Open Biology最新文献

筛选
英文 中文
Limitations of sequence dissimilarity as a predictor of prokaryotic lineage. 序列异质性作为原核生物血统预测指标的局限性
IF 4.5 3区 生物学
Open Biology Pub Date : 2025-03-01 Epub Date: 2025-03-19 DOI: 10.1098/rsob.240302
Alvar A Lavin, Juan Rivas-Santisteban
{"title":"Limitations of sequence dissimilarity as a predictor of prokaryotic lineage.","authors":"Alvar A Lavin, Juan Rivas-Santisteban","doi":"10.1098/rsob.240302","DOIUrl":"10.1098/rsob.240302","url":null,"abstract":"<p><p>The molecular clock rests upon the assumption that the observed changes among sequences capture the differentiation of lineages, or kinship, as dissimilarity increases with time. Although it has been questioned over the years, this paradigmatic principle continues to underlie the idea that the polymorphic space of a gene is so vast that it is unattainable in evolutionary time. Thus, the molecular clock has been used to obtain taxonomic annotations, proving to be very effective at delivering testable results. In this article, however, we ask how often this assumption leads to inaccuracies when inferring the lineage of prokaryotic genes. Thus, we open an interesting discussion by simulating, in realistic scenarios, the critical times in which specific 5S rRNA sequences of two distant lineages are exhausting the polymorphic space. We contend that certain genes in one lineage will become increasingly similar to those in another over time, as the space for new variants is finite, mimicking phylogenetic features by convergence or by chance, without implying true kinship.</p>","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"15 3","pages":"240302"},"PeriodicalIF":4.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Schwann cells in regeneration and cancer: an epithelial-mesenchymal transition perspective. 雪旺细胞再生和癌症:上皮-间质转变的观点。
IF 4.5 3区 生物学
Open Biology Pub Date : 2025-03-01 Epub Date: 2025-03-05 DOI: 10.1098/rsob.240337
Francisco Gracia, Berta Sanchez-Laorden, Jose A Gomez-Sanchez
{"title":"Schwann cells in regeneration and cancer: an epithelial-mesenchymal transition perspective.","authors":"Francisco Gracia, Berta Sanchez-Laorden, Jose A Gomez-Sanchez","doi":"10.1098/rsob.240337","DOIUrl":"10.1098/rsob.240337","url":null,"abstract":"<p><p>In the peripheral nervous system, glial cells, known as Schwann cells (SCs), are responsible for supporting and maintaining nerves. One of the most important characteristics of SCs is their remarkable plasticity. In various injury contexts, SCs undergo a reprogramming process that generates specialized cells to promote tissue regeneration and repair. However, in pathological conditions, this same plasticity and regenerative potential can be hijacked. Different studies highlight the activation of the epithelial-mesenchymal transition (EMT) as a driver of SC phenotypic plasticity. Although SCs are not epithelial, their neural crest origin makes EMT activation crucial for their ability to adopt repair phenotypes, mirroring the plasticity observed during development. These adaptive processes are essential for regeneration. However, EMT activation in SCs-derived tumours enhances cancer progression and aggressiveness. Furthermore, in the tumour microenvironment (TME), SCs also acquire activated phenotypes that contribute to tumour migration and invasion by activating EMT in cancer cells. In this review, we will discuss how EMT impacts SC plasticity and function from development and tissue regeneration to pathological conditions, such as cancer.</p>","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"15 3","pages":"240337"},"PeriodicalIF":4.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between circadian and photoperiodic latitudinal clines in Drosophila littoralis. 沿海果蝇昼夜与光周期纬度线的相关性。
IF 4.5 3区 生物学
Open Biology Pub Date : 2025-03-01 Epub Date: 2025-03-05 DOI: 10.1098/rsob.240403
Giulia Manoli, Pekka Lankinen, Enrico Bertolini, Charlotte Helfrich-Förster
{"title":"Correlation between circadian and photoperiodic latitudinal clines in <i>Drosophila littoralis</i>.","authors":"Giulia Manoli, Pekka Lankinen, Enrico Bertolini, Charlotte Helfrich-Förster","doi":"10.1098/rsob.240403","DOIUrl":"10.1098/rsob.240403","url":null,"abstract":"<p><p>Insects can survive harsh conditions, including Arctic winters, by entering a hormonally induced state of dormancy, known as diapause. Diapause is triggered by environmental cues such as shortening of the photoperiod (lengthening of the night). The time of entry into diapause depends on the latitude of the insects' habitat, and this applies even within a species: populations living at higher latitudes enter diapause earlier in the year than populations living at lower latitudes. A long-standing question in biology is whether the internal circadian clock, which governs daily behaviour and serves as a reference clock to measure night length, shows similar latitudinal adaptations. To address this question, we examined the onset of diapause and various behavioural and molecular parameters of the circadian clock in the cosmopolitan fly, <i>Drosophila littoralis</i>, a species distributed throughout Europe from the Black Sea (41° N) to Arctic regions (69° N). We found that all clock parameters examined showed the same correlation with latitude as the critical night length for diapause induction. We conclude that the circadian clock has adapted to the latitude and that this may result in the observed latitudinal differences in the onset of diapause.</p>","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"15 3","pages":"240403"},"PeriodicalIF":4.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering respiratory viral infections by harnessing organ-on-chip technology to explore the gut-lung axis. 利用器官芯片技术探索肠-肺轴,破解呼吸道病毒感染。
IF 4.5 3区 生物学
Open Biology Pub Date : 2025-03-01 Epub Date: 2025-03-05 DOI: 10.1098/rsob.240231
Hristina Koceva, Mona Amiratashani, Parastoo Akbarimoghaddam, Bianca Hoffmann, Gaukhar Zhurgenbayeva, Mark S Gresnigt, Vanessa Rossetto Marcelino, Christian Eggeling, Marc Thilo Figge, Maria-João Amorim, Alexander S Mosig
{"title":"Deciphering respiratory viral infections by harnessing organ-on-chip technology to explore the gut-lung axis.","authors":"Hristina Koceva, Mona Amiratashani, Parastoo Akbarimoghaddam, Bianca Hoffmann, Gaukhar Zhurgenbayeva, Mark S Gresnigt, Vanessa Rossetto Marcelino, Christian Eggeling, Marc Thilo Figge, Maria-João Amorim, Alexander S Mosig","doi":"10.1098/rsob.240231","DOIUrl":"10.1098/rsob.240231","url":null,"abstract":"<p><p>The lung microbiome has recently gained attention for potentially affecting respiratory viral infections, including influenza A virus, respiratory syncytial virus (RSV) and SARS-CoV-2. We will discuss the complexities of the lung microenvironment in the context of viral infections and the use of organ-on-chip (OoC) models in replicating the respiratory tract milieu to aid in understanding the role of temporary microbial colonization. Leveraging the innovative capabilities of OoC, particularly through integrating gut and lung models, opens new avenues to understand the mechanisms linking inter-organ crosstalk and respiratory infections. We will discuss technical aspects of OoC lung models, ranging from the selection of cell substrates for extracellular matrix mimicry, mechanical strain, breathing mechanisms and air-liquid interface to the integration of immune cells and use of microscopy tools for algorithm-based image analysis and systems biology to study viral infection <i>in vitro</i>. OoC offers exciting new options to study viral infections across host species and to investigate human cellular physiology at a personalized level. This review bridges the gap between complex biological phenomena and the technical prowess of OoC models, providing a comprehensive roadmap for researchers in the field.</p>","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"15 3","pages":"240231"},"PeriodicalIF":4.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nucleolar origins: challenging perspectives on evolution and function. 核仁起源:进化和功能的挑战观点。
IF 4.5 3区 生物学
Open Biology Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI: 10.1098/rsob.240330
Israel Muñoz-Velasco, Ana Karen Herrera-Escamilla, Alberto Vázquez-Salazar
{"title":"Nucleolar origins: challenging perspectives on evolution and function.","authors":"Israel Muñoz-Velasco, Ana Karen Herrera-Escamilla, Alberto Vázquez-Salazar","doi":"10.1098/rsob.240330","DOIUrl":"10.1098/rsob.240330","url":null,"abstract":"<p><p>The nucleolus, once considered a mere 'ribosome factory', is now recognized as a dynamic hub influencing nearly every aspect of cellular life, from genome organization to stress response and ageing. Despite being a hallmark of eukaryotic cells, recent discoveries reveal that even prokaryotes exhibit nucleolus-like structures, hinting at ancient origins for nucleolar functions. This review explores the evolutionary journey of the nucleolus, tracing its roots back to early life and examining its structural and functional diversity across domains. We highlight key nucleolar proteins that play vital roles not only in ribosome production but also in regulating cell cycle, DNA repair and cellular stress, linking nucleolar activity directly to health and disease. Dysfunctions in nucleolar processes are implicated in cancer, ribosomopathies and neurodegenerative disorders, positioning the nucleolus as a critical target for innovative therapeutic strategies. As advanced imaging and molecular techniques unlock deeper insights into both canonical and mysterious non-canonical roles, the nucleolus stands as a model for how cellular microenvironments can evolve to meet complex biological demands. By addressing open questions surrounding the evolution of the nucleolus, its organization and diverse functions, the ideas presented here aim to contribute to the ongoing discussion, challenging traditional paradigms and suggesting new avenues for uncovering the fundamental principles that drive cellular life.</p>","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"15 3","pages":"240330"},"PeriodicalIF":4.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The proteotranscriptomic characterization of venom in the white seafan Eunicella singularis elucidates the evolution of Octocorallia arsenal. 白色海洋单根unicella singularis毒液的蛋白质转录组学特征阐明了Octocorallia库的进化。
IF 4.5 3区 生物学
Open Biology Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI: 10.1098/rsob.250015
Maria Vittoria Modica, Serena Leone, Marco Gerdol, Samuele Greco, Didier Aurelle, Marco Oliverio, Giulia Fassio, Khadija El Koulali, Célia Barrachina, Sebastien Dutertre
{"title":"The proteotranscriptomic characterization of venom in the white seafan <i>Eunicella singularis</i> elucidates the evolution of Octocorallia arsenal.","authors":"Maria Vittoria Modica, Serena Leone, Marco Gerdol, Samuele Greco, Didier Aurelle, Marco Oliverio, Giulia Fassio, Khadija El Koulali, Célia Barrachina, Sebastien Dutertre","doi":"10.1098/rsob.250015","DOIUrl":"10.1098/rsob.250015","url":null,"abstract":"<p><p>All the members of the phylum Cnidaria are characterized by the production of venom in specialized structures, the nematocysts. Venom of jellyfish (Medusozoa) and sea anemones (Anthozoa) has been investigated since the 1970s, revealing a remarkable molecular diversity. Specifically, sea anemones harbour a rich repertoire of neurotoxic peptides, some of which have been developed in drug leads. However, venoms of the vast majority of Anthozoa species remain uncharacterized, particularly in the class Octocorallia. To fill this gap, we applied a proteo-transcriptomic approach to investigate venom composition in <i>Eunicella singularis</i>, a gorgonian species common in Mediterranean hard-bottom benthic communities. Our results highlighted the peculiarities of the venom of <i>E. singularis</i> with respect to sea anemones, which is reflected in the presence of several toxins with novel folds, worthy of functional characterization. A comparative genomic survey across the octocoral radiation allowed us to generalize these findings and provided insights into the evolutionary history, molecular diversification patterns and putative adaptive roles of venom toxins. A comparison of whole-body and nematocyst proteomes revealed the presence of different cytolytic toxins inside and outside the nematocysts. Two instances of differential maturation patterns of toxin precursors were also identified, highlighting the intricate regulatory pathways underlying toxin expression.</p>","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"15 3","pages":"250015"},"PeriodicalIF":4.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of resistance and disease tolerance mechanisms to oral bacterial infection in Drosophila melanogaster. 黑腹果蝇对口腔细菌感染的耐药性和疾病耐受机制的进化。
IF 4.5 3区 生物学
Open Biology Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI: 10.1098/rsob.240265
Tânia F Paulo, Priscilla A Akyaw, Tiago Paixão, Élio Sucena
{"title":"Evolution of resistance and disease tolerance mechanisms to oral bacterial infection in <i>Drosophila melanogaster</i>.","authors":"Tânia F Paulo, Priscilla A Akyaw, Tiago Paixão, Élio Sucena","doi":"10.1098/rsob.240265","DOIUrl":"10.1098/rsob.240265","url":null,"abstract":"<p><p>Pathogens exert strong selection on hosts that evolve and deploy different defensive strategies, namely minimizing pathogen exposure (avoidance), directly promoting pathogen elimination (resistance) and/or managing the deleterious effects of illness (disease tolerance). However, how the host response partitions across these processes has not been directly tested in a single host-pathogen system, let alone in the context of known adaptive trajectories resulting from experimental evolution. Here, we compare a <i>Drosophila melanogaster</i> population adapted to oral infection with its natural pathogen <i>Pseudomonas entomophila</i> (BactOral), to its control population to find no evidence for behavioural changes but measurable differences in both resistance and disease tolerance. In BactOral, no differences were detected in bacterial intake or defecation, nor gut cell renewal. However, a measurable relative decrease in bacterial loads correlates with an increase in gut-specific anti-microbial peptide production, pointing to a strengthening in resistance. Additionally, we posit that disease tolerance also contributes to the response of BactOral through a tighter control of self- and pathogen-derived damage caused by bacteria exposure. This study reveals a genetically complex and mechanistically multi-layered response, possibly reflecting the structure of adaptation to infection in natural populations.</p>","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"15 3","pages":"240265"},"PeriodicalIF":4.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sperm-borne mRNAs: potential roles in zygote genome activation and epigenetic inheritance. 精子携带的mrna:在受精卵基因组激活和表观遗传中的潜在作用。
IF 4.5 3区 生物学
Open Biology Pub Date : 2025-03-01 Epub Date: 2025-03-26 DOI: 10.1098/rsob.240321
Betina González, Candela Rocío González
{"title":"Sperm-borne mRNAs: potential roles in zygote genome activation and epigenetic inheritance.","authors":"Betina González, Candela Rocío González","doi":"10.1098/rsob.240321","DOIUrl":"10.1098/rsob.240321","url":null,"abstract":"<p><p>It is well accepted that sperm carry an RNA cargo with functions in early embryo development. However, most research has focused on the role of small RNAs, such as microRNAs, transfer RNAs and long non-coding RNAs, while protein-coding messenger RNAs (mRNAs) received less attention, even though they represent a substantial amount of the sperm RNA pool. Here, we curated mouse transcriptomic data from mature sperm and selected the most abundant mRNAs (above the 0.7 quantile). The obtained gene list was further filtered using two criteria: (i) mRNAs that are statistically higher in the one-cell embryo compared to the MII oocyte transcriptome, indicative of paternal mRNA contribution after fertilization; and (ii) mRNAs that are found bound to ribosomes in the one-cell embryo, indicative of positive translation in the zygote translatome. Our analysis identified 94 genes that form networks functionally involved in epigenetic chromatin organization, gene expression, RNA processing and translation during zygote genome activation. These findings underscore the significant role of sperm-borne mRNAs in early embryonic development and epigenetic inheritance, highlighting the need for further research to fully understand their functions.</p>","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"15 3","pages":"240321"},"PeriodicalIF":4.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-density lipoprotein cholesterol: how studying the 'good cholesterol' could improve cardiovascular health. 高密度脂蛋白胆固醇:研究“好胆固醇”如何改善心血管健康。
IF 4.5 3区 生物学
Open Biology Pub Date : 2025-02-01 Epub Date: 2025-02-19 DOI: 10.1098/rsob.240372
Lucy Diaz, Ewa Bielczyk-Maczynska
{"title":"High-density lipoprotein cholesterol: how studying the 'good cholesterol' could improve cardiovascular health.","authors":"Lucy Diaz, Ewa Bielczyk-Maczynska","doi":"10.1098/rsob.240372","DOIUrl":"10.1098/rsob.240372","url":null,"abstract":"<p><p>High cholesterol levels are associated with an increased risk of cardiovascular disease, specifically atherosclerosis, a leading cause of death worldwide. Atherosclerosis occurs when cholesterol and fat build up in plaques along blood vessel walls, restricting blood flow and preventing nutrients and oxygen from diffusing in and out of the bloodstream. High-density lipoprotein cholesterol (HDL) particles prevent the build-up of such plaques, removing excess cholesterol from the peripheral tissues and delivering it to the liver, where it can be removed from the body. This pathway is known as reverse cholesterol transport (RCT). Because HDL plays a key role in preventing plaque buildup, understanding how this molecule and RCT function in the body could help us develop much-needed new atherosclerosis therapies and prevention strategies. However, HDL metabolism is complex, and research on HDL has been less favoured than research investigating a much better-understood molecule, low-density lipoprotein cholesterol, as a treatment target. More specifically, the receptors involved in the process of taking up HDL within the liver and their relationships to one another, along with the mechanism of whole, or holoparticle uptake of HDL remain to be clarified. In this review, we discuss several outstanding mysteries in HDL metabolism, consider why previous clinical trials to improve cardiovascular health by modulating HDL levels have been unsuccessful and argue that understanding HDL metabolism is essential for crafting interventions to reduce cardiovascular disease risk.</p>","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"15 2","pages":"240372"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The fundamental role of mitochondria-endoplasmic reticulum contacts in ageing and declining healthspan. 线粒体-内质网接触在衰老和健康寿命下降中的基本作用。
IF 4.5 3区 生物学
Open Biology Pub Date : 2025-02-01 Epub Date: 2025-02-12 DOI: 10.1098/rsob.240287
Richard M Monaghan
{"title":"The fundamental role of mitochondria-endoplasmic reticulum contacts in ageing and declining healthspan.","authors":"Richard M Monaghan","doi":"10.1098/rsob.240287","DOIUrl":"10.1098/rsob.240287","url":null,"abstract":"<p><p>This open question research article highlights mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), which have emerged as crucial cellular structures that challenge our traditional understanding of organelle function. This review highlights the critical importance of MAMs as a frontier in cell biology with far-reaching implications for health, disease and ageing. MAMs serve as dynamic communication hubs between the ER and mitochondria, orchestrating essential processes such as calcium signalling, lipid metabolism and cellular stress responses. Recent research has implicated MAM dysfunction in a wide array of conditions, including neurodegenerative diseases, metabolic disorders, cardiovascular diseases and cancer. The significant lack of biological knowledge behind MAM function emphasizes the need to study these enigmatic subcellular sites in greater detail. Key open questions include the mechanisms controlling MAM formation and disassembly, the full complement of MAM-associated proteins and how MAMs contribute to cellular decision-making and ageing processes. Advancing our understanding of MAMs through interdisciplinary approaches and cutting-edge technologies promises to reveal new insights into fundamental cellular signalling pathways and potentially lead to innovative therapeutic strategies for a range of diseases. As such, MAM research represents a critical open question in biology with the potential to transform our understanding of cellular life and human health.</p>","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"15 2","pages":"240287"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信