Open Life Sciences最新文献

Hsp90 inhibitor 17-AAG reduces skin inflammation and inhibits NF-κB/NLRP3 inflammasome activation in DNCB-induced mice and TNF-α/IFN-γ-induced keratinocytes. Hsp90抑制剂17-AAG减轻dncb诱导小鼠和TNF-α/IFN-γ诱导的角质形成细胞的皮肤炎症，抑制NF-κB/NLRP3炎性体活化。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-10-19 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1377

Yuan-Yuan Chen, Xiao-Xiao Lin

{"title":"Hsp90 inhibitor 17-AAG reduces skin inflammation and inhibits NF-κB/NLRP3 inflammasome activation in DNCB-induced mice and TNF-α/IFN-γ-induced keratinocytes.","authors":"Yuan-Yuan Chen, Xiao-Xiao Lin","doi":"10.1515/biol-2025-1377","DOIUrl":"10.1515/biol-2025-1377","url":null,"abstract":"Atopic dermatitis (AD) represents the most common inflammatory skin condition with a high burden of disease persistence and relapse. In this study, we aimed to investigate the role of 17-AAG, a Hsp90 inhibitor, in inhibiting skin inflammation in AD and its effect on nuclear factor kappa-B (NF-κB)/NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome pathway. Topical application of 17-AAG was found to significantly improve inflammatory skin lesions, reduce epidermal thickness and mast cell infiltration, and decrease levels of proinflammatory cytokines in mice with AD-like skin lesions induced by using 2,4-dinitrochlorobenzene (1 % and 0.5 % DNCB). A reduced extent of p65 phosphorylation with declined protein expressions of NLRP3 and caspase-1 in the dorsal skin lesions of 17-AAG-treated AD mice compared to vehicle-treated AD mice. In HaCaT cells inflamed by tumor necrosis factor α (TNF-α)/interferon γ (IFN-γ), 17-AAG treatment significantly reduced the secretion of proinflammatory cytokines and chemokines, reduce the phosphorylation of p65, and decreased the protein expressions of NLRP3 and caspase-1. These results prove Hsp90 inhibitor 17-AAG could reduce skin inflammation and inhibit NF-κB/NLRP3 inflammasome activation in DNCB-induced mice and TNF-α/IFN-γ-induced human keratinocytes.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251377"},"PeriodicalIF":2.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral-fluid inflammatory and oxidative-stress biomarkers for peri-implantitis in Asian adults: a systematic review and stratified random-effects meta-analysis. 亚洲成人种植体周围炎的口腔液炎症和氧化应激生物标志物：系统回顾和分层随机效应荟萃分析

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-10-16 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1360

Lina Feng, Lei Zhang, Wenfeng He, Yuan Yuan, Hongxia Gao, Yanjun Ren, Xin Wang

{"title":"Oral-fluid inflammatory and oxidative-stress biomarkers for peri-implantitis in Asian adults: a systematic review and stratified random-effects meta-analysis.","authors":"Lina Feng, Lei Zhang, Wenfeng He, Yuan Yuan, Hongxia Gao, Yanjun Ren, Xin Wang","doi":"10.1515/biol-2025-1360","DOIUrl":"10.1515/biol-2025-1360","url":null,"abstract":"Peri-implantitis (PI) is an inflammatory condition where oral-fluid biomarkers can reflect disease - associated host responses. This meta - analysis evaluated biomarker differences between PI and healthy conditions in Asian adults, focusing on inflammatory cytokines (IL - 1β, IL - 6, TNF - α) and SIRT1 in peri - implant gingival crevicular fluid and saliva. Five databases were searched until August 2025. Random - effects models were used for pooled analyses, and relevant indicators were calculated. Thirteen studies were included. IL - 1β, IL - 6, and TNF - α were significantly higher in PI with low heterogeneity and stable findings. SIRT1 showed potentially favorable discriminatory performance but with limited evidence. Biomarker type affected effect - size variation, and mild small - study asymmetry for IL - 6 did not change overall conclusions. Overall, IL - 1β, IL - 6, and TNF - α can be candidate adjunctive biomarkers for PI assessment in Asian populations. SIRT1 is promising, but its diagnostic relevance conclusions are preliminary and need validation. Current evidence is limited. Further prospective studies in diverse populations and validation of clinically applicable thresholds and cost - effectiveness are needed before broader clinical translation.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251360"},"PeriodicalIF":2.3,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disseminated abscesses from Treponema denticola diagnosed by next-generation sequencing: case report. 通过下一代测序诊断密螺旋体播散性脓肿：病例报告。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-10-12 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1387

Xuhong Zhang, Shanshan Yu, Ye Liu

{"title":"Disseminated abscesses from Treponema denticola diagnosed by next-generation sequencing: case report.","authors":"Xuhong Zhang, Shanshan Yu, Ye Liu","doi":"10.1515/biol-2025-1387","DOIUrl":"https://doi.org/10.1515/biol-2025-1387","url":null,"abstract":"Treponema denticola is a fastidious oral spirochete that is difficult to detect by conventional culture, and extraoral disseminated infections are exceedingly rare. We report a rare case of disseminated abscesses involving the liver, kidney and pararenal regions caused by T. denticola, highlighting the role of next-generation sequencing (NGS) in diagnosis of uncommon abscesses. A 50-year-old female presented with a refractory lumbar abscess. Initial conventional cultures were negative, and empirical antibiotic therapy was ineffective. Abdominal computed tomography (CT) revealed liver abscess, and multiple renal and hepatic abscess. After the initial NGS analysis of the abscess fluid led to an inappropriate treatment adjustment, repeat NGS analysis of a liver biopsy specimen identified T. denticola. The patient's condition was alleviated after the administration of a combined penicillin and doxycycline regimen and radical resection of the right hepatic lobe and kidney. This case confirms that T. denticola can cause severe systemic infection. The integration of advanced diagnostic technologies and multidisciplinary collaboration is crucial in managing infections of unknown origin.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251387"},"PeriodicalIF":2.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro characterization of the candidate prebiotic potential of melon and watermelon seeds: strain-specific fermentation and targeted metabolic profiling. 甜瓜和西瓜种子候选益生元潜力的体外鉴定：菌株特异性发酵和靶向代谢分析。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-10-12 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1386

Sengul Teksoy, Lutfiye Yilmaz-Ersan

{"title":"In vitro characterization of the candidate prebiotic potential of melon and watermelon seeds: strain-specific fermentation and targeted metabolic profiling.","authors":"Sengul Teksoy, Lutfiye Yilmaz-Ersan","doi":"10.1515/biol-2025-1386","DOIUrl":"https://doi.org/10.1515/biol-2025-1386","url":null,"abstract":"This study evaluated water-extractable fractions of melon (Cucumis melo) and watermelon (Citrullus lanatus) seeds as candidate prebiotic substrates using a controlled in vitro monoculture model. Fermentative responses of five probiotic strains were assessed through growth kinetics, pH, prebiotic activity score (PAS), sugar utilization, and lactic acid and short-chain fatty acid (SCFA) profiles. Substrate, strain, and fermentation time, along with their interactions, significantly affected microbial growth and metabolic responses (p < 0.01). PAS values demonstrated distinct strain-substrate selectivity: watermelon seed elicited a strong positive response in B. bifidum but a negative response in L. casei. Despite an overall reduction in sugars at the end of fermentation, utilization patterns differed by strain; L. acidophilus was distinguished by fructose consumption, particularly in watermelon seed, and by galactose consumption in melon seed. Metabolite profiles did not directly correspond with growth responses; the watermelon seed-L. casei combination was notable for lactic acid production, while the highest total SCFA was generated in glucose medium and among probiotics by L. acidophilus. The results indicate that seed fractions do not exhibit a general superiority in fermentation but rather exhibit selective utilization patterns that differ along the axes of strain and metabolic response.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251386"},"PeriodicalIF":2.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphology of the female reproductive system and spermatheca in Notonecta maculata Fabricius, 1794 (Heteroptera: Notonectidae). 黄斑夜蛾雌性生殖系统及精囊的形态研究（异翅目：夜蛾科）。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-10-01 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1376

Selami Candan, Nurcan Özyurt Koçakoğlu, Hakan Özdamar, Hicret Arslan

{"title":"Morphology of the female reproductive system and spermatheca in Notonecta maculata Fabricius, 1794 (Heteroptera: Notonectidae).","authors":"Selami Candan, Nurcan Özyurt Koçakoğlu, Hakan Özdamar, Hicret Arslan","doi":"10.1515/biol-2025-1376","DOIUrl":"https://doi.org/10.1515/biol-2025-1376","url":null,"abstract":"Notonecta maculata Fabricius, 1794 is an ecologically important freshwater predator of mosquito larvae and other aquatic invertebrates and has potential as a biological indicator of water quality. This study presents the first detailed microscopic anatomical and histological description of the female reproductive system of N. maculata, based on stereomicroscopy, light microscopy, and scanning electron microscopy. The female reproductive system consists of a pair of ovaries, each with seven telotrophic meroistic ovarioles, a spermatheca, and a genital chamber. Each ovariole is differentiated into a terminal filament, germarium, vitellarium, and pedicel. The germarium contains trophocytes, a trophic core, and young oocytes. The vitellarium includes approximately 14 oocytes at previtellogenic, vitellogenic, and choriogenic stages. During vitellogenesis, oocytes accumulate yolk granules, and the germinal vesicle shifts peripherally. In choriogenesis, the follicular epithelium flattens, and the chorion differentiates into endo-, exo-, and extrachorion layers. The pedicel is surrounded by a single-layered columnar epithelium and a thin muscle layer. The spermatheca comprises a reservoir and duct; the reservoir shows cuticular intima, glandular epithelium, and muscle layers, with mature sperm bundles in the lumen. These findings establish a baseline for future comparative, systematic, and reproductive biology studies.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251376"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of vessel-generated waste on seasonal dynamics of water quality in the Kirtonkhola River, Bangladesh. 船舶产生的废物对孟加拉国Kirtonkhola河水质季节性动态的影响。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-10-01 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1380

Eti Khan Mitu, Md Nayem Hasan Munna, Sufiya Khatun, Sk Shahnewaz Zimi, Hafiz Ashraful Haque, Rattan Lal

{"title":"Impacts of vessel-generated waste on seasonal dynamics of water quality in the Kirtonkhola River, Bangladesh.","authors":"Eti Khan Mitu, Md Nayem Hasan Munna, Sufiya Khatun, Sk Shahnewaz Zimi, Hafiz Ashraful Haque, Rattan Lal","doi":"10.1515/biol-2025-1380","DOIUrl":"https://doi.org/10.1515/biol-2025-1380","url":null,"abstract":"Rivers play a vital role in sustaining ecosystems and human livelihoods, yet increasing anthropogenic activities threaten their ecological integrity. This study assessed seasonal variations and relationships among key water quality parameters, including pH, electrical conductivity (EC), total dissolved solids (TDS), and dissolved oxygen (DO) in the Kirtonkhola River, Bangladesh, to evaluate seasonal water-quality patterns in relation to passenger vessel activities and associated waste discharge. Monthly samples were collected from two sites with contrasting vessel activity between March 2018 and February 2019. Results showed clear seasonal patterns, with pH ranging from 5.92 to 7.69, EC from 165.33 to 357 μS/cm, TDS from 80 to 183.33 mg/L, and DO from 4.23 to 7.46 mg/L. Lower pH and DO during parts of the monsoon and higher EC and TDS during the dry season reflected seasonal physicochemical variability potentially influenced by hydrological conditions and anthropogenic inputs. Linear regression confirmed a strong relationship between EC and TDS (R 2 = 0.983 and 0.975, p < 0.001). All parameters remained within standard limits, highlighting the need for continued monitoring and improved vessel waste management.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251380"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological and biochemical characterization of bacterial isolates from diverse soil habitats in the Amhara region, Ethiopia. 埃塞俄比亚阿姆哈拉地区不同土壤生境细菌分离株的形态和生化特征。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-09-25 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1379

Tirusew Sema Kebede, Destaw Damtie, Mulugeta Kibert, Fasika Melese, Amare Bitew, Mastewal Alehegn

{"title":"Morphological and biochemical characterization of bacterial isolates from diverse soil habitats in the Amhara region, Ethiopia.","authors":"Tirusew Sema Kebede, Destaw Damtie, Mulugeta Kibert, Fasika Melese, Amare Bitew, Mastewal Alehegn","doi":"10.1515/biol-2025-1379","DOIUrl":"10.1515/biol-2025-1379","url":null,"abstract":"Soil harbors diverse microbial communities that play essential roles in ecosystem functioning; however, many microbial populations remain unexplored. In this study, bacterial isolates obtained from 11 selected soil sampling sites in the Amhara region of Ethiopia were characterized. A total of 104 morphologically distinct bacterial isolates were recovered using the serial dilution and spread plate techniques and were subsequently characterized based on their morphological and biochemical characteristics. Presumptive identification based on morphological and biochemical characteristics classified the isolates into nine bacterial genera. The Shannon diversity index (H' = 1.68) indicated moderate bacterial species diversity, whereas the Simpson diversity index (0.72) suggested a relatively even distribution of taxa within the sampled soils. The present study demonstrated that soil bacterial diversity was significantly and positively correlated with soil pH, total nitrogen (TN), and available phosphorus (AP). In contrast, organic carbon (OC), soil moisture, and temperature showed no significant association with bacterial diversity. Principal component analysis (PCA) explained 73 % of the total variation in the biochemical characteristics of the bacterial isolates. The high enzymatic activity and metabolic versatility exhibited by the isolates highlight their potential for various biotechnological applications, including bioremediation, industrial enzyme production, and agricultural biofertilizer development.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251379"},"PeriodicalIF":2.3,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13614831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149063532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of vitamin C derivatives on ATP homeostasis across diverse cell types. 维生素C衍生物对不同细胞类型ATP稳态影响的比较分析。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-09-21 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1383

Anna Goc, Waldemar Sumera, Aleksandra Niedzwiecki

{"title":"Comparative analysis of vitamin C derivatives on ATP homeostasis across diverse cell types.","authors":"Anna Goc, Waldemar Sumera, Aleksandra Niedzwiecki","doi":"10.1515/biol-2025-1383","DOIUrl":"10.1515/biol-2025-1383","url":null,"abstract":"Cellular energy homeostasis is tightly regulated by mitochondrial function and substrate availability. Vitamin C is a redox-active molecule with emerging roles in cellular metabolism; however, the metabolic impacts of structurally distinct vitamin C derivatives remain incompletely defined. In this study, we systematically compared l-ascorbic acid, dehydroascorbic acid, 6-O-palmitoyl-l-ascorbate, and mineral ascorbates (calcium, magnesium, sodium, and potassium salts) across multiple mammalian cell types. Cells were exposed to concentrations ranging from 60 to 500 µM, encompassing physiologically and pharmacologically relevant levels. The vitamin C derivatives induced cell type- and concentration-dependent modulation of intracellular ATP levels. Notably, HepG2 and renal epithelial cells exhibited robust ATP increases, whereas fibroblasts, myocytes, microglia, and skeletal muscle models displayed variable responses depending on the derivative and dose. Moreover, in skeletal muscle cells, co-treatment of standard l-ascorbic acid with select fatty acids did not yield additive bioenergetic effects, suggesting a localized, substrate-specific plateau or shared regulatory step in this specific cell model. Exposure to l-ascorbic acid induced selective increases in COX-1 without changes in SDH-A, consistent with rapid functional modulation of mitochondrial activity in myocytes and microglial cells only. Collectively, these findings demonstrate that vitamin C derivatives modulate cellular ATP levels within existing metabolic networks in a context-dependent manner, consistent with the modulation of mitochondrial-associated energy metabolism.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251383"},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune regulatory networks and gut microbiota-associated targets in endometriosis: an integrative multi-omics and network analysis. 子宫内膜异位症的免疫调节网络和肠道微生物群相关靶点：综合多组学和网络分析。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-09-08 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1372

Yan Liu, Shurong Liu, Chunyan Zhang, Lihua Pei, Jingyi Wu

{"title":"Immune regulatory networks and gut microbiota-associated targets in endometriosis: an integrative multi-omics and network analysis.","authors":"Yan Liu, Shurong Liu, Chunyan Zhang, Lihua Pei, Jingyi Wu","doi":"10.1515/biol-2025-1372","DOIUrl":"10.1515/biol-2025-1372","url":null,"abstract":"Endometriosis is an estrogen-dependent disorder characterized by chronic inflammation, immune dysregulation, and altered hormone metabolism. Although gut microbiota-derived metabolites have been implicated in shaping immune microenvironments and lesion development, the underlying regulatory mechanisms remain incompletely understood. Here, we integrated multi-omics, protein-protein interaction (PPI), SHapley Additive exPlanations (SHAP), and single-cell transcriptomics to identify core targets and delineate their interactions with microbiota-derived metabolites, followed by molecular simulations to evaluate metabolite-target binding stability. In this study, we identified 61 differentially expressed genes (DEGs) associated with microbial metabolites. Among these, MET and SELL emerged as key hub genes, with MET showing a potentially protective association and SELL exhibiting a modest positive association with endometriosis risk. Specific gut microbes, including Bacteroides, Parabacteroides, and Bifidobacterium, along with metabolites such as palmitoylethanolamide and dihydroresveratrol, were implicated in modulating immune and inflammatory pathways relevant to lesion formation. Additionally, cell-cell communication analysis indicated that the 61 DEGs were enriched in the Macrophage migration inhibitory factor (MIF) and C-X-C motif chemokine ligand family (CXCL) signaling pathways, suggesting their potential importance in the endometriotic microenvironment. Computational simulations further indicated potential binding interactions between multiple metabolites and MET and SELL. These findings delineate a multi-layered regulatory framework linking gut microbiota, metabolites, molecular targets, and immune interactions, thereby providing a foundation for mechanistic studies and targeted therapeutic strategies.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251372"},"PeriodicalIF":2.3,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of dexmedetomidine-remifentanil on hemodynamics and inflammatory responses in patients undergoing atrial fibrillation ablation. 右美托咪定-瑞芬太尼对房颤消融患者血流动力学和炎症反应的影响。

IF 2.3 4区生物学

Open Life Sciences Pub Date : 2026-09-08 eCollection Date: 2026-01-01 DOI: 10.1515/biol-2025-1364

Lu Huang, Ting Luo, Jiaojiao Guo, Shiqian Lu

{"title":"Effects of dexmedetomidine-remifentanil on hemodynamics and inflammatory responses in patients undergoing atrial fibrillation ablation.","authors":"Lu Huang, Ting Luo, Jiaojiao Guo, Shiqian Lu","doi":"10.1515/biol-2025-1364","DOIUrl":"10.1515/biol-2025-1364","url":null,"abstract":"This randomized controlled trial evaluated dexmedetomidine combined with remifentanil versus remifentanil alone for monitored anesthesia care during radiofrequency catheter ablation for atrial fibrillation. Between January and December 2023, 100 patients were stratified by age, sex, BMI, and atrial fibrillation type, then randomly assigned (1:1, block size 4, sealed envelopes) to Group A (dexmedetomidine 1 μg/kg loading then 0.2-0.4 μg/kg/h plus remifentanil, n = 50) or Group B (saline control plus remifentanil, n = 50). Baseline characteristics were comparable (all P > 0.05). Hemodynamic parameters were recorded at baseline (T 0), 10 min after induction (T 1), maintenance (T 2), 10 min before surgery end (T 3), and at surgery end (T 4). Group A showed higher mean arterial pressure, cardiac index, and cardiac output at T 1-T 4 (P < 0.05), with lower heart rate and blood pressure (P < 0.05). Ramsay Sedation Score was higher at T 3-T 4 (P < 0.05). Adverse reactions and inflammatory markers (IL-6, TNF-α, CRP) were attenuated postoperatively (P < 0.05). Dexmedetomidine combined with remifentanil provides superior hemodynamic stability, enhanced sedation, reduced inflammation, and fewer adverse events during atrial fibrillation ablation.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"21 1","pages":"20251364"},"PeriodicalIF":2.3,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0