Obesity Facts最新文献

{"title":"Subcutaneous Adipose Tissue Is Associated with Acute Kidney Injury after Abdominal Trauma Based on the Generalized Propensity Score Approach: A Retrospective Cohort Study.","authors":"Fengchan Xi,&nbsp;Jiang Li,&nbsp;Yuanchen He,&nbsp;Chuanrui Sun,&nbsp;Xiling Wang,&nbsp;Wenkui Yu","doi":"10.1159/000530000","DOIUrl":"https://doi.org/10.1159/000530000","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity is associated with an increased risk of acute kidney injury (AKI) after trauma. However, the associations between different adipose tissue depots and AKI remain unknown. Our study aimed to quantify the effect of abdominal adiposity on AKI in trauma patients.</p><p><strong>Methods: </strong>We performed a retrospective cohort study of abdominal trauma patients who were admitted to our hospital from January 2010 to March 2020. Abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured at the level of the third lumbar vertebra using computed tomography. Causal modeling based on the generalized propensity score was used to quantify the effects of body mass index (BMI), VAT, and SAT on AKI.</p><p><strong>Results: </strong>Among 324 abdominal trauma patients, 67 (20.68%) patients developed AKI. Patients with AKI had higher BMI (22.46 kg/m2 vs. 22.04 kg/m2, p = 0.014), higher SAT areas (89.06 cm2 vs. 83.39 cm2, p = 0.151), and higher VAT areas (140.02 cm2 vs. 91.48 cm2, p = 0.001) than those without AKI. By using causal modeling, we found that the risk of developing AKI increased by 8.3% (p = 0.001) and 4.8% (p = 0.022) with one unit increase in BMI (per 1 kg/m2) and ten units increase in SAT (per 10 cm2), respectively. However, VAT did not show a significant association with AKI (p = 0.327).</p><p><strong>Conclusion: </strong>SAT, but not VAT, increased the risk of AKI among abdominal trauma patients. Measurement of SAT might help identify patients at higher risk of AKI.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":"16 3","pages":"255-263"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10118140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibody Response to Inactive SARS-CoV-2 Vaccination in a Cohort of Elderly Patients Living with Obesity.","authors":"Zehra Kara,&nbsp;Rüveyda Akçin,&nbsp;Ahmet Numan Demir,&nbsp;Harika Oyku Dinc,&nbsp;Bekir Kocazeybek,&nbsp;Volkan Demirhan Yumuk","doi":"10.1159/000530315","DOIUrl":"10.1159/000530315","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity and aging negatively affect the immune system and host defense mechanisms, increasing vulnerability to and worsening prognosis of infectious diseases, leading to vaccine failure. Our aim was to investigate the antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike antigens and the risk factors affecting antibody levels in elderly patients living with obesity (PwO) after inactive SARS-CoV-2 vaccine (CoronaVac) administration.</p><p><strong>Methods: </strong>One hundred twenty-three consecutive elderly patients with obesity (age ≥65 years, body mass index [BMI] ≥30 kg/m2) and 47 adults with obesity (age 18-64 years, BMI ≥30 kg/m2) admitted between August and November 2021 were enrolled. Seventy-five nonobese elderly people (age ≥65 years, BMI 18.5-29.9 kg/m2) and 105 nonobese adults (age 18-64 years, BMI 18.5-29.9 kg/m2) were recruited from subjects who visited the Vaccination Unit. SARS-CoV-2 spike protein antibody titers were measured in patients with obesity and nonobese controls who received two doses of CoronaVac.</p><p><strong>Results: </strong>SARS-CoV-2 levels of patients with obesity were found to be significantly lower than those of nonobese elderly individuals who had non-prior infection. There was no difference in SARS-CoV-2 levels between patients with obesity and nonobese individuals with prior infection. Age and SARS-CoV-2 level were found to be highly correlated in the correlation analysis in the group of elderly individuals (r: -0.184). In multivariate regression analysis, when SARS-CoV-2 immunoglobulin class G (IgG) was regressed on age, sex, BMI, type 2 diabetes mellitus, and hypertension (HT), HT was found to be an independent factor of the SARS-CoV-2 level (β: -2,730).</p><p><strong>Conclusion: </strong>In the non-prior infection group, elderly patients with obesity generated significantly reduced antibody titers against SARS-CoV-2 spike antigen after CoronaVac vaccine compared to nonobese people. It is anticipated that the results obtained will provide invaluable information about SARS-CoV-2 vaccination strategies in this vulnerable population. Antibody titers may be measured, and booster doses should be delivered accordingly in elderly PwO for optimal protection.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":"16 4","pages":"374-380"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/92/13/ofa-2023-0016-0004-530315.PMC10443995.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10602198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Obesity on T and NK Cells after LVAD Implantation.","authors":"Eva Katharina Messer,&nbsp;Anna Lassia Meyer,&nbsp;Kristin Klaeske,&nbsp;Franz Sieg,&nbsp;Sandra Eifert,&nbsp;Dominik Schmiedel,&nbsp;Josephina Haunschild,&nbsp;Khalil Jawad,&nbsp;Diyar Saeed,&nbsp;Lea Hildebrandt,&nbsp;Michael Andrew Borger,&nbsp;Maja-Theresa Dieterlen","doi":"10.1159/000530174","DOIUrl":"10.1159/000530174","url":null,"abstract":"<p><strong>Introduction: </strong>Infections are a major problem after left ventricular assist device (LVAD) implantation that affects morbidity, mortality, and the quality of life. Obesity often increases the risk for infection. In the cohort of LVAD patients, it is unknown if obesity affects the immunological parameters involved in viral defense. Therefore, this study investigated whether overweight or obesity affects immunological parameters such as CD8+ T cells and natural killer (NK) cells.</p><p><strong>Methods: </strong>Immune cell subsets of CD8+ T cells and NK cells were compared between normal-weight (BMI 18.5-24.9 kg/m2, n = 17), pre-obese (BMI 25.0-29.9 kg/m2, n = 24), and obese (BMI ≥30 kg/m2, n = 27) patients. Cell subsets and cytokine serum levels were quantified prior to LVAD implantation and at 3, 6, and 12 months after LVAD implantation.</p><p><strong>Results: </strong>At the end of the first postoperative year, obese patients (31.8% ± 2.1%) had a lower proportion of CD8+ T cells than normal-weight patients (42.4% ± 4.1%; p = 0.04), and the percentage of CD8+ T cells was negatively correlated with BMI (p = 0.03; r = -0.329). The proportion of circulating NK cells increased after LVAD implantation patients in normal-weight (p = 0.01) and obese patients (p &lt; 0.01). Patients with pre-obesity showed a delayed increase (p &lt; 0.01) 12 months after LVAD implantation. Further, obese patients showed an increase in the percentage of CD57+ NK cells after 6 and 12 months (p = 0.01) of treatment, higher proportions of CD56bright NK cells (p = 0.01), and lower proportions of CD56dim/neg NK cells (p = 0.03) 3 months after LVAD implantation than normal-weight patients. The proportion of CD56bright NK cells positively correlated with BMI (p &lt; 0.01, r = 0.403) 1 year after LVAD implantation.</p><p><strong>Conclusions: </strong>This study documented that obesity affects CD8+ T cells and subsets of NK cells in patients with LVAD in the first year after LVAD implantation. Lower proportions of CD8+ T cells and CD56dim/neg NK cells and higher proportion of CD56bright NK cells were detected in obese but not in pre-obese and normal-weight LVAD patients during the first year after LVAD implantation. The induced immunological imbalance and phenotypic changes of T and NK cells may influence viral and bacterial immunoreactivity.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":"16 4","pages":"364-373"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/27/ofa-2023-0016-0004-530174.PMC10427956.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10602200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Needs and Demands for e-Mental Health Interventions in Individuals with Overweight and Obesity: User-Centred Design Approach.","authors":"Sheila Geiger, Jasmin Steinbach, Eva-Maria Skoda, Lisa Jahre, Vanessa Rentrop, Dilara Kocol, Christoph Jansen, Lynik Schüren, Marco Niedergethmann, Martin Teufel, Alexander Bäuerle","doi":"10.1159/000527914","DOIUrl":"10.1159/000527914","url":null,"abstract":"<p><strong>Introduction: </strong>Several studies indicate an association between mental disorders and overweight or obesity. E-Mental health interventions offer an effective way to overcome barriers to health care access for individuals with overweight and obesity. The objective of this study was to examine the needs and demands for e-mental health interventions among individuals with overweight and obesity.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from 2020 to 2021 in Germany. A total of 643 participants were recruited through specialized social media platforms and the Alfried-Krupp hospital in Essen, Germany. Sociodemographic and medical data were analysed, as well as data on depressive symptoms and on the needs and demands for e-mental health interventions.</p><p><strong>Results: </strong>Contact with and recommendation by experts appear to be key aspects in the acceptance and use of e-mental health interventions. In summary, most participants preferred a 20-30-min weekly session via smartphone over a 4-month period. The highest preference in terms of features included practicing coping skills and being provided with information; in regard to desired topics, nutrition consultation, quality of life, and adapting to new life situations were considered most important.</p><p><strong>Discussion: </strong>e-Mental health interventions can be highly beneficial for individuals, especially when developed through a user-centred design approach. The results of the study indicate which content and design are preferred and, thereby, provide valuable information for consideration when developing a tailored e-mental health intervention.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":"16 2","pages":"173-183"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/ba/ofa-0016-0173.PMC10028369.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9339503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Indicators of Inequality and Weight Change following a Behavioural Weight Loss Intervention.","authors":"Jack M Birch, Julia Mueller, Stephen J Sharp, Simon J Griffin, Michael P Kelly, Jason C G Halford, Amy L Ahern","doi":"10.1159/000528135","DOIUrl":"10.1159/000528135","url":null,"abstract":"<p><strong>Introduction: </strong>Weight loss through behavioural weight management interventions can have important health benefits for people with obesity. However, to maximise the health benefits, weight loss must be maintained. Evidence suggests that behavioural weight loss interventions do not exacerbate inequalities in the short term. However, no study has yet considered whether inequalities exist in long-term weight change following intervention. We aimed to investigate if there are inequalities in weight change following weight loss intervention.</p><p><strong>Methods: </strong>We conducted a cohort analysis of data from the Weight Loss Referrals for Adults in Primary Care (WRAP) trial (N = 1,267). WRAP randomised participants to receive a brief intervention information booklet or vouchers for 12-weeks or 52-weeks of WW (formerly WeightWatchers) and followed them for 5 years. Multiple linear regression estimated the association between exposures (indicators of inequality) and outcomes (change in weight between 1- and 5-years). Each model was adjusted for the intervention group, baseline weight, weight change between baseline and 1-year, research centre, and source of the 5-year weight data.</p><p><strong>Results: </strong>Of the 1,267 participants in WRAP, 708 had weight change data available. Mean weight change between 1- and 5-years was +3.30 kg (SD 9.10 kg). A 1 year difference in age at baseline was associated with weight change of 0.11 kg ((95% CI 0.06, 0.16), p < 0.001). We did not find evidence of associations between ethnicity, gender, education, indices of multiple deprivation, household income, or other family members participating in a weight loss programme and weight change.</p><p><strong>Conclusion: </strong>Except for age, we did not find evidence of inequalities in weight change following a behavioural intervention. Findings further support the use of behavioural weight management interventions as part of a systems-wide approach to improving population health.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":"16 2","pages":"194-203"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9346163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overweight and Obesity in Brazilian Immigrants in Massachusetts, USA: A Time Series Analysis (2009-2020).","authors":"Talita Monsores Paixão,&nbsp;Carlos Eduardo Gomes Siqueira,&nbsp;Elisa Tristan-Cheever,&nbsp;Frida Marina Fischer,&nbsp;Maria Carmen Martinez,&nbsp;Marcelo Augusto Christoffolete,&nbsp;Kirsten Meisinger,&nbsp;Liliane Reis Teixeira","doi":"10.1159/000527286","DOIUrl":"https://doi.org/10.1159/000527286","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity is considered a growing public health problem by the Brazilian Ministry of Health and a global epidemic by the World Health Organization (WHO). In 2020, the Centers for Disease Control and Prevention (CDC) estimated the prevalence of adult obesity at 31.9% in the USA. The USA is one of the main destinations for Brazilian immigrants in search of better living conditions, and Massachusetts is one of the states with the highest presence of Brazilians. Changes in lifestyle and eating habits are often associated with increases in overweight and obesity in immigrants in the USA, especially Hispanics, an official classification that does not, however, include Brazilians. The aim of this study was to describe the temporal trend of overweight and obesity in Brazilian immigrants assisted by the Cambridge Health Alliance (CHA) healthcare network in Massachusetts.</p><p><strong>Methods: </strong>This was an ecological time series study of 128,206 records of Brazilians aged between 18 and 60 years based on hospital data from 2009 to 2020.</p><p><strong>Results: </strong>Mean age was 38.9 (SD = 10.6), and 61% of the sample were women. The prevalence of overweight and obesity was 38.4% and 25.4%, respectively. Obesity exhibited an increasing trend, while eutrophy and overweight decreased during the study period.</p><p><strong>Conclusion: </strong>As little is known about the health of Brazilian immigrants in the USA, this study contributes to the literature on the subject. The observed increasing trends agree with the worldwide increase in obesity and indicate the need for future research exploring individual factors associated with immigrant acculturation.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":"16 2","pages":"109-118"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/99/ofa-0016-0109.PMC10028362.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9351415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"30th European Congress on Obesity (ECO 2023).","authors":"","doi":"10.1159/000530456","DOIUrl":"https://doi.org/10.1159/000530456","url":null,"abstract":"<p><p>This is the abstract book of 30th European Congress on Obesity (ECO 2023).</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":"16 Suppl 1 ","pages":"1-351"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/000528323","DOIUrl":"https://doi.org/10.1159/000528323","url":null,"abstract":"No. PO4.13: Del Prete, M.1; Di Sacco, G.1; Vignati, F.1; Gavazzi, L.1; Pellegrino, D.2, Dellepiane, D.1; Muratori, F.1 Abstract No. PO4.14: Muratori, F.1; Del Prete, M.1; Di Sacco, G.1; Gavazzi, L.1; Pellegrino, D.2; Dellepiane, D.1; Vignati, F.1 Abstract No. PO4.33: Dellepiane, D.1, Zappa, M. A.2; Maggioni, D.3; Gentilli, S.4; Ojeda Mercado, D.5; Del Prete, M.1; Gavazzi, L.1; Di Sacco, G.1; Vignati, F.1; Muratori, F.1 This is an Open Access article licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense), applicable to the online version of the article only. Usage and distribution for commercial purposes requires written permission.","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":"16 1","pages":"108"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/38/ofa-0016-0108.PMC9889712.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features of Non-Alcoholic Fatty Liver Disease in the Non-Lean Population.","authors":"Min-Ran Li,&nbsp;Jin-Zhong Li,&nbsp;Jie-Ying Li,&nbsp;Cun-Chuan Wang,&nbsp;Rui-Kun Yuan,&nbsp;Li-Hong Ye,&nbsp;Yun-Yan Liu,&nbsp;Xu-Jing Liang,&nbsp;Hai-Cong Zhang,&nbsp;Zhi-Quan Liu,&nbsp;Dong-Yu Zeng,&nbsp;Xue-Dong Zhang,&nbsp;De-Hua Wang,&nbsp;Jun-Qing Li,&nbsp;Tao-Yuan Li,&nbsp;Liu Yang,&nbsp;Yang Cao,&nbsp;Yun Pan,&nbsp;Xun-Ge Lin,&nbsp;Calvin Q Pan,&nbsp;Er-Hei Dai,&nbsp;Zhi-Yong Dong","doi":"10.1159/000530845","DOIUrl":"10.1159/000530845","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of non-alcoholic fatty liver disease (NAFLD) in non-lean patients is significantly increased, and obesity significantly increases the risk of cirrhosis and HCC in NAFLD patients. However, whether there is a difference in clinical manifestations of NAFLD between overweight and obesity remains unclear. The objective of this study was to assess the clinical and histological features of NAFLD among a non-lean population.</p><p><strong>Methods: </strong>Current study enrolled consecutive non-lean (body mass index [BMI] &gt;23 kg/m2) patients with NAFLD and available liver biopsy results. Patients were stratified by BMI into two groups for the comparison of their clinical and histological variables, which included the overweight (BMI 23∼&lt;28 kg/m2) and the obese (BMI ≥28 kg/m2). Risk factors for moderate to severe fibrosis (stage &gt;1) were also analyzed through the logistic regression model.</p><p><strong>Results: </strong>Among 184 non-lean patients with metabolic-associated fatty liver disease enrolled, 65 and 119 were overweight and obese, respectively. Patients in the obesity group had a significantly lower level of gamma-glutamyl transpeptidase, higher levels of platelet, glucose, prothrombin time, and more common of moderate to severe inflammatory activity when compared to those in the overweight group. However, a significant low frequency of moderate to severe fibrosis was found in the obesity group versus the overweight group (19.33% vs. 40.00%, p = 0.002). Binary logistics regression analysis of fibrosis found that aspartate transaminase (AST), BMI, alanine transaminase (ALT), and cholesterol (CHOL) were independent predictors for moderate to severe fibrosis in non-lean patients with NAFLD. Compared with the traditional fibrosis-4 (AUC = 0.77) and aminotransferase to platelet ratio index (AUC = 0.79) indexes, the combined index based on AST, BMI, ALT, and CHOL was more accurate in predicting moderate to severe fibrosis in non-lean patients with NAFLD (AUC = 0.87).</p><p><strong>Conclusions: </strong>Clinical and histological features differed between obesity and overweight patients with NAFLD. When compared to the traditional serum markers, the combination index including AST, BMI, ALT, and CHOL provided a better model to predict moderate to severe fibrosis in non-lean patients with NAFLD.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"427-434"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/3e/ofa-2023-0016-0005-530845.PMC10601616.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9893290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Emergence of Appetite and Hunger Resulting in Weight Gain and Improvement of Eating Disorder Symptomatology during and after Short-Term Off-Label Metreleptin Treatment of a Patient with Anorexia Nervosa.","authors":"Gertraud Gradl-Dietsch,&nbsp;Gabriella Milos,&nbsp;Martin Wabitsch,&nbsp;Rebecca Bell,&nbsp;Franziska Tschoepe,&nbsp;Jochen Antel,&nbsp;Johannes Hebebrand","doi":"10.1159/000527386","DOIUrl":"https://doi.org/10.1159/000527386","url":null,"abstract":"<p><p>Off-label treatment of a 15-year-old female patient with anorexia nervosa (AN) with human recombinant leptin (metreleptin) for nine days was associated with self-reported increments of appetite and hunger resulting in rapid weight gain and substantial improvement of eating disorder cognitions and of depression. The results further substantiate the effects of metreleptin on both AN and depression. We contrast these results with the widespread view that leptin is an anorexigenic hormone. Randomized controlled trials are warranted to confirm the described effects.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":"16 1","pages":"99-107"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e9/c0/ofa-0016-0099.PMC9889726.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10637020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}