Nutrients最新文献

{"title":"Development and Validation of the China Dietary Inflammatory Index (CHINA-DII).","authors":"Yuhang Chen, Zhijie Luo, Lu Cheng, Qingying Wang, Fengqin Zou, Mohammad Abidullah Warsi, Yulan Lin","doi":"10.3390/nu17101687","DOIUrl":"10.3390/nu17101687","url":null,"abstract":"<p><p><b>Objective:</b> To develop and validate the China Dietary Inflammatory Index (CHINA-DII) for Chinese adults. <b>Methods:</b> A systematic literature search was conducted to identify studies published between 2009 and 2024 reporting dietary intake levels among Chinese adults. After applying inclusion and exclusion criteria and evaluating study quality, a dietary intake database for Chinese adults was established. Following the methodology of the original Dietary Inflammatory Index (DII), the CHINA-DII was constructed and validated. A total of 256 newly diagnosed gastric cancer patients who visited the Union Hospital of Fujian Medical University between June 2023 and November 2024 were recruited. Demographic information, clinical data, and dietary data based on a food frequency questionnaire (FFQ) were collected. Spearman rank correlation was used to assess the relationship between CHINA-DII scores and high-sensitivity <i>C</i>-reactive protein (hs-CRP) levels. <b>Results:</b> A total of 33 eligible studies were included to develop a dietary intake database encompassing 27 dietary components. Among the 256 gastric cancer patients, the average CHINA-DII score was -1.91 ± 0.35, and the mean hs-CRP level was 3.68 ± 2.35 mg/L. CHINA-DII scores were positively correlated with hs-CRP levels (r = 0.20, <i>p</i> ≤ 0.001). Multivariate logistic regression analysis showed that individuals with higher CHINA-DII scores had a 1.90-fold increased risk of hs-CRP ≥ 3 mg/L compared to those with lower scores (odds ratio, OR = 1.90; 95% confidence interval, 95%CI: 1.01-3.55). For each 1-standard-deviation (SD) increase in CHINA-DII score, the risk of hs-CRP ≥ 3 mg/L increased by 1.50 times (OR = 1.50, 95% CI: 1.10-2.06). <b>Conclusions:</b> The CHINA-DII developed in this study effectively reflects the potential inflammatory impact of dietary intake in Chinese adults and is significantly positively associated with the inflammatory marker hs-CRP, indicating good validity and applicability.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between the American Heart Association Life's Essential 8 and Metabolic Syndrome Among Postmenopausal Women: Findings from NHANES 2011-2020.","authors":"Harshini Meegaswatte, Andrew J McKune, Demosthenes B Panagiotakos, Sukhuntha Osiriphun, Noppol Leksawasdi, Pornchai Rachtanapun, Martin Veysey, Nenad Naumovski, Siraphat Taesuwan","doi":"10.3390/nu17101688","DOIUrl":"10.3390/nu17101688","url":null,"abstract":"<p><p><b>Background:</b> Postmenopausal women face increased risk of developing metabolic syndrome (MetS) and cardiovascular disease (CVD) due to hormone changes during menopause. Life's Essential 8 (LE8), a relatively new cardiovascular health assessment index by the American Heart Association, may impact MetS diagnostics and potential treatment strategies. This study investigated the association between LE8 and MetS among postmenopausal women. <b>Methods</b>: National Health and Nutrition Examination Survey (NHANES) data were extracted (2011-2020). LE8 comprised eight health behaviours and factors (score of 0-100) classified into low (0-49), moderate (50-79), and high (80-100) cardiovascular health status. MetS was defined as metabolic dysfunctions comprising insulin resistance, central obesity, dyslipidaemia, impaired glucose metabolism, and hypertension. Complex survey-adjusted regression models were used. Effect modification by race and female hormone use were investigated. <b>Results</b>: 5402 postmenopausal women were included (mean age: 63.0 y), and 3152 (58.3%) met MetS criteria. LE8 scores for those with and without MetS were 58 ± 13.8 and 70 ± 14.1 (<i>p</i> < 0.001), respectively (mean ± SD). Higher LE8 scores were associated with lower odds of having MetS (Odds ratio (OR) for a 10-score increase: 0.53, 95% CI: [0.48, 0.57], <i>p</i> < 0.001). Nicotine exposure score was inversely associated with the likelihood of having MetS (0.52 [0.34, 0.80], <i>p</i> = 0.022). The association between LE8 status and odds of MetS differed by race (<i>p-interaction</i> = 0.01); 'moderate' or 'high' cardiovascular health status lowered odds of MetS in all races except other/multi-racial. <b>Conclusions</b>: The inverse relationship between LE8 scores and MetS suggests that integrating LE8 components into management strategies may help prevent CVD in postmenopausal women.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial Consequences of Excess Weight and the Importance of Physical Activity in Combating Obesity in Children and Adolescents: A Pilot Study.","authors":"Małgorzata Wąsacz, Izabela Sarzyńska, Danuta Ochojska, Joanna Błajda, Oliwia Bartkowska, Karolina Brydak, Szymon Stańczyk, Martyna Bator, Marta Kopańska","doi":"10.3390/nu17101690","DOIUrl":"10.3390/nu17101690","url":null,"abstract":"<p><p><b>Introduction:</b> Overweight and obesity among children and adolescents are a growing public health problem. The aim of this study was to determine the impact of overweight and obesity on the psychosocial functioning and physical activity levels of children and adolescents. <b>Methods:</b> This study was conducted among 100 children and adolescents aged 9-18 from three institutions in the Podkarpackie Province: a primary school, a hospital ward, and a health resort. An original questionnaire was used, containing questions about body image, emotions related to eating, self-esteem, and physical activity. All participants were classified into appropriate BMI categories based on anthropometric data. <b>Results:</b> The analysis showed that 48% of respondents admitted to eating meals in secret, and 5% did so every day for a month. As many as 65.82% of participants stated that their body shape affects the way they think about themselves, and more than two-thirds felt frustrated with their figure. Statistically significant differences were observed in the perception of one's own body and the level of its acceptance depending on the BMI category. In addition, 58.58% of respondents did not engage in physical activity to control their weight. <b>Conclusions:</b> The results of this study confirm that overweight and obesity in children and adolescents are associated with a negative body image, low self-esteem, unhealthy eating habits, and low levels of physical activity. The obtained results can be used by medical personnel, educators, and educational institutions to develop effective prevention programs aimed at counteracting the negative consequences of overweight and obesity in children and adolescents.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Vitamin D Status Attenuates Hypolipidemic and Pleiotropic Effects of Atorvastatin in Women.","authors":"Robert Krysiak, Karolina Kowalcze, Witold Szkróbka, Bogusław Okopień","doi":"10.3390/nu17101674","DOIUrl":"10.3390/nu17101674","url":null,"abstract":"<p><p><i>Background/Objectives</i>: Low vitamin D status seems to be associated with increased cardiometabolic risk, and was found to attenuate cardiometabolic benefits of statins in men. The aim of the current study was to investigate whether a different vitamin D status determines the pleiotropic effects of statins in women. <i>Methods</i>: This pilot, single-center, prospective, matched-cohort study included 78 women with hypercholesterolemia requiring statin therapy, assigned into one of three age-, plasma lipid-, and body mass index-matched groups: women with vitamin D deficiency (group I), women with vitamin D insufficiency (group II), and women with normal vitamin D homeostasis (group III). Throughout the study (16 weeks), all patients were treated with atorvastatin. The outcome of interest included plasma lipids, glucose homeostasis markers (fasting glucose, HOMA-IR and glycated hemoglobin), plasma levels of 25-hydroxyvitamin D, creatine kinase, uric acid, high-sensitivity C-reactive protein, homocysteine, fibrinogen, urinary albumin-to-creatinine ratio (UACR), and computed values of a 10-year risk of atherosclerotic events. <i>Results</i>: Compared to the control group (group III), group I was characterized by higher values of HOMA-IR, glycated hemoglobin, uric acid, hsCRP, homocysteine, fibrinogen, a UACR, and a 10-year risk of atherosclerotic events, whereas group II had higher values of hsCRP, homocysteine and a UACR. Atorvastatin reduced plasma levels of total and LDL cholesterol and a 10-year risk of atherosclerotic events in all study groups, but this effect was weakest in group I and strongest in group III. In group III, the drug decreased uric acid, hsCRP, homocysteine, fibrinogen, and the UACR. In the remaining groups, its effect was limited to a small decrease in only hsCRP (group I) or in hsCRP and homocysteine (group II). In group I, atorvastatin treatment was associated with an increase in HOMA-IR, glycated hemoglobin, and creatine kinase. <i>Conclusions:</i> Low vitamin D status may exert an unfavorable effect on the lipid-dependent and lipid-independent effects of atorvastatin in middle-aged or elderly women.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macroelement Content (Na, K, Ca, and Mg) in Microwave Foods.","authors":"Christian E García, Soraya Paz-Montelongo, Arturo Hardisson, Carmen Rubio, Ángel J Gutiérrez, Dailos González-Weller, Javier Darias-Rosales, Samuel Alejandro-Vega","doi":"10.3390/nu17101678","DOIUrl":"10.3390/nu17101678","url":null,"abstract":"<p><strong>Background/objectives: </strong>The consumption of microwave ready meals has increased significantly in recent years due to a noticeable reduction in the available time to spend cooking. However, one of the issues about this type of diet is its nutrient intake. The main objective of this study was to determine the content of macroelements (Na, K, Ca, and Mg) in samples of animal origin (omelette, chicken curry, meatballs, shredded meat, and prawns), vegetable origin (vegetable garnish, round rice, pesto pasta, cream of vegetable soup, and chickpeas with spinach), and mixed origin (pizza, lasagna, seafood paella, cannelloni, and spaghetti Bolognese).</p><p><strong>Methods: </strong>The macroelement content was determined by ICP-OES (Inductively Coupled Plasma-Optical Emission Spectrometry) in 288 samples of different microwave foods.</p><p><strong>Results: </strong>Likewise, the possible difference in the content of macroelements after the microwave heating process was studied, and significant differences in the Ca content were observed in the three analyzed food groups, indicating that there may have been migration from the container to the food. The concentrations of Na and Ca in the tails of garlic prawns (9381 ± 3102 mg Na/kg fw and 845 ± 134 mg Ca/kg fw) stood out. The vegetable side dish stood out for its higher concentration of K (3424 ± 1319 mg/kg fw). Pizza registered the highest concentrations of the four macrolements within the group of foods of mixed origin. The study of the dietary intake indicated that the consumption of some animal-based products offered a contribution to the safe and adequate intake of Na of almost 50%, which could pose a risk of dietary overdose as Na is an element found in many foods.</p><p><strong>Conclusions: </strong>It is recommended to moderate the consumption of some of the dishes analyzed mainly because of the risk of the high intake of Na.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising Rates of Obesity Amongst Children on the Autism Spectrum During the COVID-19 Pandemic.","authors":"Wing Yan Yuen, Tammy S H Lim, S V Karthik, Yijuan Yvonne Lim, Elizabeth M Teo, Yiong Huak Chan, Liang Shen, Kalyani V Mulay","doi":"10.3390/nu17101683","DOIUrl":"10.3390/nu17101683","url":null,"abstract":"<p><p><i>Background:</i> The COVID-19 pandemic has been associated with rising obesity rates. Autistic children have a higher risk of obesity than neurotypical children. Our study aims to describe the changes in overweight/obesity rates in autistic children during the pandemic, and to identify contributing factors. <i>Methods:</i> This is a retrospective case record review of patients with a clinical diagnosis of autism, who were seen at a developmental-behavioral pediatrics clinic in a tertiary academic hospital, between 1 January 2019 and 24 October 2021. We compared the average monthly rates of overweight/obese status pre- and during the pandemic. We collected data on the patients' and parents' demographics, duration of screen time per day, degree of difficulties related to autism symptoms and cognition. We analyzed factors associated with being overweight/obese during the pandemic. <i>Results:</i> 1330 patient visits were included. The mean age was 45.4 months; 78% were male; 52% were Chinese. The average monthly rate of overweight/obese status increased by 1.8% during the pandemic (17.9% pre-pandemic; 19.7% during pandemic). Factors associated with being overweight/obese during the pandemic included: Malay ethnicity (OR 2.321, <i>p</i> < 0.01), developmental delay (OR 2.80, <i>p</i> < 0.01), and lower parental education level (father OR 1.73, <i>p</i> = 0.01; mother OR 1.63, <i>p</i> = 0.03). On multivariate analysis, only Malay ethnicity (OR 2.95, <i>p</i> = 0.01) was significant. <i>Conclusions:</i> Our study demonstrates a rising overweight/obesity rate amongst children with autism spectrum disorder during the pandemic. It also identified higher-risk patient profiles (Malay race, developmental delay, lower parental education). We hope this will facilitate the implementation of preventative health measures specifically supporting the high-risk children.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle Behaviors Associated with Weight Loss Intent in Adolescent Girls: Findings from the US 2021 National Youth Risk Behavior Survey.","authors":"Elinor Fondell, Jaime Vallejos, Andrew J Piazza, Mariana C Calle","doi":"10.3390/nu17101676","DOIUrl":"10.3390/nu17101676","url":null,"abstract":"<p><p><b>Background</b>: External social influences on body image affect females differently than males, and adolescent girls are more likely to want to change their weight status. Understanding the healthy and unhealthy habits of adolescent girls is vital for developing effective and targeted health promotions and interventions. <b>Methods</b>: Using data from the 2021 Youth Risk Behavior Surveillance System (YRBS) survey, this cross-sectional study compares dietary habits, physical activity, vaping, alcohol use, sleep, and screen time in females (9th-12th grades) who intend to lose weight versus those who want to maintain their current weight. <b>Results</b>: The sample consisted of 4362 females, of which 56.7% reported an intent to lose weight. The average BMI percentile was 64.1 compared to 75.4 among those trying to lose weight and 50.1 among those not trying to lose weight. Adolescent girls intending to lose weight also reported less frequent breakfast consumption (OR 0.52; 0.40-0.69), less sleep (OR 0.72; 0.59-0.89), more screen time (OR 1.27; 1.02-1.58), engaging in muscle toning exercises (OR 1.30; 1.07-1.57), vaping (OR 1.22; 1.01-1.47), and alcohol use (OR 1.61; 1.32-1.98) compared to those not intending to lose weight. <b>Conclusions</b>: Adolescent girls trying to lose weight would likely benefit from interventions to help them improve sleep, reduce screen time, improve dietary and exercise habits, and monitor alcohol and vaping use.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of Evidence on the Role of Ready-to-Eat Cereals in Diet and Non-Communicable Disease Prevention.","authors":"E J Derbyshire, C H S Ruxton","doi":"10.3390/nu17101680","DOIUrl":"10.3390/nu17101680","url":null,"abstract":"<p><p><b>Background:</b> Ready-to-eat cereals (RTECs) are a large, heterogeneous category of cereals designed to fit into busy lifestyles with minimal preparation time. <b>Methods:</b> This systematic review evaluated nutrient intake data from seven national surveys. Using PubMed and Science Direct (1 January 2004 until 16 September 2024), we investigated RTECs in relation to their contributions to macro, micronutrient and food group intakes, breakfast/diet quality and effects on health with focus on non-communicable disease (NCD) prevention. The search was restricted to Systematic Reviews (SRs), meta-analyses (MAs), randomised controlled trials (RCTs) and observational studies. Fifty-one publications were obtained. Studies related to health outcomes and NCD risk were graded using an updated Scottish Intercollegiate Guidelines Network approach. <b>Results:</b> Grade A evidence: Based on high-quality MA, SRs, or RCTs, this showed that RTEC consumption was associated with improved nutrient intakes (particularly fibre and micronutrients), reduced cardiovascular disease and mortality. One good-quality Grade A meta-analysis showed that total whole grain intake which included cereals was associated with a reduced risk of total cancer. Grade B evidence: Based largely on observational evidence, this showed that RTEC consumption was associated with reduced risk of overweight and obesity, body mass index and composition improvements and type 2 diabetes risk. For food group intakes, breakfast/diet quality and lipid profiles, more well-designed studies were needed (Grade D evidence). <b>Conclusions:</b> There is consistent evidence that RTECs generally have positive or neutral effects on nutritional status and NCD prevention. Strongest evidence exists for RTEC and micronutrient intakes, reduced risk of cardiovascular diseases (CVDs), body weight regulation, and reduced type 2 diabetes risk. Public health messaging should recognise that RTECs, especially whole-grain, higher-fibre and lower-sugar varieties, may help to reinforce micronutrient intakes and a range of health outcomes.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of L-Glutamate as an Umami Substance for the Reduction of Salt Consumption: Lessons from Clinical Trials.","authors":"Hideki Matsumoto, Licht Miyamoto, Takaki Matsumoto, Francois Blachier","doi":"10.3390/nu17101684","DOIUrl":"10.3390/nu17101684","url":null,"abstract":"<p><p>Salt as sodium chloride is an essential mineral present in food which is involved in physiological functions such as nutrient intestinal absorption, nerve conduction, and muscle contraction. It plays a critical role in food flavoring and ingestive behavior, serving as the basis of one of the five basic tastes. However, excessive salt intake is widely recognized as a risk factor for lifestyle-related diseases, such as hypertension, making salt reduction a key strategy in terms of public health. In that overall context, the aim of this review is to recapitulate the various approaches for salt intake reduction which have been implemented, with a focus on the use of L-glutamate in umami as a sodium substitute. Umami substances, like salt, are one of the five basic tastes and have the potential to enhance the flavor of food while simultaneously reducing salt intake. Several clinical trials have shown that L-glutamate can compensate for the reduction in saltiness while improving the overall palatability of food. This characteristic makes umami substances a valuable element in the context of salt reduction. By incorporating L-glutamate into the diet, it becomes possible to maintain a balanced nutritional intake while reducing salt, making it an effective approach toward a healthier diet. At the same time, L-glutamate-induced salt intake reduction potentially alleviates stress-related indicators associated with salt reduction. Thus, the strategic use of L-glutamate as compound involved in umami taste can help compensate for changes in taste perception due to salt reduction, enabling individuals to maintain meal satisfaction while transitioning to healthier dietary habits with lower salt.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise, Diet, and Brain Health: From the Perspective of Gut Microbiota Regulation.","authors":"Li Zhang, Renhe Liu, Zheyi Song, Xin Zhang","doi":"10.3390/nu17101686","DOIUrl":"https://doi.org/10.3390/nu17101686","url":null,"abstract":"<p><p>The existing body of evidence has highlighted gut microbiota as a versatile regulator of body wellness affecting not only multiple physiological metabolisms but also the function of remote organs. Emerging studies revealed a reciprocal relationship between physical exercise and intestinal microbiota, suggesting that physical exercise could enhance gut health, including regulating intestinal barrier integrity, increasing microbial diversity, and promoting beneficial microbial metabolism. Furthermore, the beneficial outcomes of exercise on the intestine may also promote brain health through the gut-brain axis. Diet is an important factor in boosting exercise performance and also greatly impacts the structure of gut microbiota. Abundant research has reported that diet alongside exercise could exert beneficial effects on metabolism, immune regulation, and the neuropsychiatric system. In this paper, we used a narrative review, primarily searching PubMed, Web of Science, and Elsevier, to review the existing research on how moderate-intensity exercise promotes gut health, and we introduced the effects of exercise on the nervous system through the gut-brain axis. We also proposed dietary strategies targeting the regulation of gut microbiota to provide guidelines for boosting brain health. This review highlights that moderate exercise and a healthy diet promote gut and brain health.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}