Nutrients最新文献

{"title":"Adherence and Body Weight with Daily Avocado Consumption Among Latina Women of the Habitual Diet and Avocado Trial (HAT).","authors":"Tiffany Q Luong, Mopelola A Adeyemo, Penny M Kris-Etherton, Alice H Lichtenstein, Nirupa R Matthan, Kristina S Petersen, David M Reboussin, Joan Sabaté, Zhaoping Li","doi":"10.3390/nu17020367","DOIUrl":"10.3390/nu17020367","url":null,"abstract":"<p><p><b>Objectives:</b> The aim of this study was to examine the adherence, changes in weight, and, waist circumference associated with the daily consumption of a culturally preferred food, namely an avocado, among Hispanic/Latina females in the Habitual Diet and Avocado Trial (HAT). <b>Methods:</b> HAT was a multisite, randomized controlled trial conducted between 2018 and 2020. Participants in the Avocado-Supplemented Diet Group were provided with and instructed to consume one avocado/day (~2.2 servings) for 6 months; participants in the Habitual Diet Group were instructed to follow their usual diet and limit intake to ≤2 avocados/month. Avocado consumption was assessed using three random 24 h dietary recalls administered by dietitians. This analysis focused on women who self-identified as Hispanic/Latina. <b>Results:</b> Within HAT, 158 females self-identified as Hispanic/Latina (median age: 42 years, IQR: 36-54). Across the dietary recalls, the Avocado-Supplemented Group (<i>n</i> = 80) consumed 1.9-2.1 avocado servings/day; the Habitual Diet Group (<i>n</i> = 78) consumed 0.04-0.09 servings/day (<i>p</i> < 0.001). The weight and waist circumference measurements were similar between groups. Hispanic/Latina females remained adherent to daily avocado consumption for the 6-month study period, without a significant change in their body weight or waist circumference measurements. <b>Conclusions:</b> Integrating a culturally preferred food into a dietary intervention enhanced adherence amongst Latina adults, with no impact significant impact on body composition.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11768158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Interventions, Supplements, and Plant-Derived Compounds for Adjunct Vitiligo Management: A Review of the Literature.","authors":"Michael J Diaz, Jasmine T Tran, Drake Rose, Aria Wei, Deepak Lakshmipathy, Shari R Lipner","doi":"10.3390/nu17020357","DOIUrl":"10.3390/nu17020357","url":null,"abstract":"<p><p>Vitiligo is a chronic autoimmune pigmentation disorder shaped by a complex interplay of genetic predispositions and environmental triggers. While conventional therapies-phototherapy, corticosteroids, and immunosuppressants-can be effective, their benefits are often partial and temporary, with recurrence common once treatment stops. As such, there is increasing interest in exploring complementary approaches that may offer a more sustainable impact. Emerging evidence suggests that macronutrient and micronutrient-level changes could be beneficial for managing progression and, in some cases, facilitating repigmentation. Antioxidant-rich foods, such as apples, green tea, Indian gooseberry, onions, and peppers, may help mitigate oxidative stress, while inflammatory foods, such as gluten and high-phenol nuts and berries, may exacerbate the condition. Certain supplements, including high-dose vitamin D, vitamin C, vitamin E, and selenium, may enhance phototherapy outcomes. Omega-3 and other unsaturated fatty acids, in addition to prebiotics and probiotics, are under active investigation for their roles in gut health and immune regulation. Notably, plant-derived compounds, i.e., <i>Ginkgo biloba</i>, have demonstrated promise in promoting repigmentation and managing disease progression. However, it must be emphasized that these nutritional interventions remain exploratory, and more research is needed to establish their efficacy, safety, and optimal usage before they can be recommended as part of a standard treatment regimen.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11767946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and Infant Characteristics and Pumping Profiles of Women That Predominantly Pump Milk for Their Infants.","authors":"Zoya Gridneva, Ashleigh H Warden, Jacki L McEachran, Sharon L Perrella, Ching Tat Lai, Donna T Geddes","doi":"10.3390/nu17020366","DOIUrl":"10.3390/nu17020366","url":null,"abstract":"<p><strong>Background: </strong>Whilst it is inconvenient and time-intensive, predominantly (PP) and exclusively pumping (EP) mothers rely on breast expression to provide milk for their infants and to ensure continued milk supply, yet these populations are poorly understood.</p><p><strong>Methods: </strong>We assessed and characterised Western Australian PP mothers (<i>n</i> = 93) regarding 24 h milk production (MP) and infant milk intake and demographics, perinatal complications and breastfeeding difficulties, the frequencies of which were compared with published general population frequencies. Pumping efficacy and milk flow parameters during a pumping session in PP mothers (<i>n</i> = 32) were compared with those that pump occasionally (reference group, <i>n</i> = 60).</p><p><strong>Results: </strong>PP mothers had a higher frequency of pregnancy complications and breastfeeding difficulties than the general population. Exclusive pumping did not impact the 24 h MP and the amount of milk available to the infant. PP mothers had more milk ejections, longer active flow duration and lower milk removal efficacy ratios; however, responsiveness to pump (time to first milk ejection), total flow duration, time to stop pumping, percentage of available milk removed and comfort parameters were not different to the reference group.</p><p><strong>Conclusions: </strong>Despite the reported challenges, when an effective pump is used, predominant or exclusive pumping does not negatively affect the 24 h MP and the amount of milk available to the infant. Increasing awareness of the impacts of perinatal and breastfeeding complications on women may assist health professionals in early identification of mothers at high risk for early cessation of breastfeeding, escalating early postpartum intervention and targeted breastfeeding support.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11768336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Vitamin D Deficiency Is a Risk Factor for Infants' Epigenetic Gestational Age Acceleration at Birth in Japan: A Cohort Study.","authors":"Tomoko Kawai, Seung Chik Jwa, Kohei Ogawa, Hisako Tanaka, Saki Aoto, Hiromi Kamura, Naho Morisaki, Takeo Fujiwara, Kenichiro Hata","doi":"10.3390/nu17020368","DOIUrl":"10.3390/nu17020368","url":null,"abstract":"<p><strong>Background/objectives: </strong>The DNA methylation of neonatal cord blood can be used to accurately estimate gestational age. This is known as epigenetic gestational age. The greater the difference between epigenetic and chronological gestational age, the greater the association with an inappropriate perinatal fetal environment and development. Maternal vitamin D deficiency is common in Japan. The aim of this study was to investigate the associations between maternal serum vitamin D levels and epigenetic gestational age acceleration at birth in Japan.</p><p><strong>Methods: </strong>The data were obtained from the hospital-based birth cohort study conducted at the National Center for Child Health and Development in Tokyo, Japan. Maternal blood was collected in the second trimester to measure the serum vitamin D concentration. Cord blood was collected at birth to measure serum vitamin D and to extract DNA. DNA methylation was assessed using an Illumina methylation EPIC array. Epigenetic gestational age was calculated using the \"methylclock\" R package. Linear regression analysis was performed to see associations.</p><p><strong>Results: </strong>Maternal serum vitamin D levels in the second trimester were negatively associated with epigenetic gestational age acceleration at birth when calculated by Bohlin's method (regression coefficient [95% CI]: -0.022 [-0.039, -0.005], <i>n</i> = 157), which was still significant after considering infants' sex (-0.022 [-0.039, -0.005]). Cord blood serum vitamin D levels were not associated with epigenetic age acceleration. Maternal age at delivery and birth height were associated in positive and negative ways with epigenetic gestational age acceleration, respectively (0.048 [0.012, 0.085] and -0.075 [-0.146, -0.003]).</p><p><strong>Conclusions: </strong>Maternal vitamin D deficiency was related to an infant's epigenetic gestational age acceleration at birth. These findings suggest that the association between fetal development and maternal vitamin D levels may involve the fetal epigenetic regulation of the fetus.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11769275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Enhancement of Fat-Soluble Vitamin Absorption and Bioefficacy via Micellization in Combination with Selected Plant Extracts In Vitro.","authors":"Stefanie Steinbauer, Melanie Wallner, Lisa-Marie Karl, Theresa Gramatte, Katja Essl, Marcus Iken, Julian Weghuber, Bernhard Blank-Landeshammer, Clemens Röhrl","doi":"10.3390/nu17020359","DOIUrl":"10.3390/nu17020359","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Individuals with special metabolic demands are at risk of deficiencies in fat-soluble vitamins, which can be counteracted via supplementation. Here, we tested the ability of micellization alone or in combination with selected natural plant extracts to increase the intestinal absorption and bioefficacy of fat-soluble vitamins. <b>Methods:</b> Micellated and nonmicellated vitamins D3 (cholecalciferol), D2 (ergocalciferol), E (alpha tocopheryl acetate), and K2 (menaquionone-7) were tested in intestinal Caco-2 or buccal TR146 cells in combination with curcuma (<i>Curcuma longa</i>), black pepper (<i>Piper nigrum</i>), or ginger (<i>Zingiber officinale Roscoe</i>) plant extracts. The vitamin uptake was quantified via HPLC-MS, and bioefficacy was assessed via gene expression analyses or the Griess assay for nitric oxide generation. <b>Results:</b> Micellization increased the uptake of vitamin D into buccal and intestinal cells, with vitamin D3 being more efficient than vitamin D2 in increasing the expression of genes involved in calcium transport. The micellization of vitamin E acetate increased its uptake and conversion into biologically active free vitamin E in intestinal cells only. The vitamin K2 uptake into buccal and intestinal cells was increased via micellization. Plant extracts increased the uptake of select micellated vitamins, with no plant extract being effective in combination with all vitamins. The curcuma extract increased the uptake of vitamins D2/D3 but not their bioefficacy. Black pepper and ginger extracts increased the uptake of vitamin E acetate into intestinal cells but failed to increase its conversion into free vitamin E. The ginger extract augmented the uptake of vitamin K2 and increased NO generation additively. <b>Conclusions:</b> Our data substantiate the positive effects of micellization on fat-soluble vitamin absorption and bioefficacy in vitro. While the application of plant extracts in addition to micellization to further increase bioefficacy is an interesting approach, further studies are warranted to understand vitamin-specific interactions and translation into increased bioefficacy.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11769215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brussels Chicory Enhances Exhaustive Aerobic Exercise Performance and Post-Exercise Recovery, Possibly Through Promotion of Lactate Oxidation: A Pilot Randomized, Single-Blind, Placebo-Controlled, Two-Way Crossover Study.","authors":"Yihui Mao, Junhao Huang, Shuangshuang Li, Guanyu Chen, Yushi Du, Mengxi Kang, Shasha Zhu, Wenyu Zhang, Qiuhui Xu, Yihan Wang, Wenhua Ling, Xijuan Luo, Dongliang Wang","doi":"10.3390/nu17020365","DOIUrl":"10.3390/nu17020365","url":null,"abstract":"<p><strong>Background: </strong>Brussels chicory affluent in phenolic acids could inhibit atherosclerosis; however, its effects on exercise performance and post-exercise recovery are unknown. We hypothesized that Brussels chicory could enhance exhaustive aerobic exercise performance and post-exercise recovery by promoting lactate oxidation.</p><p><strong>Methods: </strong>This is a single-blind, randomized, placebo-controlled two-way cross-over trial involving 32 untrained college students (men 18) who consumed either Brussels chicory juice (100 g of Brussels chicory containing ~130 mg phenolic acids and 180 mL fresh milk) or placebo (180 mL fresh milk) for 7 days with a 2-week washout period. On the 7th day, participants received a short-term, progressive workload, high-intensity, exhaustive aerobic exercise with the Bruce protocol. Time to exhaustion and blood lactate were evaluated after exercise. C2C12 myotubes were treated with Brussels chicory phenolic acids (0.625-10 μM) to evaluate these effects on lactate metabolism and lactate dehydrogenase A (LDHA) and B (LDHB), two enzymes responsible for lactate biosynthesis and oxidation, respectively.</p><p><strong>Results: </strong>Brussels chicory consumption increased time to exhaustion by 8.3% and 12.2% for men and women participants, respectively. This administration also promoted post-exercise recovery, evidenced by a reduction in blood lactate (14.5% for men and 10.6% for women). In C2C12 myotubes, Brussels chicory protocatechuic acid and caffeic acid did not affect LHDA-mediated lactate production, whereas these compounds dose-dependently promoted LDHB-mediated lactate oxidation through an enrichment of mitochondria LDHB.</p><p><strong>Conclusions: </strong>Dietary supplementation with Brussels chicory may enhance short-term, progressive workload, high-intensity, exhaustive aerobic exercise performance and post-exercise recovery in humans, possibly by accelerating LDHB-mediated lactate oxidation.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11769108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation and Adaptation of the SCOFF Questionnaire to the Greek Language (G-SCOFF) Using a Tertiary-Setting Adolescent Sample.","authors":"Eleni G Paschalidou, Athina Markopoulou, Maria G Grammatikopoulou, Aristea Gioxari, Alexandra Foscolou, Eirini Karagiannopoulou, Tonia Vassilakou, Dimitrios G Goulis, Kyriaki Tsiroukidou, Efstratia Daskalou","doi":"10.3390/nu17020347","DOIUrl":"10.3390/nu17020347","url":null,"abstract":"<p><strong>Background/objectives: </strong>Feeding and eating disorders (FEDs) constitute an important mental health problem today, especially among youngsters. The Sick, Control, One, Fat, Food (SCOFF) questionnaire was developed 25 years ago and remains the most frequently applied screening tool for FEDs among adults and youngsters. The aim of the present study was to translate and adapt the SCOFF questionnaire to the Greek language, using a tertiary-setting adolescent sample.</p><p><strong>Methods: </strong>A total of 167 adolescents (86 boys, 81 girls) admitted to the pediatric outpatient clinics of the Georgios Gennimatas and Hippokration General hospitals completed the SCOFF questionnaire. Anthropometric indices were measured and dietary intake was recorded.</p><p><strong>Results: </strong>A total of 74 adolescents (44.3% of the sample) were classified as engaging in disordered eating behaviors and as possible patients with FEDs based on the SCOFF questionnaire. No differences were noted in the dietary intake between adolescents who screened positive and those who screened negative for FEDs. The body mass index z-score and obesity status were greater among children screening positive for FEDs compared to those screening negative (<i>p</i> < 0.01). One patient who was later diagnosed with anorexia nervosa was detected as a possible FED case by the questionnaire.</p><p><strong>Conclusions: </strong>The present study revealed that more than two out of five adolescents attending a pediatric clinic exhibited disordered eating behavior. The use of the G-SCOFF questionnaire is feasible and effective for FED triage in the Greek tertiary pediatric setting.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11768605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Caffeine Intake Combined with Self-Selected Music During Warm-Up on Anaerobic Performance: A Randomized, Double-Blind, Crossover Study.","authors":"Bopeng Qiu, Ziyu Wang, Yinkai Zhang, Yusong Cui, Penglin Diao, Kaiji Liu, Juan Del Coso, Chang Liu","doi":"10.3390/nu17020351","DOIUrl":"10.3390/nu17020351","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Both listening to music during warm-up and consuming caffeine before exercise have been independently shown to enhance athletic performance. However, the potential synergistic effects of combining these strategies remain largely unexplored. To date, only two studies have reported additional benefits to combining music during warm-up with a caffeine dose of 3 mg/kg on taekwondo-specific performance tasks. However, these studies did not evaluate whether this combination produces additive or synergistic effects on other types of sports performance. The present study aimed to assess the effects of listening to music alone or combined with caffeine intake on performance in the Wingate anaerobic test (WAnT) in physically active subjects.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Twenty-four physically active male participants took part in this randomized, double-blind, crossover experiment. Participants underwent WAnT performance evaluations under three conditions: (i) no intervention (control; CON); (ii) music plus placebo (Mus + PLA), involving the intake of a placebo (maltodextrin) 60 min prior and self-selected high-tempo music during warm-up; and (iii) music plus caffeine (Mus + CAF), involving the intake of 3 mg/kg of caffeine 60 min prior and self-selected high-tempo music during warm-up. Under all conditions, participants wore the same Bluetooth headphones (with or without music), performed a 10 min standardized warm-up, and completed the 30 s WAnT with a load of 7.5% of their body weight on a calibrated ergometer. Power output was recorded at a frequency of 1 Hz throughout the exercise. The Feeling Scale was assessed both before and after the exercise test, while heart rate (HR) and the rating of perceived exertion (RPE) were measured immediately following the exercise.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Mus + PLA and Mus + CAF significantly improved peak power, mean power, and total work compared with CON (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). Furthermore, peak power was higher in Mus + CAF than in Mus + PLA (&lt;i&gt;p&lt;/i&gt; = 0.01). Post-exercise HR and RPE showed no significant differences across conditions (&lt;i&gt;p&lt;/i&gt; &gt; 0.05). Regarding the Feeling Scale (FS) before exercise, the Mus + PLA and Mus + CAF conditions showed significantly higher scores than CON (&lt;i&gt;p&lt;/i&gt; &lt; 0.05), while no differences were found after exercise. The perceived fitness metrics displayed no significant differences among conditions (&lt;i&gt;p&lt;/i&gt; &gt; 0.05), except for self-perceived power, which was higher in Mus + CAF than in CON (&lt;i&gt;p&lt;/i&gt; = 0.03).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Self-selected music during warm-up, either alone or combined with caffeine, significantly enhanced several WAnT performance metrics, including peak power, mean power, and total work. Remarkably, combining music with caffeine further improved peak power and increased self-perceived power compared with music alone. While listening to self-selected music during warm-up provided measurable benefits on anae","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11768035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction.","authors":"Lokesh Kumar Mende, Yaswanth Kuthati, Chih-Shung Wong","doi":"10.3390/nu17020349","DOIUrl":"10.3390/nu17020349","url":null,"abstract":"<p><p><b>Background:</b> Knee osteoarthritis (OA) is a common and debilitating disorder marked by joint degradation, inflammation, and persistent pain. This study examined the possible therapeutic effects of curcumin and vitamin D on OA progression and pain in a rat knee OA model by anterior cruciate ligament transection and meniscectomy (ACLT + MMx). <b>Methods:</b> Male Wistar rats were categorized into five groups: control, curcumin-treated (100 mg/kg/day), vitamin D-treated (25 µg/kg/day), a combination of vitamin D and curcumin, and sham-operated. All supplements were administered orally on a daily basis for 12 weeks. Pain behaviors were assessed, serum biomarkers were measured, and knee histology was examined. <b>Results:</b> Both curcumin and vitamin D independently reduced pain, while the combined group exhibited better analgesic effects. Serum inflammatory cytokines demonstrated a decrease in pro-inflammatory cytokines and an elevation in anti-inflammatory cytokine interleukin-10 (IL-10) in the supplement groups. The antioxidative markers were partially recovered by curcumin and vitamin D supplement. However, the oxidative stress marker Cartilage Oligomeric Matrix Protein (COMP) was significantly reduced. Histology analysis revealed a preservation of joint architecture and cartilage integrity and decreased synovium inflammation in the groups treated with curcumin and vitamin D. <b>Conclusions:</b> Our findings indicate a dual mechanism that encompasses the role of anti-inflammation and antioxidation on knee OA progression and pain reduction, underscoring the potential of these natural chemicals as therapeutic agents for knee OA; curcumin and vitamin D supplement may be added in delaying knee OA progression and associated pain management in clinical patient care.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11768869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin K1 Administration Increases the Level of Circulating Carboxylated Osteocalcin in Critically Ill Patients.","authors":"Nadide Aydin, Thomas Kander, Ulf Schött, Sassan Hafizi","doi":"10.3390/nu17020348","DOIUrl":"10.3390/nu17020348","url":null,"abstract":"<p><strong>Background/objectives: </strong>Vitamin K-dependent proteins (VKDPs) all commonly possess specially modified γ-carboxyglutamic acid residues created in a vitamin K-dependent manner. Several liver-derived coagulation factors are well characterised VKDPs. However, much less is known about extrahepatic VKDPs, which are more diverse in their molecular structures and functions, and some of which have been implicated in inflammatory disorders. Vitamin K metabolism was shown to be impaired in critically ill patients, in whom systemic inflammation and sepsis are common features. Therefore, the aim of this study was to investigate the effect of vitamin K administration to these patients on their circulating levels of selected VKDPs. A particular novelty of this study was the measurement of specifically carboxylated forms of these proteins in addition to their overall levels.</p><p><strong>Methods: </strong>Blood samples were taken from 47 patients in the intensive care unit before and approximately 24 h after intravenous vitamin K1 (10 mg) administration, and proteins were analysed by specific immunoassay.</p><p><strong>Results: </strong>Vitamin K1 induced increases in plasma levels of carboxylated osteocalcin and total Gas6 (<i>p</i> = 0.0002 and <i>p</i> = 0.0032, respectively). No changes were detected in levels of carboxylated Gas6 or PIVKA-II (undercarboxylated prothrombin), although the latter positively correlated with undercarboxylated osteocalcin (r = 0.38).</p><p><strong>Conclusion: </strong>Injected vitamin K1 increases the blood levels of two distinct VKDPs in critically ill patients, both of which have been implicated in inflammation regulation, including the increased carboxylation of one of them.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11768845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}