Open Life Sciences最新文献_第2页

Fungal and bacterial pathogenic co-infections mainly lead to the assembly of microbial community in tobacco stems. 真菌和细菌共感染主要导致烟草茎部微生物群落的聚集。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-09-20 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1103

Can Wang, Zhipeng Xiao, Zhihui Cao, Feng Sheng, Penghua Xiang, Tingting Mu, Yunming Ma, Xuliang Lin, Mengyu Xiao, Qian Zhu, Shaolong Wu, Lin Tan

{"title":"Fungal and bacterial pathogenic co-infections mainly lead to the assembly of microbial community in tobacco stems.","authors":"Can Wang, Zhipeng Xiao, Zhihui Cao, Feng Sheng, Penghua Xiang, Tingting Mu, Yunming Ma, Xuliang Lin, Mengyu Xiao, Qian Zhu, Shaolong Wu, Lin Tan","doi":"10.1515/biol-2025-1103","DOIUrl":"10.1515/biol-2025-1103","url":null,"abstract":"Pathogenic co-infections in plants significantly impact microbial diversity and disease outcomes, yet their effects on microbial community structure and ecological processes remain unclear. Tobacco plants were co-infected with Ralstonia solanacearum and Neocosmospora falciformis. 16S ribosomal RNA and internal transcribed spacer amplicon sequencing were used to assess bacterial and fungal communities, respectively, in infected tobacco stems. The results were compared between co-infected and healthy control tobacco plants to assess the effects of infection. Co-infection reduced microbial diversity and shifted community structure, promoting ecological specialization. Network analysis revealed synergistic interactions between the pathogens, enhancing virulence through positive correlations with certain microbial taxa. Conversely, some taxa exhibited antagonistic effects, potentially limiting pathogen proliferation. Deterministic processes were found to dominate microbial community assembly under infection conditions, significantly reshaping the microbial landscape compared to healthy control plants. This study highlights the profound effects of co-infection on microbial diversity, community composition, microbial interactions, and community assembly processes in tobacco plants. These findings provide valuable insights for developing more targeted plant disease management strategies by manipulating microbial communities.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251103"},"PeriodicalIF":1.7,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global assessment of the fate of nitrogen deposition in forest ecosystems: Insights from ¹⁵N tracer studies. 森林生态系统中氮沉降命运的全球评估：来自15N示踪剂研究的见解。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-09-18 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1171

Xinlu Bai, Yaping Li, Jinhu Zhi

{"title":"Global assessment of the fate of nitrogen deposition in forest ecosystems: Insights from 15N tracer studies.","authors":"Xinlu Bai, Yaping Li, Jinhu Zhi","doi":"10.1515/biol-2025-1171","DOIUrl":"10.1515/biol-2025-1171","url":null,"abstract":"Atmospheric nitrogen (N) deposition is recognized as a pivotal nutrient input in forest ecosystems. However, significant gaps persist in our comprehension of the global-scale fate of N in forest ecosystems. In a pioneering effort, this study analyzed the fluxes and determinants of deposited N by 234 observations from 52 published articles. Our findings indicated that plant uptake, soil retention, and N losses, respectively, accounted for 27.4, 57.9, and 14.6% of the total deposited N. The fate of deposited N was significantly influenced by a suite of factors, including forest type, climatic parameters such as mean annual temperature (MAT) and precipitation (MAP), edaphic characteristics such as soil pH and the carbon to nitrogen ratio (C/N), and experimental factors like nitrogen addition rate (NR), nitrogen forms (NF), plot size (PS) for 15N studies, and the duration of study. For the uptake of deposited N, MAP emerged as the predominant positive factors, whereas NR was the dominant negative factors; for deposited N soil retention, NR was the key positive factors, while MAT was the key negative factors; for N losses, MAP was the predominant positive factors, with the C/N ratio serving as a significant negative factor. Thus, for a given forest ecosystem with relatively stable climate and soil conditions, NR, NF, and the soil C/N were the main controlling factors regulating the fate of deposited N. These insights significantly advance our grasp of the N cycle in forest ecosystems. Consecutive monitoring of the impact of deposited N on soil N transformations and carbon sequestration is needed in future studies.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251171"},"PeriodicalIF":1.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycitein alleviates inflammation and apoptosis in keratinocytes via ROS-associated PI3K-Akt signalling pathway. 糖苷通过ros相关的PI3K-Akt信号通路减轻角化细胞的炎症和凋亡。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-09-17 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1162

Wenqian Sun, Jinyu Chen, LiHong He, Yating Chen

{"title":"Glycitein alleviates inflammation and apoptosis in keratinocytes via ROS-associated PI3K-Akt signalling pathway.","authors":"Wenqian Sun, Jinyu Chen, LiHong He, Yating Chen","doi":"10.1515/biol-2025-1162","DOIUrl":"10.1515/biol-2025-1162","url":null,"abstract":"A chronic inflammatory skin disorder, psoriasis, affects 2-3% of people worldwide. A bioactive substance, glycitein (GCN), has several pharmacological characteristics. This work aims to evaluate the effects of GCN on the in vitro proliferation and death of human HaCaT keratinocytes. An in vitro model was created to simulate psoriatic features utilizing HaCaT keratinocytes activated by M5 cytokines. The 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide test was used to quantify cell viability, whereas the BrdU assay was used to assess the proliferation rate. Using a DCFH-DA probe and an Annexin V-FITC/propidium iodide detection kit, flow cytometry was used to examine the generation of reactive oxygen species (ROS) and apoptosis, respectively. Western blot and quantitative polymerase chain reaction were employed to determine the amounts of phosphorylated Akt (p-Akt) and Akt proteins. GCN dramatically decreased the inflammation and hyperproliferation that cytokines caused in HaCaT keratinocytes. The alteration of mitochondrial membrane potential promoted apoptosis and caused cell cycle arrest at the sub-G1 phase, which indicates apoptotic DNA fragmentation. The suppression of the PI3K/Akt signalling pathway was linked to increased intracellular ROS levels brought on by GCN therapy. These results imply that GCN reduces inflammation and keratinocyte hyperproliferation by controlling cell cycle progression and apoptosis via ROS-associated inhibition of the PI3K/Akt pathway.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251162"},"PeriodicalIF":1.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biogenic Cu/Ni nanotherapeutics from Descurainia sophia (L.) Webb ex Prantl seeds for the treatment of lung cancer. 柏树生物源Cu/Ni纳米药物的研究Webb ex Prantl种子用于治疗肺癌。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1160

Xiao Zou, Jingsheng Chen, Jiaojiao Hu

{"title":"Biogenic Cu/Ni nanotherapeutics from Descurainia sophia (L.) Webb ex Prantl seeds for the treatment of lung cancer.","authors":"Xiao Zou, Jingsheng Chen, Jiaojiao Hu","doi":"10.1515/biol-2025-1160","DOIUrl":"10.1515/biol-2025-1160","url":null,"abstract":"Descurainia sophia (L.) Webb ex Pran known as Flixweed is recognized as an ethnomedicinal plant in Chinese traditional medicine, offering numerous therapeutic benefits. Antioxidant chemicals found in this medicinal plant protect cellular integrity from various sources of damage and may help prevent cancer. In this study, we investigated copper/nickel nanoparticles (Cu/NiBMNPs@Flixweed) that were green-mediated following principles of green chemistry, utilizing the aqueous extract of D. sophia seeds for the treatment of lung carcinoma. The effectiveness of these Cu/Ni nanoparticles' effectiveness was tested against three common human lung cancer cell lines. Methods such as X-ray diffraction (XRD), field emission-scanning electron microscopy (FE-SEM), Fourier transform-infrared spectroscopy, and energy dispersive X-ray were used to analyze the Cu/Ni nanoparticles produced through environmentally friendly methods. The XRD pattern revealed that the crystalline structure of the generated NPs is seen in the XRD pattern. According to the FE-SEM results, the nanoparticles had an average size of 68.52 nm and a semi-spherical shape. The IC50 values of Cu/NiBMNPs@Flixweed against HLC-1, LC-2/ad, and PC-14 cells were found to be 170, 98, and 57 μg/mL, respectively. The IC50 values of Cu/NiBMNPs@Flixweed against 2,2-diphenyl-1-picrylhydrazyl free radicals was 30 μg/mL. Recent research indicates that Cu/NiBMNPs@Flixweed may be a promising option to assist in the treatment various types of lung cancer.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251160"},"PeriodicalIF":1.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dapagliflozin attenuates atrial fibrosis via the HMGB1/RAGE pathway in atrial fibrillation rats. 达格列净通过HMGB1/RAGE通路减轻房颤大鼠心房纤维化。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1163

Zhenni Tan, Jianxiang Chang, Yin Li, Xiang Sun, Fanxiang Liu, Yang Chen, Lin Pan

{"title":"Dapagliflozin attenuates atrial fibrosis via the HMGB1/RAGE pathway in atrial fibrillation rats.","authors":"Zhenni Tan, Jianxiang Chang, Yin Li, Xiang Sun, Fanxiang Liu, Yang Chen, Lin Pan","doi":"10.1515/biol-2025-1163","DOIUrl":"10.1515/biol-2025-1163","url":null,"abstract":"Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia. A key pathological feature of AF is atrial fibrosis, which promotes arrhythmogenic remodeling. While myocardial fibrosis has been widely observed in AF models, the underlying molecular mechanisms driving fibrotic progression remain incompletely understood. AF rats were modeled using acetylcholine, followed by treatment with different concentrations of dapagliflozin (DAPA) or positive control amiodarone. To elucidate the role of the high-mobility group box 1 (HMGB1)/receptor for advanced glycation end products (RAGE) pathway in AF, lipopolysaccharide (LPS; an HMGB1/RAGE pathway activator) and FPS-ZM1 (a RAGE inhibitor) were employed. Cardiac function, myocardial fibrosis, and inflammation-related proteins were assessed using echocardiography, enzyme-linked immunosorbent assay, histological staining, Western blotting, and reverse transcription quantitative polymerase chain reaction. AF rats exhibited marked cardiac dysfunction, fibrosis, and increased expression of inflammatory markers. DAPA restored cardiac function, attenuating fibrosis and inflammation. LPS aggravated cardiac injury, while DAPA attenuated the damage, with the greatest protective effects observed in the LPS + DAPA + FPS-ZM1 group. DAPA attenuates atrial fibrosis and cardiac dysfunction in AF rats by inhibiting the HMGB1/RAGE pathway. This study suggests the potential of DAPA as a therapeutic option for AF.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251163"},"PeriodicalIF":1.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on the impact of curcumin on immune responses in breast cancer. 姜黄素对乳腺癌免疫反应影响的研究进展。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1089

Xiao Han, Renzhe Tang, Peng Wang, Li Liu

引用次数: 0

Analgesic and toxicological evaluation of cannabidiol-rich Moroccan Cannabis sativa L. (Khardala variety) extract: Evidence from an in vivo and in silico study. 富含大麻二酚的摩洛哥大麻L. （Khardala品种）提取物的镇痛和毒理学评价：来自体内和硅研究的证据。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1141

Hind Ibork, Zakaria Ait Lhaj, Farhan Siddique, Sara El Idrissi, Farid Khallouki, Rafik El Mernissi, Lhoussain Hajji, Hanane Khalki, Mohammed Bourhia, Ahmad Mohammad Salamatullah, Ousman B Mahamat, Khalid Taghzouti, Oualid Abboussi

{"title":"Analgesic and toxicological evaluation of cannabidiol-rich Moroccan Cannabis sativa L. (Khardala variety) extract: Evidence from an in vivo and in silico study.","authors":"Hind Ibork, Zakaria Ait Lhaj, Farhan Siddique, Sara El Idrissi, Farid Khallouki, Rafik El Mernissi, Lhoussain Hajji, Hanane Khalki, Mohammed Bourhia, Ahmad Mohammad Salamatullah, Ousman B Mahamat, Khalid Taghzouti, Oualid Abboussi","doi":"10.1515/biol-2025-1141","DOIUrl":"10.1515/biol-2025-1141","url":null,"abstract":"The legalization of cannabis for industrial and medicinal purposes has significantly expanded worldwide. This study delves into the analgesic potential toxicity study of chloroformic extract from the Moroccan Cannabis sativa L. (C. sativa) cultivar, Khardala (KH extract). Our findings reveal that the lethal dose of KH extract is ≥5,000 mg/kg, with mice given 2,000 mg/kg exhibiting neurotoxic symptoms, including piloerection, aggressiveness, and fear, along with marked hepato-renal toxicity indicated by elevated levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin, and creatinine in both male and female subjects. Importantly, no toxicity was observed at 250 mg/kg and 500 mg/kg doses. Remarkably, at a dose of 500 mg/kg, the KH extract demonstrated a potent analgesic effect superior to cannabidiol (CBD), suggesting a synergistic interaction among the extract's bioactive compounds, such as CBD, cannabidivarin (CBDV), Delta 9 tetrahydrocannabinol (THC), cannabigerol (CBG), Delta 9 tetrahydrocannabivarin (THCV), and β-caryophyllene. In silico analysis supports these findings, showing the strong binding potential of THC, THCV, CBG, and CBDV to delta opioid receptors, with G-scores >-5.0 kcal/mol, highlighting the promising analgesic efficacy of this cannabis cultivar extract. This study underscores the therapeutic potential of the KH cultivar, positioning it as a promising candidate for pain management therapies.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251141"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wound healing and signaling pathways. 伤口愈合和信号通路。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1166

Zhe Liu, Yudong Fang

引用次数: 0

To explore the relationship between endometrial hyperemia and polycystic ovary syndrome. 探讨子宫内膜充血与多囊卵巢综合征的关系。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1154

Shuang Wang, Feng-Hua Li, Wei Zhang, Hong-Chu Bao, Cui-Fang Hao

{"title":"To explore the relationship between endometrial hyperemia and polycystic ovary syndrome.","authors":"Shuang Wang, Feng-Hua Li, Wei Zhang, Hong-Chu Bao, Cui-Fang Hao","doi":"10.1515/biol-2025-1154","DOIUrl":"10.1515/biol-2025-1154","url":null,"abstract":"The aim of this study is to investigate the characteristics and etiology of endometrial hyperemia in patients with polycystic ovary syndrome (PCOS) through two complementary approaches: clinical data analysis to characterize endometrial hyperemia and clinical trials to elucidate its underlying causes. ELISA was employed to quantify inflammatory mediators in endometrial tissue, while reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blot analyses were conducted to assess the expression levels of molecules associated with endoplasmic reticulum stress (ERS). Additionally, RT-qPCR was used to determine the mRNA expression levels of HIF-1α, VEGF, and EPO. Compared with non-PCOS patients, those with PCOS exhibited a significantly higher prevalence of chronic endometritis (CE) (P < 0.05) along with increased levels of inflammatory factors (P < 0.05). Furthermore, the mRNA expression levels of HIF-1α, VEGF, and EPO, as well as ERS-related molecules, were significantly elevated in PCOS patients (P < 0.05). These findings indicate that women with PCOS are more likely to suffer from CE and that endometrial hyperemia is the primary manifestation of CE in these patients. The results further suggest that endometrial hypoxia-induced ERS may contribute to the development of endometrial hyperemia in PCOS patients.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251154"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of immunotherapy and whole-brain radiotherapy on prognosis of patients with multiple brain metastases: A retrospective cohort study. 免疫治疗联合全脑放疗对多发性脑转移患者预后的影响：一项回顾性队列研究。

IF 1.7 4区生物学

Open Life Sciences Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.1515/biol-2025-1102

Pengwei Yan, Changzhai Wang, Duixian Tuoligan, Aji Kabinuer, Sheng Li, Xue Song, Huanfeng Zhu

{"title":"Combination of immunotherapy and whole-brain radiotherapy on prognosis of patients with multiple brain metastases: A retrospective cohort study.","authors":"Pengwei Yan, Changzhai Wang, Duixian Tuoligan, Aji Kabinuer, Sheng Li, Xue Song, Huanfeng Zhu","doi":"10.1515/biol-2025-1102","DOIUrl":"10.1515/biol-2025-1102","url":null,"abstract":"Brain metastases (BMs) usually occur in the advanced stage of cancers with a poor prognosis. This study aimed to compare the clinical efficacy and effects on cognitive function of immunotherapy combined with whole brain radiotherapy (WBRT) and immunotherapy combined with WBRT plus sequential integrated boost (SEB) in the treatment of multiple BMs. A total of 57 patients diagnosed with BMs were included in Kezhou People's Hospital Affiliated to Nanjing Medical University between 2021 and 2023. Patients were allocated into the WBRT group (n = 27) and the WBRT + SEB group (n = 30) based on whether to receive a boost. The WBRT + SEB group showed a higher complete response rate and objective response rate compared to the WBRT group (26.7 vs 14.8%, 90.0 vs 66.7%) (all P < 0.05). The two groups had a median overall survival (OS) time of 11.2 months (95% confidence interval [CI]: 9.3-13.1) and 9.4 months (95% CI: 6.2-12.6), respectively, with no statistically significant difference (P = 0.176). There was no difference in the levels of mini-mental state examination score at 1, 3, and 6 months, as well as the risk of adverse events, after WBRT between the two groups. In conclusion, SEB may improve the remission rate of lesions but not prolong the OS time. The boost would neither increase serious side effects nor would it aggravate cognitive impairment caused by WBRT.","PeriodicalId":19605,"journal":{"name":"Open Life Sciences","volume":"20 1","pages":"20251102"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0