to better understand the factors influencing orthodontic and oral health outcomes in children with ASD.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Clear Aligner Therapy on Quality of Life and Anxiety Levels: An Exploratory Study in Patients With Disabilities.","authors":"Kelly Regina Micheletti-Cerqueira, Luciana Tiemi Inagaki-Nomura, Mariana Emi Nagata, Carlos Eduardo de Oliveira Lima, Pedro Marcelo Tondelli, Mariane de Araújo Fonseca Figueiredo, João Armando Brancher","doi":"10.1111/ocr.70178","DOIUrl":"https://doi.org/10.1111/ocr.70178","url":null,"abstract":"<p><strong>Introduction: </strong>Considering the orthodontic needs of individuals with disabilities and the potential impact of such treatments on both quality of life (QoL) and anxiety, this study aims to assess the effects of using clear aligner therapy (Invisalign) on QoL and anxiety levels in this population.</p><p><strong>Materials and methods: </strong>Fourteen patients with malocclusion and disabilities were enrolled. Initial orthodontic examinations were performed, and questionnaires were administered to assess QoL and anxiety using the WHOQoL-BREF and the State-Trait Anxiety Inventory (STAI-T), respectively, with assessments completed at baseline (T0), three months (T1), and six months (T2) after the start of therapy. The maximum sampling error was evaluated using Pearson's Coefficient of Variation. The normality of the sample distributions was assessed using the Shapiro-Wilk test. For within-group comparisons across the three time points, Friedman's nonparametric test for paired samples was employed, with a post hoc 2-to-2 Pairwise Comparison test. The correlation between QoL and anxiety levels was evaluated with Spearman's rank correlation coefficient (p < 0.05).</p><p><strong>Results: </strong>A statistically significant decrease was observed in the Environment domain at T2 compared to T0 and T1 (p = 0.0126), as well as a significant increase in the Overall Quality of Life domain from T1 to T2 (p = 0.0145). The correlation analysis revealed significant associations among the domains of the WHOQoL-BREF and STAI-T.</p><p><strong>Conclusions: </strong>An improvement in the overall quality of life among children and adolescents with disabilities was observed during clear aligner therapy; nonetheless, further controlled studies are needed to confirm this association.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histomorphometric Effects of Thymoquinone and High-Frequency Vibration on Bone Formation During Retention After Rapid Palatal Expansion: A Controlled Rat Study","authors":"Özge Özdal Zincir,&nbsp;Aylin Paşaoğlu Bozkurt,&nbsp;Aslı Emincik","doi":"10.1111/ocr.70139","DOIUrl":"10.1111/ocr.70139","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Relapse after rapid palatal expansion (RPE) is associated with insufficient bone formation in the midpalatal suture during retention. This study evaluated the effects of thymoquinone (TQ) and high-frequency vibration force (VF) on bone formation after RPE in a rat model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>24 male Wistar rats were randomly divided into three groups (<i>n</i> = 8): control (RPE only), vibration (RPE + 111 Hz vibration) and TQ (RPE + TQ). RPE was performed for 5 days with a 50-g force followed by a 12-day retention period. VF was applied for 20 min/day during retention, while TQ was administered orogastrically at 10 mg/kg/day. Histomorphometric analysis included osteoblast, osteoclast, and capillary numbers, mineralized area, fibrous area, and osteocalcin immunoreactivity. Data were analysed using ANOVA or Kruskal–Wallis tests with Bonferroni correction (α = 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both VF and TQ groups showed significantly higher osteoblast counts than the control group (VF: 20.5 ± 3.56; TQ: 19.3 ± 2.80; control: 10.6 ± 2.16; <i>p</i> &lt; 0.001). Capillary numbers were also higher in the VF (9.83 ± 2.78) and TQ groups (10.0 ± 2.82) than in the control group (3.50 ± 1.76) (<i>p</i> &lt; 0.01). Mineralized area values were greater in the VF (41.06 ± 5.58) and TQ groups (38.35 ± 8.48) than in the control group (23.77 ± 3.37) (<i>p</i> &lt; 0.001). Fibrous area values were lower in both experimental groups (<i>p</i> &lt; 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>TQ and high-frequency vibration enhanced bone formation and angiogenesis during retention after RPE. These approaches may represent adjunctive strategies to improve post-expansion bone remodelling, although further clinical studies are required.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"29 5","pages":"917-925"},"PeriodicalIF":2.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147932281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Evaluation of Zygomaticomaxillary Complex Displacement and Rotational Centre in Adults Induced by Maxillary Skeletal Expander, Analysed With CBCT and Heuristic Search Algorithm","authors":"Lingling Hu,&nbsp;Ning Chang,&nbsp;Zhijian Xie,&nbsp;Ziyuan Yang,&nbsp;Ting Kang,&nbsp;Haiping Lu,&nbsp;Yingjia Sun,&nbsp;Xuepeng Chen","doi":"10.1111/ocr.70135","DOIUrl":"10.1111/ocr.70135","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To precisely identify the three-dimensional (3D) centre of rotation (CoR) of the zygomaticomaxillary complex (ZMC) in patients undergoing rapid palatal expansion with a maxillary skeletal expander (MSE) using a heuristic search algorithm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this retrospective study, 17 adult patients (mean age 24.0 ± 6.0 years) with maxillary constriction were treated with MSE. Cone-beam computed tomography (CBCT) scans were acquired before treatment (T0) and after the active expansion phase (T1). A heuristic search algorithm was applied to 3D reconstructed models to iteratively compute the patient-specific CoR by minimising the error between predicted and actual displacements of 10 ZMC landmarks. A 95% 3D confidence ellipsoid analysis was performed to quantify the spatial distribution and variability of CoRs. Landmark displacements were statistically analysed using paired <i>t</i>-test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant lateral, anterior and inferior displacements were observed in all ZMC landmarks following MSE expansion. The algorithm identified the CoR for each side not as a fixed anatomical point but as a confined 3D region with individual variability. After standardisation, the CoR was consistently located biomechanically near the superior orbital fissure, approximately aligned with the orbital longitudinal axis in the coronal plane. The 95% confidence ellipsoid further confirmed the regional distribution and side-related differences in CoR variability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>During MSE expansion, the ZMC undergoes complex 3D rotational movement around a patient-specific yet spatially consistent biomechanical region near the superior orbital fissure. This updated understanding of midfacial biomechanics may support more personalised and mechanics-guided orthodontic treatment planning.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: MR-33-25-072630</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"29 5","pages":"877-887"},"PeriodicalIF":2.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNAs in Oral Bio-Fluids as Predictive Biomarkers of Orthodontic Tooth Movement: A Systematic Review","authors":"Nikita Mohelay,&nbsp;Puneet Batra,&nbsp;Aditya Talwar","doi":"10.1111/ocr.70137","DOIUrl":"10.1111/ocr.70137","url":null,"abstract":"<div>\u0000 \u0000 <p>This systematic review was designed to assess scientific evidence of the association of microRNA expression during orthodontic tooth movement through various time points. A systematic review was performed in accordance with the PRISMA checklist. A search strategy was developed in electronic databases including Med Line, Scopus, EBSCO Host and ProQuest Dissertations &amp; Theses Global until June 2025. Eligibility criteria included studies that investigated microRNA expression in saliva/GCF during orthodontic treatment. The risk of bias of the included studies was analysed using the QUADAS-2 and RoB-2 tools. The search retrieved 2800 records, of which nine studies were selected. Minor variations in GCF collection were noted, while stimulated saliva was collected in one study. RT-PCR and the Fluro meter accounted for the majority of miRNA estimation. Thirteen miRNAs were identified as target biomarkers for OTM regulation. Despite the high risk of bias, the evidence from the current systematic review indicates that microRNAs can be considered as potential biomarkers of orthodontic tooth movement in oral biofluids.</p>\u0000 <p><b>Trial Registration:</b> Prospero ID-CRD420251153064</p>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"29 5","pages":"814-828"},"PeriodicalIF":2.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}