Ophthalmic and Physiological Optics最新文献

{"title":"Quantifying natural higher order aberration(s) in emmetropic human eyes and objectively evaluating retinal image quality.","authors":"Vinay Gupta, Aafreen Bari, Shahnaz Anjum, Ankit Yadav, Rohit Saxena, Rajesh Sinha","doi":"10.1111/opo.13456","DOIUrl":"10.1111/opo.13456","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to quantify the internal, corneal and total higher order aberrations (HOAs) in the healthy human eye using ray tracing technology in bright and dim light conditions. The study also aimed to evaluate the retinal image quality and contrast modulation at different spatial frequencies, objectively using image-quality metrics derived from wavefront aberrations.</p><p><strong>Methodology: </strong>A cross-sectional prospective observational study was conducted on 521 emmetropic young adults. HOAs including coma, trefoil, spherical aberration and secondary astigmatism were measured separately for the cornea, internal and total eye using a ray-tracing wavefront aberrometer at mesopic and photopic pupil sizes. The Strehl ratio, derived from the point spread function (PSF), was used to evaluate the retinal image quality of the eye. Contrast modulation at spatial frequencies of 5, 10 and 15 cycles per degree was assessed through the modulation transfer function (MTF).</p><p><strong>Results: </strong>Mean age of participants was 25.4 ± 4.8 years (54.5% male). The total HOAs of internal, corneal and total eye were 0.186 ± 0.075, 0.191 ± 0.112 and 0.222 ± 0.075 μ, respectively for a 5-mm pupil (dim light condition), and 0.069 ± 0.031, 0.061 ± 0.094 and 0.076 ± 0.031 μ, respectively, for a 3-mm pupil (bright light condition). The Strehl ratio was 0.16 ± 0.124 (5 mm pupil) and 0.601 ± 0.19 (3 mm pupil). A normative database was created and correlations drawn for the HOAs, PSF and MTF (using image quality metrics) for the cornea, internal and total eye at mesopic and photopic pupil sizes.</p><p><strong>Conclusion: </strong>These findings provide normal population (young healthy adults) reference ranges for HOAs, retinal image quality and contrast modulation at higher spatial frequencies using ray tracing technology. The presence of these natural wavefront aberrations enhances the visual performance and may not need to be corrected. The separate assessment of aberrations and derived image quality metrics for the cornea, internal and total eye can serve as a benchmark for diagnosing and monitoring ocular conditions and allows targeted treatment planning.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"769-778"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying tear exchange during rigid contact lens wear using corneoscleral profilometry: A proof of concept study.","authors":"Asif Iqbal, Damien Fisher, David Alonso-Caneiro, Michael J Collins, Stephen J Vincent","doi":"10.1111/opo.13450","DOIUrl":"10.1111/opo.13450","url":null,"abstract":"<p><strong>Introduction: </strong>Tear exchange during contact lens wear is essential for ocular surface integrity, facilitating debris removal, and maintaining corneal metabolism. Fluorophotometry and fluorogram methods are typically used to measure tear exchange, which require hardware modifications to a slit lamp biomicroscope. This manuscript introduces an alternative method using a corneoscleral profilometer, the Eye Surface Profiler (ESP), to quantify tear exchange during corneal and scleral rigid lens wear by assessing fluorescence intensity changes over time.</p><p><strong>Methods: </strong>As a proof of concept, a healthy participant wore a corneal and a scleral rigid lens on separate days. After lens application, 2% sodium fluorescein was instilled, and ESP images were captured at intervals over a 30-min period for corneal and a 90-min period for the scleral lens. Fluorescence intensity data were extracted and analysed using MATLAB, restricted to a region of interest centred on the contact lens. The fluorescence intensity was fitted with an exponential decay curve to quantify tear exchange.</p><p><strong>Results: </strong>Fluorescence intensity decreased over time for both lenses, with a faster decay rate being observed for the corneal lens. The scleral lens showed an initial ingress of fluorescein into the fluid reservoir, then a slow decay in fluorescence intensity due to limited tear exchange. The decay rate for the corneal lens was approximately four times faster than the scleral lens, with the time to reach 50% decay of ~42 min for the corneal lens compared to ~157 min for the scleral lens.</p><p><strong>Conclusion: </strong>A new method was developed to quantify tear exchange using a commercially available corneoscleral profilometer, offering a wider field of view than existing techniques. This approach has clinical potential in scleral lens practice for identifying landing zone misalignment and improving the understanding of post-lens tear dynamics, particularly in cases involving scleral lens modifications or patients experiencing midday fogging.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"598-606"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional variations in corneal oedema during open-eye fenestrated scleral lens wear.","authors":"Asif Iqbal, Damien Fisher, David Alonso-Caneiro, Michael J Collins, Stephen J Vincent","doi":"10.1111/opo.13489","DOIUrl":"10.1111/opo.13489","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the magnitude of central, mid-peripheral and peripheral stromal corneal oedema induced during short-term fenestrated and non-fenestrated scleral lens wear.</p><p><strong>Methods: </strong>Nine healthy participants wore a non-fenestrated and a fenestrated (0.3-mm diameter limbal fenestration) scleral lens (KATT™, Capricornia Contact Lenses), hexafocon B material (Dk 141 × 10^-11 cm³ O₂(cm)/[(s) (cm²) (mmHg)]) in one eye under open-eye conditions for 90 min on two separate days. Scleral lens thickness, fluid reservoir thickness and stromal corneal oedema were measured using high-resolution optical coherence tomography. Stromal oedema was quantified across the central (0-2.5 mm from the corneal apex), mid-peripheral (-3.0 to -1.0 mm from the scleral spur) and peripheral (-1.0 to 0 mm from the scleral spur) cornea with the lens in situ. The magnitude of oedema was corrected based on variations in fluid reservoir thickness between the lens conditions.</p><p><strong>Results: </strong>There was a significant effect of lens type (p = 0.04) on stromal oedema, with less oedema observed with the fenestrated (0.36 ± 0.45%) compared to the non-fenestrated lenses (1.24 ± 0.27%), averaged across all corneal locations. A significant lens type by corneal location interaction was also observed (p = 0.05), with less oedema observed in the peripheral region for the fenestrated (-0.15 ± 0.98%) compared to the non-fenestrated lenses (1.81 ± 0.57%) (p = 0.048). A fenestration location by corneal location interaction was also observed (p = 0.02), indicating a greater reduction in oedema closer to the fenestration.</p><p><strong>Conclusions: </strong>Central and mid-peripheral stromal oedema was similar during fenestrated and non-fenestrated lens wear; however, fenestrated lenses displayed significantly less oedema in the peripheral cornea. This is most likely due to increased oxygen delivery in proximity to the fenestration.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"618-626"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ageing of adults who are blind: A scoping review.","authors":"Aline K Honingh, Astrid Kok, Mitchel Mesker, Johannes C F Ket, Erik Olsman, Bert Veneberg, Paula S Sterkenburg","doi":"10.1111/opo.13472","DOIUrl":"10.1111/opo.13472","url":null,"abstract":"<p><p>The ageing process of adults with a disability may differ from the typical ageing process, yet few studies have addressed ageing of adults who are blind. However, a broad scope of literature exists on ageing with a visual impairment that includes adults who are blind. People who are blind may age differently than people with a visual impairment. Furthermore, it cannot be inferred from studies on the ageing of visually impaired adults that changes are due to the ageing process alone, since vision may decline further as well. This article presents a scoping review of studies on the ageing of adults who are blind, examining the areas of decline due to ageing, differences compared to non-blind adults, additional contributing factors and support. A systematic literature search was performed from inception up to July-October 2023 in Scopus, Medline, Embase, CINAHL, APA PsycInfo and Web of Science. Thirteen articles met the eligibility criteria. Analysis led to four broad areas: physical, sensory, cognitive and psychological. In several of these areas, the decline due to ageing was similar for people who were blind or non-blind. Declines specific to people who were blind were in spatial memory and engagement to the outer world. Two abilities were identified where blind people outperformed sighted people: attention and working memory and active tactile acuity. Overall, ageing blind adults were shown to have additional risks and hence need extra support. Interventions may focus on physical and cognitive exercise, braille training, risk screening, education and social activities. More research is needed to replicate studies and disambiguate results, to include areas that have not been investigated specifically for this group, to differentiate between different types of blindness and to investigate systematically the needs and support of blind adults who are ageing.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"713-725"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic accuracy and feasibility of paediatric visual field tests: A systematic review.","authors":"Maria Riaz, Nicole C Ross, D Luisa Mayer","doi":"10.1111/opo.13449","DOIUrl":"10.1111/opo.13449","url":null,"abstract":"<p><strong>Purpose: </strong>Alternative non-standard paediatric visual field (VF) tests have been developed to address the challenges associated with standard approaches. However, diagnostic accuracy of these new VF tests has not yet been rigorously evaluated. This systematic review aims to explore diagnostic accuracy and feasibility of non-standard VF tests in paediatric patients.</p><p><strong>Methods: </strong>The following databases were searched for English language studies comparing a non-standard paediatric VF test to standard methods, such as standard automated perimetry (SAP), manual kinetic perimetry (MKP) and confrontation testing (CT): EMBASE, PubMed, Ovid MEDLINE, Web of Science, Scopus, VisionCite, Cochrane Library, ClinicalTrials.gov, African Index Medicus, LILACS, Trip and grey literature databases. Studies included were of children ≤18 years old with suspected or known VF defects (n > 3). Case reports, case series, editorials and letters were excluded. This review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool.</p><p><strong>Results: </strong>Thirty studies (n = 2074 children, age range: 2 months to 18 years) published between 1990 and 2023 met the inclusion/exclusion criteria. Twenty index tests were reported, sorted into four categories of methods: behavioural/observational (5), electrophysiological (2), modifications of standard perimetry (11) and eye tracking (2). Risk of bias, based on the QUADAS-2 results, was unclear or high for most studies. Sensitivities of 10 studies (behavioural/observational [2]; electrophysiological [2]; modifications of standard perimetry [2] and eye tracking [4]) were 60%-100%, 75%, 80%-94% and 70%-100%, and specificities were 98%-100%, 86%-88%, 68%-100% and 50%-100%, respectively.</p><p><strong>Conclusions: </strong>Alternative non-standard paediatric VF tests, and behavioural/observational methods in particular, show potential for adequate diagnostic accuracy and feasibility, although limited to certain conditions and ages. Studies with complete reporting and low risk of bias are needed to determine the diagnostic accuracy and feasibility of non-standard paediatric VF tests.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"726-741"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective and objective measurements of the amplitude of accommodation: Revisiting the existing methods and clinical evaluation of newer techniques.","authors":"Raquel Salvador-Roger, José J Esteve-Taboada, Abinaya Priya Venkataraman, Alberto Domínguez-Vicent","doi":"10.1111/opo.13482","DOIUrl":"10.1111/opo.13482","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the repeatability and agreement of established and newer methods for measuring the amplitude of accommodation in non-presbyopic and early presbyopic individuals.</p><p><strong>Methods: </strong>The amplitude of accommodation of 81 participants was measured using five different methods (two push-up techniques, two minus lens techniques and one objective technique) with different measurement principles. Among these, two new techniques were introduced: an electronic push-up and a minus lens technique with a tunable lens. Three repeated measurements were performed with each method. The repeatability limit and non-parametric Bland-Altman analysis were used to describe the repeatability and agreement of each method.</p><p><strong>Results: </strong>The repeatability limit was between ±0.7 D and ±1.4 D for the minus lens techniques, around ±1.8 D for the push-up methods and ±1.4 D for the objective procedure. The largest differences in median values were found between the push-up and objective methods.</p><p><strong>Conclusions: </strong>Push-up methods are most likely to overestimate accommodation, while the objective method gives the lowest results. New techniques show good repeatability for measuring the amplitude of accommodation. Among the subjective methods, the minus lens technique with the tunable lens gives the best repeatability, is one of the fastest and gives results most similar to the objective method.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"761-768"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain structural and functional magnetic resonance imaging alterations in individuals with convergence insufficiency.","authors":"Yuxia Wang, Gantian Huang, Ye Wu, Ling Xiong, Yufei Chen, Haoran Li, Fenghua Long, Qian Li, Huaiqiang Sun, Graham J Kemp, Longqian Liu, Qiyong Gong, Fei Li","doi":"10.1111/opo.13459","DOIUrl":"10.1111/opo.13459","url":null,"abstract":"<p><strong>Purpose: </strong>Individuals with convergence insufficiency (CI) encounter challenges in turning their eyes inward during near work. It is unclear how this relates to brain structural and functional alterations. This study aimed to explore the neural mechanism underlying CI using multimodal brain magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>Thirty-four CI participants and 35 healthy controls (HC) were recruited, who underwent visual examinations and brain MRI scanning. Structural MRI data were analysed to calculate cortical thickness, volume and surface area. Fractional amplitude of low-frequency fluctuation (fALFF) and seed-based functional connectivity were obtained from resting-state functional MRI data. The brain structural and functional metrics were compared between the two groups followed by correlation analyses between clinical measurements and significant brain features.</p><p><strong>Results: </strong>Relative to HC, individuals with CI had lower grey matter volume (GMV) and surface area in the right frontal eye fields, parietal eye fields and left medial orbitofrontal cortex, higher GMV and surface area in the right middle frontal and inferior temporal gyri and higher fALFF of the left cerebellum and functional connection between bilateral cerebellums. GMV of the right middle frontal gyrus and fALFF in the left cerebellum were positively correlated with the near point of convergence in all participants.</p><p><strong>Conclusions: </strong>Lower structural metrics in the visual and oculomotor cortices and higher functional activity in the cerebellum may underpin convergence dysfunction and visual fatigue, while higher structural metrics in the right middle frontal and inferior temporal gyri reflect partial compensation for the visual and oculomotor cortex defects, thereby maintaining attention and parallax information processing. This study may enhance understanding of the neural mechanism of CI by revealing the impact of abnormal visual experiences of CI on the brain with disassociated structural and functional alterations in the vergence system.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"656-665"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charles Bonnet Syndrome associated with unilateral vision loss: A new diagnostic perspective.","authors":"Giovanni Forte, Natalie Assaf, Paolo Forte, Jasleen K Jolly","doi":"10.1111/opo.13481","DOIUrl":"10.1111/opo.13481","url":null,"abstract":"<p><strong>Purpose: </strong>To increase recognition of Charles Bonnet Syndrome (CBS) beyond its conventional association with 'significant vision loss', which is indicated in the current literature as a diagnostic criterion.</p><p><strong>Methods: </strong>Clinical observation of CBS associated with unilateral visual loss following enucleation due to choroidal melanoma. Comprehensive visual assessments were performed. The cognitive function was assessed with the Montreal Cognitive Assessment (MoCA)-BLIND. The phenomenology, occurrence and impact of visual hallucinations were evaluated using the University of Miami Parkinson's Disease Hallucinations Questionnaire (UM-PDHQ). A critical literature review of CBS cases associated with vision loss in one eye only was conducted.</p><p><strong>Results: </strong>In this case and in an additional nine reported cases in the literature, CBS hallucinations occurred following unilateral vision loss despite preserved visual function in the fellow eye. These hallucinations are phenomenologically consistent with those observed after severe bilateral vision loss, indicating that both conditions can lead to the development of CBS.</p><p><strong>Conclusions: </strong>CBS should be screened in all patients who have experienced any degree of vision loss.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"681-688"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oblique effects with multisegment spectacle lenses: 1. Images of a point object.","authors":"W Neil Charman, David A Atchison, Matt Jaskulski","doi":"10.1111/opo.13469","DOIUrl":"10.1111/opo.13469","url":null,"abstract":"<p><strong>Introduction: </strong>Multisegment (MS) spectacles are intended to slow myopia progression by modifying images falling on the peripheral retina. Some published optical treatments of these lenses assume normal incidence of light at the surfaces, but images falling on the peripheral retina are usually associated with oblique ray pencils. Here, we model representative images of point objects produced by the Hoya MiyoSmart MS spectacle lens when oblique ray pencils are used.</p><p><strong>Methods: </strong>Various imaging aspects of the MS lens alone and in combination with a suitable accommodating eye model for a 4D myope were evaluated using the Optical Design program Ansys Zemax OpticStudio. Configurations studied included object points at vergences of zero and -4 D, with the objects being either on the lens axis or at a field angle of about 30°. The effect on foveal vision of rotating the axis of the eye with respect to that of the lens was also considered. Images of point objects were described in terms of spot diagrams and fast Fourier transform point-spread functions.</p><p><strong>Results: </strong>Symmetry and overall optical quality of images decreased with the obliquity of the ray pencils, due to the increased off-axis aberrations of the lens and the eye. Images of near object points were strongly affected by the level of accommodation: optimal retinal image quality occurred when accommodation brought the carrier lens focus close to the retina, rather than that of the lenslets.</p><p><strong>Conclusions: </strong>Attempts to understand why MS lenses slow myopia progression need to consider the way in which through-focus retinal image quality changes with obliquity of the ray pencils across the visual field and the possible effects of ocular accommodation.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"779-789"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional accommodative controls in near heterophoria targets do not improve accommodative responses in young adults.","authors":"John Siderov, Baskar Theagarayan, Muneebah Zahir, Niall J Hynes","doi":"10.1111/opo.13476","DOIUrl":"10.1111/opo.13476","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated newly designed tests to measure near heterophoria, comparing them to the Maddox Wing and Howell card, and assessed whether accommodative responses differed between the different heterophoria test targets.</p><p><strong>Methods: </strong>Near horizontal heterophoria of 20 visually normal young adults was measured using the Maddox Wing, Howell Card and two versions of a newly designed Huddersfield Heterophoria Test (HHT) card. The HHT cards are based on the Prentice method, either with or without an additional spatially defined grating superimposed on the scale. The addition of a spatially defined grating has been suggested to control accommodation better. A single examiner was used to take measurements on two separate occasions, presenting each test in a random order. Monocular accommodative responses to each heterophoria target were also obtained in a separate session by another examiner.</p><p><strong>Results: </strong>Heterophoria measurements between the four tests were not significantly different, neither clinically nor statistically. Differences in test-retest measurements between test and retest conditions were small and not significantly different. Mean accommodative responses were also not significantly different between the test targets.</p><p><strong>Conclusions: </strong>Differences in target configurations in the Maddox Wing, Howell card or new HHT cards did not influence accommodative responses in a sample of young adults. The newly designed HHT cards (or other variations of the Prentice method) may be used to measure near horizontal heterophoria in a young adult population either with or without additional horizontal lines superimposed on the scale.</p>","PeriodicalId":19522,"journal":{"name":"Ophthalmic and Physiological Optics","volume":" ","pages":"752-760"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}