Nutrients最新文献

{"title":"Prenatal Vitamin D, Multivitamin, and Folic Acid Supplementation and Brain Structure in Children with ADHD and ASD Traits: The Generation R Study.","authors":"Daan van Rooij, Yuchan Mou, Tonya White, Trudy Voortman, Pauline W Jansen, Jan K Buitelaar","doi":"10.3390/nu17182979","DOIUrl":"10.3390/nu17182979","url":null,"abstract":"<p><strong>Background/objectives: </strong>Maternal vitamin supplementation (including folic acid, vitamin D, and multivitamin supplements) during pregnancy may lower the likelihood of neurodevelopmental disorders in offspring. This study examines the associations between maternal vitamin suppletion during pregnancy and morphological patterns in offsprings' brain structure and traits of Autism Spectrum Disorder (ASD) and Attention-Deficit Hyperactivity Disorder (ADHD) in a large population-based study of child development.</p><p><strong>Methods: </strong>The study cohort included a total of 3937 children (aged 9-11) participating in the Generation R cohort in Rotterdam, the Netherlands. Maternal vitamin D and folateserum levels, multivitamin supplement use, and overall dietary quality (as assessed by the Food Frequency Questionnaire, FFQ) during pregnancy were used as predictors. T1 structural MRI scans were acquired and segmented using Freesurfer to assess brain morphometry. Cortical and subcortical brain volumes of children were separated into four independent components and used as mediators. ADHD and ASD traits, as measured by parent-completed questionnaires (Child Behavior CheckList and Social Responsiveness Scale, respectively) were used as outcome variables.</p><p><strong>Results: </strong>Results show that (1) maternal vitamin D, multivitamin supplementation, and better diet quality were associated with fewer ADHD or ASD traits in the offspring; (2) vitamin D and diet quality were associated with larger-volume childhood brain components; (3) larger-volume brain components were associated with fewer ADHD and ASD traits; (4) part of the association between dietary factors in pregnancy and offspring ADHD and ASD traits was mediated through the brain volumes of the children.</p><p><strong>Conclusions: </strong>Though all observed effect sizes were small, further population-based research should be performed to further delineate the effects of gestational multivitamin and vitamin D exposure and investigate whether this may be an avenue for preventive interventions.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 18","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composite Meal-Related Behaviors and Health Indicators: Insight from Large-Scale Nationwide Data on Korean Adults.","authors":"Seongryu Bae, Hyuntae Park","doi":"10.3390/nu17182982","DOIUrl":"10.3390/nu17182982","url":null,"abstract":"<p><p><b>Objectives:</b> Multidimensional dietary patterns provide a more comprehensive assessment of meal-related behavior than single behaviors, yet evidence on their variation across adulthood and association with health factors relevant to healthy aging is limited. This study examined meal-related behavior pattern distribution by age and identified predictors of unhealthy patterns. <b>Methods:</b> Data from 47,332 adults aged ≥ 18 years in the Korea National Health and Nutrition Examination Survey (2014-2022) were analyzed. Participants were divided into three age groups: young adults (18-39 years), middle-aged adults (40-64 years), and older adults (≥65 years). Within each age group, participants were further classified into three categories based on their adherence to three key meal-related behaviors: High adherence (all three behaviors: regular breakfast, shared mealtimes, and infrequent eating out), Moderate adherence (two behaviors), or Low adherence (one or none). Group differences in sociodemographic, clinical variables, nutrient intake, biochemical markers, and lifestyle factors were tested using ANOVA and Pearson's chi-square, and predictors were identified with multinomial logistic regression. <b>Results</b>: Older adults most frequently showed the High adherence group (51.1%) but had the lowest prevalence of shared mealtimes (66.3%), suggesting social vulnerabilities despite healthy individual habits. Young adults had the highest Low pattern prevalence, which was primarily driven by infrequent breakfast and frequent eating out. Across all ages, poorer patterns were consistently associated with living alone, prolonged sedentary time, and adverse metabolic profiles. Middle-aged adults exhibited moderate adherence to healthy behaviors but showed the highest prevalence of chronic disease. In older adults, poorer patterns were associated with lower intakes of energy, carbohydrate, protein, and dietary fiber intake, alongside higher rates of living alone and sedentary behavior. <b>Conclusions:</b> Composite meal-related behaviors differed across age groups as follows: Young adults most frequently exhibited low adherence, middle-aged adults showed moderate adherence but bore the highest burden of chronic diseases, while older adults demonstrated high breakfast adherence and low frequency of eating out, but faced nutritional insufficiency and social vulnerability. These findings suggest the need for personalized interventions for each age group.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 18","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public Health, Nutritional Behavior, and Nutritional Status: An Editorial Synthesis and Roadmap for Precision Nutrition.","authors":"Sabina Lachowicz-Wiśniewska, Agata Kotowska","doi":"10.3390/nu17182968","DOIUrl":"10.3390/nu17182968","url":null,"abstract":"<p><p>In the face of growing lifestyle-related health concerns across many populations-such as obesity and poor diet-understanding the determinants of these behaviors is crucial for designing effective public health strategies [...].</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 18","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Ketogenic Diet Through a Metabolomic Lens: Biochemical Pathways, Therapeutic Applications, and Analytical Challenges.","authors":"Katarzyna Idzikowska, Paulina Gątarek, Anna Gajda, Piotr Safiński, Lukasz Przyslo, Joanna Kałużna-Czaplińska","doi":"10.3390/nu17182969","DOIUrl":"10.3390/nu17182969","url":null,"abstract":"<p><strong>Background: </strong>The ketogenic diet (KD), a high-fat and low-carbohydrate dietary approach, has been used therapeutically in drug-resistant epilepsy and other neurological and metabolic disorders. Recent interest has shifted toward understanding its broader metabolic effects through metabolomics. This review aims to summarize current knowledge on the biochemical mechanisms and therapeutic implications of the KD, with a particular focus on metabolomic profiling and neurological health.</p><p><strong>Methods: </strong>This narrative review synthesizes findings from the last five years of metabolomic studies investigating the biochemical consequences of the KD and its variants, including the classical KD, modified Atkins diet (MAD), medium-chain triglyceride diet (MCT), and low glycemic index treatment (LGIT). The review integrates data on analytical techniques, such as liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS), and evaluates alterations in key metabolic pathways.</p><p><strong>Results: </strong>The KD significantly modulates energy metabolism, shifting adenosine triphosphate (ATP) production from glycolysis to fatty acid oxidation and ketone body utilization. It affects mitochondrial function, one-carbon metabolism, redox balance, neurotransmitter regulation, and gut-brain axis signaling. Metabolomic profiling has identified β-hydroxybutyrate (βHB) as a key regulatory metabolite influencing mitochondrial respiration. Long-term KD use may impact renal and hepatic function, necessitating clinical caution and individualized nutritional monitoring.</p><p><strong>Conclusions: </strong>Metabolomic analysis provides critical insights into the multifaceted effects of the KD, supporting its role as a targeted metabolic therapy in neurological diseases. However, potential risks linked to prolonged ketosis warrant further investigation. Future studies should focus on personalized applications and long-term safety profiles of KD variants across patient populations.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 18","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron: More than Meets the Eye.","authors":"Ethan R Naquin, Richa Garg, William J Chen, Eshani Karmakar, Amogh Prasad, Saicharan Mandadi, Kiran Depala, Jyotsna S Gopianand, Jaya P Gnana-Prakasam","doi":"10.3390/nu17182964","DOIUrl":"10.3390/nu17182964","url":null,"abstract":"<p><p>Iron is an essential micronutrient integral to ocular physiology, supporting biochemical processes such as mitochondrial respiration, DNA synthesis and phototransduction. Disruptions in systemic or local iron homeostasis, whether due to overload or deficiency, have been increasingly implicated in the pathogenesis of a broad range of anterior and posterior segment ocular disorders. Iron deficiency may compromise retinal bioenergetics, impair cellular repair, and increase susceptibility to oxidative stress, while iron overload facilitates the generation of reactive oxygen species, contributing to lipid peroxidation, mitochondrial dysfunction, and ferroptosis. Dysregulated iron metabolism has been associated with several ocular pathologies, including age-related macular degeneration, diabetic retinopathy, glaucoma, retinal detachment, cataracts, and anemic retinopathy. The eye possesses specialized iron regulatory mechanisms involving proteins such as transferrin, ferritin, ferroportin, and hepcidin that govern iron transport, storage, and export across ocular barriers. Aberrations in these pathways are now recognized as contributing factors in disease progression. This narrative review explores the complex dual role of iron overload and deficiency in ocular diseases. It highlights the molecular mechanisms underlying iron-mediated pathologies in both the posterior and anterior segments of the eye, along with the clinical manifestations of iron imbalance. Current therapeutic approaches are discussed, including oral and parenteral iron supplementation for deficiency and emerging chelation-based or antioxidant strategies to address iron overload, while highlighting their limitations. Key challenges remain in developing targeted ocular delivery systems that optimize bioavailability and minimize systemic toxicity. Hence, maintaining iron homeostasis is critical for visual function, and further research is needed to refine therapeutic interventions and clarify the mechanistic role of iron in ocular health and disease.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 18","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Adherence to the Mediterranean Diet on Vascular Health and Healthy Aging in Women: Assessment Using CAVI.","authors":"Inés Llamas-Ramos, Rocío Llamas-Ramos, María Cortés Rodríguez, Emiliano Rodríguez-Sánchez, Manuel A Gómez-Marcos, Marta Gómez-Sánchez, Leticia Gómez-Sánchez","doi":"10.3390/nu17182963","DOIUrl":"10.3390/nu17182963","url":null,"abstract":"<p><p><b>Background:</b> Vascular aging, characterized by a progressive increase in arterial stiffness, is associated with an increased risk of cardiovascular disease. The Mediterranean diet (MD) has been shown to have protective effects on cardiovascular health, but its relationship with vascular aging, as assessed by the Cardio-Ankle Vascular Index (CAVI), is not yet well established. <b>Objective:</b> To analyze the association between adherence to the MD and vascular aging estimated with CAVI in a sample of Spanish women with no history of previous cardiovascular disease. <b>Methods:</b> A cross-sectional study was conducted in 1468 women (aged 30-80 years), classified into three categories according to CAVI: healthy vascular aging (HVA), normal (NVA), and early (EVA). Adherence to the MD was assessed using the MEDAS questionnaire validated in Spain. ANOVA and chi-square tests were used to compare baseline characteristics, and multinomial logistic regression was used to analyze the association between MD adherence and vascular aging status, adjusting for age, sex, and drug treatment. <b>Results:</b> The CAVI increased progressively with age (<i>p</i> < 0.001) and was associated with higher blood pressure, dyslipidemia, hyperglycemia, and diabetes mellitus. Adherence to the MD was significantly higher in groups with lower arterial stiffness (<i>p</i> < 0.001). In the multivariate analysis, greater adherence to MD was associated with a higher probability of healthy vascular aging compared to NVA (OR: 1.872; 95% CI: 1.366-2.566; <i>p</i> < 0.001) and EVA (OR: 1.738; 95% CI: 1.363-2.218; <i>p</i> < 0.001). <b>Conclusions:</b> Greater adherence to the MD is associated with a healthier vascular aging profile. Promoting this dietary pattern may be an effective strategy for preventing arterial stiffness and reducing the cardiovascular risk associated with aging.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 18","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of <i>Cistanche deserticola</i> Y.C. Ma Supplementation on Muscle Strength and Recovery: A Randomized Controlled Trial.","authors":"Biaoxu Tao, Weihao Lian, Rongrong Min, Xiaoyu Zhang, Liqi Chen, Sun Hao, Ze Li, Chengzhe Ma, Haojie Zhang, Chang Liu","doi":"10.3390/nu17182965","DOIUrl":"10.3390/nu17182965","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effects of <i>Cistanche deserticola</i> Y.C. Ma (CD) supplementation on muscle strength and recovery in individuals with and without resistance training experience.</p><p><strong>Methods: </strong>A randomized, double-blind, placebo-controlled trial was conducted with 48 male participants, including 24 resistance-trained and 24 untrained individuals. Participants were stratified by training status and randomly assigned to either the CD or placebo (PLAC) group. All subjects completed a standardized resistance training program three times per week for eight weeks. The CD group received 5 g of CD extract twice daily, while the PLAC group consumed a matched placebo. Assessments included one-repetition maximum (1RM) for bench press and squat, maximal voluntary isometric contraction (MVIC), and repetitions to failure (RTF). Blood biomarkers including serum testosterone, cortisol, C-reactive protein (CRP), and creatine kinase (CK) were also measured.</p><p><strong>Results: </strong>No significant differences in dietary energy intake or macro-nutrient composition were observed based on two 5-day dietary records collected before baseline testing and at the end of the intervention. Among untrained individuals, the CD group showed significantly greater improvements in 1RM bench press and squat compared with the PLAC group (<i>p</i> < 0.05), with MVIC and RTF also significantly increased (<i>p</i> < 0.01). Serum cortisol levels were reduced (<i>p</i> < 0.05), and significant improvements were observed in testosterone, CRP, and CK (<i>p</i> < 0.01). In trained individuals, CD supplementation led to significant increases in 1RM squat and MVIC (<i>p</i> < 0.05), along with improvements in testosterone and cortisol levels (<i>p</i> < 0.05) and marked reductions in CRP and CK (<i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>Daily supplementation with 5 g of CD extract for eight consecutive weeks significantly enhanced muscle strength and endurance in males with different training backgrounds and facilitated post-exercise recovery by modulating hormonal responses and reducing stress levels and inflammation. These findings provide experimental evidence supporting the application of CD in sports nutrition.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 18","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Essential Amino Acid Supplementation on Hippocampal Neurotrophin, Dopaminergic and Serotonergic Changes in an Overtraining Mouse Model.","authors":"Lior Binman, Tavor Ben-Zeev, Asher Harris, Chagai Levi, Inbal Weissman, David D Church, Arny A Ferrando, Jay R Hoffman","doi":"10.3390/nu17182957","DOIUrl":"10.3390/nu17182957","url":null,"abstract":"<p><p><b>Background/Objectives</b>: This study examined the efficacy of essential amino acid (EAA) supplementation on changes in behavior and hippocampal neurotrophin, dopaminergic and serotonergic markers to a volume overload stress resembling an overtraining syndrome. <b>Methods</b>: Thirty-two 3-month-old male C57Bl/6J mice were randomized into four groups: Resistance training (RT), resistance training with overtraining (RTO), resistance training with overtraining and EAA (RTOEAA), or control. Mice in RTOEAA received EAA supplementation (1.5 g·kg·day^-1), while the other groups received a sham treatment. A 5-week resistance training protocol was employed. Training volume was increased two-fold during the final two weeks for RTO and RTOEAA to cause the OTS. EAA intervention for RTOEAA occurred during the OTS. <b>Results</b>: A significant decline in the maximum resistance carrying load in RTO compared to RT (<i>p</i> = 0.002) and RTOEAA (<i>p</i> = 0.029) confirmed that the animals in that group were overtrained. Significantly greater average latency times for RTO compared to RT (<i>p</i> = 0.009) and C (<i>p</i> = 0.05) indicated that the OTS caused spatial memory deficits in animals that were not supplemented. These latter changes may have been related to the significant declines in brain derived neurotrophic (BDNF) expression and elevations in dopamine 1 receptor (D1R) expressions. Increased resiliency for RTOEAA may have been related to the effect of EAA on stimulating significant increases in the expression of hippocampal tyrosine receptor kinase B (TrkB) and serotonin receptors (5-HT1A). <b>Conclusions</b>: EAA supplementation during a resistance model of overtraining appeared to provide increased resiliency to OTS by maintaining neurotrophin expression and enhancing serotonergic adaptation.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 18","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review of Contextual and Individual Factors for Hospital-Acquired Malnutrition Development in Adult Hospital Inpatients: Guiding a Proactive Preventative Approach.","authors":"Vivien Hui In Cheung, Ching Shan Wan","doi":"10.3390/nu17182970","DOIUrl":"10.3390/nu17182970","url":null,"abstract":"<p><strong>Background: </strong>Preventing nutritional decline during hospitalisation is imperative in reducing the development of complications such as malnutrition and pressure injuries. However, existing malnutrition screening and assessment tools employ a reactive rather than proactive approach, using predictors to identify inpatients who are already malnourished instead of those at risk of developing hospital-acquired malnutrition. Therefore, this review aimed to identify key contextual and individual factors contributing to nutritional deterioration and their interrelatedness, and to inform strategies for preventing hospital-acquired malnutrition.</p><p><strong>Methods: </strong>A scoping review of five databases (Medline, CINAHL, Embase, All EBM Reviews and PsycINFO) up to June 2024 was conducted to include English-language studies that reported statistically significant risk factors for changes in nutritional status during hospitalisation. A directed acyclic graphing method was used to visualise the interlinkage between contextual and individual risk factors identified. PRISMA Extension for Scoping Reviews was followed in reporting.</p><p><strong>Results: </strong>Of 8215 retrieved abstracts, 51 studies were included. Four contextual (ward type; food service satisfaction; medical-related mealtime interruption; nutrition care collaboration) and four individual factors (nutritional status prior admission; hospital length of stay; multimorbidity; disease acuity) were found to significantly predict nutritional decline during hospitalisation and were closely interrelated.</p><p><strong>Conclusions: </strong>More contextual risk factors are modifiable, suggesting a need for organisational strategies to optimise collaborative nutrition care and improve patient satisfaction with hospital food services to promote early nutritional intervention, particularly within the first three days of admission and for inpatients with multimorbidity, high disease acuity, or pre-existing malnourishment.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 18","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Diet and Exercise on Mitochondrial Health in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Role of Ceramides.","authors":"Jonas M McCaffrey, Jamal A Ibdah","doi":"10.3390/nu17182972","DOIUrl":"10.3390/nu17182972","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) impacts nearly a quarter of the world's population and encompasses a range of disease states, from simple steatosis to more advanced stages like metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and cirrhosis. A key driver of disease progression is mitochondrial dysfunction, characterized by impaired fatty acid oxidation and an overall decline in mitochondrial health. Emerging evidence has implicated ceramides-bioactive sphingolipids that serve roles in apoptotic pathways and as signals of nutrient excess-as important contributors to this dysfunction. Ceramide accumulation within mitochondria mirrors impairments seen in MASLD, specifically elevations in oxidative stress, disrupted fatty acid oxidation, and impaired mitochondrial dynamics. Ceramides may serve as an important molecular link between nutrient overload and mitochondrial dysfunction in the pathogenesis of MASLD. Given the limited availability of effective pharmacologic therapies for MASLD, lifestyle interventions like dietary modification and physical activity remain the cornerstone of disease management worldwide. In this review, we provide an overview of the current understanding of the role of ceramides in mediating the effects of diet and exercise on MASLD through their influence on mitochondrial health.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 18","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12473040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}