Orthodontics & Craniofacial Research最新文献

{"title":"Gender Distribution Among Invited Speakers at the Italian Orthodontic Society (SIDO) Conferences Held Between 2013 and 2023: A Cross-Sectional Analysis.","authors":"Valentina Lanteri, Alessandro Bruni, Andrea Abate, Cinzia Maspero, Elis Kola, Alessandro Ugolini","doi":"10.1111/ocr.70001","DOIUrl":"https://doi.org/10.1111/ocr.70001","url":null,"abstract":"<p><p>Scientific conferences play a key role in shaping professional visibility and recognition. Investigating gender balance among invited speakers can provide insight into broader patterns of inclusion in the context of orthodontic congresses. The purpose of this study was to evaluate gender representation among invited speakers at the Italian Orthodontic Society (SIDO) congresses from 2013 to 2023, identifying trends and potential disparities during this decade-long period. A cross-sectional review of the abstract books and programmes of the SIDO Spring and Winter congresses held between 2013 and 2023 was conducted. The gender, country of origin, affiliation, topic of presentation and H-index were recorded for each invited speakers. Presentations lasting less than 30 min, involving more than three speakers, focusing on non-orthodontic topics (e.g., dental hygiene or dental technician presentations) or held during sponsored sessions, roundtables and collateral events were excluded. Descriptive statistics were performed to summarise speaker characteristics. Univariate and multivariate logistic regression analyses were conducted to examine the effect of predictor variables, including year of presentation, country (non-Italian speakers), H-index (≥ 8) and affiliation (non-academic) on the likelihood of a speaker being female. The Mantel-Haenszel test for homogeneity of odds ratios (OR) was used to assess whether trends in female representation were consistent over time. The predefined level of statistical significance was set at p < 0.05 (two-sided). The analysis revealed a significant gender imbalance, with male speakers accounting for 77.2% and female speakers 22.8% throughout the study period (p < 0.001). Logistic regression indicated that the likelihood of a speaker being female increased by 6% for each additional year (OR: 1.055, 95% CI: 1.010-1.110, p = 0.015), while other variables such as country of origin, H-index and affiliation were not significant. The majority of speakers were from Italy (62.3%), followed by the United States (9.6%) and Spain (3.2%). The topics discussed most frequently were Interdisciplinary (14.2%), New Technologies (8.4%) and Clear Aligner Treatment (8.2%). A large proportion of the invited speakers lacked academic affiliation (36.4%). Although the proportion of female speakers at SIDO congresses remains limited, the data reveal a steady annual increase in female representation. Nevertheless, a substantial gender imbalance persists, indicating that initiatives aimed at improving diversity could contribute to a more balanced representation in the future.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building and Evaluating an Orthodontic Natural Language Processing Model for Automated Clinical Note Information Extraction.","authors":"Jay S Patel, Divakar Karanth","doi":"10.1111/ocr.12944","DOIUrl":"https://doi.org/10.1111/ocr.12944","url":null,"abstract":"<p><strong>Introduction: </strong>Malocclusion presents functional and aesthetic challenges, necessitating accurate diagnosis and treatment. However, variability in orthodontic treatment planning persists due to subjective assessments, limiting consistency and objectivity. Electronic dental records (EDRs) contain vast patient data that could address these challenges, but much of the rich clinical information is documented as free text, complicating analysis. This study aims to develop an Orthodontic Natural Language Processing (ONLP) model to extract structured orthodontics-related information from unstructured EDRs and identify critical features influencing malocclusion using machine learning (ML).</p><p><strong>Methods: </strong>Data from 7693 orthodontic patients were analysed to train, test and validate the ONLP and ML models. A gold-standard dataset was created through manual review. The ONLP model utilised supervised (Named Entity Recognition-NER) and unsupervised (K-means clustering) approaches to structure information from free text. Machine learning models, including Logistic Regression, Gaussian Naive Bayes, Random Forest and XGBoost, were subsequently applied to identify feature importance for malocclusion classification.</p><p><strong>Results: </strong>The ONLP model achieved 89% sensitivity, 92% specificity and 91% accuracy in extracting orthodontics-related information. The supervised model demonstrated 84% accuracy, 82% F1-score and 84% recall, excelling in identifying Classes I and III malocclusions but showing reduced sensitivity for Class II. Machine learning analysis highlighted key features for malocclusion classification: maxillary crowding, overjet and arch perimeter discrepancy for Class I; maxillary spacing and anterior crossbite for Class II; and dental midline deviation and occlusal wear for Class III.</p><p><strong>Conclusion: </strong>This study demonstrates a novel approach to automating orthodontic data extraction using the ONLP model, enabling advanced big data analytics and enhancing data-driven orthodontic research and care.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Bioactive NanoAg-ACP Microparticles on the Bond Strength of a Commercial Orthodontic Adhesive and Enamel Resistance to Demineralization.","authors":"Kelton Cronquist, Linfeng Wu, Brian R Morrow, Ayman Al Dayeh, Antheunis Versluis, Liang Hong","doi":"10.1111/ocr.12948","DOIUrl":"https://doi.org/10.1111/ocr.12948","url":null,"abstract":"<p><strong>Objective: </strong>This study was to assess the effects of nanoAg-ACP microparticles as additional fillers on the shear bond strength of Phase II Dual Cure orthodontic adhesive and the enamel demineralisation of teeth using such adhesive.</p><p><strong>Materials and methods: </strong>Experimental adhesive was formulated by incorporating 2.5 wt% nanoAg-ACP microparticles into Phase II Dual Cure immediately before use. Brackets were bonded to extracted human premolars using Phase II Dual Cure for one group and experimental adhesive for the second. Samples in each group were randomly assigned to three sub-groups for different post-bonding treatments. Debonding force was measured after post-bonding treatments and used to calculate shear bond strength. DIAGNOdent was used to assess enamel demineralisation for sub-groups treated with acid gels.</p><p><strong>Results: </strong>The shear bond strength for Phase II Dual Cure and experimental adhesive was 19.06 ± 2.88 and 13.90 ± 2.22 MPa, respectively, after 24-h aging, 15.98 ± 5.44 and 15.31 ± 4.22 MPa, respectively, after 5-month aging, and 14.72 ± 3.15 and 14.46 ± 4.66 MPa, respectively, after 3-week demineralisation following 5-month aging. After being aged for 5 months and demineralised for 3 weeks, samples bonded using Phase II Dual Cure had a higher DIAGNOdent value of 65.00 ± 14.66 compared to 49.77 ± 20.64 for samples bonded using experimental adhesive (p < 0.05).</p><p><strong>Conclusions: </strong>NanoAg-ACP microparticles could be added into Phase II Dual Cure as fillers to resist demineralisation without impairing the shear bond strength. The results warrant further investigation of nanoAg-ACP microparticles as fillers for orthodontic adhesives using more clinically relevant in vitro models to confirm their potential clinical application in orthodontic treatments.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Lipstick Application on the Attractiveness of Smile in Women With and Without Malocclusions: An Eye-Tracking Study.","authors":"Gil Guilherme Gasparello, Mohamad Jamal Bark, Giovanna Purkote Yamaguchi, Rosilene Andrea Machado, Joel Suárez, Orlando Tanaka","doi":"10.1111/ocr.12947","DOIUrl":"https://doi.org/10.1111/ocr.12947","url":null,"abstract":"<p><strong>Introduction: </strong>The use of cosmetics, particularly lipstick, has historically enhanced facial appeal. This study evaluates laypeople's perceptions of the attractiveness and employability of two female models from different age groups, each with varying malocclusions, both with and without lipstick.</p><p><strong>Materials and methods: </strong>This cross-sectional study involved 77 lay participants who assessed digitally edited photographs of young and older female models with varying malocclusions (IOTN 1, 3 and 5), each shown with and without red lipstick. Eye-tracking technology and questionnaires were used to evaluate perceptions of attractiveness and employability. Data were analysed using one-way ANOVA and post hoc tests, and Pearson's chi-squared test.</p><p><strong>Results: </strong>IOTN 1 with lipstick was rated 49.71 ± 25.74 and without lipstick 47.88 ± 25.44. These were significantly higher than IOTN 3 with lipstick (40.62 ± 24.16; p = 0.015), IOTN 3 without lipstick (39.23 ± 23.85; p = 0.002), IOTN 5 with lipstick (34.25 ± 24.77; p < 0.001) and IOTN 5 without lipstick (31.39 ± 23.30; p < 0.001). Employability ratings also varied significantly when comparing IOTN 1 and IOTN 5 images (p < 0.001). Eye-tracking heat maps revealed that the mouth was the primary area of visual focus across all conditions, regardless of lipstick use.</p><p><strong>Conclusion: </strong>Malocclusion significantly impacts visual attention and attractiveness perception, with the mouth being the primary focus. While lipstick influences attention dispersion, it does not shift the main focus from the mouth. Heat map analysis confirmed that the mouth area remains the primary focus across all images, regardless of lipstick use.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging Generative Artificial Intelligence in Teaching, Scholarship and Dental Education: Use Cases and Reflections.","authors":"Jonas Bianchi, Meixun Zheng","doi":"10.1111/ocr.12949","DOIUrl":"https://doi.org/10.1111/ocr.12949","url":null,"abstract":"<p><p>The objective of this narrative review is to explore the role of generative artificial intelligence (genAI) in dental education, highlighting its emerging applications, potential benefits and implementation challenges. Since the launch of ChatGPT in 2022, genAI tools have gained traction in academic and clinical settings, enabling content generation, translation, summarisation, exam preparation and basic clinical planning. This review presents a series of illustrative use cases demonstrating how genAI has been integrated into teaching, research and clinical workflows in dental and orthodontic training. Each example underscores how AI can support faculty in course design, assist students with learning complex concepts and provide real time feedback for exam analysis and academic writing. However, the implementation of genAI is not without limitations. The review addresses common concerns, including misinformation, data privacy, fabricated references and ethical use in clinical contexts. Although the benefits of genAI are promising, this review emphasises the importance of human oversight and institutional policies to guide ethical and effective use. In conclusion, genAI offers valuable support in dental education when used responsibly. Continued dialogue among educators, students and policymakers is essential to ensure that AI tools are integrated thoughtfully and equitably into academic practice.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of Sympathetic Sensory Coupling to Craniofacial Nociception.","authors":"Brian Edwin Cairns","doi":"10.1111/ocr.12945","DOIUrl":"https://doi.org/10.1111/ocr.12945","url":null,"abstract":"<p><p>Stress and anxiety are associated with increased pain intensity in temporomandibular disorders (TMDs) patients. It is possible that this association is due to a direct interaction between the sympathetic and sensory nervous systems. This narrative review examines evidence for a potential sympathetic sensory interaction in deep craniofacial tissues and the trigeminal ganglion. Research articles were identified using PubMed with the mesh terms adrenergic, ganglion neuron, masseter, sensory, signaling, temporomandibular and trigeminal and, subsequently, from the reference lists of those articles identified. The masticatory muscles and temporomandibular joint are innervated by sympathetic efferent fibres from the superior cervical ganglion, which primarily innervates blood vessels. As trigeminal sensory afferent fibres are often found near blood vessels, the anatomical relationship for potential sympathetic sensory coupling is present in the temporomandibular joint and masticatory muscles. Trigeminal afferent fibres express α₁, α₂, β₁ and β₂ adrenergic receptors as well as two of the four neuropeptide Y receptors. Stimulation of α₁ receptors in the masticatory muscle mechanically sensitises nociceptors through a direct effect, but desensitises proprioceptors and spindle afferent fibres through an indirect effect on mechanosensitive organelles. Stimulation of β₂ adrenergic receptors increases the mechanical activation threshold of masticatory muscle afferent fibres. There is also evidence that stimulation of β adrenergic receptors on immune cells contributes to nociception in temporomandibular joint arthritis. In contrast, α₁ adrenergic receptor activation underlies nociception in masticatory muscle myositis. Taken together, the current research provides support for the concept that sympathetic sensory coupling could play a role in the pathogenesis of TMD-related pain.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Differential Fibrocartilage Degradation Between Sexes in a Burn-Synovectomy Temporomandibular Osteoarthritis Mouse Model.","authors":"Amy Z Lu, Jeffrey Nickel, Ginny Ching-Yun Hsu","doi":"10.1111/ocr.12946","DOIUrl":"https://doi.org/10.1111/ocr.12946","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular joint osteoarthritis is a degenerative disease with a higher prevalence in women, yet its sex-specific mechanisms remain unclear. This study investigates fibrocartilage degradation in a burn-synovectomy TMJ OA mouse model, hypothesizing that female mice exhibit greater cartilage degradation due to differential inflammatory responses.</p><p><strong>Methods: </strong>PRG4-CreERT2; Ai9 mice (12-week-old males and females) underwent burn-synovectomy injuries and were euthanized at 1, 3, and 9 weeks for histological and immunofluorescence analyses. PRG4 and MMP-13 expression were assessed to evaluate fibrocartilage integrity and degradation. Statistical significance was determined using ANOVA and post hoc testing.</p><p><strong>Results: </strong>Female mice showed significantly higher Osteoarthritis Research Society International (OARSI) scores and MMP-13/PRG4 ratios at later time points, indicating sustained degradation. PRG4 expression increased similarly in both sexes in all time points, but MMP-13 expression was significantly higher in females at 9 weeks, suggesting heightened cartilage catabolism.</p><p><strong>Conclusion: </strong>This study highlights sex-based differences in TMJ OA progression, reinforcing the importance of targeted therapeutic strategies. The burn-synovectomy model effectively replicates TMJ OA pathology, making it a valuable tool for future research.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthodontists' Perspectives on Teleorthodontics: What Does Qualitative Data Tell Us?","authors":"Reem A Alansari, Abdulraheem A Alwafi, Mohamed Bamashmous, Samar M Adel, Nikhillesh Vaiid","doi":"10.1111/ocr.12943","DOIUrl":"https://doi.org/10.1111/ocr.12943","url":null,"abstract":"<p><strong>Objective: </strong>To have an in-depth understanding of orthodontists' perspectives on the practice of teleorthodontics.</p><p><strong>Methods: </strong>This was a qualitative study which used one-on-one, in-depth, semi-structured interviews with 19 orthodontists who have offered teleorthodontic care. The interviews were audio-recorded, transcribed verbatim, and analysed using thematic analysis.</p><p><strong>Results: </strong>The analysis identified two main themes and related subthemes. Respondents described a space-time continuum, where teleorthodontics created time and virtual space to see patients, saving crucial time and physical clinic space. This, however, did not always lead to increased efficiency and quality. Participants also described a human-machine continuum, illustrating how teleorthodontics' digital components became additional tools in the orthodontists' arsenal. These tools had variable utility and impact on their practice, with many being better provided in person.</p><p><strong>Conclusions: </strong>The findings highlight the need for tailored integration of teleorthodontics to enhance treatment effectiveness, efficiency, and overall quality care.</p><p><strong>Practical implications: </strong>Data gathered will lead to a better understanding of orthodontists' use and barriers of teleorthodontics and can help with long-term planning to increase efficiency and quality of care.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrocephalus in Connection to Genetic Mutation in Cranial Neural Crest Cells.","authors":"Samar Jalali, Ali Mohazeb, Nika Rezaeikalantari, Yang Fu, Yasamin Mohazeb, Guanjun Jiao, Xinli Zhang","doi":"10.1111/ocr.12942","DOIUrl":"https://doi.org/10.1111/ocr.12942","url":null,"abstract":"<p><p>Hydrocephalus, a pathological condition due to the accumulation of cerebrospinal fluid (CSF) in the brain's ventricles, has been recognised as a relatively common brain abnormality in newborns and young adults with or without craniofacial anomaly. It can cause physical, behavioural and cognitive symptoms and, in severe cases, may result in lethality. Hydrocephalus can result from various underlying conditions, and its multifactorial nature makes pinpointing a single pathophysiological aetiology challenging. Notably, the relatively high prevalence of hydrocephalus (up to 100%) in the cranial neural crest cells (CNCCs) conditional knockout mouse models of various genes using Wnt1-Cre has been reported, given the extremely low (0.01% to 0.86%) spontaneous occurrence of hydrocephalus in different strains of lab mice. Surprisingly, there were no reports on the connections of hydrocephalus with CNCCs, although the prominent role of CNCCs in normal development and pathologic conditions of craniofacial and neural tissues has been extensively studied and highly recognised. In this review, besides revealing the high prevalence of hydrocephalus (5.4%-100%), we primarily summarised the in vivo findings of hydrocephalus and the associated pathological changes of brain and craniofacial skeletal tissues with the genetically modified mouse (GMM) models of various genes knocked out in CNCCs. Significantly, the functional gene knockout in Wnt1 expressing cells can lead to hydrocephalus and associated brain and craniofacial skeletal pathologies, irrespective of the ectopic midbrain Wnt1 activation observed in Wnt1-Cre driver mice. However, the specific contributions and underpinning mechanisms of the main structures of the CSF system, including CNCCs-derived choroid plexus, to hydrocephalus pathophysiology are yet to be fully elucidated.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis Prediction of Facemask With Miniplate Therapy in Patients With Cleft Lip With/Without Palate.","authors":"Sungmin Cha, Il-Sik Cho, Il-Hyung Yang, Sungmi Jeon, Jee Hyeok Chung, Mihee Hong, Jin-Young Choi, Seung-Hak Baek","doi":"10.1111/ocr.12941","DOIUrl":"https://doi.org/10.1111/ocr.12941","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prognosis prediction of facemask with miniplate (FMMP) therapy in patients with cleft lip with/without palate (CL/P).</p><p><strong>Materials and methods: </strong>The subjects were 103 CL/P patients treated with FMMP therapy. Twenty-five cephalometric variables were measured at preadolescence (T0) and young adulthood (T1). At T1, the subjects were allocated into the FMMP-surgery group (1) when three of the following conditions were met: ANB < -3°, Wits appraisal < -5 mm, APDI > 90° and AB-MP < 60° and (2) when patients were undergoing presurgical orthodontic treatment or had already undergone orthognathic surgery. The mean ages of T0 and T1 and the mean FMMP duration were 8.4, 19.5 and 5.2 years in the FMMP-surgery group (27.2%, n = 28) and 8.5, 18.1 and 4.1 years in the FMMP-nonsurgery group (72.8%, n = 75). Binary logistic regression analysis and receiver operating characteristics analysis were performed.</p><p><strong>Results: </strong>Compared to the FMMP-nonsurgery group, the FMMP-surgery group exhibited a more forward mandibular position and a flatter maxillary occlusal plane at T0, a similar amount of change in the position of point-A, greater forward mandibular growth with larger counterclockwise rotation and an increase in posterior vertical dimension, leading to exacerbation of the skeletal Class III pattern during T1-T0. Four T0 cephalometric predictors (A to N-perpendicular, APDI, FMA and ODI) were identified with high prediction values of accuracy (85.4%) and sensitivity (prediction/actual FMMP-nonsurgery, 93.3%) and moderate value of specificity (prediction/actual FMMP-surgery, 64.3%).</p><p><strong>Conclusion: </strong>These four T0 cephalometric variables were identified as predictors for determining the prognosis in FMMP treatment for patients with CL/P.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}