结直肠癌患者穴位埋线针刺前后t淋巴细胞亚群变化的观察。

IF 1.7 4区 生物学 Q3 BIOLOGY
Open Life Sciences Pub Date : 2025-05-20 eCollection Date: 2025-01-01 DOI:10.1515/biol-2022-1060
Caide Yang, Jinlian Bao, Dengke Li
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引用次数: 0

摘要

本研究旨在探讨穴位埋线(ACE)针刺观察前后结直肠癌(CRC)患者外周血t淋巴细胞亚群的变化。选取2017年4月至2022年5月就诊的80例结直肠癌手术患者作为研究样本,采用方便抽样法。将患者随机分为对照组(n = 40,接受常规化疗)和观察组(n = 40,接受4周ACE针刺治疗)。观察组患者的完全缓解率和部分缓解率均高于对照组,但差异无统计学意义(P < 0.05)。观察组化疗期间CD3+、CD4+ T淋巴细胞和自然杀伤细胞减少较少。与对照组比较,干预后观察组患者CD3+、CD4+ T细胞百分比显著升高,CD8+ T细胞水平下降。CD4+/CD8+比值较高,差异有统计学意义(P < 0.05)。针刺治疗可以维持结直肠癌患者化疗期间外周血t淋巴细胞亚群的正态分布,从而更好地维持患者的免疫状态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes in T-lymphocyte subpopulations in patients with colorectal cancer before and after acupoint catgut embedding acupuncture observation.

This study aims to explore changes in peripheral blood T-lymphocyte subsets in colorectal cancer (CRC) patients before and after acupoint catgut embedding (ACE) acupuncture observation. Eighty CRC surgical patients who visited from April 2017 to May 2022 were selected as study samples using the convenience sampling method. Patients were randomly divided into a control group (n = 40, receiving conventional chemotherapy) and an observation group (n = 40, receiving 4 weeks of additional ACE acupuncture). The observation group showed higher rates of complete and partial remission compared to the control, though the difference was not statistically significant (P > 0.05). The observation group experienced less reduction in CD3+, CD4+ T lymphocytes, and natural killer cells during chemotherapy. Compared with the control group, the percentage of CD3+ and CD4+ T cells in the observation group significantly increased after the intervention, while CD8+ T-cell levels decreased. The CD4+/CD8+ ratio was at a higher level, and the discrepancy was statistically obvious (P < 0.05). Acupuncture therapy can maintain the normal distribution of peripheral blood T-lymphocyte subpopulations during chemotherapy in patients with CRC, thus better maintaining the immune status of patients.

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来源期刊
CiteScore
2.50
自引率
4.50%
发文量
131
审稿时长
43 weeks
期刊介绍: Open Life Sciences (previously Central European Journal of Biology) is a fast growing peer-reviewed journal, devoted to scholarly research in all areas of life sciences, such as molecular biology, plant science, biotechnology, cell biology, biochemistry, biophysics, microbiology and virology, ecology, differentiation and development, genetics and many others. Open Life Sciences assures top quality of published data through critical peer review and editorial involvement throughout the whole publication process. Thanks to the Open Access model of publishing, it also offers unrestricted access to published articles for all users.
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