Nutrients最新文献

{"title":"The Association of Food Insecurity and Risk of Mortality: A Systematic Review and Meta-Analysis of Large-Scale Cohorts.","authors":"Cyrus Jalili, Seyedeh Parisa Moosavian, Farhang Hameed Awlqadr, Sanaz Mehrabani, Reza Bagheri, Matin Sedighy, Shirley Hodder, Faramarz Jalili, Mohammad Ali Hojjati Kermani, Maryam Zamir Nasta, Sajjad Moradi, Fred Dutheil","doi":"10.3390/nu17111937","DOIUrl":"10.3390/nu17111937","url":null,"abstract":"<p><p><b>Objectives:</b> Food insecurity (FI) represents a significant global public health issue, yet existing literature presents inconsistent findings regarding its association with mortality risk. This systematic review and meta-analysis aimed to synthesize available evidence to evaluate the relationship between FI and mortality. <b>Setting:</b> A systematic search was conducted using the ISI Web of Science, PubMed/MEDLINE, and Embase databases without any date limitation until February 18, 2025. Hazard ratios (HR) and 95% confidence intervals (CI) were pooled using a random-effects model, while validated methods examined quality and publication bias via Newcastle-Ottawa Scale, Egger's regression asymmetry, and Begg's rank correlation tests, respectively. <b>Results:</b> Findings from 19 studies demonstrated a significant association between FI and increased risk of mortality (HR = 1.23; 95% CI: 1.16, 1.30; <i>I</i>² = 83.1%; <i>p</i> < 0.001; n = 19). Subgroup analyses indicated a dose-response relationship, with mortality risk increasing by FI severity: mild (HR = 1.16; 95% CI: 1.10, 1.22; <i>I</i>² = 0.0%; <i>p</i> < 0.001; n = 9), moderate (HR = 1.19; 95% CI: 1.07, 1.31; <i>I</i>² = 83.2%; <i>p</i> = 0.001; n = 10) and severe (HR = 1.52; 95% CI: 1.25, 1.86; <i>I</i>² = 94.9%; <i>p</i> < 0.001; n = 10). Additional subgroup analyses revealed a significant association between FI and both all-cause mortality (HR = 1.26; 95% CI: 1.18, 1.35; <i>I</i>² = 82.0%; <i>p</i> < 0.001; n = 16), and cardiovascular-related mortality (HR = 1.24; 95% CI: 1.11, 1.39; <i>I</i>² = 42.8%; <i>p</i> < 0.001; n = 7), but not cancer-related mortality. <b>Conclusions</b>: Persistent FI appears to contribute to an increased risk of mortality. Hence, it is important to maintain continuity and strengthen current programs aimed at combating FI, which may help reduce FI-related mortality.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Nutritional Status and Early Postoperative Infection Risk in Kidney Transplant Patients.","authors":"Elena González García, Tamara Arroyo, Mercedes Galván, María José Becerra, Margarita Gallego, Israel Mauro, Yanieli Hernández, Almudena Pérez-Torres, María Ovidia López Oliva, María José Santana, Carlos Jiménez","doi":"10.3390/nu17111935","DOIUrl":"10.3390/nu17111935","url":null,"abstract":"<p><p>Malnutrition is one of the stronger predictors of morbi-mortality in end-stage kidney disease patients. Moreover, malnutrition in hospitalized patients severely affects multiple clinical outcomes, increasing the risk of complications. The Nutritional Risk Index and Geriatric Nutritional Risk Index are indexes used to evaluate the risk of malnutrition in hospitalized adults, which have been validated for dialysis patients and have been reported to be a validated prognostic index of nutrition-related morbidity and mortality. <b>Objectives</b>: The aim of this study is to evaluate the prevalence of early postoperative infections and their possible relationship with malnutrition in renal transplantation. <b>Methods</b>: We conducted a retrospective observational study, including all patients who received a kidney transplant, a total of 140, between January 2020 and December 2023, at a tertiary-level Spanish hospital. <b>Results</b>: The average GNRI was 110.1 ± 11.6, equivalent to adequate nutrition, and only 16.4% of patients were at risk of malnutrition. The mean NRI was 111.4 ± 11.8, equivalent to no risk of malnutrition, and only 17.2% of patients had a moderate-to-severe risk of malnutrition. A total of 30 patients (21.4%) required oral nutritional supplementation at discharge, especially modular protein supplements (86.7%), and 52 patients (37.1%) presented an infection during their stay. The most frequent infections were urinary tract infections (69.8% of the total). Malnutrition calculated by the GNRI or NRI correlated to a longer postoperative hospital stay and a higher rate of infectious complications (<i>p</i> < 0.05). <b>Conclusions</b>: Malnourished patients have a higher risk of early postoperative complications, including infection, and a longer hospitalization stay. The evaluation of nutritional status for the diagnosis and treatment of malnutrition is strongly recommended in ESKD patients on the waiting list for a kidney transplant.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Low Glycemic Index/Slow Digesting (LGI/SD) Carbohydrate Product on Maternal Glycemia and Neonatal Body Composition in Obese Pregnant Women: The NIGOHealth Randomized Clinical Trial.","authors":"Mercedes G Bermúdez, María García-Ricobaraza, José Antonio García-Santos, M Teresa Segura, Alberto Puertas-Prieto, José Luis Gallo-Vallejo, Carmen Padilla-Vinuesa, Berthold Koletzko, Geraldine E Baggs, Elena Oliveros, Ricardo Rueda, Cristina Campoy","doi":"10.3390/nu17111942","DOIUrl":"10.3390/nu17111942","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Obesity during pregnancy is strongly related to increased insulin resistance, and subsequent development of metabolic syndrome-like disorders, such as glucose intolerance, pre-eclampsia, as well as preterm birth, and cesarean delivery. Nutrition can influence the evolution of glycemic response and may help improve adverse pregnancy outcomes and long-term complications. The main objective of the Nutritional Intervention during Gestation and Offspring Health (NIGOHealth) randomized clinical trial (ClinicalTrials.gov Identifier: NCT02285764) was to investigate the potential effects of a low glycemic index/slow digesting (LGI/SD) carbohydrate product on maternal glycemia (glucose AUC at 27⁺⁰-28⁺⁶ weeks; maternal fasting blood glucose (MFBG) at 34⁺⁰-36⁺⁰ weeks), and neonatal body composition. <b>Methods:</b> Obese pregnant women were randomized: 230 in the intervention group (IG), who consumed two servings of an LGI/SD study product daily from 15 weeks of pregnancy until delivery, and 102 participants in the Standard of Care (SOC) group. <b>Results:</b> When analyzing baseline characteristics, significant differences were found in glucose metabolic parameters with higher values for IG than for the SOC group, compromising the group's comparability. Despite this, a statistical analysis was conducted (intention-to-treat analysis/evaluable cohort): no differences were detected regarding maternal blood glucose AUC at 27⁺⁰-28⁺⁶ weeks, nor for MFBG at 34⁺⁰-36⁺⁰ weeks. Nonetheless, HbA1c (%) at 34⁺⁰-36⁺⁰ weeks was significantly lower in the IG vs. the SOC group (5.26 ± 0.03, 5.31 ± 0.04, <i>p</i> = 0.007) after adjusting for baseline conditions. <b>Conclusion</b>: This result might suggest a potential effect of the intervention on Evaluable participants. However, it should be taken with caution, due to the limitations of the study. More RCTs should be carried out to explore the effects of LGI/SD products on glycemic response in obese pregnant women.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid Metabolism and Relevance to Chronic Disease.","authors":"Harald Mangge","doi":"10.3390/nu17111936","DOIUrl":"10.3390/nu17111936","url":null,"abstract":"<p><p>Lipid metabolism is involved in the development and progression of widespread chronic diseases, making it a crucial area of study in medicine and public health [...].</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-Theanine Mitigates Chronic Alcoholic Intestinal Injury by Regulating Intestinal Alcohol and Linoleic-Arachidonic Acid Metabolism in Rats.","authors":"Jiayou Gu, Simin Tan, Jiahao Yang, Xuhui Dang, Kehong Liu, Zhihua Gong, Wenjun Xiao","doi":"10.3390/nu17111943","DOIUrl":"10.3390/nu17111943","url":null,"abstract":"<p><p><b>Background</b>: Chronic alcohol intake impairs intestinal function, while L-theanine (LTA) may support intestinal health. However, the protective effects of LTA to chronic alcoholic intestinal injuries remain unclear. <b>Methods</b>: SD rats were administered LTA for 8 weeks and then co-administered Lieber-DeCarli liquid alcohol feed and LTA for 4 weeks to establish a chronic alcoholic intestinal injury model and investigate the mitigating influence of LTA on chronic alcoholic intestinal injury. <b>Results</b>: LTA alleviated duodenal pathology and intestinal permeability injury and reduced intestinal oxidative stress and inflammatory response, thereby mitigating chronic alcoholic intestinal injury. Additionally, LTA ameliorated disturbances in the gut microbiota induced by chronic alcohol intake by increasing the beneficial bacteria abundance (<i>Ruminococcus</i> and <i>Odoribacter</i>) and decreasing the harmful bacteria abundance (<i>Enterococcus</i>). Moreover, LTA altered the metabolic profiles associated with ethanol and linoleic (LA) and arachidonic acid (AA) metabolism. ADH6, ALDH2, and ACSS1 mRNA and protein levels were upregulated by LTA, whereas those for CYP2E1, FADS2, ALOX-5, and COX-1 were downregulated. Concurrently, LTA increased the levels of metabolites, such as acetyl-CoA, and decreased the levels of ethanol, acetaldehyde, acetic acid, LA, AA, PGE2, 13-HPODE, and LTB4. <b>Conclusions</b>: L-theanine mitigates chronic alcoholic intestinal injury by regulating intestinal alcohol and LA-AA metabolism. Our findings support the functional potential of the dietary supplement LTA and highlight its potential for addressing chronic intestinal injury caused by chronic alcohol intake.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12157802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Isomaltulose on Glycemic Response in Diabetic and Healthy Populations: A Meta-Analysis.","authors":"Zhaojie Chen, Fangting Gu, Jianyong Wu","doi":"10.3390/nu17111940","DOIUrl":"10.3390/nu17111940","url":null,"abstract":"<p><strong>Background: </strong>Effective management of postprandial glycemic control is critical for diabetic patients, as elevated postprandial glucose levels can lead to complications such as cardiovascular disease and neuropathy. This study evaluates isomaltulose, a low-glycemic-index carbohydrate, as an alternative to sucrose in mitigating postprandial glucose spikes.</p><p><strong>Objectives: </strong>To synthesize evidence from existing studies and assess the efficacy of isomaltulose in reducing postprandial glycemic levels compared to sucrose in diabetic populations.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted following PRISMA guidelines. Searches were performed across PubMed, Cochrane Library, and ClinicalTrials.gov for randomized controlled trials or crossover studies comparing isomaltulose and sucrose. Data were extracted, and the Cochrane Risk of Bias tool was used to assess study quality.</p><p><strong>Results: </strong>Ten studies were included, involving 367 participants. The meta-analysis showed that isomaltulose significantly reduced plasma glucose level at 60 min post-meal, though the actual effect could be modest in terms of clinical relevance compared to sucrose (MD: -7.99, 95% CI: -8.58, -7.39, <i>p</i> < 0.00001). Notable variability in the study results was observed, which may be attributed to multiple factors such as participant demographics and meal composition.</p><p><strong>Conclusions: </strong>The findings from the analysis are supportive for the use of isomaltulose as a beneficial dietary alternative to sucrose for managing postprandial glycemic levels in diabetic patients. Future research effort is suggested to focus on larger, diverse populations to enhance generalizability and explore the impact of dietary context on glycemic response.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12157287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unintended Consequences of Obesity Pharmacotherapy: A Nutritional Approach to Ensuring Better Patient Outcomes.","authors":"Werd Al-Najim, António Raposo, Mona N BinMowyna, Carel W le Roux","doi":"10.3390/nu17111934","DOIUrl":"10.3390/nu17111934","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Obesity pharmacotherapy vastly improved the treatment of the disease of obesity. However, GLP-1 receptor agonists and GIP/GLP-1 dual agonists may lead to nutritional complications, including severe caloric restriction, micronutrient deficiencies, lean body mass loss, dehydration, and ketosis. We examine these risks and outlines dietitian-led strategies to support improved safety and effectiveness. <b>Methods:</b> This narrative review was conducted in three stages: literature search, screening of abstracts and full texts, and synthesis of findings. Searches were carried out in April and May 2025 across PubMed, Embase, Scopus, ScienceDirect, Web of Science, and Google Scholar using keywords related to obesity pharmacotherapy and nutrition. <b>Results:</b> Clinical observations and trial data suggest that some individuals may consume fewer than 800 kcal/day during the initial stages of treatment. Prolonged energy and protein deficits can increase the risk of sarcopenia, metabolic dysfunction, and reduce treatment adherence. Additional risks include inadequate micronutrient intake due to reduced dietary variety, dehydration linked to gastrointestinal symptoms and hypodipsia, and rare but serious cases of ketoacidosis. Patients at heightened risk include older adults, those with low baseline muscle mass, and individuals with restrictive eating patterns. <b>Conclusions</b>: Obesity medications introduce unique nutritional risks that are not yet addressed by standardised clinical protocols. Registered dietitians play a critical role in assessing intake patterns, monitoring for red flags, and delivering targeted nutritional support. Integrating structured dietary assessment tools, checklists, and risk-specific guidance into pharmacotherapy pathways can enhance safety, promote adherence, and improve long-term outcomes.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12157928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Oral Nutrition Supplementation with or Without Multi-Domain Intervention Program on Cognitive Function and Overall Health in Older Adults: A Randomized Controlled Trial.","authors":"Hae-Jin Kang, Eun-Hye Lee, Seong-Hye Choi, So-Young Moon, Jee-Hyang Jeong, Yoo-Kyoung Park","doi":"10.3390/nu17111941","DOIUrl":"10.3390/nu17111941","url":null,"abstract":"<p><p><b>Objectives:</b> The global rise in dementia prevalence is escalating the socioeconomic burden, prompting efforts in prevention and treatment. This study aimed to evaluate the effects of an 8-week oral nutrition supplement (ONS) program with or without a multi-domain intervention program (MIP) in patients with mild cognitive impairment. <b>Methods</b>: Forty-nine patients with mild cognitive impairment were divided into three groups: (1) ONS (ONS), (2) ONS+MIP (ONS+MIP), and (3) control (CON). Korean-style dementia prevention MIP was used in the ONS+MIP group. Two packs of ONS per day were provided to the ONS group during the intervention period. Cognitive function, nutritional evaluation, body composition analysis, and physical performance were measured. The paired <i>t</i>-test and one-way analysis of variance were used for statistical analyses. <b>Results</b>: A final analysis was performed on the final 46 participants. After intervention, the cognitive function test (Repeatable Battery for the Assessment of Neuropsychological Status, RBANS) scores of the ONS+MIP group were significantly increased compared to the baseline scores. However, no significant changes were observed in the ONS and CON groups. Eating behavior and food quality also improved in the ONS+MIP group, with a significant difference among the three groups. There was no significant change in body composition in all groups; however, grip strength (left hand), muscular endurance, and the total SPPB score improved in the ONS+MIP group. The total SPPB score decreased in the CON group. <b>Conclusions</b>: Along with ONS intake, intensive education and continuous monitoring through multi-domain interventions are important to improve cognitive function. Trial registration: Clinical Research Information Service identifier: KCT0007253.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12157949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-Second-Trimester Dietary Inflammatory Index and Anemia Risk in the Third Trimester: A Prospective Cohort Study.","authors":"Cong Huang, Zhitan Zhang, Junwei He, Zixin Zhong, Yuxin Ma, Xun Huang, Fan Xia, Hongzhuan Tan, Jing Deng, Mengshi Chen","doi":"10.3390/nu17111938","DOIUrl":"10.3390/nu17111938","url":null,"abstract":"<p><p><b>Objectives:</b> Dietary conditions are closely related to maternal health. This study aims to investigate the causal relationship between the first-second-trimester Dietary Inflammatory Index (DII) and developing anemia in the third trimester. <b>Methods:</b> This prospective cohort study comprised 545 pregnant women, with dietary data assessed via a semi-quantitative food frequency questionnaire (FFQ). Hemoglobin levels were obtained by hospital laboratory tests and used to diagnose anemia. Multivariable logistic regression models-adjusted for baseline serum iron, age, pre-pregnancy body mass index (BMI), occupation, education, history of adverse pregnancy outcomes, parity, serum iron, passive smoking exposure, and iron supplementation use during pregnancy-were employed to evaluate the relationships between the first-trimester DII, second-trimester DII, first-second-trimester average DII, and third-trimester anemia. <b>Results:</b> After multivariable adjustment, the first-second-trimester average DII in the pro-inflammatory diet group demonstrated a 3.73-fold elevated risk of third-trimester anemia compared to the anti-inflammatory diet group (Odds Ratio [OR] = 3.73, 95% Confidence Interval [CI]: 1.50-9.25). <b>Conclusions:</b> Pro-inflammatory dietary patterns during pregnancy exhibit a significant correlation with developing third-trimester anemia. This study demonstrates that reducing dietary pro-inflammatory components through prenatal nutrition programs may lower third-trimester anemia risk. Notably, this study carries potential risks of bias, including self-reporting bias in dietary data and incompletely controlled confounding factors (such as unmeasured biomarkers).</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12157288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Bacopa monnieri</i>: Preclinical and Clinical Evidence of Neuroactive Effects, Safety of Use and the Search for Improved Bioavailability.","authors":"Anna Gościniak, Anna Stasiłowicz-Krzemień, Marta Szeląg, Jakub Pawlak, Izabela Skiera, Hanna Kwiatkowska, Natasza Nowak, Krzysztof Bernady, Piotr Trzaskoma, Oskar Zimak-Krótkopad, Judyta Cielecka-Piontek","doi":"10.3390/nu17111939","DOIUrl":"10.3390/nu17111939","url":null,"abstract":"<p><p><i>Bacopa monnieri</i>, also known as Brahmi or Waterhyssop, is a plant used in Ayurveda for its memory-enhancing properties and control of blood sugar levels. It contains active compounds such as alkaloids, saponins, and cucurbitacins, which have various biological activities. The plant has been studied for its potential in treating Alzheimer's disease, Parkinson's disease, attention deficit hyperactivity disorder (ADHD), and depression. Animal studies have shown promising results in reducing symptoms and protecting against neurodegeneration. Concerning safety, <i>Bacopa monnieri</i> has been found to be generally non-toxic, with no serious side effects reported. However, interactions with certain medications and contraindications in conditions like hyperthyroidism should be considered. Further research is needed to determine optimal dosages and ensure safety, especially for pregnant and breastfeeding women.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}