{"title":"结直肠癌患者穴位埋线针刺前后t淋巴细胞亚群变化的观察。","authors":"Caide Yang, Jinlian Bao, Dengke Li","doi":"10.1515/biol-2022-1060","DOIUrl":null,"url":null,"abstract":"<p><p>This study aims to explore changes in peripheral blood T-lymphocyte subsets in colorectal cancer (CRC) patients before and after acupoint catgut embedding (ACE) acupuncture observation. Eighty CRC surgical patients who visited from April 2017 to May 2022 were selected as study samples using the convenience sampling method. Patients were randomly divided into a control group (<i>n</i> = 40, receiving conventional chemotherapy) and an observation group (<i>n</i> = 40, receiving 4 weeks of additional ACE acupuncture). The observation group showed higher rates of complete and partial remission compared to the control, though the difference was not statistically significant (<i>P</i> > 0.05). The observation group experienced less reduction in CD<sup>3+</sup>, CD<sup>4+</sup> T lymphocytes, and natural killer cells during chemotherapy. Compared with the control group, the percentage of CD<sup>3+</sup> and CD<sup>4+</sup> T cells in the observation group significantly increased after the intervention, while CD<sup>8+</sup> T-cell levels decreased. The CD<sup>4+</sup>/CD<sup>8+</sup> ratio was at a higher level, and the discrepancy was statistically obvious (<i>P</i> < 0.05). Acupuncture therapy can maintain the normal distribution of peripheral blood T-lymphocyte subpopulations during chemotherapy in patients with CRC, thus better maintaining the immune status of patients.</p>","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20221060"},"PeriodicalIF":1.7000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103184/pdf/","citationCount":"0","resultStr":"{\"title\":\"Changes in T-lymphocyte subpopulations in patients with colorectal cancer before and after acupoint catgut embedding acupuncture observation.\",\"authors\":\"Caide Yang, Jinlian Bao, Dengke Li\",\"doi\":\"10.1515/biol-2022-1060\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study aims to explore changes in peripheral blood T-lymphocyte subsets in colorectal cancer (CRC) patients before and after acupoint catgut embedding (ACE) acupuncture observation. Eighty CRC surgical patients who visited from April 2017 to May 2022 were selected as study samples using the convenience sampling method. Patients were randomly divided into a control group (<i>n</i> = 40, receiving conventional chemotherapy) and an observation group (<i>n</i> = 40, receiving 4 weeks of additional ACE acupuncture). The observation group showed higher rates of complete and partial remission compared to the control, though the difference was not statistically significant (<i>P</i> > 0.05). The observation group experienced less reduction in CD<sup>3+</sup>, CD<sup>4+</sup> T lymphocytes, and natural killer cells during chemotherapy. Compared with the control group, the percentage of CD<sup>3+</sup> and CD<sup>4+</sup> T cells in the observation group significantly increased after the intervention, while CD<sup>8+</sup> T-cell levels decreased. The CD<sup>4+</sup>/CD<sup>8+</sup> ratio was at a higher level, and the discrepancy was statistically obvious (<i>P</i> < 0.05). Acupuncture therapy can maintain the normal distribution of peripheral blood T-lymphocyte subpopulations during chemotherapy in patients with CRC, thus better maintaining the immune status of patients.</p>\",\"PeriodicalId\":19605,\"journal\":{\"name\":\"Open Life Sciences\",\"volume\":\"20 1\",\"pages\":\"20221060\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103184/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Life Sciences\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1515/biol-2022-1060\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Life Sciences","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1515/biol-2022-1060","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"BIOLOGY","Score":null,"Total":0}
Changes in T-lymphocyte subpopulations in patients with colorectal cancer before and after acupoint catgut embedding acupuncture observation.
This study aims to explore changes in peripheral blood T-lymphocyte subsets in colorectal cancer (CRC) patients before and after acupoint catgut embedding (ACE) acupuncture observation. Eighty CRC surgical patients who visited from April 2017 to May 2022 were selected as study samples using the convenience sampling method. Patients were randomly divided into a control group (n = 40, receiving conventional chemotherapy) and an observation group (n = 40, receiving 4 weeks of additional ACE acupuncture). The observation group showed higher rates of complete and partial remission compared to the control, though the difference was not statistically significant (P > 0.05). The observation group experienced less reduction in CD3+, CD4+ T lymphocytes, and natural killer cells during chemotherapy. Compared with the control group, the percentage of CD3+ and CD4+ T cells in the observation group significantly increased after the intervention, while CD8+ T-cell levels decreased. The CD4+/CD8+ ratio was at a higher level, and the discrepancy was statistically obvious (P < 0.05). Acupuncture therapy can maintain the normal distribution of peripheral blood T-lymphocyte subpopulations during chemotherapy in patients with CRC, thus better maintaining the immune status of patients.
期刊介绍:
Open Life Sciences (previously Central European Journal of Biology) is a fast growing peer-reviewed journal, devoted to scholarly research in all areas of life sciences, such as molecular biology, plant science, biotechnology, cell biology, biochemistry, biophysics, microbiology and virology, ecology, differentiation and development, genetics and many others. Open Life Sciences assures top quality of published data through critical peer review and editorial involvement throughout the whole publication process. Thanks to the Open Access model of publishing, it also offers unrestricted access to published articles for all users.