OBESITY AND CLINICAL CHARACTERISTICS OF INFLAMMATORY BOWEL DISEASE.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Obesity Facts Pub Date : 2025-03-28 DOI:10.1159/000545436

Roberto Mancone, Livia Biancone, Sara Concetta Schiavone, Mariasofia Fiorillo, Chiara Menna, Stefano Migliozzi, Benedetto Neri

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Abstract

Background: The frequency of obesity and possible correlations with characteristics and outcome of inflammatory bowel disease (IBD) are undefined. Primary aim was to assess the Body Mass Index (BMI) distribution in IBD patients in follow-up. Secondary aim was to compare clinical characteristics and course of IBD in normal weight versus overweight or obese patients.

Methods: Adult IBD patients in regular follow-up were prospectively enrolled and BMI was recorded during outpatient visits. Comparisons were assessed by Student t-test, Mann-Whitney u-test and Chi-square test, as appropriate.

Results: In the 300 IBD patients enrolled (150 Crohn's Disease, CD, 150 Ulcerative Colitis, UC), BMI distribution included: 16 (5.3%) underweight, 170 (56.7%) normal weight, 92 (30.7%) overweight, 22 (7.3%) obese patients. For the secondary aim, the 16 underweight patients were excluded, thus leaving 284 patients for the analysis (141 [49.6%] CD; 143 [50.4%] UC). Among these, 114 (40.2%) were overweight/obese and 170 (59.8%) normal weight. CD group included 89 (63.1%) normal weight and 52 (36.9%) overweight/obese patients. Perianal disease and refractoriness to biologics were more frequent in overweight/obese than normal weight CD patients (9 [10.1%] vs 12 [23%], p=0.03; 0 [0%] vs 4 [23.4%], p=0.01). In UC group, there were 81 (56.6%) normal weight and 62 (63.4%) overweight or obese patients.

Conclusions: In IBD patients in follow up, the proportion of underweight patients is low. Overweight and obese CD patients showed a higher frequency of perianal disease and refractoriness to biologics. BMI may influence phenotype and responsiveness to biologics in CD.

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肥胖与炎症性肠病的临床特征

背景：肥胖的频率及其与炎症性肠病（IBD）的特征和结局的可能相关性尚不明确。主要目的是在随访中评估IBD患者的身体质量指数（BMI）分布。次要目的是比较正常体重与超重或肥胖患者IBD的临床特征和病程。方法：前瞻性纳入定期随访的成年IBD患者，并在门诊就诊时记录BMI。比较采用学生t检验、Mann-Whitney u检验和卡方检验。结果：入选的300例IBD患者（150例克罗恩病，CD， 150例溃疡性结肠炎，UC）， BMI分布包括：体重不足16例（5.3%），正常体重170例（56.7%），超重92例（30.7%），肥胖22例（7.3%）。对于次要目的，16例体重过轻的患者被排除在外，从而留下284例患者进行分析(141例[49.6%]CD；143 [50.4%] uc)。其中超重/肥胖114人（40.2%），体重正常170人（59.8%）。CD组89例（63.1%）体重正常，52例（36.9%）超重/肥胖。超重/肥胖患者的肛周疾病和对生物制剂的难治性比正常体重的CD患者更常见(9 [10.1%]vs 12 [23%], p=0.03；0 [0%] vs 4 [23.4%], p=0.01)。UC组体重正常81例（56.6%），超重或肥胖62例（63.4%）。结论：在IBD患者随访中，体重过轻患者比例较低。超重和肥胖的乳糜泻患者出现肛周疾病的频率更高，对生物制剂的耐受性也更高。BMI可能影响CD患者的表型和对生物制剂的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Facts 医学-内分泌学与代谢

CiteScore

6.80

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Obesity Facts'' publishes articles covering all aspects of obesity, in particular epidemiology, etiology and pathogenesis, treatment, and the prevention of adiposity. As obesity is related to many disease processes, the journal is also dedicated to all topics pertaining to comorbidity and covers psychological and sociocultural aspects as well as influences of nutrition and exercise on body weight. The editors carefully select papers to present only the most recent findings in clinical practice and research. All professionals concerned with obesity issues will find this journal a most valuable update to keep them abreast of the latest scientific developments.