BAP1 complexes with YY1 and RBBP7 and its downstream targets in ccRCC cells.

IF 1.7 4区生物学 Q3 BIOLOGY

Open Life Sciences Pub Date : 2025-07-18 eCollection Date: 2025-01-01 DOI:10.1515/biol-2025-1140

Ying Wu, Xue-Ying Li, Jin-Dong Chen, You-Fu Pan

引用次数: 0

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. A few genes, such as BAP1, are associated with the tumorigenesis of ccRCC. Mutations in BAP1 are related to a proportion of ccRCCs. In this study, to explore the functional role of BAP1 in ccRCC, the potential interacting proteins with BAP1 in ccRCC cells are to be identified, and the gene expression profiles of BAP1 knockdown 786-O cells are to be analyzed.

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BAP1与YY1和RBBP7的复合物及其在ccRCC细胞中的下游靶点。

透明细胞肾细胞癌（ccRCC）是最常见的肾癌类型。一些基因，如BAP1，与ccRCC的肿瘤发生有关。BAP1突变与一定比例的ccrcc有关。本研究为探讨BAP1在ccRCC中的功能作用，将鉴定ccRCC细胞中可能与BAP1相互作用的蛋白，并分析BAP1敲低786-O细胞的基因表达谱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Life Sciences BIOLOGY-

CiteScore

2.50

自引率

4.50%

发文量

131

审稿时长

43 weeks

期刊介绍： Open Life Sciences (previously Central European Journal of Biology) is a fast growing peer-reviewed journal, devoted to scholarly research in all areas of life sciences, such as molecular biology, plant science, biotechnology, cell biology, biochemistry, biophysics, microbiology and virology, ecology, differentiation and development, genetics and many others. Open Life Sciences assures top quality of published data through critical peer review and editorial involvement throughout the whole publication process. Thanks to the Open Access model of publishing, it also offers unrestricted access to published articles for all users.