Open Life Sciences最新文献_第4页

CircRNA circuits orchestrate lactate metabolism in gastrointestinal cancer progression. CircRNA回路在胃肠道癌症进展中协调乳酸代谢。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-07-29 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1351

Qingjuan Chen, Haiqing Zhou, Zhen Shen, Yadong Zhou, Jianlong Ding, Changhu Duan, Xia Cao, Ying Liu, Ling Wang, Wenjing He

{"title":"CircRNA circuits orchestrate lactate metabolism in gastrointestinal cancer progression.","authors":"Qingjuan Chen, Haiqing Zhou, Zhen Shen, Yadong Zhou, Jianlong Ding, Changhu Duan, Xia Cao, Ying Liu, Ling Wang, Wenjing He","doi":"10.1515/biol-2025-1351","DOIUrl":"10.1515/biol-2025-1351","url":null,"abstract":"Circular RNAs (circRNAs) have emerged as pivotal modulators of cancer metabolic reprogramming, orchestrating glycolysis and lactate metabolism to fuel malignant progression. Acting predominantly as competing endogenous RNAs (ceRNAs), circRNAs sequester tumor-suppressor microRNAs, thereby upregulating glycolytic enzymes, transporters, and key metabolic regulators. Across gastric, colorectal, esophageal, pancreatic, and hepatocellular carcinomas, oncogenic circRNAs converge to enhance glucose uptake, lactate production, and ATP generation, sustaining proliferation, metastasis, stemness, and therapy resistance. In contrast, tumor-suppressive circRNAs attenuate glycolytic flux, depriving cancer cells of energy and biosynthetic precursors. Mechanistic diversity-spanning circRNA-microRNA-hexokinase 2 and circRNA-microRNA-lactate dehydrogenase A axes, as well as hypoxia-induced circRNA signaling networks-underscores their cancer-type specificity and potential as precision oncology targets. Despite promising diagnostic and therapeutic implications, challenges remain in delivery, specificity, and functional annotation. Future advances will rely on multi-omics integration, high-throughput functional screening, and validation in patient-derived models to identify clinically actionable circRNA-metabolism regulatory circuits. Mapping these interactions offers not only biomarkers for prognosis and therapy response but also potential intervention points to rewire tumor metabolism.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251351"},"PeriodicalIF":2.3,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13410167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148621054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced biomaterial-based approaches for medication-related osteonecrosis of the jaw. 基于先进生物材料的颌骨药物相关骨坏死治疗方法。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-07-29 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1346

Rui Huang, Shiyu Jia, Wei Yin

{"title":"Advanced biomaterial-based approaches for medication-related osteonecrosis of the jaw.","authors":"Rui Huang, Shiyu Jia, Wei Yin","doi":"10.1515/biol-2025-1346","DOIUrl":"10.1515/biol-2025-1346","url":null,"abstract":"Medication-related osteonecrosis of the jaw (MRONJ) is a debilitating adverse effect linked to anti-resorptive and anti-angiogenic therapies, with an incidence of 4.34 % (6.22 % in oncology patients and 0.59 % in osteoporosis patients) based on a pooled analysis of 92 observational studies (2015-2020), characterized by persistent bone exposure and poor healing. Conventional treatment modalities often yield suboptimal outcomes, with recurrence and procedural morbidity. In recent years, biomaterial-based strategies have emerged as promising alternatives by targeting MRONJ's complex pathophysiology, including imbalances in bone remodeling, impaired angiogenesis, immune dysregulation, and infection. This review highlights advances in functional biomaterials for bisphosphonate sequestration, restoration of osteo-angiogenic homeostasis, and immune modulation. These platforms have shown efficacy in promoting tissue regeneration while reducing systemic toxicity. However, clinical translation is limited by biosafety, scalability, and regulatory hurdles, such as instability in the oral environment and mismatched scaffold degradation rates. Future efforts should prioritize multifunctional, intelligent, and patient-specific biomaterials, alongside the establishment of standardized preclinical models and clinical trials. Combinatory strategies have great potential for synergistic treatment and addressing the multiple pathological factors of MRONJ. By integrating materials engineering with mechanistic understanding, this review synthesizes current evidence to highlight the transformative potential of biomaterials for MRONJ prevention and therapy.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251346"},"PeriodicalIF":2.3,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13410182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growth factor receptors IGF-1R and VEGFR2 are associated with the prognosis of patients with esophageal cancer after esophagectomy. 生长因子受体IGF-1R和VEGFR2与食管癌患者食管切除术后的预后相关。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-07-27 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1354

Tiehong Zhang

{"title":"Growth factor receptors IGF-1R and VEGFR2 are associated with the prognosis of patients with esophageal cancer after esophagectomy.","authors":"Tiehong Zhang","doi":"10.1515/biol-2025-1354","DOIUrl":"10.1515/biol-2025-1354","url":null,"abstract":"This single-center retrospective study evaluated the prognostic value of IGF-1R, VEGFR2, PDGFR, and c-MET expression in 94 patients with pathologically confirmed ESCC who underwent esophagectomy, and explored the potential relevance of combining immune checkpoint inhibitors (ICIs) with growth factor receptor tyrosine kinase inhibitors (TKIs). A prognostic nomogram was developed for clinically available factors and growth factor receptors with significant prognostic value, and the nomogram was validated with ROC curve analyses. Among the four growth factor receptors, VEGFR2 and IGF-1R expression differed significantly between death and survival groups. Worse prognosis was associated with advanced clinical stage, deeper tumor invasion, greater nodal involvement, high VEGFR2 expression, and high IGF-1R expression (clinical stage: HR = 2.15, 95 % CI: 1.45-3.20; T stage: HR = 1.78, 95 % CI: 1.12-2.83; N stage: HR = 2.42, 95 % CI: 1.61-3.64; VEGFR2: HR = 1.61, 95 % CI: 1.04-2.49; IGF-1R: HR = 1.74, 95 % CI: 1.12-2.70). PDGFR and c-MET expression were not significantly associated with cancer-specific survival. Although the nomogram showed prognostic performance (AUC = 0.512), the small sample size precluded formal histology-specific stratified analysis, limiting assessment of subtype-specific prognostic effects.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251354"},"PeriodicalIF":2.3,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13401192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adiponectin improves clozapine-induced lipid accumulation and inflammation without affecting insulin resistance. 脂联素改善氯氮平诱导的脂质积累和炎症，而不影响胰岛素抵抗。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-07-20 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1333

I-Lun Tsai, Shih-Chao Lin, Lin Lin, Pei-Shan Tsai, Shiow-Yi Chen

{"title":"Adiponectin improves clozapine-induced lipid accumulation and inflammation without affecting insulin resistance.","authors":"I-Lun Tsai, Shih-Chao Lin, Lin Lin, Pei-Shan Tsai, Shiow-Yi Chen","doi":"10.1515/biol-2025-1333","DOIUrl":"10.1515/biol-2025-1333","url":null,"abstract":"Clozapine, an atypical antipsychotic, is effective for treatment-resistant schizophrenia but frequently causes metabolic adverse effects, including hepatic lipid accumu-lation, inflammation and insulin resistance. Adiponectin, an adipocyte-derived cytokine with anti-inflammatory and insulin-sensitizing properties, may counteract these effects; however, its ability to mitigate clozapine-induced hepatic alterations remains unclear. This study examined whether adiponectin overexpression reduces clozapine-induced lipid accumulation, inflammatory signaling, and whether it restores insulin-related Akt signaling in human HepG2 liver cells. Cells were treated with 25 μM clozapine for 24 or 48 h, and adiponectin was overexpressed by plasmid transfection. Lipid accumulation was quantified by BODIPY staining. AdipoR1 and AdipoR2 expression was analyzed by qPCR, and protein levels of FASN, phosphorylated NF-κB, and phosphorylated Akt were assessed by Western blotting. Clozapine increased lipid accumulation, upregulated FASN, and reduced AdipoR1 and AdipoR2 expression. Adiponectin overexpression significantly decreased lipid levels, which was associated with reduced NF-κB phosphorylation, suggesting attenuation of inflammatory signaling. However, adiponectin did not restore insulin-stimulated Akt phosphorylation. In summary, adiponectin selectively reduced clozapine-induced lipid accumulation and inflammatory signaling in HepG2 cells, whereas impaired insulin-stimulated Akt phosphorylation remained unchanged under the present experimental conditions. These findings indicate a selective protective role of adiponectin and suggest its potential as a modulator of clozapine-induced metabolic side effects.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251333"},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13377577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-dependent effects of hypoxia on mitochondrial dynamics, dysfunction and apoptosis in C8-D1A astrocytes. 缺氧对C8-D1A星形细胞线粒体动力学、功能障碍和凋亡的时间依赖性影响。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-07-14 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1353

Youjuan Chen, Jing Hou, Meiyuan Tian, Erwa Hao, Yaogang Zhang, Dengliang Huang, Tao Zhang, Yanyan Ma

{"title":"Time-dependent effects of hypoxia on mitochondrial dynamics, dysfunction and apoptosis in C8-D1A astrocytes.","authors":"Youjuan Chen, Jing Hou, Meiyuan Tian, Erwa Hao, Yaogang Zhang, Dengliang Huang, Tao Zhang, Yanyan Ma","doi":"10.1515/biol-2025-1353","DOIUrl":"10.1515/biol-2025-1353","url":null,"abstract":"This study aimed to investigate the effects of hypoxia on mitochondrial function in C8-D1A astrocytes and to evaluate its association with apoptosis. Mouse C8-D1A astrocytes were allocated to a normoxia group (21 % O2, 5 % CO2, 37 °C) or a hypoxia group (1 % O2, 5 % CO2, 37 °C) and cultured for 24 h, 48 h, or 72 h. Compared with the normoxia group, the hypoxia group demonstrated a significant reduction in mean mitochondrial fluorescence intensity (p < 0.01) and a significant increase in mitochondrial ROS levels. Regarding mitochondrial dynamics-related proteins, Mfn1 expression was significantly decreased, and Mfn2 expression was significantly decreased at 72 h (p < 0.01). Drp1 expression was significantly increased at all time points (p < 0.01), and Fis1 expression was significantly upregulated (p < 0.01). The proportion of cells exhibiting reduced mitochondrial membrane potential was significantly higher in the hypoxia group. The percentage of apoptotic cells was significantly increased. TEM analysis revealed structural abnormalities of mitochondria in cells exposed to hypoxia. Hypoxia may promote apoptosis in C8-D1A astrocytes through disruption of mitochondrial morphology, function, and dynamics. These alterations are associated with decreased mitochondrial content and increased ROS production, which may contribute to mitochondrial dysfunction and apoptosis under hypoxic conditions.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251353"},"PeriodicalIF":2.3,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The emergence of the ectodysplasin pathway. 外胞浆异常通路的出现。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-07-14 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1345

Wilfred Donald Stein, Thomas Litman

引用次数: 0

Microbiological diagnosis of the scalp and hair in 20-40 year olds - preliminary studies. 20-40岁人群头皮和头发的微生物诊断——初步研究。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-07-14 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1343

Katarzyna Duda-Grychtoł, Karolina Oleś, Marta Palacz-Wróbel

{"title":"Microbiological diagnosis of the scalp and hair in 20-40 year olds - preliminary studies.","authors":"Katarzyna Duda-Grychtoł, Karolina Oleś, Marta Palacz-Wróbel","doi":"10.1515/biol-2025-1343","DOIUrl":"10.1515/biol-2025-1343","url":null,"abstract":"Microbiome refers to the collection of microorganisms living in the human body. Skin, intestines and upper respiratory tract are particularly inhabited by microorganisms. The microbiota of the scalp and hair, though so far little understood, is particularly abundant in terms of microorganisms, which play an important role in maintaining the health of the scalp by inhibiting pathogens and promoting optimal skin condition. Dysbiosis of the scalp microbiota can be influenced by many factors, both exo and endogenous leading to the development of pathological conditions such as dandruff or seborrhoeic dermatitis. The aim of this preliminary study was the microbiological diagnosis of the scalp and hair in the group of individuals aged 20-40 years old. The samples for the research have been obtained from three different sites on the scalp of 6 individuals aged 20 to 40. The material for the study was collected using contact plates for total bacterial counts - Rodac Contact Test. The colonies grown on the microbiological media were characterised in terms of their size and shape. Subsequently, Gram staining was performed to assign the colonies of the bacteria to Gram-positive or Gram-negative bacteria, as well as fungi characterisation of the scalp and hair was conducted using a trichological camera. Finally, on the basis of the study following conclusions have been drawn. There were observed differences in the appearance of microbial colonies between younger and older people and in the group of 40-year-old, there was a significantly less colony diversity monitored. In terms of bacteria, Gram-positive cocci got isolated most frequently. In addition, yeast as well as filamentous fungi occurred abundant in the middle of the head of the research participants.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251343"},"PeriodicalIF":2.3,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of red palm oil intervention on serum lipids, hepatic antioxidant capacity and gut microbiota in high-fat diet-fed mice. 红棕榈油干预对高脂饮食小鼠血脂、肝脏抗氧化能力和肠道菌群的影响

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-07-13 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1350

Chengyu Ma, Hairui Yu, Lingyao Li, Jiayi Zhang, Leyong Yu, Xiaojing Wu, Govindhrajan Sattanathan, Baobin Lu

{"title":"Effects of red palm oil intervention on serum lipids, hepatic antioxidant capacity and gut microbiota in high-fat diet-fed mice.","authors":"Chengyu Ma, Hairui Yu, Lingyao Li, Jiayi Zhang, Leyong Yu, Xiaojing Wu, Govindhrajan Sattanathan, Baobin Lu","doi":"10.1515/biol-2025-1350","DOIUrl":"10.1515/biol-2025-1350","url":null,"abstract":"High-fat diets (HFDs) can induce oxidative stress and gut microbiota imbalance, highlighting the need to explore functional dietary lipids such as red palm oil (RPO) for metabolic health improvement. This study investigated the effects of RPO intervention administered through oral gavage on growth performance, serum lipid profile, hepatic antioxidant capacity, and gut microbiota in HFD-fed mice. Compared to the high-fat control (HO) group, RPO treatment significantly reduced triglycerides (TG) and total cholesterol (TC), and increased high-density lipoprotein cholesterol (HDL-C). Furthermore, hepatic antioxidant capacity was markedly enhanced, as evidenced by improved superoxide dismutase (SOD) and catalase (CAT) activities and decreased malondialdehyde (MDA) levels in the HFD group receiving RPO. Moreover, RPO supplementation reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and attenuated hepatic steatosis. Gut microbiota analysis showed that RPO administration enhanced the relative abundance of beneficial bacteria while reducing potentially harmful taxa. Overall, these findings demonstrate that oral gavage of RPO can effectively alleviate HFD-induced metabolic disturbances by improving lipid metabolism, enhancing hepatic antioxidant defenses, and modulating gut microbial composition.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251350"},"PeriodicalIF":2.3,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13355683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148423069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant oil complex: dual activation of peroxisome proliferator-activated receptors α and γ to enhance skin barrier function. 植物油复合物：双重激活过氧化物酶体增殖物激活受体α和γ以增强皮肤屏障功能。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-07-07 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1347

Sen Sun, Yanfang Yang, Huijun Wu, Laidi Zhang, Heyang Liu, Lingyan Shen, Hui Xue, Yuankun Liu, Hong Tao

{"title":"Plant oil complex: dual activation of peroxisome proliferator-activated receptors α and γ to enhance skin barrier function.","authors":"Sen Sun, Yanfang Yang, Huijun Wu, Laidi Zhang, Heyang Liu, Lingyan Shen, Hui Xue, Yuankun Liu, Hong Tao","doi":"10.1515/biol-2025-1347","DOIUrl":"10.1515/biol-2025-1347","url":null,"abstract":"This study aimed to identify novel natural peroxisome proliferator-activated receptor (PPAR) agonists and evaluate the effects of avocado oil unsaponifiable (AOU), Ganoderma lucidum spore oil (GLSO), and Ximenia americana seed oil (XASO) on skin barrier repair at cellular and human levels, elucidating their combined mechanisms. The oils were extracted using molecular distillation, supercritical CO2 extraction, and cold pressing. PPAR activation was assessed via luciferase activity in human embryonic kidney 293 cells (HEK 293T). A blend of the three oils (AGX) was further examined in HaCaT cells using immunofluorescence. A three-dimensional (3D) human skin model was used to evaluate AGX's effects on barrier-related genes (FLG, LOR, DSG1, TGM1, CLDN1, CER). A clinical trial measured transepidermal water loss (TEWL) and stratum corneum hydration (SCH). AGX significantly activated PPARα-LBD and PPARγ-LBD transcription and upregulated FLG, LOR, DSG1, TGM1, and CLDN1 (p < 0.01). In vivo, both 2 % and 4 % AGX reduced TEWL and increased SCH (p < 0.05). AOU and XASO activated PPAR pathway genes (e.g., ANGPTL4, ILK) and downregulated MMP1. AGX repaired the skin barrier via PPAR pathways and may be a promising therapy for dermatological conditions involving barrier impairment.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251347"},"PeriodicalIF":2.3,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hysteroscopic observation of the association between endometrial polyps and endometriosis: a retrospective cohort study. 子宫内膜息肉与子宫内膜异位症的宫腔镜观察：一项回顾性队列研究。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-07-07 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1338

Hui Liu, Lianhua Tang

{"title":"Hysteroscopic observation of the association between endometrial polyps and endometriosis: a retrospective cohort study.","authors":"Hui Liu, Lianhua Tang","doi":"10.1515/biol-2025-1338","DOIUrl":"10.1515/biol-2025-1338","url":null,"abstract":"This single-centre retrospective study (100 women with endometrial polyps, mean age 41.8 ± 8.2 years) investigated the association between endometrial polyps and endometriosis. Endometriosis was confirmed in 13 % of patients. Multiple polyps were significantly more common in the endometriosis group (69.2 % vs. 42.5 %, P = 0.046). Women with endometriosis had higher CA125 levels (89.3 ± 45.2 vs. 18.6 ± 12.3 U/mL, P < 0.001) and higher rates of dysmenorrhoea (100 % vs. 35.6 %, P < 0.001). Independent predictors of endometriosis were dysmenorrhoea (aOR[95 % CI] = 8.45 [2.34-30.52], P = 0.001), CA125 > 35 U/mL (aOR[95 % CI] = 12.67 [3.82-42.01], P < 0.001), and multiple polyps (aOR[95 % CI] = 3.12 [1.08-9.01,], P = 0.036). CA125 > 35 U/mL showed an area under the curve (AUC) of 0.852 (95 % CI: 0.778-0.926), and the combined model achieved an AUC of 0.938 (95 % CI: 0.885-0.991) with a bootstrap-corrected AUC of 0.925. During a median follow-up of 17.5 months, polyp recurrence was significantly higher in women with EM (45.5 % vs. 17.6 %, P = 0.047). These findings demonstrate that the combination of multiple polyps, dysmenorrhoea, and elevated CA125 levels should raise suspicion for concurrent EM in women with EPs, suggesting potential shared pathophysiological mechanisms with important implications for clinical management, surgical planning, and fertility counselling.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251338"},"PeriodicalIF":2.3,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0