Obesity Facts最新文献

{"title":"Nomogram for Predicting Suboptimal Weight Loss at Three Years after Roux-en-Y Gastric Bypass Surgery in Chinese Patients with Obesity and Type 2 Diabetes.","authors":"Yiming Si, Hongwei Zhang, Xiaodong Han, Weijie Liu, Yinfang Tu, Xiaojing Ma, Haoyong Yu, Yuqian Bao","doi":"10.1159/000542923","DOIUrl":"10.1159/000542923","url":null,"abstract":"<p><strong>Introduction: </strong>Strategies to address suboptimal weight loss after Roux-en-Y gastric bypass (RYGB) can be developed if at-risk patients are identified in advance. This study aimed to build a pre-surgery prediction nomogram for early prediction of insufficient weight loss (IWL) or weight regain (WR) after bariatric surgery in Chinese patients.</p><p><strong>Methods: </strong>In this retrospective study, 187 patients with obesity and type 2 diabetes who underwent laparoscopic RYGB were followed yearly for 3 years. Suboptimal weight loss included IWL and WR. IWL was defined as a total weight loss percentage of <25% at 1 year postoperatively, and WR was defined as a maximum weight loss percentage of >20% at 3 years postoperatively. Multivariate logistic regression was performed to identify independent predictors and to establish a nomogram to predict the occurrence of suboptimal weight loss.</p><p><strong>Results: </strong>Multivariate logistic regression revealed that male sex (OR 4.268, 95% CI: 1.413-12.890), body mass index (OR 0.816, 95% CI: 0.705-0.946), and glycated hemoglobin (OR 1.493, 95% CI: 1.049-2.126) were independent predictors of IWL/WR. The AUC value of the nomogram constructed from the above three factors was 0.781. The Hosmer-Lemeshow test showed that the model had a good fit (p = 0.143). The calibration curve of the nomogram is close to an ideal diagonal line. Furthermore, the decision curve analysis demonstrated the good net benefits of the model.</p><p><strong>Conclusions: </strong>A nomogram based on pre-surgery factors was developed to predict postoperative IWL/WR. This provides a convenient and useful tool for predicting suboptimal weight loss before surgery.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"157-168"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID-19 Pandemic on Psychosocial Distress in Adolescents with Obesity Compared to Those with Type 1 Diabetes: Results from the KICK-COVID Study in Germany.","authors":"Susann Weihrauch-Blüher, Susanna Wiegand, Sascha Tittel, Susanne Greber-Platzer, Stefanie Lanzinger, Clemens Kamrath, Kirsten Minden, Claudia Sengler, Sabine Linke, Antje Büssenschütt, Felix Reschke, Julia Göldel, Petra Warschburger, Reinhard W Holl","doi":"10.1159/000542756","DOIUrl":"10.1159/000542756","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to investigate the impact of the COVID-19 pandemic on psychosocial well-being in adolescents with obesity compared to those with type 1 diabetes.</p><p><strong>Methods: </strong>As part of the German KICK-COVID Study, adolescents aged 12-21 with overweight or obesity from the German/Austrian Adiposity Follow-up Registry (APV) completed well-being, anxiety, and depression questionnaires (WHO-5, GAD-7, PHQ-9) during routine visits amidst the COVID-19 pandemic. By multivariable linear regression models, adjusted for age, gender, and immigration background, the association between psychosocial distress, anthropometrics, and cardiometabolic risk factors was analyzed. Data were compared to those of youth with type 1 diabetes from the German/Austrian Diabetes Follow-up Registry (DPV) and normative values from the general population. Additionally, a mediation analysis examined the impact of loneliness on mental health through media consumption.</p><p><strong>Results: </strong>From June 2021 to September 2023, 235 adolescents from 6 German and 1 Austrian pediatric obesity centers were enrolled. Results were compared to 235 age- and gender-matched participants from the DPV registry (54.04% males; mean age 15.21 ± 1.66 years) and normative values. Youth with type 1 diabetes were more anxious about their health risk, but distress factors were more pronounced in the APV group (p < 0.001). Girls from the APV group showed higher mental distress than boys across all applied questionnaires, but not for age, BMI-SDS, and migration background as predictors. Perception of loneliness correlated with poorer mental health outcomes, but it was not associated to media consumption. Comparisons with normative values revealed significantly higher depression and anxiety scores (p < 0.001) and lower well-being scores in the APV group (p < 0.01).</p><p><strong>Conclusions: </strong>Youth with obesity and diabetes experienced significant psychosocial distress during the COVID-19 pandemic. Disease-specific differences were observed on the level of single items: Adolescents with type 1 diabetes expressed heightened concern about their health risks, while those with obesity reported lower self-esteem, increased suicidal thoughts, and fluctuating appetite. Female gender appeared to pose an additional risk factor. Media consumption was notably higher in the APV cohort. Healthcare providers should be vigilant regarding psychological comorbidities in youth with chronic conditions, particularly during periods of heightened stress.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"305-318"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postprandial Symptoms in a Mixed-Meal-Test after Bariatric Surgery: Clinical Experience and a Critical Review of Dumping Syndrome Definition and Management.","authors":"Azat Samigullin, Julia Weihrauch, Mirko Otto, Andrea Rech, Sandra Buchenberger, Michael Morcos, Per M Humpert","doi":"10.1159/000541780","DOIUrl":"10.1159/000541780","url":null,"abstract":"<p><strong>Introduction: </strong>Despite recent attempts to reach a consensus on the diagnostic criteria and treatment of dumping syndrome (DS) after bariatric surgery, many questions about the clinical applicability and significance of standardized provocation tests remain unanswered. The objective of this study was to retrospectively evaluate a mixed-meal-test (MMT) based on general nutritional recommendations after bariatric surgery and its clinical value in diagnosing DS.</p><p><strong>Methods: </strong>The MMT contained 15.5 g of protein, 10 g of fat, 20.7 g of carbohydrates, and 3.1 g of dietary fiber, totaling 241 kcal. Symptoms based on the Sigstad Score, along with blood sugar, hematocrit, pulse rate, and blood pressure, were collected as primary readouts. The analysis included 58 MMTs from 56 patients who reported postprandial symptoms indicative of DS and were referred to the clinic by surgeons or general practitioners.</p><p><strong>Results: </strong>Although all individuals reported significant symptoms at home, the MMT showed a positive symptom score (Sigstad Score ≥7) in only 16 cases (28%). Neither a heart rate increase >10 BPM nor the 3% hematocrit increase suggested as cut-offs for early DS by the consensus paper were associated with the Sigstad Score or individually reported symptoms. None of the participants had a postprandial glucose decrease below 50 mg/dL; one fell below 60 mg/dL and 14 fell below 70 mg/dL. A blood glucose decrease below 70 mg/dL was not associated with symptoms.</p><p><strong>Conclusion: </strong>The MMT showed that only a minority of patients reported classical DS symptoms under controlled conditions. Changes in hematocrit, heart rate, and blood sugar decrease below 70 mg/dL did not help to predict symptoms in the individuals studied. The data, in the context of existing evidence, suggest that provocation tests have little value in clinical practice and that DS as a clinical entity after bariatric surgery should be reevaluated.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"31-38"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics of Sarcopenia in Nonalcoholic Fatty Liver Disease: A Systemic Scoping Review.","authors":"Tingdan Ye, Ke Mi, Lin Zhu, Jonathan Li, Calvin Q Pan","doi":"10.1159/000541650","DOIUrl":"10.1159/000541650","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic scoping review aimed to synthesize existing research findings on the clinical manifestations in patients with nonalcoholic fatty liver disease (NAFLD) and sarcopenia.</p><p><strong>Methods: </strong>Adhering to scoping review guidelines, we comprehensively searched five databases for literature on sarcopenia's clinical manifestations in NAFLD patients from December 2013 to December 2023, meticulously compiling and synthesizing the findings.</p><p><strong>Results: </strong>A total of 312 articles were identified, with 9 studies included in the final review. Of these, 90% were cross-sectional investigations, with 70% from Asian cohorts. Comparative analysis between patients solely afflicted with NAFLD and those additionally experiencing sarcopenia revealed discernible trends. Individuals with both conditions tended to be older, have a higher body mass index, and show a higher prevalence among females, underscoring the influence of unhealthy lifestyles and obesity. Furthermore, comorbidities like metabolic syndrome, hypertension, and diabetes have been implicated in sarcopenia manifestation among NAFLD patients. Nonetheless, the lack of standardized diagnostic criteria and patterns poses an ongoing clinical challenge for this subgroup.</p><p><strong>Conclusions: </strong>Our review highlights distinct clinical characteristics evident in NAFLD patients with sarcopenia. However, comprehensive investigations remain scarce, impeding accurate early detection and intervention. Future research should prioritize bridging these gaps and fostering enhanced clinical management strategies.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"72-85"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Abdominal Volume Index with Asymptomatic Intracranial Arterial Stenosis in Rural Chinese Adults: A Population-Based Study.","authors":"Qiuting Wang, Xinhao Yang, Zhengyu Yang, Xinyan Hu, Jiehong Yuan, Maoyu Li, Xiaotong Ma, Xiang Wang, Chengxuan Qiu, Qinjian Sun","doi":"10.1159/000543790","DOIUrl":"10.1159/000543790","url":null,"abstract":"<p><strong>Introduction: </strong>The abdominal volume index (AVI), a novel anthropometric index that reflects abdominal obesity, has been related to atherosclerosis. We sought to investigate the association of AVI with the severity and burden of asymptomatic intracranial arterial stenosis (aICAS) in a rural Chinese population.</p><p><strong>Methods: </strong>The population-based cross-sectional study included 1,994 participants who were aged ≥40 years and living in Kongcun Town, Pingyin County, Shandong, and who had no history of clinical stroke or transient ischemic attack. We detected aICAS by combining transcranial Doppler ultrasound with magnetic resonance angiography. We used multiple logistic regression models to investigate the association between AVI and aICAS.</p><p><strong>Results: </strong>Of the 1,994 participants, 146 were diagnosed with aICAS, including 51 with mild aICAS and 95 with moderate-to-severe aICAS. Controlling for confounding factors, a greater AVI was significantly associated with an adjusted odds ratio (OR) (95% confidence interval [CI]) of 1.08 (1.02-1.14) for having aICAS, 1.11 (1.04-1.18) for moderate-to-severe aICAS, and 1.12 (1.01-1.23) for multiple moderate-to-severe aICAS. We detected a statistical interaction of AVI with hypertension on aICAS (p for interaction = 0.011). Stratified analysis by hypertension showed a significantly independent association between AVI and aICAS in participants with hypertension (upper versus lower tertile of AVI: OR = 2.90; 95% CI: 1.65-5.10, p < 0.001) but not in those without hypertension.</p><p><strong>Conclusion: </strong>A greater AVI is independently associated with aICAS, especially among individuals with hypertension. Moreover, AVI may help to identify both the severity and burden of aICAS.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"260-268"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food and Health Literacy in Patients Awaiting Metabolic-Bariatric Surgery.","authors":"Anne Jacobs, Leontien M G Nijland, Ingrid H M Steenhuis, Ruben N van Veen, Ronald S L Liem, Hanno Pijl, Lies Ter Beek, Rob A E M Tollenaar, Valerie M Monpellier","doi":"10.1159/000541408","DOIUrl":"10.1159/000541408","url":null,"abstract":"<p><strong>Introduction: </strong>Specialized lifestyle programmes for patients undergoing metabolic-bariatric surgery (MBS) are provided to facilitate adjustment and adherence to a healthy lifestyle after surgery. However, pre-programme food and health literacy in MBS patients is often unknown. In the general population, approximately three-quarters of people exhibit sufficient health literacy. This study aimed to examine food and health literacy of patients awaiting MBS and to identify patient-specific factors associated with these literacies.</p><p><strong>Methods: </strong>Patients awaiting MBS completed questionnaires on food literacy (Self-Perceived Food Literacy scale) and health literacy (European Health Literacy Survey Questionnaire-16) at the start of a preoperative lifestyle programme. Linear and logistic regression analyses were used to identify associations between multiple variables and preoperative food and health literacy.</p><p><strong>Results: </strong>Among 216 patients, the preoperative mean food literacy score was 3.49 ± 0.44, on a five-point scale. Furthermore, 96.3% of patients showed sufficient health literacy, with scores of 13 or more out of 16. Patients with sufficient health literacy had higher food literacy scores (β 0.508; 95% CI: 0.208-0.809, p < 0.001).</p><p><strong>Conclusion: </strong>This study among people living with obesity awaiting MBS suggests that food literacy is comparable, and health literacy is higher than in the general population. These findings emphasize the complexity of the aetiology of obesity due to factors that extend beyond food and health literacy.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-9"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the 40-Item and 24-Item Short Version of the Person-Centred Obesity Care Instrument for Patients Living with Obesity.","authors":"Paige I Crompvoets, Anna Petra Nieboer, Elisabeth F C van Rossum, Jane M Cramm","doi":"10.1159/000541499","DOIUrl":"10.1159/000541499","url":null,"abstract":"<p><strong>Introduction: </strong>Person-centred care (PCC) may hold promise for improved healthcare experiences and outcomes among patients living with obesity. A validated instrument to assess the delivery of PCC to patients living with obesity is, however, currently lacking. This study aimed to validate such an instrument. In this article, we describe the development and psychometric testing of the 40-item and 24-item short version of the Person-Centred Obesity Care (PCOC) instrument.</p><p><strong>Methods: </strong>A total of 590 individuals living with obesity (BMI 33.4 ± 3.9) from a representative Dutch sample completed the 49-item PCOC instrument measuring the eight dimensions of PCC (patient preferences, physical comfort, coordination of care, emotional support, access to care, continuity and transition, information and education, and family and friends), and two measures of satisfaction with care. We performed confirmatory factor analyses to verify the factor structure of the instrument and examined its reliability and validity.</p><p><strong>Results: </strong>Fit indicators of the first model with all 49 items showed that the model left room for improvement (comparative fit index [CFI] <0.90). A 40-item version was obtained with satisfactory-to-good fit (standardized root mean square residual [SRMR] = 0.05, root mean square error of approximation [RMSEA] = 0.06, CFI = 0.90). The instrument demonstrated good reliability, and the relationship between the PCOC and two indicators of satisfaction with care supported the validity of the scale. Shortening the instrument only further improved the fit indicators, resulting in the development of a 24-item short version (SRMR = 0.04, RMSEA = 0.05, CFI = 0.96), with similar results in terms of reliability and validity.</p><p><strong>Conclusion: </strong>The 40-item PCOC instrument and the 24-item short version showed to be reliable and valid instruments for the assessment of PCC among patients living with obesity. Based on the results, the 40 and 24-item PCOC are promising tools that can be used by clinicians and researchers to explore PCC delivery for patients living with obesity.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"10-20"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/000544896","DOIUrl":"10.1159/000544896","url":null,"abstract":"","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"319-320"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased Quality of Life in Patients Who Desire Body Contouring Surgery after Bariatric Metabolic Surgery: A Multicenter Longitudinal Analysis.","authors":"Phillip J Dijkhorst, Robin A Debi, Claire E E de Vries, Dennis J S Makarawung, Aebele B Mink van der Molen, Steve M M de Castro, Ruben N van Veen","doi":"10.1159/000543632","DOIUrl":"10.1159/000543632","url":null,"abstract":"<p><strong>Introduction: </strong>Excess skin after bariatric metabolic surgery may negatively impact quality of life (QoL). Nevertheless, not every eligible patient undergoes body contouring surgery (BCS), which may be explained by differences in QoL. The objective of this study was to assess the differences in QoL between patients with and without a desire for BCS after bariatric metabolic surgery and to identify predictive factors that contribute to this desire.</p><p><strong>Methods: </strong>Patients completed the BODY-Q and a question regarding any desire for BCS, 6 months and yearly after bariatric metabolic surgery. BODY-Q outcomes were compared between patients with and without a desire for BCS and corrected for excess skin.</p><p><strong>Results: </strong>A total of 380 patients who completed 3 years of follow-up were included. Of these patients, 69.5% desired BCS. Patients who did not desire BCS demonstrated significantly higher QoL scores across all domains at every follow-up moment compared to patients who desired BCS (except physical functioning at 3 years). These associations were largely explained by the amount and burden of excess skin. Younger age was the only significant predictor for desiring BCS when correcting for excess skin.</p><p><strong>Conclusion: </strong>Patients with a desire for BCS demonstrated significantly lower QoL compared to patients without a desire due to a high burden of excess skin, which emphasizes the need for effective treatments aiming to improve QoL such as BCS.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"287-295"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Serum Ferritin with Total and Regional Fat Measured by Dual-Energy X-Ray Absorptiometry in a Nationally Representative Survey.","authors":"Yuan Chen, Chao Wang, Yanyan Xiao, Tian Hu, Xuerong Yang, Guohua Mu, Hao Lu, Junfei Xu, Chi Chen","doi":"10.1159/000542896","DOIUrl":"10.1159/000542896","url":null,"abstract":"<p><strong>Introduction: </strong>Fat distribution is a stronger predictor for cardiometabolic morbidity and mortality. We aimed to investigate the association of elevated iron stores, measured as serum ferritin levels, with total and regional body fat.</p><p><strong>Methods: </strong>Data from 2,646 adults from the National Health and Nutrition Examination Survey 2017-2018 were analyzed. Dual-energy X-ray absorptiometry was used to measure overall and regional body fat. The fat mass index (FMI) was calculated by dividing the fat mass (kg) by the square of body height (m2). The leg fat mass to trunk fat mass ratio (LTR) was used to assess the relative distribution of leg fat compared to trunk fat.</p><p><strong>Results: </strong>Medians (IQR) of serum ferritin levels were 0.168 μg/mL (0.104-0.269) for men and 0.053 μg/mL (0.026-0.102) for women. After adjusting for sociodemographic, lifestyle, and metabolic factors, serum ferritin showed a significant positive association with total FMI (β = 2.662) and trunk FMI (β = 0.983), and a negative association with leg FMI (β = -0.324) and LTR (β = -0.160) in men. In women, serum ferritin showed a significant positive association with total FMI (β = 4.658), trunk FMI (β = 2.085), and negative association with LTR (β = -0.312). Significant positive trends were observed for serum ferritin with total and trunk FMI in men and women, using the lowest serum ferritin quartile as the reference group. Additionally, significant negative trends were observed for serum ferritin with leg FMI and LTR in men. The mediation analysis revealed that C-reactive protein mediated 16.4% and 22.6% of the potential effects of serum ferritin on trunk FMI in men and women, respectively.</p><p><strong>Conclusion: </strong>Higher ferritin levels were associated with greater total and trunk fat but lower leg fat. Further prospective and mechanistic studies are warranted to confirm the study results.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"139-148"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}