{"title":"口服短双歧杆菌对女性面部皮肤影响的影像学和微生物分析：一项随机、双盲、安慰剂对照研究。","authors":"Yuriko Nishikawa, Chendong Xu, Shin Yoshimoto, Noriko Katsumata, Noriyuki Iwabuchi, Naotake Yanagisawa, Shigeo Koido, Miyuki Tanaka, Jin-Zhong Xiao, Daisuke Asaoka, Toshifumi Ohkusa, Nobuhiro Sato","doi":"10.3390/nu17182976","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Oral probiotic intake is suggested to have positive effects on skin. We aimed to elucidate the effects of oral <i>Bifidobacterium breve</i> M-16V intake on skin by analyzing facial images, the skin myco/microbiota, and the gut microbiota.</p><p><strong>Methods: </strong>We conducted a randomized, double-blind, placebo-controlled study in Japan. Healthy women aged over 30 years were randomly allocated to either the <i>B. breve</i> (1 × 1010 colony-forming units (CFU)/sachet, two sachets daily) or the placebo group and consumed the corresponding study food for 12 weeks. Facial images were taken at weeks 0, 4, 8, and 12 using VISIA evolution. Stool and skin samples were collected at weeks 0 and 12. The primary outcome was the change in the total VISIA score from baseline.</p><p><strong>Results: </strong>A total of 120 females aged 30-79 years were assigned to the <i>B. breve</i> (<i>n</i> = 59) or placebo (<i>n</i> = 61) group. The total VISIA score worsened in the placebo group at week 8 (<i>p</i> = 0.029) but not in the <i>B. breve</i> group. Compared with that of the placebo group, the VISIA brown spot score of the <i>B. breve</i> group improved at weeks 4 (<i>p</i> = 0.013) and 8 (<i>p</i> = 0.041). The VISIA pore score improved at weeks 4 (<i>p</i> = 0.013), 8 (<i>p</i> = 0.041), and 12 (<i>p</i> = 0.004) within the <i>B. breve</i> group. Genus-level analysis of the gut microbiota revealed a significant increase in <i>Blautia</i> abundance in the <i>B. breve</i> group. The frequency of adverse events was not different between the groups.</p><p><strong>Conclusions: </strong>Oral <i>B. breve</i> M-16V administration may suppress skin deterioration, including the appearance of brown spots, on the faces of adult females.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 18","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472256/pdf/","citationCount":"0","resultStr":"{\"title\":\"Imaging and Microorganism Analyses of the Effects of Oral <i>Bifidobacterium breve</i> Intake on Facial Skin in Females: A Randomized, Double-Blind, Placebo-Controlled Study.\",\"authors\":\"Yuriko Nishikawa, Chendong Xu, Shin Yoshimoto, Noriko Katsumata, Noriyuki Iwabuchi, Naotake Yanagisawa, Shigeo Koido, Miyuki Tanaka, Jin-Zhong Xiao, Daisuke Asaoka, Toshifumi Ohkusa, Nobuhiro Sato\",\"doi\":\"10.3390/nu17182976\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Oral probiotic intake is suggested to have positive effects on skin. We aimed to elucidate the effects of oral <i>Bifidobacterium breve</i> M-16V intake on skin by analyzing facial images, the skin myco/microbiota, and the gut microbiota.</p><p><strong>Methods: </strong>We conducted a randomized, double-blind, placebo-controlled study in Japan. Healthy women aged over 30 years were randomly allocated to either the <i>B. breve</i> (1 × 1010 colony-forming units (CFU)/sachet, two sachets daily) or the placebo group and consumed the corresponding study food for 12 weeks. Facial images were taken at weeks 0, 4, 8, and 12 using VISIA evolution. Stool and skin samples were collected at weeks 0 and 12. The primary outcome was the change in the total VISIA score from baseline.</p><p><strong>Results: </strong>A total of 120 females aged 30-79 years were assigned to the <i>B. breve</i> (<i>n</i> = 59) or placebo (<i>n</i> = 61) group. The total VISIA score worsened in the placebo group at week 8 (<i>p</i> = 0.029) but not in the <i>B. breve</i> group. Compared with that of the placebo group, the VISIA brown spot score of the <i>B. breve</i> group improved at weeks 4 (<i>p</i> = 0.013) and 8 (<i>p</i> = 0.041). The VISIA pore score improved at weeks 4 (<i>p</i> = 0.013), 8 (<i>p</i> = 0.041), and 12 (<i>p</i> = 0.004) within the <i>B. breve</i> group. Genus-level analysis of the gut microbiota revealed a significant increase in <i>Blautia</i> abundance in the <i>B. breve</i> group. The frequency of adverse events was not different between the groups.</p><p><strong>Conclusions: </strong>Oral <i>B. breve</i> M-16V administration may suppress skin deterioration, including the appearance of brown spots, on the faces of adult females.</p>\",\"PeriodicalId\":19486,\"journal\":{\"name\":\"Nutrients\",\"volume\":\"17 18\",\"pages\":\"\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2025-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472256/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrients\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3390/nu17182976\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrients","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/nu17182976","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Imaging and Microorganism Analyses of the Effects of Oral Bifidobacterium breve Intake on Facial Skin in Females: A Randomized, Double-Blind, Placebo-Controlled Study.
Background: Oral probiotic intake is suggested to have positive effects on skin. We aimed to elucidate the effects of oral Bifidobacterium breve M-16V intake on skin by analyzing facial images, the skin myco/microbiota, and the gut microbiota.
Methods: We conducted a randomized, double-blind, placebo-controlled study in Japan. Healthy women aged over 30 years were randomly allocated to either the B. breve (1 × 1010 colony-forming units (CFU)/sachet, two sachets daily) or the placebo group and consumed the corresponding study food for 12 weeks. Facial images were taken at weeks 0, 4, 8, and 12 using VISIA evolution. Stool and skin samples were collected at weeks 0 and 12. The primary outcome was the change in the total VISIA score from baseline.
Results: A total of 120 females aged 30-79 years were assigned to the B. breve (n = 59) or placebo (n = 61) group. The total VISIA score worsened in the placebo group at week 8 (p = 0.029) but not in the B. breve group. Compared with that of the placebo group, the VISIA brown spot score of the B. breve group improved at weeks 4 (p = 0.013) and 8 (p = 0.041). The VISIA pore score improved at weeks 4 (p = 0.013), 8 (p = 0.041), and 12 (p = 0.004) within the B. breve group. Genus-level analysis of the gut microbiota revealed a significant increase in Blautia abundance in the B. breve group. The frequency of adverse events was not different between the groups.
Conclusions: Oral B. breve M-16V administration may suppress skin deterioration, including the appearance of brown spots, on the faces of adult females.
期刊介绍：
Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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