Imaging and Microorganism Analyses of the Effects of Oral Bifidobacterium breve Intake on Facial Skin in Females: A Randomized, Double-Blind, Placebo-Controlled Study.

IF 5 2区医学 Q1 NUTRITION & DIETETICS

Nutrients Pub Date : 2025-09-17 DOI:10.3390/nu17182976

Yuriko Nishikawa, Chendong Xu, Shin Yoshimoto, Noriko Katsumata, Noriyuki Iwabuchi, Naotake Yanagisawa, Shigeo Koido, Miyuki Tanaka, Jin-Zhong Xiao, Daisuke Asaoka, Toshifumi Ohkusa, Nobuhiro Sato

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引用次数: 0

Abstract

Background: Oral probiotic intake is suggested to have positive effects on skin. We aimed to elucidate the effects of oral Bifidobacterium breve M-16V intake on skin by analyzing facial images, the skin myco/microbiota, and the gut microbiota.

Methods: We conducted a randomized, double-blind, placebo-controlled study in Japan. Healthy women aged over 30 years were randomly allocated to either the B. breve (1 × 1010 colony-forming units (CFU)/sachet, two sachets daily) or the placebo group and consumed the corresponding study food for 12 weeks. Facial images were taken at weeks 0, 4, 8, and 12 using VISIA evolution. Stool and skin samples were collected at weeks 0 and 12. The primary outcome was the change in the total VISIA score from baseline.

Results: A total of 120 females aged 30-79 years were assigned to the B. breve (n = 59) or placebo (n = 61) group. The total VISIA score worsened in the placebo group at week 8 (p = 0.029) but not in the B. breve group. Compared with that of the placebo group, the VISIA brown spot score of the B. breve group improved at weeks 4 (p = 0.013) and 8 (p = 0.041). The VISIA pore score improved at weeks 4 (p = 0.013), 8 (p = 0.041), and 12 (p = 0.004) within the B. breve group. Genus-level analysis of the gut microbiota revealed a significant increase in Blautia abundance in the B. breve group. The frequency of adverse events was not different between the groups.

Conclusions: Oral B. breve M-16V administration may suppress skin deterioration, including the appearance of brown spots, on the faces of adult females.

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口服短双歧杆菌对女性面部皮肤影响的影像学和微生物分析：一项随机、双盲、安慰剂对照研究。

背景：口服益生菌被认为对皮肤有积极作用。我们旨在通过分析面部图像、皮肤菌群/微生物群和肠道微生物群，阐明口服短双歧杆菌M-16V对皮肤的影响。方法：我们在日本进行了一项随机、双盲、安慰剂对照研究。30岁以上的健康女性被随机分配到短芽孢杆菌组（1 × 1010菌落形成单位(CFU)/小袋，每天2小袋）或安慰剂组，并在12周内食用相应的研究食物。在第0、4、8和12周使用VISIA进化技术拍摄面部图像。在第0周和第12周采集粪便和皮肤样本。主要结果是总VISIA评分从基线的变化。结果：共有120名30-79岁的女性被分配到短芽杆菌组（n = 59）或安慰剂组（n = 61）。安慰剂组的总VISIA评分在第8周恶化（p = 0.029），而短芽孢杆菌组没有。与安慰剂组相比，短芽孢杆菌组的VISIA褐斑评分在第4周（p = 0.013）和第8周（p = 0.041）有所改善。短芽孢杆菌组的VISIA毛孔评分在第4周（p = 0.013）、第8周（p = 0.041）和第12周（p = 0.004）有所改善。肠道菌群的属水平分析显示，短芽孢杆菌组的蓝菌丰度显著增加。两组间不良事件发生的频率无显著差异。结论：口服短芽孢杆菌M-16V可抑制成年女性面部皮肤恶化，包括棕色斑点的出现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrients NUTRITION & DIETETICS-

CiteScore

9.20

自引率

15.30%

发文量

4599

审稿时长

16.74 days

期刊介绍： Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.