Open Veterinary Journal最新文献

{"title":"The immunostimulatory effects of fucoidan on the cellular and humoral immune response in Wistar rats.","authors":"Rochmah Kurnijasanti, Giftania Wardani, Muhammad Rais Mustafa, Sri Agus Sudjarwo","doi":"10.5455/OVJ.2024.v14.i8.7","DOIUrl":"10.5455/OVJ.2024.v14.i8.7","url":null,"abstract":"<p><strong>Background: </strong>Natural product active ingredients are currently being studied rigorously worldwide and offer a viable substitute for traditional immunotherapy for various medical disorders.</p><p><strong>Aim: </strong>The objective of the study was to investigate the immunostimulatory properties of fucoidan in albino Wistar rats.</p><p><strong>Methods: </strong>For the current study, forty rats were divided into five groups of rats that were used in good condition. In-vivo experiments of fucoidan were carried out in Wistar albino rats, such as the cyclophosphamide-caused myelosuppression, the delayed-type hypersensitivity (DTH) response, the phagocytic activity, the haemagglutinating antibody (HA) titer, and the neutrophil adhesion test.</p><p><strong>Results: </strong>The phagocytic index increased significantly in response to Fucoidan in a dose-dependent manner, as well as enhanced DTH reaction, and HA titer caused by sheep red blood cells sheep red blood cells. Additionally, fucoidan decreased myelosuppression in rats after cyclophosphamide treatment and enhanced neutrophil adhesion with nylon fiber.</p><p><strong>Conclusion: </strong>These findings imply that fucoidan has immunostimulant properties and could potentially utilised to treat immune-depression diseases.</p>","PeriodicalId":19531,"journal":{"name":"Open Veterinary Journal","volume":"14 8","pages":"1794-1800"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorative effect of transfersome gel of kepok banana peel extract (<i>Musa balbisiana</i>) against photoaging in Wistar rat skin.","authors":"Elly Mayangsari, Arifa Mustika, Nurdiana Nurdiana, Nozlena Abdul Samad","doi":"10.5455/OVJ.2024.v14.i8.28","DOIUrl":"10.5455/OVJ.2024.v14.i8.28","url":null,"abstract":"<p><strong>Background: </strong>Repeated acute exposure to ultraviolet B (UVB) rays can cause photoaging. <i>Musa balbisiana</i> peel contains flavonoid compounds which act as antioxidants. However, the physicochemicals of flavonoids are unstable, have high molecular weight, and are easily oxidized, causing their use is still limited and transdermal delivery to be inefficient.</p><p><strong>Aim: </strong>To investigate the ameliorative effect of transfersome gel of <i>M. balbisiana</i> peels against photoaging in Wistar rat skin.</p><p><strong>Methods: </strong>Transfersome gel was characterized by transmission electron microscopy (TEM). <i>In vivo</i> research was used to determine the ameliorative effects of <i>M. balbisiana</i> peel. The composition of transfersome consists of ethanol extracts of <i>M. balbisiana</i> peel, soybean phosphatidylcholine, and tween 80. The gel was applied three times a week for 4 weeks with a total UVB radiation dose of 840 mJ/cm². To evaluate the repair mechanism by measuring the degree of wrinkles, epidermal thickening, dermal thinning, collagen fiber irregularity, <i>matrix metalloproteinase</i> 1 (MMP-1), and transforming growth factor-β (TGF-β) expression, malondialdehyde (MDA) and tumor necrosis factor-α (TNFα) levels.</p><p><strong>Results: </strong>TEM results show that gel transfersome <i>M. balbisiana</i> peel has a round morphology with a diameter of ±50 nm and no aggregation, which are defined as nanoparticles. Transfersome gel ameliorated the degree of wrinkle, epidermal thickening, dermal thinning, and irregularity of collagen fibers caused by UVB exposure, suppresses lipid peroxidation by decreasing MDA and TNFα level, also collagen imbalance by inhibiting MMP-1 expression and activating TGF-β expression, which was found statistically significantly different from non-transfersome gel group.</p><p><strong>Conclusion: </strong>Transfersome gel of <i>M. balbisiana</i> peel can act as an alternative medicine to ameliorate clinical photoaging due to exposure to UVB.</p>","PeriodicalId":19531,"journal":{"name":"Open Veterinary Journal","volume":"14 8","pages":"1990-1998"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring blood pressure dynamics and oxidative stress markers in an animal model of polycystic ovary syndrome.","authors":"Yudit Oktanella, Hana Ismiawati, Hafizh Zakaria, Handayu Untari","doi":"10.5455/OVJ.2024.v14.i8.14","DOIUrl":"10.5455/OVJ.2024.v14.i8.14","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a hormonal disorder characterized by elevated androgen levels, heightened insulin secretion, and dysregulation of luteinizing hormone and follicle-stimulating hormone. This disorder results in metabolic disruptions, while the irregular estrous cycles associated with PCOS impact cellular functions like growth, movement, and alterations in cell adhesion within the tissue matrix.</p><p><strong>Aim: </strong>This study aims to identify the blood tension, serum malondialdehyde (MDA) levels, and serum Metalloproteinase-1 (MMP-1) in rat models of PCOS. The study was conducted using female Wistar rats aged 6 months weighing between 130 and 180 g.</p><p><strong>Methods: </strong>The rats were divided into three treatment groups: negative control, induction of testosterone propionate (TP) at a dose of 100 mg/kg BW IP for 12 days, and induction of estradiol valerate (EV) at a dose of 2 mg/kg BW IP for 2 days. Data were analyzed quantitatively using a one-way analysis of variance followed by a Posthoc Test using the least significant difference with a confidence level of 95%.</p><p><strong>Results: </strong>The research results indicate that the average blood pressure of TP Group and EV Group did not differ significantly from the negative control (<i>p</i> > 0.05). Serum MDA levels were significantly different in the TP Group compared to the negative control (<i>p</i> < 0.05). On the other hand, MMP-1 levels showed no significant difference (<i>p</i> > 0.05) among all the treatment groups.</p><p><strong>Conclusion: </strong>The findings of this study suggest that TP induction in a rat model of PCOS can potentially contribute to oxidative stress and lipid peroxidation, but does not significantly affect blood pressure or serum MMP-1 levels.</p>","PeriodicalId":19531,"journal":{"name":"Open Veterinary Journal","volume":"14 8","pages":"1858-1865"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimalarial activity of borrelidin and fumagilin in <i>Plasmodium berghei</i>-infected mice.","authors":"Risqa Novita, Agik Suprayogi, Andria Agusta, Arifin Budiman Nugraha, Tomoyoshi Nozaki, Kurnia Agustini, Huda Shalahudin Darusman","doi":"10.5455/OVJ.2024.v14.i8.30","DOIUrl":"10.5455/OVJ.2024.v14.i8.30","url":null,"abstract":"<p><strong>Background: </strong>Malaria remains a significant global health burden, with drug resistance posing a major challenge to its control. The emergence of resistance to antimalarial drugs represents a critical issue in malaria management, as it heightens the likelihood of morbidity and mortality associated with the disease. There is an urgent requirement for a novel candidate drug with a distinct mechanism of action.</p><p><strong>Aim: </strong>In light of the ongoing challenges in malaria management, particularly the emergence of drug resistance, this study aimed to investigate the efficacy of a novel combination therapy of borrelidin and fumagilin against <i>Plasmodium berghei</i> infection on Swiss Webster mice. The findings of this study could contribute to developing new and effective antimalarial treatments.</p><p><strong>Methods: </strong>This study employed a unique approach, using Swiss Webster mice aged 6-8 weeks and dividing them into five groups, each with five mice. The therapeutic efficacy of the combination treatment was evaluated through a comprehensive assessment of parasitemia levels, survival rates, and histological changes in the liver and spleen. This rigorous methodology ensures the reliability and validity of our findings.</p><p><strong>Results: </strong>The combination of borrelidin and fumagilin led to the lowest parasitemia at 5%, contrasting with the control group reaching 15%. Moreover, the combination group exhibited the highest inhibition rate of 69.6% on day nine post-infection. Histopathological alterations were limited to sinusoid dilation, hepatocyte ballooning, and the presence of hemozoin.</p><p><strong>Conclusion: </strong>These findings suggest that the combination of borrelidin and fumagilin holds promise as a potential antimalarial therapy.</p>","PeriodicalId":19531,"journal":{"name":"Open Veterinary Journal","volume":"14 8","pages":"2007-2015"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical study of scrapie in naturally affected sheep in the east of Libya.","authors":"Fawzia Mohamed, Ayiman Aboulqassim, Monier Sharif, Salh Belgasem, Abraheem Omar, Nagi Saeed","doi":"10.5455/OVJ.2024.v14.i8.12","DOIUrl":"10.5455/OVJ.2024.v14.i8.12","url":null,"abstract":"<p><strong>Background: </strong>The most common natural prion disease that primarily affects sheep and goats is scrapie. It belongs to a group of disorders known as transmissible spongiform encephalopathies, which impact both humans and animals.</p><p><strong>Aim: </strong>The research is aimed to examine and confirm the presence of scrapie in Libya using immunohistochemistry (IHC) techniques.</p><p><strong>Methods: </strong>Brain samples were collected from thirty-three sheep older than two years of age showing clinical signs resembling to scrapie during the period between 2018 and 2023, regardless of race or gender. Three animals, six months old, healthy, and without any symptoms, were used as negative controls. Different parts of the brain, including the obex and cerebellum, were taken from each case. The IHC technique used in this study involved staining with monoclonal antibody L42 and DAB (3,3'-diaminobenzidine) as a chromogenic substrate.</p><p><strong>Results: </strong>The IHC examination showed the expression of prion proteins in brain tissue in twenty-three samples. The staining intensity was markedly observed in the neuronal cell bodies and around blood vessels.</p><p><strong>Conclusion: </strong>The findings of this study provide evidence that scrapie exists in Libya.</p>","PeriodicalId":19531,"journal":{"name":"Open Veterinary Journal","volume":"14 8","pages":"1843-1849"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and molecular identification of the lumpy skin disease virus in cattle in the Mekong Delta of Vietnam.","authors":"Tran Ngoc Bich, Le Quang Trung, Truong Van Hieu, Vo Tuan Khai Huyen, Thai Quoc Hieu, Huynh Truong Giang, Nguyen Tran Phuoc Chien","doi":"10.5455/OVJ.2024.v14.i8.16","DOIUrl":"10.5455/OVJ.2024.v14.i8.16","url":null,"abstract":"<p><strong>Background: </strong>Lumpy skin disease (LSD) is caused by a virus belonging to the genus <i>Capripoxvirus</i>, exhibiting clinical symptoms ranging from mild signs to the development of nodules. LSD emerged in Asia and Southeast Asia, including Vietnam, in October 2020 and has since spread throughout the region, resulting in productivity and economic losses.</p><p><strong>Aim: </strong>This study aimed to investigate the virus-causing papular dermatitis in cattle from the Mekong Delta region of Vietnam by analyzing its GPCR gene and assessing its evolutionary relationship with sequences in the GenBank database.</p><p><strong>Methods: </strong>Blood samples (<i>n</i> = 180) were collected from cattle farms in Ben Tre, Tien Giang, and Tra Vinh provinces. PCR targeting the P32 antigen gene was utilized to detect LSDV presence, and GPCR gene amplification was performed to assess genetic variability.</p><p><strong>Results: </strong>LSDV was detected in 8.33% (15/180) of the samples using PCR targeting the P32 antigen gene. Each sample that tested positive for LSDV demonstrated complete amplification of the GPCR gene. Sequence alignments and phylogenetic analyses of the GPCR gene revealed that Mekong Delta LSDV isolates shared genetic similarities and possessed a 12-nucleotide insertion comparable to strains from China in 2019 and Northern Vietnam in 2020.</p><p><strong>Conclusion: </strong>This study provides preliminary insights into the molecular characteristics of LSDV in cattle from the Mekong Delta region of Vietnam. The observed genetic relatedness to other LSDV sequences from Asia and Southeast Asia underscores the importance of regional surveillance and control measures. These findings contribute to the development of effective strategies for LSDV control and prevention.</p>","PeriodicalId":19531,"journal":{"name":"Open Veterinary Journal","volume":"14 8","pages":"1877-1895"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and diagnostic evaluation of a wild ocelot (<i>Leopardus pardalis</i>) specimen.","authors":"María Flórez Solarte, Juliana Loaiza, Marcela Eraso, Cristina Úsuga-Monroy, Horwald A B Llano, Andrea Pizarro, Diana Stasiukynas, Juan Felipe Zapata","doi":"10.5455/OVJ.2024.v14.i8.15","DOIUrl":"10.5455/OVJ.2024.v14.i8.15","url":null,"abstract":"<p><strong>Background: </strong>Monitoring the health of wild animals under the principles of one health contributes to the prevention of diseases and the preservation of human and animal health, thus contributing to the conservation of species.</p><p><strong>Aim: </strong>The current study describes the clinical and paraclinical status of an ocelot (<i>Leopardus pardalis</i>) captured in Buriticá, Antioquia, Colombia, for research purposes with the aim of contributing to the construction of animal health reference values in the wild, considering the scarcity of published data for the country on capture, management, and paraclinical parameters related to this species.</p><p><strong>Methods: </strong>For this, hematological parameters, blood chemistry, urine cytochemical analyses, and coprological examinations were carried out.</p><p><strong>Results: </strong>The hematological values of the captured individual do not show relevant differences concerning those reported in the literature in both captive and free specimens. However, differences were identified between the reference blood chemistry and urine cytochemical values between reports of animals in captivity and the wild, revealing the need to develop reference standards for animals in the wild that guarantee adequate management of these species and favor their conservation. A possible picture of renal failure and multiple parasitic infections of epidemiological importance was found.</p><p><strong>Conclusion: </strong>This study reports for the first time a urine infection by <i>Capillaria</i> <i>sp</i>. and an infection by <i>Dicrocoelium</i> spp. in fecal matter for the species.</p>","PeriodicalId":19531,"journal":{"name":"Open Veterinary Journal","volume":"14 8","pages":"1866-1876"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging of a subcutaneous abscessation in the back of a calf with hindlimb paralysis.","authors":"Takeshi Tsuka, Noriyo Usaki, Midori Hatanaka, Yusuke Murahata, Takashi Takeuchi, Yuji Sunden, Takehito Morita, Yoshiharu Okamoto, Miyuu Tanaka, Takeshi Izawa, Mitsuru Kuwamura, Norio Yamagishi","doi":"10.5455/OVJ.2024.v14.i8.40","DOIUrl":"10.5455/OVJ.2024.v14.i8.40","url":null,"abstract":"<p><strong>Background: </strong>Ultrasonography is not chosen as the common imaging modality to diagnose spinal cord diseases. The present report indicates good diagnostic efficacy of ultrasonography for identifying spinal cord compressed by subcutaneous mass when scanning through the defected vertebral laminae and spinous process.</p><p><strong>Case description: </strong>A five-month-old female Holstein calf presented with progressive hindlimb paralysis following a surgical resection of a back mass conducted at 21 days of age. The mass was subsequently histopathologically diagnosed as a pulmonary choristoma. Alongside hindlimb paralysis, the calf developed a swollen back at the lumbar region where the mass was removed. This suggested regrowth of the resected mass, causing injury to the underlying spinal cord. Ultrasonography identified the subcutaneous involvement of the capsular mass, which had three anechoic cavities separated by the echogenic septal structures. The spinal cord could be ultrasonographically demonstrated as adjacent to the mass through the defected vertebral laminae and spinous process in the second and third lumbar vertebras. Ultrasound-guided centesis allowed the collection of purulent exudates in which <i>Escherichia coli</i> was isolated. Myelography and subsequent computed tomography (CT) revealed a partial blockage of the intradural flow of contrast media at the levels of the second and third lumbar vertebras, diagnosed as spina bifida on the CT images. When applying ultrasonography to the spinal cord within a saline pool soon after the subcutaneous abscess was successfully resected, the spinal cord was characterized by the interrupted and partly extended hyperechogenic line of the central canal within the echogenic parenchyma. The echotexture of the spinal cord showed damage due to compression from the subcutaneous abscess. The animal had a sub-optimal postoperative outcome, including limited improvement of the neurological signs.</p><p><strong>Conclusion: </strong>In the present case, combining ultrasonography, radiography (myelography), and CT was very effective for diagnosing spina bifida, with the subcutaneous abscess inducing spinal cord compression. Additionally, using intraoperative ultrasonographic scanning to evaluate the degree of spinal cord damage can contribute to predicting the postoperative outcome.</p>","PeriodicalId":19531,"journal":{"name":"Open Veterinary Journal","volume":"14 8","pages":"2097-2109"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower lip avulsion: Surgery and management using stem cell metabolites preparation in a domestic cat.","authors":"Lina Susanti, Suryo Kuncorojakti, Shafira Oktaviani, Mardina Girada Simarmata","doi":"10.5455/OVJ.2024.v14.i8.39","DOIUrl":"10.5455/OVJ.2024.v14.i8.39","url":null,"abstract":"<p><strong>Background: </strong>Lower lip avulsion is a separation between the lip and the associated soft tissue from the mandible. The degree of these types of injuries varies and heavily affects the outcome of the case.</p><p><strong>Case description: </strong>This study reported an extensive lower lip avulsion managed by surgery and stem cell metabolite preparation. A one year and nine month-old domestic cats was referred for lower lip avulsion surgery to the Veterinary Teaching Hospital Airlangga University. Owing to the limited amount of tissue, immediate successful results cannot be achieved after the first surgery. Furthermore, tissue necrosis and lack of physical restraint to the cat at home contributed to the delayed union between the soft tissue and mandible, resulting in repeated surgery. Stem cell metabolites preparation was applied at the surgical site and was incorporated into the therapy to support tissue growth.</p><p><strong>Conclusion: </strong>The combination of surgical treatment and stem cell metabolite preparation resulted in good wound healing in the present case.</p>","PeriodicalId":19531,"journal":{"name":"Open Veterinary Journal","volume":"14 8","pages":"2092-2096"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of breed's difference on the hemogram and biochemistry profile of goats raised in Libya during winter.","authors":"Fathia Mahmoud Benashour, Fahima Ali Alnagar, Mansur E Shmela, Amal O Buker, Mouna A Abdunnabi, Adel M Gdura, Mohammed A Alssaie","doi":"10.5455/OVJ.2024.v14.i8.26","DOIUrl":"10.5455/OVJ.2024.v14.i8.26","url":null,"abstract":"<p><strong>Background: </strong>In Libya, goats are considered as one of the most important livestock in which there are many breeds of goats such as Kurdi, Hegazi, Cyprus, Shami, and Mahali. A little hematological and biochemical information is known on these goat breeds raised in Libya.</p><p><strong>Aim: </strong>The main purpose was to verify the effect of breed variations on the hematological and biochemical parameters of goat breeds raised in Libya.</p><p><strong>Methods: </strong>The blood samples were collected in the winter season from 70 clinically healthy animals of different breeds for hematology and biochemical analysis.</p><p><strong>Results: </strong>Regarding the effect of breeds on blood hematology, significantly higher number (<i>p</i> < 0.01) of Mid cells were found in Hegazi (3.12 ± 1.30 × 10³/µl) and Cyprus (2.41 ± 1.69 × 10³/µl) when compared to other goat's breeds including Kurdi (2.28 ± 0.95 × 10³/µl), Shami (1.90 ± 0.84 × 10³/µl), and Mahali (1.37 ± 0.88 × 10³/µl). Moreover, the percentage of Mid cells was highest in Hegazi (22.34% ± 9.40%), 11.40% ± 4.34%), followed by Kurdi (17.71% ± 8.16%), Cyprus (15.84% ± 8.33%), Shami (13.38% ± 5.76%), and lowest in Mahali (11.40% ± 4.34%). There are significant differences (<i>p</i> < 0. 01) in hemoglobin (Hb), red blood cells (RBCs), hematocrit (HCT), mean corpuscular hemoglobin (MCH), red cell width distribution-coefficient of variation (RDW-CV, %), and red cell distribution width-standard deviation (RDW-SD, fl) values among all different breeds of Libyan goats. The results of biochemistry displayed significant changes among the studied goats' breeds, where the highest serum alanine aminotransferase (ALT, U/L) activity was observed in Cyprus (17.81 ± 7.95) and Shami (17.27 ± 1.15) compared with Hegazi (15.31 ± 6.13) and Mahali (14.60 ± 0.46), while Kurdi breed (11.68 ± 7.95) showed the lowest ALT activity. Moreover, significant differences (<i>p</i> < 0.01) in serum lactate dehydrogenase (LDH, U/l), total and direct bilirubin, glucose (GLU), creatinine, lipid profile, and electrolyte levels were recorded among different breeds used in this study. On the other hand, non-significant variations (<i>p</i> >0. 05) are reported in aspartate aminotransferase (U/l), alkaline phosphatase (U/l), total protein (g/dl), albumin (g/dl), urea and magnesium (Mg, mg/dl) levels.</p><p><strong>Conclusion: </strong>These results showed a significant difference between some blood parameters of goat breeds raised in Libya. This could aid veterinarians in interpreting laboratory data properly in order to improve the management and conservation of those breeds.</p>","PeriodicalId":19531,"journal":{"name":"Open Veterinary Journal","volume":"14 8","pages":"1968-1982"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}