Orthodontics & Craniofacial Research最新文献

{"title":"In Vitro Comparison of the Effectiveness of Different Attachment Shapes and Locations on Extrusion of the Upper Left Lateral Incisor Using Thermoplastic Aligners.","authors":"Alexandra Bojrab, Amin Akbari, Dustin Broyles, Janine Magura, Megann Lear, George Eckert, Jie Chen, Hakan Turkkahraman, R Scott Conley","doi":"10.1111/ocr.12887","DOIUrl":"https://doi.org/10.1111/ocr.12887","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to compare the effectiveness of different attachment shapes and locations on the extrusion of the upper left lateral incisor (UL2) using thermoplastic aligners.</p><p><strong>Materials and methods: </strong>Seven typodonts were digitally printed with hemi-ellipsoid or rectangular attachments in the incisal, middle or cervical third of the UL2. Five clear aligners were fabricated for each typodont; each was tested twice. Forces and moments were measured with an orthodontic force tester during 0.2 mm simulated extrusion of the UL2. Analysis of variance (ANOVA) was used to determine the effects of group, tooth, and the group-by-tooth interaction on the outcomes. A two-sided 5% significance level was used for all tests.</p><p><strong>Results: </strong>Altering attachment shape and location had a statistically significant effect on the forces and moments generated in each trial (p < 0.01), except for rectangular incisal and hemi-ellipsoid cervical (p > 0.05). The rectangular middle attachment generated the highest extrusive force (Fz = 7.498 N), followed by hemi-ellipsoid cervical (Fz = 6.338 N) and rectangular incisal (Fz = 5.948 N).</p><p><strong>Conclusions: </strong>Varying direct attachment shape and location on the UL2 during extrusion has a significant effect on the forces and moments generated by thermoplastic aligners. The rectangular attachment located in the middle third generated the most effective extrusive force and least unwanted moment. For anchorage teeth, hemi-ellipsoid attachments located in the cervical third were found to be the most effective in minimising the reciprocal intrusive forces and unwanted moments.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Relationship Between ACTN3 rs1815739 Polymorphism and Openbite Cases: A Prospective Study.","authors":"Elif Aslıhan Yaylacı, Elvan Onem Ozbilen, Beste Tacal Aslan, Tolga Polat","doi":"10.1111/ocr.12886","DOIUrl":"https://doi.org/10.1111/ocr.12886","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine whether ACTN3 rs1815739 polymorphism, which causes the deficiency of the alpha-actinin-3 muscle protein, is related to the formation of open bite malocclusion.</p><p><strong>Materials and methods: </strong>Fifty-eight participants (18.5 ± 3.6 years old) with anterior open bite (n = 29) and normal overbite (n = 29) who presented to Marmara University, Department of Orthodontics for treatment were included in the study. Initial cephalometric radiographs were used for the diagnosis of malocclusion. The case group was divided into three subgroups according to degree of open bite. For DNA isolation, oral epithelial cells were collected with buccal swabs (Van Allen Way, Carlsbad, USA), and the real-time PCR method was used for the genotyping of all polymorphisms. The results were statistically analysed, and the threshold for statistical significance was set at p < 0.05.</p><p><strong>Results: </strong>The frequencies of RR, RX and XX genotypes of ACTN3 rs1815739 polymorphism were found as 6 (20.7%), 14 (48.3%) and 9 (31.0%) in the control group and 8 (8%), 9 (31.0%) and 12 (41.4%) in the case group, respectively. There was no statistically significant difference between the groups in terms of the presence of the examined polymorphism (p > 0.05). However, the intra-group evaluation of case group revealed a significant difference in the prevalence of XX genotype (83.3%) for the subgroup with an open bite of -5 mm or above.</p><p><strong>Conclusion: </strong>Although no significant difference was observed between the case and control groups, a possible association was identified between ACTN3 rs1815739 polymorphism and an increased severity of open bite malocclusion.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformative Advances in Digital Orthodontics","authors":"Sung-Hoon Lim","doi":"10.1111/ocr.12871","DOIUrl":"10.1111/ocr.12871","url":null,"abstract":"","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"27 S2","pages":"4-5"},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different Effects of Fixed Appliances and Clear Aligners on the Microbiome and Metabolome of Dental Plaque.","authors":"Wuyi Gong, Kaiyong Zhou, Sijin Li, Zhihang Yue, Qiongyu Zhang, Yongming Li, Xiaohui Mi","doi":"10.1111/ocr.12883","DOIUrl":"https://doi.org/10.1111/ocr.12883","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to uncover the microbial and metabolic changes in dental plaque during orthodontic treatments with fixed appliances (FAs) and clear aligners (CAs).</p><p><strong>Materials and methods: </strong>Twenty participants were grouped by the treatment modality they received, with 10 participants each in the FA and CA groups. Supragingival plaques were collected before orthodontic treatment (T0), after 1-3 months (T1) and more than 6 months (T2) of orthodontic treatment. 16S rRNA gene sequencing and liquid chromatography-tandem mass spectrometry were employed to analyse the plaque samples.</p><p><strong>Results: </strong>No significant change was observed in the alpha and beta diversity at different time points and between the two treatment modalities. The relative abundance of genera Veillonella, Mogibacterium and unclassified_c__Actinobacteria, and species Actinomyces massiliensis, Prevotella pallens and Prevotella jejuni experienced the most significant changes. The most differential metabolites were amino acids, nucleosides and organoheterocyclic compounds. Compared to T0, downregulation of nucleotide metabolism at T1 and upregulation of amino acid metabolism at T2 were found in the FA group. Compared with the FA group, the CA group experienced metabolite enrichment in several immune pathways at T1, while linoleic acid metabolism, riboflavin metabolism and nucleotide metabolism were downregulated at T2 in the CA group. Significant correlations were identified between most differential plaque microorganisms and metabolites.</p><p><strong>Conclusion: </strong>This study implied that exposure to FAs for more than 6 months resulted in the accumulation of oral disease-related bacteria in dental plaque and a metabolic shift towards a cariogenic state, whereas CAs could lead to a transient proinflammatory state.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CBCT Analysis of the Hyoid and Pharyngeal Airway Changes in Class III Patients With Orthognathic Surgery.","authors":"Si-Mai Chen, Hua-Yang Cai, Xing-Zhi Yan, Jie-Li Ni, Li-Ran Wang, Chen-Jie Cai, Qi Cai, Dong-Dong Wan, Ya-Jing Qian, Wei-Wen Fang, Fan Lei, Yang Zhang, Shu-Yu Guo, Peter A Mossey","doi":"10.1111/ocr.12881","DOIUrl":"https://doi.org/10.1111/ocr.12881","url":null,"abstract":"<p><strong>Aim: </strong>This study was designed to investigate the response of the respiratory structures to orthognathic surgery in patients with Class III malocclusion, with a specific emphasis on the vertical placement of the hyoid bone. The correlations of these changes were also analysed, followed by further subgroup analyses based on preoperative conditions.</p><p><strong>Materials and methods: </strong>Dolphin software was used to obtain cephalometric landmarks, airway and hyoid bone measurements from pre- and postoperative CBCT scans of 31 patients. Statistical analyses included paired t-tests and Pearson's correlation analysis.</p><p><strong>Results: </strong>Stomatological mandibular values and the nasopharynx height showed significant changes. Pearson's correlation identified significant correlations between changes in B and H horizontal coordinates (p < 0.05), as well as between changes in H longitudinal coordinates and specific airway dynamics (p < 0.05). Patients with a lower preoperative hyoid position experienced a more pronounced decrease in hypopharyngeal airway volume after surgery compared to those with a higher preoperative hyoid position, as evidenced by the significant mean differences and p values (p < 0.01).</p><p><strong>Conclusions: </strong>Class III patients experienced airway constriction following orthognathic surgery, particularly those with a lower preoperative hyoid bone position, who showed a more significant decrease in hypopharyngeal airway volume postsurgery compared to those with a higher preoperative hyoid position. These findings underscored the importance of individualised surgical planning and highlighted the need for further research with dynamic assessments to optimise respiratory outcomes.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on Current Knowledge of Paediatric Obstructive Sleep Apnoea: From Animal to Human Studies.","authors":"Takashi Ono, Carlos Flores-Mir","doi":"10.1111/ocr.12882","DOIUrl":"https://doi.org/10.1111/ocr.12882","url":null,"abstract":"<p><p>Orthodontists' interest in paediatric obstructive sleep apnoea (PedOSA) has grown in popularity recently. We have seen growth modification treatment modalities, including maxillary expansion, promising the prevention or cure of PedOSA. Clinical approaches such as palatal expansion and mandibular and maxillary complex advancement have been proposed to manage PedOSA. These hypotheses should be adequately tested before clinical recommendations are formulated. This review aimed to narratively synthesise our current understanding of PedOSA management with craniofacial growth modification alternatives. Basic research on the biological basis of PedOSA has been conducted in animal models. Laboratory-based PedOSA studies wish to provide insight into the molecular biological mechanisms by which human PedOSA affects growth-associated structural and emotional growth and development. In the proposed IH animal model, mandibular growth (especially posterior anteroposterior and transverse dimensions) and condylar head bone density were more sensitive to IH exposure in adolescents but less in juvenile rats. Nevertheless, clear-cut statistical growth differences were limited. This suggests that IH, in this rat model, influenced mandibular morphology and metabolism later than earlier craniofacial growth stages. No impact was found for the maxillofacial complex in any plane of space. The existing human studies on the causes, risk factors, consequences, symptomatology, diagnosis and effects of PedOSA are discussed. However, there is a pressing need for further research to clarify whether craniofacial disturbances are consequences or facilitators of PedOSA. Several hypotheses about the potential impact of impaired craniofacial growth as a facilitator for PedOSA currently circulate.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Comparative Analysis of Root Parallelism in First Premolar Extraction Cases: Clear Aligner Versus Fixed Orthodontic Appliance.","authors":"Waseem S Al-Gumaei, Fan Jian, Xiaoqi Zhang, Yufei Tang, Yi Yang, Haoxin Zhang, Wenli Lai, Hu Long","doi":"10.1111/ocr.12874","DOIUrl":"https://doi.org/10.1111/ocr.12874","url":null,"abstract":"<p><strong>Objective: </strong>To compare the three-dimensional root parallelism (mesiodistally and buccolingually) between orthodontic therapy with the Invisalign clear aligners (CA) and fixed appliances (FA) among the first premolar-extraction patients, using cone-beam computed tomography (CBCT).</p><p><strong>Materials and methods: </strong>Sixty participants with similar American Board of Orthodontics discrepancy index scores as baseline characteristics were included and divided into CA and FA groups (30 per group). Post-treatment mesiodistal and buccolingual root parallelisms were analysed through CBCT using Invivo 6.0.3 software. Descriptive and analytical statistics were performed with a p < 0.05, considered statistically significant.</p><p><strong>Results: </strong>Mesiodistal dental root parallelism in the U1-U2 and L1-L2 pairings between CA and FA groups were found to be significantly different with inferior parallelism in the CA group (p < 0.05). Conversely, the U3-U5 and L5-L6 pairings exhibited superior parallelism in the CA group (p < 0.05). However, other pairings, including U1-U1, U2-U3, U5-U6, U6-U7, L1-L1, L2-L3, L3-L5, and L6-L7, showed no significant differences in mesiodistal parallelism between groups (p > 0.05). Regarding the buccolingual dental root parallelism, significant differences were also noted in the U5-U6 and L5-L6 pairings with superior parallelism in the CA group (p < 0.05). However, in the U1-U1, U2-U3, U3-U5, U6-U7, L1-L1, L2-L3, L3-L5, and L6-L7 pairings, no significant differences in buccolingual parallelism were observed (p > 0.05).</p><p><strong>Conclusion: </strong>In this study, our findings indicate that in cases involving the extraction of first premolars, Invisalign clear aligners may offer comparable or even superior three-dimensional root parallelism compared to fixed orthodontic appliances, with the exception of the mesiodistal dimension in upper and lower incisors, where their performance is less effective.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Evaluation of Changes in the Nose and Upper Lip After Secondary Alveolar Bone Grafting in Patients With Unilateral Cleft Lip and Palate.","authors":"Attapong Deedklin, Araya Pisek, Supaporn Kongsomboon, Poonsak Pisek","doi":"10.1111/ocr.12879","DOIUrl":"https://doi.org/10.1111/ocr.12879","url":null,"abstract":"<p><strong>Introduction: </strong>Alveolar bone grafting (ABG) influences facial soft tissue changes, but the precise effects on the nose and upper lip remain unclear. This study used three-dimensional (3D) facial images to evaluate nose and upper lip alterations after ABG. We further enhanced the visualisation of these changes by generating 3D superimpositions, colour maps and deviation analyses of key critical landmarks in these regions.</p><p><strong>Materials and methods: </strong>Forty patients (8-20 years old) with non-syndromic unilateral cleft lip and cleft palate (UCLP) underwent ABG using the iliac bone from September 2022 to September 2023. Three-dimensional facial images were analysed 1 month before and 3 months after surgery to evaluate the spatial displacement of 18 nose and upper lip landmarks to assess changes after ABG. Colour maps were constructed, and 3D deviation analysis was also performed. Paired sample t tests and Wilcoxon's signed-rank tests were used to analyse alterations.</p><p><strong>Results: </strong>The 3D analysis uncovered significant forward movement on the cleft side only. This included nasal alar, alar curvature and subalar points. The labrale superius of the upper lip showed similar movement. Conversely, other landmarks showed minimal changes in all directions.</p><p><strong>Conclusions: </strong>ABG can improve the nasal contour on the cleft side. After ABG, significant forward movement occurs in the cleft side of the nasal alar, alar curvature and subalar regions. Although these changes are minimal, they contribute to the overall improvement in facial aesthetics.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of Inflammatory Cytokines in Gingival Crevicular Fluid and Plasma in Patients With Grade C Periodontitis During Orthodontic Treatment: A Longitudinal Case Series Report.","authors":"Tian-Yi Xin, Zi-Lu Zhu, Liu-Jing Chen, Bin Han, Rui-Li Yang, Jie Shi","doi":"10.1111/ocr.12880","DOIUrl":"https://doi.org/10.1111/ocr.12880","url":null,"abstract":"<p><strong>Aim: </strong>To examine the immune responses in patients diagnosed as grade C periodontitis during orthodontic treatment.</p><p><strong>Materials and methods: </strong>Our study included seven orthodontic patients with grade C periodontitis and measured their levels of inflammatory cytokines in gingival crevicular fluid and plasma before orthodontic treatment, during the alignment and levelling phase, and during the detailing and finishing phase. The key signal pathways in the orthodontic process of patients with periodontitis were detected by KEGG analysis.</p><p><strong>Results: </strong>Studies have shown that orthodontic treatment brings great improvement to patients with grade C periodontitis, and most of the local/systemic inflammatory cytokines can be reduced after orthodontic treatment. Simultaneously, orthodontic treatment can reduce the percentage of IFN-γ⁺ Th1 cells in patients with grade C periodontitis. Through KEGG analysis, the IL-17 signalling pathway and TNF signalling pathway are closely interrelated in the orthodontic treatment of patients diagnosed with grade C periodontitis (p-value < 0.001).</p><p><strong>Conclusion: </strong>Orthodontic treatment can effectively control the local and system levels of inflammation in patients with grade C periodontitis, with IL-17A and TNF-α as potential distinctive inflammatory markers for orthodontic-periodontal combined treatment in individuals with periodontitis.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Current Evidence Support the Discussion Around the Guidance Theory? A Systematic Review and Meta-Analysis on the Association Between Maxillary Lateral Incisor Agenesis and Displacement or Impaction of the Permanent Canine.","authors":"Spyridon N Papageorgiou, Jadbinder Seehra, Martyn T Cobourne, Georgios Kanavakis","doi":"10.1111/ocr.12878","DOIUrl":"https://doi.org/10.1111/ocr.12878","url":null,"abstract":"<p><p>Palatal impaction of the maxillary canine is commonly considered as a genetic condition, while the lateral incisor root has been suggested to guide maxillary permanent canine eruption. This review assessed whether agenesis of the maxillary lateral incisor is associated with eruption disturbances of the maxillary canine (displacement or impaction). Unrestricted searches in six databases for observational case-control human studies until May 2024 assessing eruption disturbances of the permanent maxillary canine in conjunction with permanent maxillary lateral incisor agenesis were performed. Study selection, data extraction and risk-of-bias assessment with the Joanna Briggs Institute's tool were performed in duplicate. Random-effects meta-analyses of odds ratios (ORs) with their 95% confidence intervals (CIs) were performed, followed by meta-regressions and sensitivity analyses. Seventeen reports pertaining to 17 case-control studies were included covering 10,155 patients (11.6 year-old/46% male on average). Maxillary lateral incisor agenesis was associated with eruption disturbance of the maxillary canine (17 studies; OR = 3.88; 95% CI = 2.05-7.34; p < 0.001; I² = 58). Lateral incisor agenesis was more associated with canine displacement (7 studies; OR = 7.56; 95% CI = 2.10-27.18; p = 0.008; I² = 57) and to a lesser degree with canine impaction (10 studies; OR = 2.39; 95% CI = 1.28-4.48; p = 0.01). No significant effects of patient age or sex were seen, and the results were robust to study design and precision. The quality of evidence was low due to the inclusion of observational case-control studies with methodological issues and residual confounding. Evidence indicates that permanent maxillary lateral incisor agenesis is associated with eruption disturbances of the permanent maxillary canine, including mainly displacement, but also impaction. Trial Registration: PROSPERO database number: CRD42024549898.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}