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The Efficacy and Safety of Adjustable Intragastric Balloon for Weight Loss: A Systematic Review and Meta-Analysis. 可调节胃内球囊减肥的有效性和安全性:一项系统综述和荟萃分析。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-02-13 DOI: 10.1159/000542921
Chuqi Xia, Yinuo Wang, Guowu Sun, Wanyang Lei, Daoming Liang
{"title":"The Efficacy and Safety of Adjustable Intragastric Balloon for Weight Loss: A Systematic Review and Meta-Analysis.","authors":"Chuqi Xia, Yinuo Wang, Guowu Sun, Wanyang Lei, Daoming Liang","doi":"10.1159/000542921","DOIUrl":"10.1159/000542921","url":null,"abstract":"<p><strong>Introduction: </strong>Adjustable intragastric balloon (aIGB), known as a novel minimally invasive therapy for obesity, provides a sustained alternative for weight loss. Weight loss is achieved by implanting a balloon into the patient's stomach, with the volume of the balloon being adjustable through the injection or extraction of physiological saline. Its key distinction from other intragastric balloons lies in post-implantation volume control. Currently, the efficacy and safety of aIGB have not been well described.</p><p><strong>Methods: </strong>MEDLINE, Embase, and the Cochrane Library were searched for relevant articles. Efficacy and safety of aIGB were evaluated by total body weight loss (TWL) after treatment and severe adverse events.</p><p><strong>Results: </strong>A total of 12 eligible studies with 4,981 patients were included. The average inserting time was 9.9 months, and the pooled mean TWL was 16.4% (95% CI: 0.153-0.175, I2 = 91.2%). The pooled prevalence of patients choosing upward balloon adjustment was 34.2% (95% CI: 0.220-0.485, I2 = 96.5), and all reported additional weight loss with a mean of 6.3 (4.8-9.3) kg. The pooled prevalence of patients choosing downward balloon adjustment was 9.2% (95% CI: 0.065-0.119, I2 = 73.9%), and the pooled prevalence of alleviating intolerance in these patients was 90.8% (95% CI: 0.817-0.974, I2 = 53.4%). The pooled prevalence of intolerance and early removal within 3 months was 5.7% (95% CI: 0.035-0.078, I2 = 79.8%), and the pooled prevalence of stomach ulcer was 1.1% (95% CI: 0.008-0.014, I2 = 5.1%). There was no obvious publication bias detected for these outcomes. Leave-one-out and subgroup analysis demonstrated the results were statistically reliable.</p><p><strong>Conclusion: </strong>aIGB has the ability of significant and sustained weight loss and can effectively manage both intolerance and weight loss plateaus by adjusting the balloon volume during treatment.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-13"},"PeriodicalIF":3.9,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between Type of Bariatric Surgery and Obstructive Sleep Apnoea, Employment Outcomes, and Body Image Satisfaction: A Systematic Review and Meta-Analysis. 减肥手术类型与阻塞性睡眠呼吸暂停、就业结果和身体形象满意度之间的关系:系统回顾和荟萃分析。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2024-10-03 DOI: 10.1159/000541782
Beatrice Leyaro, Daniel Boakye, Lyz Howie, Abdulmajid Ali, Raymond Carragher
{"title":"Associations between Type of Bariatric Surgery and Obstructive Sleep Apnoea, Employment Outcomes, and Body Image Satisfaction: A Systematic Review and Meta-Analysis.","authors":"Beatrice Leyaro, Daniel Boakye, Lyz Howie, Abdulmajid Ali, Raymond Carragher","doi":"10.1159/000541782","DOIUrl":"10.1159/000541782","url":null,"abstract":"<p><strong>Introduction: </strong>Bariatric surgery has been shown to provide significant patient benefits in terms of weight loss and mitigation of obesity-linked comorbidities, as well as providing improvements in occupational productivity and patient quality of life. However, the choice of which bariatric surgery procedure provides the most patient benefit in each of these cases is still in question. In this review, we provide a systematic review, with the objective of evaluating associations between different bariatric surgery procedures and mitigation of obesity-linked comorbidities, improvement in occupational productivity, and patient quality of life, concentrating on three areas: obstructive sleep apnoea (OSA), employment prospects, and body image.</p><p><strong>Methods: </strong>The CINAHL, PubMed, Web of Science, and CENTRAL databases were searched for eligible studies. Summary risk ratio (RR) and 95% confidence intervals were estimated using random-effects models. Thirty-three studies were included in this review, including 29 cohort studies and 4 randomised clinical trials (RCTs).</p><p><strong>Results: </strong>Pooled analysis of the observational studies showed significantly lower OSA remission in sleeve gastrectomy (SG) compared to Roux-en-Y gastric bypass (RYGB) across both short-term (1-2 years) and longer term (3+ years) follow-up periods (RR = 0.91, 95% CI = 0.84-0.99, p = 0.02; and RR = 0.88, 95% CI = 0.65-0.99, p = 0.03, respectively). In contrast, a meta-analysis of the RCT studies found no difference in OSA remission between SG and RYGB (RR = 1.01, 95% CI = 0.81-1.25, p = 0.93). An analysis of four studies showed significantly higher OSA remission for SG versus adjustable gastric banding (RR = 1.83, 95% CI = 1.57-2.14, p < 0.001). No significant difference was observed regarding improvement in employment status between SG and RYGB (RR = 0.77, 95% CI = 0.32-1.87, p = 0.57). A narrative synthesis of studies on body image reported no significant differences between body image scores and surgery types.</p><p><strong>Conclusion: </strong>This review found significantly lower OSA remission in SG as compared to RYGB across different follow-up periods, while no significant statistical difference was observed in RCT studies. Further studies are recommended to assess the effectiveness of the various bariatric surgeries in relation to improving employment status and body image, where primary studies are lacking.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"57-71"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
European Association for the Study of Obesity (EASO) Position Statement on Medical Nutrition Therapy for the Management of Individuals with Overweight or Obesity and Cancer. 欧洲肥胖症研究学会(EASO)关于医学营养疗法治疗超重或肥胖癌症患者的立场声明。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1159/000542155
Giovanna Muscogiuri, Luigi Barrea, Silvia Bettini, Marwan El Ghoch, Niki Katsiki, Liisa Tolvanen, Ludovica Verde, Annamaria Colao, Luca Busetto, Volkan Demirhan Yumuk, Maria Hassapidou
{"title":"European Association for the Study of Obesity (EASO) Position Statement on Medical Nutrition Therapy for the Management of Individuals with Overweight or Obesity and Cancer.","authors":"Giovanna Muscogiuri, Luigi Barrea, Silvia Bettini, Marwan El Ghoch, Niki Katsiki, Liisa Tolvanen, Ludovica Verde, Annamaria Colao, Luca Busetto, Volkan Demirhan Yumuk, Maria Hassapidou","doi":"10.1159/000542155","DOIUrl":"10.1159/000542155","url":null,"abstract":"<p><p>Obesity, a prevalent and multifactorial disease, is linked to a range of metabolic abnormalities, including insulin resistance, dyslipidemia, and chronic inflammation. These imbalances not only contribute to cardiometabolic diseases but also play a significant role in cancer pathogenesis. The rising prevalence of obesity underscores the need to investigate dietary strategies for effective weight management for individuals with overweight or obesity and cancer. This European Society for the Study of Obesity (EASO) position statement aimed to summarize current evidence on the role of obesity in cancer and to provide insights on the major nutritional interventions, including the Mediterranean diet (MedDiet), the ketogenic diet (KD), and the intermittent fasting (IF), that should be adopted to manage individuals with overweight or obesity and cancer. The MedDiet, characterized by high consumption of plant-based foods and moderate intake of olive oil, fish, and nuts, has been associated with a reduced cancer risk. The KD and the IF are emerging dietary interventions with potential benefits for weight loss and metabolic health. KD, by inducing ketosis, and IF, through periodic fasting cycles, may offer anticancer effects by modifying tumor metabolism and improving insulin sensitivity. Despite the promising results, current evidence on these dietary approaches in cancer management in individuals with overweight or obesity is limited and inconsistent, with challenges including variability in adherence and the need for personalized dietary plans.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"86-105"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in Body Mass Index during the COVID-19 Pandemic among Indonesian Adolescents: The Role of Sex, Urban Area, Baseline BMI, and Appetitive Traits. 2019冠状病毒病大流行期间印度尼西亚青少年体重指数(BMI)的变化:性别、城市地区、基线BMI和食欲特征的作用
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1159/000543078
Eveline Sarintohe, William J Burk, Jacqueline M Vink, Junilla K Larsen
{"title":"Changes in Body Mass Index during the COVID-19 Pandemic among Indonesian Adolescents: The Role of Sex, Urban Area, Baseline BMI, and Appetitive Traits.","authors":"Eveline Sarintohe, William J Burk, Jacqueline M Vink, Junilla K Larsen","doi":"10.1159/000543078","DOIUrl":"10.1159/000543078","url":null,"abstract":"<p><strong>Introduction: </strong>Little is known about how the COVID-19 situation affected weight development among Indonesian adolescents. This longitudinal study examined whether, and for whom, the COVID-19 situation affected weight outcomes over time among adolescents from private schools and higher socio-economic positions in Indonesia, where being overweight is a rather prevalent characteristic. This study specifically examined whether appetitive traits (i.e., emotional overeating, food responsiveness) as well as baseline zBMI, sex, and urban area could explain changes in zBMI.</p><p><strong>Methods: </strong>At baseline, 411 adolescents from 5 private schools in Indonesia (53.3% males, Mage = 12.02 years, SD = 0.45) filled out questionnaires on appetitive traits and background characteristics. In addition, their height and weight were measured. Of these, 336 adolescents (81.8%) also participated at follow-up. At follow-up, height and weight were measured or reported. We used linear regression to analyze the association between predictors and interactions with zBMI.</p><p><strong>Results: </strong>The results showed a significant decrease in zBMI over time, with a lower average zBMI during COVID-19 compared to before COVID-19. Female adolescents and adolescents with higher baseline zBMI values particularly tended to show this zBMI decreasing pattern. We did not find statistically significant main effects of baseline emotional overeating, food responsiveness, and urban area or any interactions.</p><p><strong>Conclusions: </strong>Indonesian adolescents appeared to decrease in terms of zBMI during COVID-19, particularly females and adolescents with higher pre-COVID-19 zBMI. Our findings suggest that (culturally-specific) contextual changes (i.e., less exposure to the Indonesian food environment at schools and more exposure to the home environment) might have a beneficial impact in terms of preventing overweight among Indonesian adolescents, particularly among those being more vulnerable (i.e., having higher baseline zBMI).</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"169-177"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burden of Disease and Cost of Illness of Overweight and Obesity in Portugal. 葡萄牙超重和肥胖症的疾病负担和疾病成本。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2024-11-05 DOI: 10.1159/000541781
Margarida Borges, Filipa Sampaio, João Costa, Paula Freitas, Carlos Matias Dias, Vânia Gaio, Vasco Conde, Débora Figueira, Bernardete Pinheiro, Luís Silva Miguel
{"title":"Burden of Disease and Cost of Illness of Overweight and Obesity in Portugal.","authors":"Margarida Borges, Filipa Sampaio, João Costa, Paula Freitas, Carlos Matias Dias, Vânia Gaio, Vasco Conde, Débora Figueira, Bernardete Pinheiro, Luís Silva Miguel","doi":"10.1159/000541781","DOIUrl":"10.1159/000541781","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of overweight and obesity has increased in the last decades, posing significant health and economic impacts globally. These conditions are related to several non-communicable diseases, including cardiovascular disease, type II diabetes, and cancer. This study estimated the disease burden and healthcare costs associated with overweight and obesity in the adult population in mainland Portugal, in 2018.</p><p><strong>Method: </strong>Burden of disease was measured in disability-adjusted life years (DALYs) following Global Burden of Disease (GBD) methodology. DALYs were calculated as the sum of years of life lost (YLL) and years lived with disability (YLD). The analyses included morbidity, mortality, and related costs directly related to overweight and obesity, as well as the attributable morbidity, mortality, and related costs of 25 selected diseases related to obesity (DrO). A prevalence-based cost analysis was conducted a from the perspective of the public National Health Service, including costs related to inpatient, outpatient care, and pharmacological treatment.</p><p><strong>Results: </strong>In 2018, total DALY amounted to 260,943, with 75% due to premature death (196,438 YLL) and 25% due to disability (64,505 YLD). The economic burden of overweight and obesity was estimated at approximately EUR 1,148 million. Of these, approximately EUR 13.3 million (1%) were costs related to the treatment of obesity, and the remaining were costs of DrO attributed to overweight and obesity. Outpatient care corresponded to 43% of total costs, pharmacological treatment 38%, and inpatient care 19%. Cardiovascular and cerebrovascular diseases were the largest contributor to total costs (38%), followed by type II diabetes (34%).</p><p><strong>Conclusion: </strong>Overweight and obesity incur a large disease and economic burden to the public healthcare sector, representing approximately 0.6% of the country's gross domestic product and 5.8% of public health expenditures.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"107-120"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Challenges of Diagnosing Gestational Diabetes after Bariatric Surgery: Where Do We Stand? 减肥手术后诊断妊娠糖尿病的挑战:我们的现状如何?
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2024-10-09 DOI: 10.1159/000541623
Diana Rodrigues-Martins, Inês Nunes, Mariana P Monteiro
{"title":"The Challenges of Diagnosing Gestational Diabetes after Bariatric Surgery: Where Do We Stand?","authors":"Diana Rodrigues-Martins, Inês Nunes, Mariana P Monteiro","doi":"10.1159/000541623","DOIUrl":"10.1159/000541623","url":null,"abstract":"<p><strong>Background: </strong>Obesity, gestational diabetes mellitus (GDM), and bariatric metabolic surgery (BMS) are increasingly common conditions during pregnancy.</p><p><strong>Summary: </strong>However, clinical knowledge regarding GDM that occurs after BMS remains full of uncertainties. Given its prevalence and potential consequences for the dyad pregnant and offspring, it is imperative to increase knowledge about GDM after BMS, define diagnostic criteria and consequently strategies capable of improving pregnancy outcomes.</p><p><strong>Key messages: </strong>This paper aimed to review GDM screening methods after BMS and gives insights regarding new paths of research on this paramount obstetric condition.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"187-192"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Body Mass Index on Outcomes of Cervical Cerclage: A Systematic Review and Meta-Analysis. 体重指数对宫颈环扎术结果的影响:系统回顾和荟萃分析。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2024-11-27 DOI: 10.1159/000542543
Lihua Yang, Hua Yang
{"title":"Impact of Body Mass Index on Outcomes of Cervical Cerclage: A Systematic Review and Meta-Analysis.","authors":"Lihua Yang, Hua Yang","doi":"10.1159/000542543","DOIUrl":"10.1159/000542543","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of the review was to examine the impact of maternal body mass index (BMI) on outcomes of cervical cerclage for cervical insufficiency.</p><p><strong>Methods: </strong>This prospectively registered review (CRD42024512436) searched PubMed, Embase, Scopus, and Web of Science for comparative studies published before 6 March 2024. Maternal and neonatal outcomes of females undergoing cerclage were compared based on BMI.</p><p><strong>Results: </strong>Seven studies were included. Pooled data showed that the risk of preterm birth (PTB) (<37 weeks) was significantly increased in the obese vs. non-obese group (odds ratio 1.32, 95% confidence interval [CI]: 1.15, 1.51; I2 = 36%). Gestation age at delivery in weeks was also found to be significantly lower in the obese group (MD: -2.47, 95% CI: -4.83, -0.12; I2 = 96%). There was no significant difference in the risk of preterm premature rupture of membranes and chorioamnionitis between the two groups. Still, the rate of cesarean sections was significantly higher in the obese group. Neonatal birth weight in grams was not found to be significantly different between obese and non-obese groups but the risk of neonatal intensive care unit (NICU) admission was significantly increased in the obese group.</p><p><strong>Conclusion: </strong>Low-quality evidence indicates that obesity may lead to an increased risk of PTB in women undergoing cervical cerclage. The risk of cesarean section and NICU admission is also increased in obese females.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"193-205"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The One Anastomosis Gastric Bypass Is a Suitable Alternative to Roux-en-Y Gastric Bypass in Patients with Body Mass Index ≥50 kg/m2: A Propensity Score-Matched Analysis. 对于体重指数大于 50 kg/m2 的患者,单吻合胃旁路术是鲁克斯-全 Y 胃旁路术的合适替代方案:倾向分数匹配分析。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2024-11-21 DOI: 10.1159/000542681
Lindsy van der Laan, Dionne Sizoo, Loek J M de Heide, André P van Beek, Marloes Emous
{"title":"The One Anastomosis Gastric Bypass Is a Suitable Alternative to Roux-en-Y Gastric Bypass in Patients with Body Mass Index ≥50 kg/m2: A Propensity Score-Matched Analysis.","authors":"Lindsy van der Laan, Dionne Sizoo, Loek J M de Heide, André P van Beek, Marloes Emous","doi":"10.1159/000542681","DOIUrl":"10.1159/000542681","url":null,"abstract":"<p><strong>Introduction: </strong>Body mass index (BMI) ≥50 kg/m2 is more challenging for the metabolic bariatric surgeon because of a thicker abdominal wall, more visceral fat, and hepatomegaly by liver steatosis. This study aimed to give an overview of 5-year outcomes after one anastomosis gastric bypass (OAGB) and Roux-en-Y gastric bypass (RYGB) in these patients in terms of weight loss, remission of comorbidities, and complications.</p><p><strong>Methods: </strong>This retrospective single-center cohort study focused on patients with BMI ≥50 kg/m2 undergoing OAGB or RYGB between 2015 and 2017 at a nonacademic teaching hospital in the Netherlands. A 1:1 propensity score-matched (PSM) comparison was conducted.</p><p><strong>Results: </strong>In total, 158 patients underwent OAGB and 32 patients RYGB. After performing a 1:1 PSM, we obtained two nearly identical cohorts of 28 patients. Follow-up data after 5 years were available in 79% of the patients after OAGB and 82% of the patients after RYGB. Both procedures resulted in equal weight loss, remission of comorbidities, and short-term complications. More minor midterm complications were seen after OAGB (50% versus 18%; p = 0.011) due to reflux complaints (50% versus 7%; p < 0.001). The number of patients with major midterm complications did not differ (7% after OAGB versus 14% after RYGB; p = 0.388). The only major complication after OAGB was conversion to RYGB due to reflux in 7.1% of the patients. In contrast, major complications following RYGB were more diverse.</p><p><strong>Conclusion: </strong>Both procedures resulted in similar weight loss, remission of comorbidities, short-term and major midterm complications, making OAGB a suitable alternative to RYGB for patients with a BMI ≥50 kg/m2.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"149-156"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Omentin Increases Glucose Uptake, but Not Insulin Sensitivity in Human Myotubes Dependent on Extracellular Lactotransferrin. 网织红蛋白能提高葡萄糖摄取量,但不能提高依赖细胞外乳转铁蛋白的人体肌管对胰岛素的敏感性。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2024-11-11 DOI: 10.1159/000541915
Jacqueline M Ratter-Rieck, Alexandra Zepina, Corinna Niersmann, Karin Röhrig, Fabien Riols, Mark Haid, Jutta Lintelmann, Stefanie M Hauck, Michael Roden, Cora Weigert, Christian Herder
{"title":"Omentin Increases Glucose Uptake, but Not Insulin Sensitivity in Human Myotubes Dependent on Extracellular Lactotransferrin.","authors":"Jacqueline M Ratter-Rieck, Alexandra Zepina, Corinna Niersmann, Karin Röhrig, Fabien Riols, Mark Haid, Jutta Lintelmann, Stefanie M Hauck, Michael Roden, Cora Weigert, Christian Herder","doi":"10.1159/000541915","DOIUrl":"10.1159/000541915","url":null,"abstract":"<p><strong>Introduction: </strong>Omentin (intelectin-1) is an adipokine produced by the stromal vascular fraction of visceral adipose tissue and has been positively associated with insulin sensitivity. The underlying mechanism of action, however, is largely unknown. It has been described that omentin may increase insulin sensitivity and glucose uptake of adipocytes, but effects on other insulin-sensitive tissues such as skeletal muscle are unexplored. We therefore investigated effects of omentin on insulin sensitivity and metabolism of primary human myotubes.</p><p><strong>Methods: </strong>Primary human myotubes were treated with 0.5 or 2 µg/mL omentin and subsequently protein detection, glucose uptake assay, lactate assay, and lipidomics analysis were performed.</p><p><strong>Results: </strong>Omentin did not affect skeletal muscle insulin signaling, as assessed by basal and insulin-stimulated phosphorylation of IRS1 and AKT. Omentin increased basal, but not insulin-stimulated glucose uptake. While increased glycolytic activity was confirmed by elevated lactate release after omentin treatment, effects on cellular lipid composition were limited to an increase in total triacylglycerol concentration. Increased glucose uptake by omentin was counteracted by addition of extracellular lactotransferrin, which can bind to omentin.</p><p><strong>Conclusions: </strong>Overall, increased basal glucose uptake in skeletal muscle cells suggests differential effects of omentin on insulin-sensitive tissues. Moreover, an involvement of lactotransferrin in omentin's mechanism of action may partially explain contradictory results of epidemiological studies on the role of omentin in different diseases.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"121-129"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-Related Arterial Stiffening Is Associated with a Body Shape Index and Lean Body Mass Index: A Retrospective Cohort Study in Healthy Japanese Population. 年龄相关性动脉硬化与体型指数(ABSI)和瘦体重指数相关——日本健康人群的回顾性队列研究
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2025-01-27 DOI: 10.1159/000543791
Daiji Nagayama, Yasuhiro Watanabe, Kentaro Fujishiro, Kenji Suzuki, Masahiro Ohira, Kohji Shirai, Atsuhito Saiki
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