Ophthalmic epidemiology最新文献

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Racial and Ethnic Disparities in Prescription of a Novel Agent in Medical Management of Primary Open-Angle Glaucoma. 原发性开角型青光眼医疗管理中新型药物处方的种族和民族差异。
IF 1.7 4区 医学
Ophthalmic epidemiology Pub Date : 2025-08-01 Epub Date: 2024-10-10 DOI: 10.1080/09286586.2024.2401046
Andy Kuo, Sophie Yue, David C Kaelber, Ang Li
{"title":"Racial and Ethnic Disparities in Prescription of a Novel Agent in Medical Management of Primary Open-Angle Glaucoma.","authors":"Andy Kuo, Sophie Yue, David C Kaelber, Ang Li","doi":"10.1080/09286586.2024.2401046","DOIUrl":"10.1080/09286586.2024.2401046","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate racial and ethnic inequalities in prescription of Netarsudil, one of two anti-glaucoma medications with a novel mechanism to be introduced in the past two decades, among patients with primary open-angle glaucoma.</p><p><strong>Methods: </strong>This retrospective cohort matched study, based on electronic health records consisting of 92 million patients in the U.S, utilized Propensity Score Match, Relative Risk, Kaplan-Meier survival, and Chi-Square analysis to identify differences in rates of Netarsudil prescribing between racial and ethnic groups (non-Hispanic White, non-Hispanic Black, non-Hispanic Other Race, and Hispanic).</p><p><strong>Results: </strong>Among the sample of patients that met Primary Open-Angle Glaucoma inclusion criteria (55,942), more White patients were prescribed Netarsudil than Black; (RR:1.24, 95% CI: 1.15-1.34) and Hispanic; (RR:1.63, 95% CI: 1.29-2.07) patients. White patients had higher prescription rates than Black patients in the Midwest (6.5% vs 4.2%; <i>p</i> < 0.0001) and West (11.2% vs 7.1%; <i>p</i> = 0.0002), higher rates than Hispanic patients in the South (4.9% vs. 2.0%; <i>p</i> < 0.0001) and West (11.2% vs. 7.8%; <i>p</i> < 0.008), but lower rates than Black patients in the Northeast (7.2% vs. 13.2%; <i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>Differences in Netarsudil prescription rates within the United States exist between White and Black patients, and White and Hispanic patients. These differences exist when stratified by regions within the U.S. by varying degrees. Future studies are needed to investigate factors contributing to disparities in accessing new medications and to identify ways to eliminate such barriers to improve equity in care of glaucoma patients, especially among those historically disadvantaged.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"374-381"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Air Pollution and the Prevalence of Keratoconus: Is There a Connection? 空气污染与角膜病的发病率:两者之间有联系吗?
IF 1.7 4区 医学
Ophthalmic epidemiology Pub Date : 2025-08-01 Epub Date: 2024-10-10 DOI: 10.1080/09286586.2024.2399765
Tristan Jurkiewicz, Anne-Sophie Marty
{"title":"Air Pollution and the Prevalence of Keratoconus: Is There a Connection?","authors":"Tristan Jurkiewicz, Anne-Sophie Marty","doi":"10.1080/09286586.2024.2399765","DOIUrl":"10.1080/09286586.2024.2399765","url":null,"abstract":"<p><strong>Purpose: </strong>Keratoconus is a progressive, asymmetrical corneal ectasia with multifactorial origin. Three identified risk factors for keratoconus include exposure to ultraviolet (UV) rays, eye rubbing, and atopy. Other factors like pollution would play a role in the physiopathology of keratoconus. In this study we investigate the effects of particles matter (PM) of 2.5 and 10 μm, but also nitrogen dioxide (NO<sub>2</sub>) and the correlation with the prevalence in the scientific literature.</p><p><strong>Method: </strong>A literature review was performed using four databases (PubMed, Research gate, Google scholar and International Journal of Keratoconus and Ectatic Corneal Diseases) according to strict selection criteria. Levels of fine particles and nitrogen dioxide were extracted from available World Health Organization (WHO) databases and correlated with prevalences from epidemiological studies.</p><p><strong>Results: </strong>The mean pollution rate in the selected studies was 26.88 ± 25.26 μg/m<sup>3</sup> for PM<sub>2.5</sub> , 58.23 ± 60.98 μg/m<sup>3</sup> for PM<sub>10</sub> and 24.79 ± 12.58 μg/m<sup>3</sup> for NO<sub>2</sub>. Pearson correlation tests revealed a significant positive correlation between prevalence of keratoconus with particles rate of PM<sub>2.5</sub> (<i>R</i> = 0.58; <i>p</i> < 0.001), PM<sub>10</sub> (<i>R</i> = 0.67; <i>p</i> < 0.001) and NO<sub>2</sub> (<i>R</i> = 0.64; <i>p</i> = 0.00016).</p><p><strong>Conclusion: </strong>Fine particles appear to be a risk factor for keratoconus. These pollutants may act indirectly by exacerbating known risk factors such as atopy and eye rubbing. Atmospheric pollution may also have a direct effect on the cornea, by disturbing the structure of the epithelium and increasing cell apoptosis.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"394-402"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological Characteristics Associated with Astigmatism in a Population of 3- to 5-Year-Old Children in Los Angeles, CA. 加利福尼亚州洛杉矶市 3 至 5 岁儿童散光的流行病学特征。
IF 1.7 4区 医学
Ophthalmic epidemiology Pub Date : 2025-08-01 Epub Date: 2024-10-10 DOI: 10.1080/09286586.2024.2410302
J Ben Margines, Connie Huang, Andrew Young, Fei Yu, Anne L Coleman
{"title":"Epidemiological Characteristics Associated with Astigmatism in a Population of 3- to 5-Year-Old Children in Los Angeles, CA.","authors":"J Ben Margines, Connie Huang, Andrew Young, Fei Yu, Anne L Coleman","doi":"10.1080/09286586.2024.2410302","DOIUrl":"10.1080/09286586.2024.2410302","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the prevalence of astigmatism among the heretofore largest published sample of preschool children and to do so among different age, gender, and racial and ethnic subgroups.</p><p><strong>Methods: </strong>This study included data from 79,330 preschoolers (49.0% female, 79.4% Latino, mean age 4.29 ± 0.66 years) who were screened using a Retinomax autorefractor between 2012 and 2017. Cylindrical power and astigmatism defined as 1.50 D or more of cylinder were the dependent variables. Children were stratified by age, race/ethnicity, and gender. T-test and chi-square analyses were performed.</p><p><strong>Results: </strong>The average cylinder of the sample was found to be 0.65 ± 0.78 D and 11% of the children were astigmatic. Among all children, these values remain stable from age 3 (0.66 ± 0.76 D, 11.2%) to age 4 (0.66 ± 0.79 D, 11.4%, <i>p</i> = .53), but they decrease significantly from age 4 to age 5 (0.61 ± 0.80 D, 10.%, <i>p</i> < .01). Latinos have the highest average cylinder power and prevalence of astigmatism at 0.68 ± 0.82 D and 12.3%, and unlike most other race/ethnic subgroups, they do not experience an age-dependent decrease in astigmatism. While female and male students have equivalent cylindrical refractions broadly, Asian and African American females have higher levels of astigmatism than their male counterparts.</p><p><strong>Conclusion: </strong>The data further demonstrate that Latino children in Los Angeles have significantly higher rates of astigmatism, which does not decrease during preschool years. These results emphasize the need for comprehensive school-based screening, especially among Latino enclaves in Los Angeles.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"437-442"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucagon-Like Peptide-1 Receptor Agonists are Not Associated with an Increased Risk of Progressing to Vision-Threatening Diabetic Retinopathy. 胰高血糖素样肽-1 受体激动剂与恶化为危及视力的糖尿病视网膜病变的风险增加无关。
IF 1.7 4区 医学
Ophthalmic epidemiology Pub Date : 2025-08-01 Epub Date: 2024-10-10 DOI: 10.1080/09286586.2024.2399764
Zujaja Tauqeer, Peter Bracha, Peiying Hua, Yinxi Yu, Qi N Cui, Brian L VanderBeek
{"title":"Glucagon-Like Peptide-1 Receptor Agonists are Not Associated with an Increased Risk of Progressing to Vision-Threatening Diabetic Retinopathy.","authors":"Zujaja Tauqeer, Peter Bracha, Peiying Hua, Yinxi Yu, Qi N Cui, Brian L VanderBeek","doi":"10.1080/09286586.2024.2399764","DOIUrl":"10.1080/09286586.2024.2399764","url":null,"abstract":"<p><strong>Purpose: </strong>Glucagon-like peptide-1 receptor agonists (GLP-1RA) are used to treat type 2 diabetes mellitus (DM) by augmenting insulin release and sensitivity. We assessed the overall risk for development of vision-threatening diabetic retinopathy (VTDR), proliferative diabetic retinopathy (PDR), and diabetic macular edema (DME), among GLP-1RA users.</p><p><strong>Methods: </strong>A retrospective cohort of patients with NPDR newly started on a GLP-1RA from a national insurance claims database was compared to a cohort of patients treated with other oral anti-diabetic agents and matched for age, sex, race, index year, and number of active diabetic medications. Exclusions occurred for < 2 years in the database before diagnosis; prior diagnoses of PDR, DME, vitreous hemorrhage, and/or other retinal vascular diseases; and prior intraocular treatment for VTDR.</p><p><strong>Results: </strong>A total of 6093 users of GLP-1RA were matched to 14,122 controls. In the GLP-1RA cohort, 632 (10.1%), 76 (1.2%), and 544 (8.9%) patients progressed to VTDR, PDR, or DME, respectively. This is compared to 1332 (9.5%) VTDR, 165 (1.2%) PDR, or 1148 (8.1%) DME in the control group. Accounting for underlying DM severity with IPTW, no difference in hazard was seen in the GLP-1RA cohort compared to controls for progression to VTDR (HR = 1.02, 95%CI: 0.92-1.14 <i>p</i> = 0.69), DME (HR = 1.06, 95%CI: 0.95-1.1.9, <i>p</i> = 0.31), or PDR (HR = 0.81, 95%CI: 0.58-1.12, <i>p</i> = 0.20).</p><p><strong>Conclusion: </strong>We found no difference in the risk for vision-threatening diabetic retinopathy, nor for its component diseases, DME or PDR, with GLP-1RA use compared to other oral anti-hyperglycemic agents in patients with NPDR.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"390-393"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and Progression of Diabetic Retinopathy in Urban India: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study, 15yr Follow up. 印度城市糖尿病视网膜病变的发病率和进展:Sankara Nethralaya 糖尿病视网膜病变流行病学和分子遗传学研究,15 年随访。
IF 1.7 4区 医学
Ophthalmic epidemiology Pub Date : 2025-08-01 Epub Date: 2024-11-12 DOI: 10.1080/09286586.2024.2419015
Keerthana Raghu, Janani Surya R, Padmaja Kumari Rani, Tarun Sharma, Rajiv Raman
{"title":"Incidence and Progression of Diabetic Retinopathy in Urban India: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study, 15yr Follow up.","authors":"Keerthana Raghu, Janani Surya R, Padmaja Kumari Rani, Tarun Sharma, Rajiv Raman","doi":"10.1080/09286586.2024.2419015","DOIUrl":"10.1080/09286586.2024.2419015","url":null,"abstract":"<p><p><b><i>Purpose</i>:</b> To evaluate the 15 year incidence and progression of Diabetic Retinopathy (DR) and identify risk factors among Indian population.<b><i>Methods</i>:</b> From a cross-sectional study of 1425 subjects, 911 participants took part in the 4-year follow-up. Out of these 911 participants, 140 returned for the 15-year follow-up, with baseline examinations conducted between 2003 and 2006, and subsequent follow-ups occurring from 2007 to 2011 and the current 15-year follow-up from 2018 to 2021. Of the 140 participants, 112 were eligible for analysis after excluding individuals with ungradable fundus photographs.<b><i>Results</i>:</b> The 15-year incidence of any diabetic retinopathy (DR) was 5%, with mild NPDR and moderate NPDR at 1.57% and 2.7%, respectively. Proliferative DR was observed in 0.71% of cases, while diabetic macular edema (DME) and sight-threatening diabetic retinopathy (STDR) rates were 0.48% and 1.10%, respectively. Age-standardized rates revealed a significant association with increasing age and incident any DR and STDR. DR progression over 15 years included 7.5% one-step and 1.75% two-step progressions, while regression was limited to 1.75% one-step regression. Multiple logistic regression analyses revealed that baseline duration of diabetes, systolic blood pressure, HbA1c levels, and the presence of anemia influenced the incidence of any DR, DME, and STDR. Smoking and higher HbA1c were identified as risk factors for one-step progression of DR.<b><i>Conclusion</i>:</b> This study provides crucial insights into the long-term incidence, progression, and regression of DR among individuals with Type 2 diabetes in India.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"428-436"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loss to Follow-Up in Intermediate Age-Related Macular Degeneration Patients Enrolled in the University of Colorado AMD Registry. 在科罗拉多大学AMD注册中心登记的中度年龄相关性黄斑变性患者的随访损失
IF 1.7 4区 医学
Ophthalmic epidemiology Pub Date : 2025-08-01 Epub Date: 2024-12-05 DOI: 10.1080/09286586.2024.2428193
Arden J McReynolds, Jennifer L Patnaik, Emily A Auer, Anne M Lynch
{"title":"Loss to Follow-Up in Intermediate Age-Related Macular Degeneration Patients Enrolled in the University of Colorado AMD Registry.","authors":"Arden J McReynolds, Jennifer L Patnaik, Emily A Auer, Anne M Lynch","doi":"10.1080/09286586.2024.2428193","DOIUrl":"10.1080/09286586.2024.2428193","url":null,"abstract":"","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"443-445"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decomposition of Economic Inequality in Age-Related Macular Degeneration by Using Oaxaca-Blinder Decomposition: Tehran Geriatric Eye Study. 利用 Oaxaca-Blinder 分解法分解老年性黄斑变性的经济不平等:德黑兰老年眼科研究
IF 1.7 4区 医学
Ophthalmic epidemiology Pub Date : 2025-08-01 Epub Date: 2024-11-12 DOI: 10.1080/09286586.2024.2415047
Hassan Hashemi, Reza Pakzad, Mohamadreza Aghamirsalim, Alireza Hashemi, Mehdi Khabazkhoob
{"title":"Decomposition of Economic Inequality in Age-Related Macular Degeneration by Using Oaxaca-Blinder Decomposition: Tehran Geriatric Eye Study.","authors":"Hassan Hashemi, Reza Pakzad, Mohamadreza Aghamirsalim, Alireza Hashemi, Mehdi Khabazkhoob","doi":"10.1080/09286586.2024.2415047","DOIUrl":"10.1080/09286586.2024.2415047","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate economic inequality in age-related macular degeneration (AMD) and decompose it into its determinants using Oaxaca-Blinder decomposition (OBD).</p><p><strong>Methods: </strong>The Tehran Geriatric Eye Study was a cross-sectional study conducted on individuals aged 60 years and older, utilizing stratified random cluster sampling. Each participant received a comprehensive optometric, and slit-lamp examination. Diagnosis and classification of AMD were conducted utilizing fundus camera images.</p><p><strong>Results: </strong>The data of the 3268 participants were analyzed. According to OBD, a significant difference was found in AMD between the rich and poor groups (8.36%) disfavoring the poor (<i>p</i> < 0.001). The explained and unexplained portions comprised 93.37% and 6.63% of the difference (<i>p</i> < 0.001 and <i>p</i> = 0.405, respectively). Among study variables, age (coefficient = 4.70; <i>p</i> < 0.001), economic status (coefficient = 3.58; <i>p</i> = 0.004), and myopia (coefficient = 0.73; <i>p</i> = 0.001) were significant determinants of inequality in the explained portion.</p><p><strong>Conclusion: </strong>A significant disparity in the prevalence of AMD was observed between individuals of different socioeconomic statuses, primarily attributed to the explained factors. Factors such as age, economic status, and myopia were found to have the most substantial impact in exacerbating the inequality that disadvantaged the poor group (contributing percentages: 52.17%, 39.73%, and 8.10%, respectively). The findings of this research can be valuable for health policymakers in prioritizing and addressing the determinants of inequality within the population.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"446-454"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Access to a Patient Portal is Associated with a Higher Rate of Diabetic Eye Examination Completion. 访问患者门户网站与更高的糖尿病眼科检查完成率有关。
IF 1.7 4区 医学
Ophthalmic epidemiology Pub Date : 2025-08-01 Epub Date: 2024-10-10 DOI: 10.1080/09286586.2024.2406506
Selin Gumustop, Andrew Popelka, David J Ramsey
{"title":"Access to a Patient Portal is Associated with a Higher Rate of Diabetic Eye Examination Completion.","authors":"Selin Gumustop, Andrew Popelka, David J Ramsey","doi":"10.1080/09286586.2024.2406506","DOIUrl":"10.1080/09286586.2024.2406506","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate factors associated with a higher completion rate of annual diabetic eye examinations.</p><p><strong>Methods: </strong>This retrospective, cross-sectional study included patients diagnosed with diabetes mellitus (DM) who were aged 18-75 years and receiving primary care in a suburban integrated delivery network (IDN). Patient demographic, sociomedical, biometric characteristics, and Healthcare Effectiveness Data and Information Set (HEDIS) measures within the Comprehensive Diabetes Care bundle were extracted from the electronic health record (EHR) and analyzed by using multivariate logistic regression to assess factors associated with completion of an eye exam (retinal) performed during the study year.</p><p><strong>Results: </strong>Among 19,901 primary care patients with DM, 35.15% completed an eye examination in 2021. After adjusting for demographic and biometric characteristics, the two factors most closely associated with completing a diabetic eye examination were having had a primary care office visit (adjusted odds ratio [aOR], 3.525; 95% confidence interval [CI], 3.210-3.871, <i>p</i> < 0.001) or an eye examination in the prior year (aOR, 2.948; 95% CI, 2.752-3.158, <i>p</i> < 0.001). The next most important factor to emerge was having an activated, online patient portal (PP; aOR, 1.737; 95% CI, 1.592-1.896; <i>p</i> < 0.001) or PP recently activated within the prior year (aOR, 1.387; 95% CI, 1.220-1.576, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Surveillance for diabetic retinopathy relies on annual diabetic eye examinations yet adherence to that standard remains unacceptably low. Our study suggests that engagement of patients through an online PP could help increase this rate.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"420-427"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Effects of mRNA-COVID 19 Vaccines on Corneal Endothelium. mRNA-COVID - 19疫苗对角膜内皮细胞影响的评价
IF 1.7 4区 医学
Ophthalmic epidemiology Pub Date : 2025-07-14 DOI: 10.1080/09286586.2025.2522724
Fatma Sumer, Sevgi Subasi
{"title":"Evaluation of the Effects of mRNA-COVID 19 Vaccines on Corneal Endothelium.","authors":"Fatma Sumer, Sevgi Subasi","doi":"10.1080/09286586.2025.2522724","DOIUrl":"https://doi.org/10.1080/09286586.2025.2522724","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to compare corneal topographic and specular microscopic parameters before and after vaccination with activated (Pfizer -BioNTech (BNT162b2)) SARS-CoV-2 mRNA vaccine.</p><p><strong>Methods: </strong>128 eyes of 64 patients were evaluated in this prospective study. The time interval between pre and post-vaccination examinations was nearly two and a half months (75.6 ± 4.5 days).The topographic evaluation was made with Sirius corneal topography (Sirius, CSO Inc, Florence, Italy) and specular microscopy was made with Tomey EM-4000 specular microscopy (Tomey GmbH, Japan). All patients underwent detailed ophthalmologic examination including best-corrected visual acuity assessment (BCVA), measurement of intraocular pressure (IOP), anterior segment evaluation with biomicroscopy, and dilated fundus examination.</p><p><strong>Results: </strong>The significant change in the topographic evaluation was the post-vaccine (542.0 (534.25-548.0)) increase in central corneal thickness compared to pre-vaccine values (528.0 (520.25-537.75) (<i>p</i> = 0.001). The endothelial cell density (ECD) was 2597 (2550.0-2646.50) before vaccination and 2378.0 (2299.0-2419.0) at least two months after vaccination (<i>p</i> < 0.001). The median mean coefficient of variation (CV) value was 39.0(38.0-42.0) before vaccination measurements and 42 (40-44) after vaccination measurements (<i>p</i> < 0.001). The mean hexagonality was 50.0 (48.25-52.0) before vaccination and 48(46-49) after vaccination (<i>p</i> < 0.001).The median central corneal thickness (CCT) value was 533(526-538) before vaccination and 548 (543.50-556) after vaccination (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Changes in corneal endothelium occur in the short term after two-doses of the Pfizer-BioNTech (BNT162b2) COVID-19 mRNA vaccine. Hence the endothelium should be closely monitored in those with a low endothelial count or who have had a corneal graft.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing the Use of Administrative Claims with the Electronic Health Record Data for Identifying Diabetic Retinopathy Examinations. 比较使用行政索赔与电子健康记录数据识别糖尿病视网膜病变检查。
IF 1.7 4区 医学
Ophthalmic epidemiology Pub Date : 2025-07-08 DOI: 10.1080/09286586.2025.2528675
Thomas Su, Alison Gibbons, Diep Tran, Cindy X Cai
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