Nutrients最新文献

{"title":"Ketogenic Dietary Therapies and β-Hydroxybutyrate as Modulators of Mitochondrial Function: From Molecular Mechanisms to Clinical Translation.","authors":"Ji-Hoon Na, Young-Mock Lee","doi":"10.3390/nu18193256","DOIUrl":"10.3390/nu18193256","url":null,"abstract":"<p><p>Ketogenic dietary therapies (KDTs) have been used for a century in drug-resistant epilepsy, and β-hydroxybutyrate (BHB), the major ketone body, is recognized as a signaling metabolite. This review examines how KDTs and BHB modulate mitochondrial function and evaluates evidence supporting these mechanisms. BHB is oxidized through D-β-hydroxybutyrate dehydrogenase 1 and succinyl-CoA:3-oxoacid-CoA transferase and alters redox balance and oxidative phosphorylation. It also inhibits class I histone deacetylases, serves as the substrate for lysine β-hydroxybutyrylation, activates hydroxycarboxylic acid receptor 2, and blocks the NLR family pyrin domain-containing 3 inflammasome. These pathways influence redox defense, organelle quality, and inflammation. However, ketogenic feeding suppresses mitochondrial one-carbon metabolism and some signaling effects occur only at BHB concentrations exceeding those typically achieved through dietary ketosis. Clinical benefits are best established in drug-resistant epilepsy and appear genotype-dependent in primary mitochondrial disease, with potential benefit in mitochondrial DNA (mtDNA) variant carriers but possible harm in DNA polymerase gamma-related disease and mtDNA deletion myopathy. Outside neurology, human evidence includes a hemodynamic response to infused 3-hydroxybutyrate in heart failure, sustained glycemic improvement in non-randomized diabetes cohorts, and small trials in psychiatric and oncological populations. Most clinical studies have not directly measured mitochondrial outcomes. Proposed mitochondrial mechanisms of KDTs and BHB remain plausible but are not established explanations for clinical benefit. Genotype-stratified trials, ketone exposure assessment, and direct measurement of mitochondrial variables in patients are needed.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 19","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary and Parenteral Nutritional Management of Short Bowel Syndrome with Intestinal Failure in Adults: A Narrative Review.","authors":"Brigida Barberio, Beatrice Varotto, Matteo D'Angelo, Lara Tessari, Gianni Di Lecce, Pietro Pirro, Francesco Cesaroni, Sara Cusano, Luisa Bertin, Fabiana Zingone, Patrizia Burra, Luca Busetto, Edoardo Vincenzo Savarino, Giulia Tognana","doi":"10.3390/nu18193263","DOIUrl":"10.3390/nu18193263","url":null,"abstract":"<p><p>Short bowel syndrome (SBS) is the leading cause of chronic intestinal failure in adults, arising when the residual small bowel can no longer absorb the macronutrients, water, and electrolytes needed to sustain health without intravenous supplementation. Its management is, at its core, a nutritional problem. This narrative review summarises and critically appraises current evidence and guideline recommendations on the two pillars of that management: dietary (oral/enteral) therapy and parenteral nutritional support. We frame both around the two variables that dominate clinical behaviour, namely residual intestinal anatomy and the phase of intestinal adaptation, and translate them into anatomy-tailored dietary strategies, rational fluid and electrolyte replacement, micronutrient surveillance, and the composition, delivery, and complications of (home) parenteral nutrition. We also position the pharmacological adjuncts, culminating in glucagon-like peptide-2 (GLP-2) analogues, within a stepwise strategy to reduce parenteral support dependence. The goal throughout is a practical, physiology-anchored approach that maximises enteral autonomy and quality of life while preventing the metabolic, hepatic and catheter-related complications of long-term intravenous feeding. The literature was identified through structured but non-systematic searches of PubMed/MEDLINE, Embase and the Cochrane Library, and the nature of the evidence supporting each recommendation, ranging from randomised trials to expert consensus, is indicated throughout the text.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 19","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Fructooligosaccharide Is Associated with Improved Insulin Resistance, Reduced <i>Romboutsia ilealis</i> Abundance, and Modulation of GLP-1 Production in High-Fat Diet-Induced Obese Mice.","authors":"Lais Yuki Tuzino Kamia, Lauren Lewis, Zack Nobles, Gar Yee Koh","doi":"10.3390/nu18193258","DOIUrl":"10.3390/nu18193258","url":null,"abstract":"<p><strong>Background/objectives: </strong>Obesity disrupts glucose homeostasis and insulin signaling, partly through altered gut hormone secretion and intestinal inflammation. Our previous work demonstrated that fructooligosaccharides (FOS), a prebiotic fiber, suppressed colonic inflammation, and modulated gut microbiota when administered with vitamin D supplementation. However, the effects of FOS on metabolic alterations, glucagon-like peptide-1 (GLP-1) production under obesogenic stimulation remains unclear. Here, we examined the effects of FOS on insulin resistance and GLP-1 production in high-fat diet (HFD)-induced obese mice.</p><p><strong>Methods: </strong>Six-week-old male and female C57BL/6J mice were assigned to control or HFDs ± 5% FOS for 10 weeks. Body weight, visceral fat, fasting glucose, insulin, triglycerides, and insulin resistance index (HOMA-IR) were assessed. Serum GLP-1 was quantified by ELISA. Colonic expressions of <i>Glp1r</i>, <i>Pi3k</i>, and <i>Akt</i> were evaluated by qRT-PCR and western blotting, respectively. Cecal abundance of <i>Akkermansia muciniphila</i> (AM), <i>Dubosiella newyorkensis</i> (DN), and <i>Romboutsia ilealis</i> (RI) was quantified by qPCR.</p><p><strong>Results: </strong>FOS attenuated HFD-induced metabolic dysfunction, lowering serum insulin and HOMA-IR in both sexes. Notably, FOS elicited sex-dependent physical improvements of which it suppressed body weight gain by 10% in male mice and reduced visceral fat accumulation by 36% in female mice. The phenotypic changes in male mice were associated with an increase in GLP-1. Further, FOS modulated colonic PI3K/Akt signaling in a sex-dependent manner and downregulated HFD-associated increases in <i>Glp1r</i> mRNA expression. Consistent with our previous work, FOS suppressed RI abundance, and this reduction was associated with lower colonic <i>Tlr4</i> mRNA expression and improved insulin-resistance index.</p><p><strong>Conclusions: </strong>FOS improves insulin sensitivity in HFD-induced obesity and specifically enhanced GLP-1 production in male mice. Though the mechanism remained elucidated, the observed phenotype changes may be attributed to a combination of altered colonic PI3K/Akt pathways and targeted bacterial shifts. These effects appear to be sex-dependent and support FOS as a promising dietary strategy for maintenance of metabolic health.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 19","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Body-Mass-Scaled Protein and Leucine Supplementation on Body Composition and Cardiometabolic Blood Markers During Weight Loss in Older Men-A Randomized Controlled Trial.","authors":"Benedict Wei Jun Pang, Yifan Yang, Bobby Kyungbeom Cheon","doi":"10.3390/nu18193255","DOIUrl":"10.3390/nu18193255","url":null,"abstract":"<p><p><b>Background:</b> Overweight and obesity are burgeoning health epidemics. Diets including alternate-day fasting (ADF) promote weight loss but risk significant muscle loss, posing health implications to seniors at risk of sarcopenia. Leucine, the key muscle protein synthesis (MPS) driver, effectively stimulates MPS with lower calorie intake than protein. However, the effects of body-mass-scaled protein and leucine intakes are unclear. <b>Objectives:</b> To evaluate body-mass-scaled leucine or protein supplementation on body composition, sarcopenic, and cardiometabolic markers in older men during ADF. <b>Methods:</b> Sixty-one older men (BMI ≥ 23.0 kg/m²) underwent 28 days of ADF, randomized across three calorie-matched supplement groups: Control (C: 0.0 g/kg protein, 0.0 g/kg leucine), Leucine (L: 0.0 g/kg protein, 0.08 g/kg leucine), or Protein (P: 0.4 g/kg protein, 0.04 g/kg leucine), consuming three doses on feeding days and one on fasting days. Dual-energy X-ray absorptiometry, sarcopenic metrics, and blood markers (blood pressure, lipid panels, diabetic profiles) were measured. <b>Results:</b> There were no significant interactions (<i>p</i> > 0.05) in body composition, sarcopenic or health outcomes, except for diastolic blood pressure (<i>p</i> = 0.016) and HDL cholesterol (<i>p</i> = 0.013). There were significant main effects of time (<i>p</i> ≤ 0.05) with reductions in all body composition measures (excluding bone mineral density, <i>p</i> = 0.274), systolic blood pressure and lipid profiles (total and LDL cholesterol, total/HDL cholesterol ratio, triglycerides), and improvements in all muscle strength and functional sarcopenic outcomes. <b>Conclusions:</b> Dietary interventions alone that increase leucine and/or protein intake did not result in additional measurable improvements during this four-week intervention on body composition, sarcopenic, and cardiometabolic outcomes during weight loss.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 19","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein Intake and Resistance Training Across Clinical Populations: A PRISMA-Guided Rapid Review of Observational and Randomized Evidence.","authors":"Csilla Dézsi, Viktor Gulyás-Oldal, Ekaterine Paschali, Imre Gálóczi, Sándor Nagy, Károly Szili","doi":"10.3390/nu18193259","DOIUrl":"10.3390/nu18193259","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Guidance on protein and physical activity rests on population-wide minima with little differentiation by age or disease. We examined how protein intake and resistance training relate to muscle, function and mortality across clinical populations. <b>Methods:</b> PRISMA-guided rapid review: Fifty-eight logged PubMed queries returned 7544 unique records for screening (the analytic corpus); Europe PMC, Semantic Scholar and ClinicalTrials.gov were tested for coverage only. Estimates were extracted by a deterministic script and adjudicated by the authors; random-effects models were fitted within strata sharing an effect measure and contrast, and randomized evidence was tabulated, not pooled. Screening was single-reviewer outside a duplicate-screened sample (889 records); risk of bias was rated in duplicate. <b>Results:</b> In randomized trials, added protein increased strength with resistance training (+2.01%) but not without it (+0.13%); no trial of protein with resistance training reported mortality. Meeting activity guidelines was associated with lower mortality (HR 0.76, 95% CI 0.72-0.79; k = 16; <i>I</i>² = 64%; low certainty). Plant protein was associated with lower mortality (HR 0.76, 0.63-0.93; k = 4; very low certainty). After excluding studies at high risk of bias, the protein strata fell to single studies. The direction of protein-outcome associations differed between populations. <b>Conclusions:</b> Protein with resistance training is a plausible strategy for preserving muscle and function; effects on survival are untested, and population-specific protein ranges are provisional and hypothesis-generating.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 19","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of Full Enteral Feeding and Longitudinal Gut Microbiome Development in Infants Admitted to the Neonatal Intensive Care Unit.","authors":"Jeongmin Shin, Hyun Ho Kim, Sae Yun Kim, Hyun Mi Kang, Young-Ah Youn","doi":"10.3390/nu18193262","DOIUrl":"10.3390/nu18193262","url":null,"abstract":"<p><strong>Background/objectives: </strong>Delayed achievement of full enteral feeding (FEF) is common in neonatal intensive care unit (NICU) infants but is closely linked to gestational age (GA). We examined whether time to FEF is associated with gut microbiome development from birth to 6 months of corrected age (CA) beyond GA.</p><p><strong>Methods: </strong>We profiled 694 stool samples from 328 NICU infants, collected at first stool, discharge, and 4- and 6-month CA, by <i>16S rRNA</i> gene sequencing. Infants were classified as Early FEF (<14 days, n = 293) or Delayed FEF (≥14 days, n = 35), and time to FEF was also analyzed continuously. Linear mixed models and PERMANOVA were adjusted for GA.</p><p><strong>Results: </strong>Composition at first stool did not differ between groups. At discharge, the Delayed group had higher Proteobacteria, lower Firmicutes, lower <i>Streptococcus</i> (<i>q</i> = 0.028), and a different community structure in unadjusted analyses, but none of these differences remained after GA adjustment. No phylum showed a GA-adjusted trajectory difference, and alpha diversity did not differ. In an exploratory continuous analysis, longer time to FEF was associated with higher Bacteroidetes at discharge and 4-month CA.</p><p><strong>Conclusions: </strong>Most microbiome differences associated with delayed FEF were not independent of GA. Time to FEF may reflect maturity and illness severity rather than act as an independent determinant of the gut microbiome.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 19","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Omega-3 Intake, Supplement Use and Omega-3 Status in Elite (Tier 3) Male Gaelic Football Players: A Cross-Sectional Study.","authors":"Mark Flanagan, Lisa Ryan","doi":"10.3390/nu18193261","DOIUrl":"10.3390/nu18193261","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Omega-3 polyunsaturated fatty acids <i>(n</i>-3PUFA) are recognised for their roles in cardiovascular and brain health, with emerging evidence suggesting potential benefits for athletic performance and recovery. However, dietary intake and biological status of <i>n</i>-3PUFA remain poorly understood in athletes from intermittent team sports in Ireland, such as Gaelic football players. Through combining self-reported intake and biological assessment, this study provides, to our knowledge, the first comprehensive characterisation of <i>n</i>-3PUFA intake, supplementation practices, barriers to intake and biological status in this population. <b>Methods</b>: Players from nine intercounty Gaelic football teams (<i>n</i> = 76, 24.7 ± 3.2 years) completed a validated food frequency questionnaire to assess dietary <i>n</i>-3PUFA intake. A subgroup of participants (<i>n</i> = 20, 25.6 ± 3.5 years, 88.5 ± 5.7 kg) completed dry blood spot sampling to determine their Omega-3 Index (O3i). <b>Results</b>: A total of 63% (<i>n</i> = 48) of participants met or exceeded the European Food Safety Authority Adequate Intake (AI) of 250-500 mg/day for EPA+DHA. Supplement users were significantly more likely to meet or exceed the AI compared with non-users (89.7% vs. 35.1%; <i>p</i> < 0.001). In the subgroup assessed, the mean O3i was 6.06 ± 0.93%, with no participant achieving an O3i of ≥8%. Dietary intake was not significantly correlated with O3i (ρ = -0.09, 95% CI [-0.51, 0.37]), however, this analysis was likely underpowered due to the small subsample assessed. Barriers to fish consumption included sensory factors (29%), cooking ability (23%) and a lack of knowledge on <i>n</i>-3PUFA (20%). <b>Conclusions</b>: The subsample assessed (<i>n</i> = 20) had an O3i below the cardioprotective threshold of 8%, however, implications for performance or recovery remain unclear. Given the cross-sectional design and small biomarker sample, intake-status findings should be interpreted as descriptive. Targeted interventions addressing both intake and supplementation practices may be needed to improve <i>n</i>-3PUFA intake and status in this population.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 19","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition, Lifestyle, and Environmental Exposures in Endometriosis: Toward Personalized Supportive Care.","authors":"Antonella Iaconis, Marika Cordaro","doi":"10.3390/nu18193252","DOIUrl":"10.3390/nu18193252","url":null,"abstract":"<p><p>Endometriosis is a chronic, estrogen-dependent inflammatory disease primarily associated with pelvic pain, infertility, and fatigue, as well as gastrointestinal symptoms, resulting in a significant reduction in quality of life [...].</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 19","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-Life Gut Microbiota and the Pediatric Gut-Lung Axis: A Systematic Review of Clinical, Preclinical, and Mechanistic Evidence.","authors":"Salvatore Michele Carnazzo, Alessandro Vitello, Andrea Domenico Praticò, Marcello Maida, Vassilios Fanos","doi":"10.3390/nu18193260","DOIUrl":"10.3390/nu18193260","url":null,"abstract":"<p><p><b>Background/Objectives:</b> The early-life gut microbiota plays a pivotal role in immune maturation and may influence respiratory health through the gut-lung axis. However, evidence linking microbial development, dysbiosis, microbial metabolites, and microbiota-targeted interventions to pediatric respiratory outcomes remains heterogeneous. This systematic review aimed to synthesize clinical and preclinical evidence on the pediatric gut-lung axis and its underlying mechanisms. <b>Methods:</b> This systematic review followed PRISMA 2020 guidelines and a prospectively registered PROSPERO protocol (CRD420251062905). PubMed, Scopus, and Web of Science were searched for studies published from January 2014 to March 2025. Eligible primary studies included randomized controlled trials, observational studies, and mechanistically relevant animal models. Risk of bias was assessed using RoB 2, the Newcastle-Ottawa Scale, and SYRCLE's tool, respectively. Reviews were examined separately to provide mechanistic and translational context without contributing to the primary evidence synthesis. <b>Results:</b> Twenty-five primary studies (11 clinical and 14 preclinical) were included in the systematic evidence synthesis, while 54 reviews provided complementary contextual evidence. Early gut and airway microbial communities showed substantial overlap after birth followed by progressive niche-specific divergence. Early-life dysbiosis, including depletion of beneficial taxa and expansion of potentially pathogenic bacteria, was associated with asthma, recurrent wheezing, respiratory infections, and neonatal lung injury. Short-chain fatty acids emerged as key mediators of gut-lung immune signaling. Clinical trials suggested potential respiratory and immunological benefits of probiotic and synbiotic interventions, while preclinical models supported mechanistic links involving intestinal barrier dysfunction, microbial metabolites, and inflammatory pathways. <b>Conclusions:</b> Current evidence supports a biologically plausible and clinically relevant pediatric gut-lung axis. However, methodological heterogeneity and the limited availability of longitudinal clinical studies warrant cautious interpretation and further well-designed research before microbiota-targeted strategies can be routinely translated into pediatric respiratory care.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 19","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary and Nutritional Considerations for Metabolic Dysfunction-Associated Steatotic Liver Disease in Psoriasis and Hidradenitis Suppurativa: A Narrative Review.","authors":"Woo Chiao Tay, Choon Fong Liew, Yu Jun Wong, Grace Lai-Hung Wong, Hazel H Oon","doi":"10.3390/nu18193253","DOIUrl":"10.3390/nu18193253","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognised in patients with chronic inflammatory skin disease, particularly psoriasis, for which epidemiological evidence of increased MASLD prevalence is relatively strong; corresponding data in hidradenitis suppurativa (HS) remain more limited. This narrative review examines the epidemiological and biological links between psoriasis, HS and MASLD, and evaluates dietary and nutritional strategies relevant to their multidisciplinary management. Particular emphasis is placed on distinguishing direct evidence in patients with concomitant inflammatory skin disease and MASLD from evidence derived from dermatology cohorts without liver-specific outcomes and from general MASLD populations. Mediterranean-style dietary patterns, energy restriction and weight loss, improved diet quality, and reduced intake of ultra-processed foods and added sugars are supported principally by MASLD and cardiometabolic data, with more limited direct evidence in psoriasis or HS. The review also discusses nutritional considerations during incretin-based therapy, including reduced food intake, preservation of lean mass, micronutrient adequacy and gastrointestinal adverse effects, while highlighting areas in which recommendations remain extrapolated or expert-derived. For dermatologists, the practical emphasis is on recognition of metabolic risk, general dietary counselling and appropriate multidisciplinary referral. Overall, nutritional management is an important component of MASLD care, but dedicated intervention studies in patients with concomitant psoriasis or HS remain a major evidence gap.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 19","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}