{"title":"Relationship Between Knowledge, Attitudes, and Practices for the Consumption of <i>Spirulina</i>-Enriched Fruit and Vegetable Juices: Structural Equation Modelling and Consumers' Preference Evaluation Approach.","authors":"Miona Belović, Lato Pezo, Goran Radivojević, Mirjana Penić, Jasmina Lazarević, Bojana Filipčev, Uroš Čakar, Jasmina Vitas, Biljana Cvetković","doi":"10.3390/nu18081309","DOIUrl":"10.3390/nu18081309","url":null,"abstract":"<p><p><b>Background/Objectives:</b> The presented study aimed to understand the relationship between knowledge, attitudes, and practices, as well as consumers' preferences for the consumption of <i>Spirulina</i>-enriched fruit and vegetable juices. <b>Methods:</b> A survey about the consumers' attitudes towards consumption of algae in general and especially <i>Spirulina</i> was conducted to better understand the target groups and marketing strategies for this novel non-alcoholic beverage product. Knowledge-Attitude-Practice (KAP) model in combination with structural equation modelling (SEM) was applied to test the hypothesised relationships between the variables. Additionally, consumers' preference test was done using a seven-point hedonic scale and ranking of the six juice samples: plain sour cherry juice (SC1), sour cherry juice with 0.8% (SC2) and 1.6% (SC3) of blue <i>Spirulina</i> powder; plain tomato juice (T1), tomato juice with 0.8% (T2) and 1.6% (T3) of blue <i>Spirulina</i> powder. <b>Results:</b> The SEM results showed that there is a limited direct impact of knowledge on social motivation, while personal behaviour strongly predicts social motivation. Namely, perceived nutritional value and health benefits were shown to be the main factors for consumers' willingness to drink <i>Spirulina</i>-enriched juice. <b>Conclusions:</b> The result of the consumer preference evaluation exposed that the juices containing sour cherry and <i>Spirulina</i> achieved better sensory acceptance and ranking than those containing tomato, pointing out the importance of the product matrix for achieving consumer acceptance.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13119012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multi-Target Modulation of Metabolic and Steroidogenic Pathways by <i>Cinnamomum burmannii</i> and <i>Myristica fragrans</i> in Polycystic Ovary Syndrome: An Integrative Transcriptomics, Metabolomic, Pharmacoinformatics and Experimental Validation.","authors":"Taruna Ikrar, Salmon Charles Siahaan, Hendy Hendarto, Arifa Mustika, Eighty Mardiyan Kurniawati, Wiskara Jatipradresthya, Edwin Hadinata, Nurpudji Astuti Taslim, Dante Saksono Harbuwono, Raymond Rubianto Tjandrawinata, Fahrul Nurkolis","doi":"10.3390/nu18081305","DOIUrl":"10.3390/nu18081305","url":null,"abstract":"<p><p><b>Background:</b> Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder characterized by interconnected dysregulation of steroidogenesis and insulin signaling. Multi-target therapeutic strategies are increasingly needed to address its heterogeneous pathophysiology. <b>Methods:</b> An integrative approach combining transcriptomic analysis of GSE137684, including stratification of normoandrogenic and hyperandrogenic PCOS subtypes to capture androgen-related heterogeneity, network pharmacology, molecular docking, and in vitro validation was employed. Principal component analysis (PCA), differential expression analysis, and enrichment analyses were used to identify candidate genes and pathways. Molecular docking evaluated interactions between phytochemicals from <i>Cinnamomum burmannii</i> and <i>Myristica fragrans</i> and key PCOS targets. Functional validation was performed in insulin-resistant 3T3-L1 adipocytes and DHEA-induced KGN cells, assessing cell viability, lipid accumulation, glucose uptake, gene expression, and hormone levels. <b>Results:</b> PCA revealed partial separation between PCOS and the control samples, with PC1 and PC2 explaining 44.8% and 12.5% of variance, respectively. No genes remained significant after multiple testing correction; however, nominally significant candidates (<i>p</i> < 0.01) highlighted pathways related to steroidogenesis and metabolic regulation. Network analysis identified key hub genes including CYP17A1, CYP19A1, AKT1, ESR1, and MAPK1. Molecular docking demonstrated strong binding affinities, with top compounds showing binding energies up to -11.4 kcal/mol (CYP17A1) and -10.9 kcal/mol (AKT1). In vitro, cell viability remained above 80% across all tested concentrations, indicating low cytotoxicity. Treatment significantly reduced lipid accumulation and enhanced glucose uptake in insulin-resistant 3T3-L1 cells (<i>p</i> < 0.05). Additionally, expression of AKT1 and MAPK1 was significantly restored (<i>p</i> < 0.05). In KGN cells, testosterone levels were significantly decreased while the estradiol levels increased (<i>p</i> < 0.05), accompanied by the downregulation of CYP17A1 and upregulation of CYP19A1 (<i>p</i> < 0.05). The combination treatment exhibited more consistent effects across metabolic and hormonal endpoints. <b>Conclusions:</b><i>Cinnamomum burmannii</i> and <i>Myristica fragrans</i> exert multi-target effects on metabolic and steroidogenic pathways relevant to PCOS. This integrative study demonstrates that transcriptomics-guided network pharmacology combined with experimental validation can identify synergistic phytotherapeutic strategies for complex endocrine disorders.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NutrientsPub Date : 2026-04-21DOI: 10.3390/nu18081307
Ron Shaoul, Andrew S Day
{"title":"The Role of Nutrition in Pediatric Gastrointestinal Diseases.","authors":"Ron Shaoul, Andrew S Day","doi":"10.3390/nu18081307","DOIUrl":"10.3390/nu18081307","url":null,"abstract":"<p><p>Nutrition has both a supportive and therapeutic role in the management of many gastrointestinal (GI) diseases [...].</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phytochemical Diversity of <i>Punica granatum</i> L. and Its Multi-Target Biological Functions.","authors":"Zofia Kobylińska, Aleksandra Bochno, Ewelina Och, Martyna Kotula, Patrycja Kielar, Sabina Galiniak, Mateusz Mołoń","doi":"10.3390/nu18081306","DOIUrl":"10.3390/nu18081306","url":null,"abstract":"<p><p><i>Punica granatum</i> L. is a nutritionally relevant fruit with a complex phytochemical profile that varies across its anatomical fractions, including peel, arils, juice, seeds, and seed oil. Although pomegranate is widely recognized for its health-promoting potential, the nutritional significance of its matrix-dependent composition, bioavailability, and gut microbiota-mediated metabolism remains insufficiently integrated. This review aimed to critically evaluate the phytochemical diversity of pomegranate and its nutrition-related multi-target biological functions, with particular emphasis on food matrices, bioaccessibility, and translational relevance. A structured review of peer-reviewed studies indexed in major scientific databases from 2000 to January 2026 was conducted. Eligible reports included analytical, preclinical, and clinical studies addressing the composition of pomegranate-derived materials and their biological effects, with attention to extraction matrix, processing, bioavailability, microbial biotransformation, and mechanisms of action. Pomegranate exhibits marked matrix-specific phytochemical diversity. Peel is particularly rich in ellagitannins, especially punicalagin and punicalin; arils and juices are enriched in anthocyanins and flavonols; and seed oil contains high levels of punicic acid. Reported biological activities include antioxidant, anti-inflammatory, antimicrobial, metabolic, anti-aging, and anticancer effects. These actions appear to result from synergistic interactions among multiple bioactive compounds rather than from a single dominant constituent. Importantly, gut microbiota-driven conversion of ellagitannins and ellagic acid into urolithins is a major determinant of systemic bioactivity and may contribute to interindividual variability in response. The health effects of pomegranate should be interpreted within a nutrition-focused, matrix-dependent framework integrating composition, processing, bioavailability, and microbiota-derived metabolism.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NutrientsPub Date : 2026-04-21DOI: 10.3390/nu18081310
Katherine H Fearon, Corbin M Dameron, Shannon L Kelleher, Amer Al-Nimr, Michael E Zegans
{"title":"Rethinking Vitamin A Deficiency: Its Causes, Ophthalmologic Presentation, and Management Gaps at a New England Tertiary Hospital.","authors":"Katherine H Fearon, Corbin M Dameron, Shannon L Kelleher, Amer Al-Nimr, Michael E Zegans","doi":"10.3390/nu18081310","DOIUrl":"10.3390/nu18081310","url":null,"abstract":"<p><p><b>Background/Objectives</b>: To evaluate ocular disease and eye care utilization among adults with vitamin A deficiency (VAD) in a high-resource healthcare setting, with particular emphasis on nutritional etiologies, clinical nutrition oversight, and outcomes associated with severity of deficiency. <b>Methods</b>: A retrospective chart review was conducted at Dartmouth Hitchcock Medical Center (DHMC) from 1 January 2019 through 31 December 2022. Adults (>18 years) with measured serum retinol concentrations were identified, and data were extracted on retinol concentration, diagnosis, referring service, and vital status. Patients with VAD (serum retinol <32.5 µg/dL per our laboratory threshold) underwent detailed chart review, including social determinants of health and documented nutritional risk factors. For patients with VAD who received an ophthalmologic evaluation, slit lamp findings, ocular symptoms, duration of deficiency, and vitamin A treatment were assessed. <b>Results</b>: VAD was identified in 752 of 2725 patients (27.7%) tested for VAD, and 330 patients had concentrations below the World Health Organization (WHO) threshold for VAD (<20 µg/dL). Hepatic, nutritional, and malabsorptive conditions were prominent contributors, including cirrhosis related to alcohol use or hepatitis C virus (30%), malnutrition or malabsorption following bariatric surgery (24%), and pancreatic insufficiency (20.1%). Food insecurity data were incomplete but showed no significant association with vitamin A concentration. Despite biochemical evidence of deficiency, only 72 patients with VAD (9.6%) underwent ophthalmologic evaluation, and only three were referred specifically due to VAD. Clinical signs or symptoms consistent with xerophthalmia were observed in 21% of those evaluated, and 18% demonstrated corneal findings. Vitamin A supplementation was documented in just over half of symptomatic patients, with objective or symptomatic improvement noted in three cases. VAD was explicitly acknowledged in only 9.7% of ophthalmology notes. Increasing severity of VAD was strongly associated with mortality (<i>p</i> < 0.001), independent of food insecurity, which showed no association with serum retinol concentrations. <b>Conclusions</b>: In this high-resource clinical setting, VAD is common in an at-risk population and largely driven by nutrition-related disease states affecting absorption, metabolism, and hepatic storage. Despite clear biochemical deficiency and associated mortality risk, VAD is underrecognized, undertreated, and infrequently linked to ocular evaluation, highlighting a critical gap in nutrition-focused screening, interdisciplinary communication, and proactive vitamin A assessment in medically complex adults.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NutrientsPub Date : 2026-04-21DOI: 10.3390/nu18081308
Nina Ciuciuc, Rodica Ana Ungur, Alexandra-Ioana Roșioară, Monica Popa, Dana Manuela Sîrbu, Daniela Curșeu, Codruța Alina Popescu, Iulia Szerasz, Bogdana Adriana Năsui
{"title":"Pro- and Anti-Inflammatory Dietary Patterns and Lifestyle Factors Associated with Gastroesophageal Reflux Symptoms in Romanian Adults: A Cross-Sectional Study.","authors":"Nina Ciuciuc, Rodica Ana Ungur, Alexandra-Ioana Roșioară, Monica Popa, Dana Manuela Sîrbu, Daniela Curșeu, Codruța Alina Popescu, Iulia Szerasz, Bogdana Adriana Năsui","doi":"10.3390/nu18081308","DOIUrl":"10.3390/nu18081308","url":null,"abstract":"<p><p><b>Background</b>: Gastroesophageal reflux disease (GERD) is a common digestive disorder with a substantial impact on quality of life. Emerging evidence suggests that dietary patterns and lifestyle behaviors are associated with the occurrence and severity of GERD symptoms; however, integrated data from Romania remain limited. <b>Objective</b>: The aim of this study was to evaluate associations between pro- and anti-inflammatory dietary patterns, lifestyle-related behavioral factors, and the presence and severity of gastroesophageal reflux symptoms in an adult Romanian population. <b>Methods</b>: A national cross-sectional observational study was conducted using a self-administered online questionnaire. All participants included in the study reported a prior diagnosis of gastroesophageal reflux disease (GERD), and participant classification was based exclusively on current symptomatology assessed using the GERD-Q score. Therefore, comparisons were not performed between patients and a healthy population, but rather between individuals at different stages of clinical expression of the same condition, characterized by a fluctuating course. The instrument included standardized GERD-Q items for symptom assessment, together with questions regarding dietary intake and lifestyle behaviors. Pro-inflammatory (PRO), anti-inflammatory (ANTI), and combined (PRO-ANTI) dietary scores were established. Statistical analyses included comparative and correlational tests as well as multivariable logistic regression models. <b>Results</b>: Among the 340 participants included in the study, 72.4% reported symptoms consistent with GERD according to the GERD-Q score. A higher pro-inflammatory dietary score was significantly associated with GERD, with participants in the highest PRO category showing more than a fourfold higher likelihood of GERD in multivariable analyses. Consumption of spicy foods and carbonated beverages was associated with an increased risk of GERD in univariate analyses; however, these associations did not remain significant in multivariable models. Late meals (defined as consumption of one's last meal of the day less than two hours before bedtime) were independently associated with GERD. Combined analyses indicated a higher risk among participants who reported eating late meals, particularly when combined with large evening meals. Most foods considered protective, along with classical lifestyle factors (smoking, alcohol consumption, and sleeping position), were not independently associated with GERD. <b>Conclusions</b>: These findings suggest that overall dietary patterns with pro-inflammatory potential and meal timing in relation to the sleep-wake cycle may be more consistently associated with GERD symptoms in this sample than isolated food items or traditional lifestyle risk factors. Nutritional and behavioral interventions focused on improving overall dietary patterns and avoiding late meals may represent potential strategies for GERD managem","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NutrientsPub Date : 2026-04-21DOI: 10.3390/nu18081304
Omolola A Adedokun, Brooke Jenkins, Jacqueline Corum, Jean Noble, Olumuyiwa Moses Desmennu
{"title":"Personal Factors and Nutrition Intentions of Participants in a Nutrition Education Program for Limited-Resource Adults in Substance Use Recovery.","authors":"Omolola A Adedokun, Brooke Jenkins, Jacqueline Corum, Jean Noble, Olumuyiwa Moses Desmennu","doi":"10.3390/nu18081304","DOIUrl":"10.3390/nu18081304","url":null,"abstract":"<p><p><b>Background/Objectives</b>: This exploratory, cross-sectional study examined the relationships between personal factors and the nutrition intentions of participants in Healthy Choices for Your Recovering Body (HCYRB), a nutrition education program for limited-resource adults in substance use recovery (SUR). <b>Methods</b>: The study used a single-sample survey design where HCYRB participants (<i>n</i> = 2163) completed a post-participation survey. Linear regression models were tested to assess the effects of personal factors such as nutrition knowledge, cooking skills, self-efficacy beliefs and current nutrition and physical activity practices on participants' nutrition intentions. Variables were measured with a self-reported survey that participants completed after participation in HCRYB. <b>Results</b>: The final model (R<sup>2</sup> = 0.39) showed statistically significant effects of self-efficacy beliefs, specifically, food resource management confidence and confidence to choose nutritious foods; current levels of water, soda, and energy drink consumption; physical activity level; and gender on nutrition intentions. <b>Conclusions</b>: Overall, the findings suggest that nutrition-related self-efficacy and current practices influence nutrition intentions of HCYRB participants. Future programs may focus on building participants' nutrition-related confidence during SUR to enhance intentions and eventual behavior change. Such strategies may include programming activities that promote and affirm participants' current positive nutrition-related behaviors (e.g., adequate consumption of water and involvement in physical activity). As participants master these healthy practices throughout the nutrition education experience, they will be more likely to gain confidence and motivation toward continuing the behavior throughout their recovery journey.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NutrientsPub Date : 2026-04-21DOI: 10.3390/nu18081303
Shareena Sreedharan, Alpana Pande, Anurag Pande, Muhammed Majeed, Javier Villela-Castrejon, Luis Cisneros-Zevallos
{"title":"Correction: Sreedharan et al. The Neuroprotective Effects of <i>Oroxylum indicum</i> Extract in SHSY-5Y Neuronal Cells by Upregulating BDNF Gene Expression Under LPS Induced Inflammation. <i>Nutrients</i> 2024, <i>16</i>, 1887.","authors":"Shareena Sreedharan, Alpana Pande, Anurag Pande, Muhammed Majeed, Javier Villela-Castrejon, Luis Cisneros-Zevallos","doi":"10.3390/nu18081303","DOIUrl":"10.3390/nu18081303","url":null,"abstract":"<p><p>Javier Villela-Castrejon was not included as an author in the original publication [...].</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NutrientsPub Date : 2026-04-21DOI: 10.3390/nu18081311
Hongwei Ma, Mengen Xu, Ying Yu, Ziyi Xia, Muhammad Farhan Rahim, Min A, Ziyang Wang, Chengxu Xu, Jiakui Li
{"title":"<i>Bacillus licheniformis</i> Alleviates DSS-Induced Ulcerative Colitis in Mice by Repairing the Intestinal Barrier and Regulating Gut Microbiota and Its Metabolism.","authors":"Hongwei Ma, Mengen Xu, Ying Yu, Ziyi Xia, Muhammad Farhan Rahim, Min A, Ziyang Wang, Chengxu Xu, Jiakui Li","doi":"10.3390/nu18081311","DOIUrl":"10.3390/nu18081311","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel disease (IBD) is a gut-based idiopathic disease characterized by chronic and relapsing inflammatory progression and intricate pathophysiology. It is now known that the key etiologies of IBD include immune dysregulation, imbalances in the gut microbiota, and metabolic disruptions. Probiotics are now the potential treatment for IBD, due to their ability to regulate the host immune system and microbiota of the gut.</p><p><strong>Methods: </strong>The current study analytically tested the preventive benefit of <i>Bacillus licheniformis</i> BL-01 on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) and also expounded on its molecular pathogenesis.</p><p><strong>Results: </strong>Our results demonstrate that supplementation with BL-01 effectively mitigates DSS-induced weight loss, an elevated disease activity index (DAI), and colonic tissue injury in mice. Concomitantly, BL-01 rectifies dysregulated inflammatory cytokine profiles, attenuates oxidative stress, and restores the expression of colonic tight junction proteins as well as the number of goblet cells. Furthermore, BL-01 modulates the gut microbiota diversity by increasing the abundance of beneficial bacterial genera such as <i>Duncaniella</i> and decreasing the abundance of pathogenic genera such as <i>Helicobacter</i>. Notably, BL-01 restores DSS-induced microbial metabolic dysregulation, modulates key metabolic pathways including arachidonic acid metabolism and steroid hormone biosynthesis, and regulates associated metabolites to ameliorate UC. Finally, <i>Bacillus licheniformis</i> BL-01 mitigates oxidative stress, reverses gut dysbiosis and metabolic disorders, and has a protective effect on UC.</p><p><strong>Conclusions: </strong>The findings give new information on the development of probiotic-based therapeutics in the prevention and treatment of IBD.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13119003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NutrientsPub Date : 2026-04-20DOI: 10.3390/nu18081300
Mariusz Jaworski
{"title":"From Policy to Practice: Advancing Institutional Readiness in Sustainable Food Systems.","authors":"Mariusz Jaworski","doi":"10.3390/nu18081300","DOIUrl":"10.3390/nu18081300","url":null,"abstract":"<p><p>The transformation of food systems toward greater sustainability has become one of the key challenges in public health [...].</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"18 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13119366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}