Obesity Facts最新文献

{"title":"Relationship of Fat Deposition in the Liver and Pancreas with Cholecystectomy.","authors":"Loren Skudder-Hill, Ivana R Sequeira-Bisson, Juyeon Ko, Sally Poppitt, Maxim S Petrov","doi":"10.1159/000545781","DOIUrl":"10.1159/000545781","url":null,"abstract":"<p><strong>Introduction: </strong>Rates of cholecystectomy in the general population continue to rise despite little being known about its long-term metabolic implications. Existing studies have suggested that cholecystectomy may be linked to type 2 diabetes mellitus and metabolic syndrome, though there is yet to be quality investigation of its associations with important ectopic fat depots - hepatic fat and intrapancreatic fat. The aim of the present study was to investigate the relationship of cholecystectomy with both hepatic and intrapancreatic fat.</p><p><strong>Methods: </strong>The study involved 367 participants who underwent abdominal scanning, with hepatic and intrapancreatic fat quantified using gold-standard MRI-based methods. Linear regression analyses were adjusted for age, sex, ethnicity, BMI, fasting plasma glucose, fasting insulin, triglyceride, LDL-C, and HDL-C.</p><p><strong>Results: </strong>In the most adjusted model, cholecystectomy was significantly negatively associated with hepatic fat (β coefficient = -3.671; p = 0.019) but not intrapancreatic fat (β coefficient = 0.133; p = 0.586). In analyses stratified by BMI, this association with hepatic fat was significant in the obese group only (β coefficient = -7.163; p = 0.048). The association with intrapancreatic fat was not influenced by BMI.</p><p><strong>Conclusion: </strong>Cholecystectomy is significantly associated with lower hepatic fat in obese individuals. This affirms that people with indications for cholecystectomy should not be dissuaded from undergoing the procedure based on fears of harmful effects of increasing hepatic fat content.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-13"},"PeriodicalIF":3.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Obesity-Related Indices with Rapid Kidney Function Decline and Chronic Kidney Disease: A Study from a Large Longitudinal Cohort in China.","authors":"Linshan Yang, Shengyu Huang, Shuyue Sheng, Xiaobin Liu, Shaolin Ma, Feng Zhu","doi":"10.1159/000545356","DOIUrl":"10.1159/000545356","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity has been established as a significant risk factor for rapid kidney function decline (RKFD) and chronic kidney disease (CKD). However, the comparative prognostic value of various obesity-related indices in predicting RKFD and CKD remains inadequately elucidated. The objective of this study was to explore the correlations between ten obesity-related indices: body mass index (BMI), Chinese visceral adiposity index (CVAI), waist-to-height ratio, visceral adiposity index (VAI), body roundness index (BRI), a body shape index (ABSI), lipid accumulation product (LAP), waist triglyceride index (WTI), relative fat mass (RFM), and conicity index (C-index) and RKFD and CKD.</p><p><strong>Methods: </strong>This retrospective longitudinal cohort study leveraged data sourced from the China Health and Retirement Longitudinal Study (CHARLS). Multivariate logistic regression models with covariate adjustment were employed to assess independent associations between obesity-related indices and clinical outcomes. Restricted cubic spline (RCS) regression analyses were performed to characterize potential nonlinear relationships. Predictive performance was quantified through receiver operating characteristic (ROC) curve analysis, with area under the curve (AUC) comparisons.</p><p><strong>Results: </strong>A total of 1,620 participants were enrolled in this study. Among them, 109 participants developed RKFD, and 60 progressed to CKD. Adjusted logistic regression revealed significant positive associations between CVAI, VAI, LAP, WTI, and RKFD risk, while BRI and C-index demonstrated per standard deviation increases associated with CKD progression. RCS curve analysis demonstrated that CVAI and LAP exhibited a nonlinear relationship with the risk of RKFD, while VAI and WTI had a linear relationship. Moreover, the C-index had a nonlinear relationship with the risk of CKD, whereas BRI had a linear relationship. ROC analysis revealed WTI as the superior RKFD predictor and ABSI as the optimal CKD progression indicator among the evaluated obesity-related indices.</p><p><strong>Conclusion: </strong>This study comprehensively investigated the associations between ten obesity-related indices and both RKFD and CKD. Our findings indicated that CVAI, VAI, LAP, and WTI were associated with RKFD, with WTI exhibiting the highest predictive value. Furthermore, BRI and C-index were associated with CKD, with ABSI demonstrating the highest predictive value for the progression to CKD.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-14"},"PeriodicalIF":3.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why and How to Improve Nutritional Care for Pregnant Women after Bariatric Surgery: The NUMASURG Study Protocol.","authors":"Cécile Ciangura, Claire Rives-Lange, Bénédicte Lelièvre, Martine Laville, Marie-Aline Charles, Bérénice Ségrestin, Barbara Heude","doi":"10.1159/000545123","DOIUrl":"10.1159/000545123","url":null,"abstract":"<p><strong>Introduction: </strong>Pregnancies after bariatric surgery (BS) are considered at risk because of increased rate of maternal micronutrient deficiencies, small for gestational age, and prematurity. Longer-term data on child health are scarce and conflicting. The objective of the NUMASURG project is to understand the consequences of micronutrient deficiencies during pregnancy after BS for the mother and the offspring and to better document the child's health outcomes after maternal BS.</p><p><strong>Methods: </strong>NUMASURG is a collaborative project bringing together clinicians, biologists, epidemiologists, clinical researchers, and the French Obesity Research Center of Excellence network. The project is organized into four specific tasks: (1) establish a cohort of 1,000 pregnant women with a history of BS; (2) establish reference values for nutritional biomarkers during pregnancy (vitamins A, B9, B12, 25[OH]-D, zinc, ferritin) from two birth cohorts of the French general population (EDEN and ELFE); (3) compare the nutritional status between pregnant women after BS and women from the general population and investigate the associations between nutritional biomarkers and small for gestational age and prematurity in both populations; and (4) describe the health of children born from mothers with a history of BS using the French national health data system. Started in September 2023, the project will run for 4 years.</p><p><strong>Conclusion: </strong>The NUMASURG project will allow for implementing updated recommendations concerning the monitoring and nutritional supplementation of pregnant women with a history of BS. Ultimate objective are to improve the nutritional status of these women and consequently limit the main risks currently observed during pregnancy after BS. Structuring a clinical database will help standardize practices and enable future research projects in this area and will be a key first step in creating a prospective cohort of children born from mothers with a history of BS.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-11"},"PeriodicalIF":3.9,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Türkiye Consensus Report on the Multidisciplinary Obesity Treatment in Adults.","authors":"Alper Sonmez, Fahri Bayram, Oktay Banli, Ibrahim Demirci, Sinem Kiyici, Meral Kucuk Yetgin, Taner Bayraktaroglu, Feray Akbas, Halil Coskun, Serhat Ocakli, Nihat Aksakal, Muhammed Taha Demirpolat, Samet Yardimci, Ferhat Cay, Gokcem Yalin Kocamaz, Dilek Yazici, Ozgur Sevim, Harun Karabacak, Hasan Altun, Zehra Yagmur Sahin Alak, Ceren Iseri, Asim Cingi, Halil Ozguc, Fatih Mehmet Avsar, Mustafa Taskin, Nihal Zekiye Erdem, Aziz Sumer, Mustafa Cesur, Eren Halit Taskin, Volkan Demirhan Yumuk","doi":"10.1159/000545605","DOIUrl":"10.1159/000545605","url":null,"abstract":"<p><p>Obesity is the world's most dangerous and rapidly growing health problem. Treating people living with obesity is not limited to the weight-loss process. They should also be followed up with a multidisciplinary approach to maintain the weight loss achieved. There is a lack of structural and functional standardization in obesity centers that undertake medical and surgical treatment. This consensus report, prepared by professional organizations for treating obesity, aimed to ensure that all obesity centers can perform standard patient management using evidence-based workflow diagrams. The report covers all the steps, starting from the initial evaluation process. It describes how to make treatment decisions jointly, defines the responsibilities of obesity councils, and designates the follow-up procedures of medically or surgically treated patients. The consensus report underlines that all healthcare professionals treating obesity are complementary. No discipline can achieve absolute success in treating people with obesity on its own. It is mandatory to implement a sustainable and practical collaboration based on current scientific evidence in treating and following up individuals with obesity.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-20"},"PeriodicalIF":3.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spanish GIRO Guideline: A Paradigm Shift in the Management of Obesity in Adults.","authors":"Albert Lecube, Sharona Azriel, Esther Barreiro, Guadalupe Blay, Juana Carretero-Gómez, Andreea Ciudin, José Manuel Fernández, Lilliam Flores, Ana de Hollanda, Eva Martínez, Inka Miñambres, Violeta Moizé, Cristóbal Morales, Violeta Ramírez, Javier Salvador, María José Soler, Marta Supervía, Víctor Valentí, Germán Vicente-Rodríguez, Nuria Vilarrasa, María M Malagón","doi":"10.1159/000544880","DOIUrl":"10.1159/000544880","url":null,"abstract":"<p><strong>Introduction: </strong>Current obesogenic environments, along with intrinsic factors, contribute to the obesity pandemic, which impacts the quality of life and healthcare for individuals with obesity. In addition, discrimination and stigma related to obesity remain widespread in our society. In this scenario, the Spanish Society for the Study of Obesity (SEEDO), in collaboration with 38 recognized scientific societies and 12 patients' organization, has elaborated the Spanish guideline for obesity management in adults, referred to as the GIRO guideline. GIRO aims to drive a shift in obesity management and serve as a guide for healthcare professionals (HCPs) to address this chronic and multifactorial disease.</p><p><strong>Methods: </strong>A comprehensive systematic review was conducted and completed with experts' contribution, with a particular focus on Spanish society. The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. Experts selected the recommendations and determined their strength through consensus.</p><p><strong>Results: </strong>A total of 121 recommendations were proposed, including 32 adopted from the Canadian Adult Obesity Clinical Practice Guidelines and 89 specific recommendations created for the Spanish context, and were distributed across five areas of application: (1) recognition of obesity as a chronic disease, (2) obesity assessment, (3) multidisciplinary approach to obesity treatment, (4) recommendations for obesity management in special populations, and (5) implementation of the GIRO guideline and future challenges.</p><p><strong>Conclusion: </strong>The GIRO recommendations are intended to serve as a useful and interactive tool for HCPs, policymakers, and other stakeholders to ensure access to and quality of healthcare for individuals living with obesity.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-13"},"PeriodicalIF":3.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and Clinical Characteristics of Inflammatory Bowel Disease.","authors":"Roberto Mancone, Livia Biancone, Sara Concetta Schiavone, Mariasofia Fiorillo, Chiara Menna, Stefano Migliozzi, Benedetto Neri","doi":"10.1159/000545436","DOIUrl":"10.1159/000545436","url":null,"abstract":"<p><strong>Introduction: </strong>The frequency of obesity and possible correlations with characteristics and outcome of inflammatory bowel disease (IBD) are undefined. Primary aim was to assess the body mass index (BMI) distribution in IBD patients in follow-up. Secondary aim was to compare clinical characteristics and course of IBD in normal weight versus overweight or obese patients.</p><p><strong>Methods: </strong>Adult IBD patients in regular follow-up were prospectively enrolled and BMI was recorded during outpatient visits. Comparisons were assessed by the Student t-test, Mann-Whitney U test and Chi-square test, as appropriate.</p><p><strong>Results: </strong>In the 300 IBD patients enrolled (150 Crohn's disease [CD], 150 ulcerative colitis [UC]), BMI distribution included: 16 (5.3%) underweight, 170 (56.7%) normal weight, 92 (30.7%) overweight, 22 (7.3%) obese patients. For the secondary aim, the 16 underweight patients were excluded, thus leaving 284 patients for the analysis (141 [49.6%] CD; 143 [50.4%] UC). Among these, 114 (40.2%) were overweight/obese and 170 (59.8%) normal weight. CD group included 89 (63.1%) normal weight and 52 (36.9%) overweight/obese patients. Perianal disease and refractoriness to biologics were more frequent in overweight/obese than normal weight CD patients (9 [10.1%] vs. 12 [23%], p = 0.03; 0 [0%] vs. 4 [23.4%], p = 0.01). In UC group, there were 81 (56.6%) normal weight and 62 (63.4%) overweight or obese patients.</p><p><strong>Conclusion: </strong>In IBD patients in follow-up, the proportion of underweight patients is low. Overweight and obese CD patients showed a higher frequency of perianal disease and refractoriness to biologics. BMI may influence phenotype and responsiveness to biologics in CD.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-16"},"PeriodicalIF":3.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Gallstones Increases with Multiple Dimensions of Obesity Indexes: A Prospective Study Based on the UK Biobank.","authors":"Jin Zhou, Wenqian Yu, Guoheng Jiang, Hongyu Li, Jing Luo, Shiyi Li, Linjun Xie, Xuan Bai, Jing Xia, Min Mao, Min Gao, Jiong Lu, Xin Wang","doi":"10.1159/000545346","DOIUrl":"10.1159/000545346","url":null,"abstract":"<p><strong>Introduction: </strong>Numerous cohort studies have consistently shown a significant link between obesity and an increased risk of gallstones. However, body mass index (BMI) alone may not fully capture the complexity of obesity. This study aimed to analyze the associations between different obesity indexes and the incidence of gallstones, using a competing risk model.</p><p><strong>Methods: </strong>A total of 459,523 UK Biobank participants without gallstones at baseline were analyzed. Cox proportional hazards models, competing risk models, and restricted cubic spline were performed to assess the longitudinal associations between 11 obesity indexes including a body shape index (ABSI), body adiposity index (BAI), body roundness index (BRI), conicity index (ConI), cardiometabolic index (CMI), hip circumference (HC), visceral adiposity index (VAI), lipid accumulation product (LAP), waist circumference (WC), waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR) apart from BMI and gallstone occurrence risk, respectively.</p><p><strong>Results: </strong>Over a follow-up period of 12.54 years, a total of 14,951 participants developed gallstones. After adjusting for confounding factors, competing risk regression analyses revealed that BMI, BRI, BAI, confidence interval, CMI, HC, LAP, VAI, WC, and WHtR were all positively associated with an increased risk of gallstones. ABSI and WHR showed a \"J-shaped\" association with the incidence of gallstones, suggesting a nonlinear relationship. Sensitivity analyses confirmed the consistency of the results even after excluding participants who developed gallstones within 1 year of follow-up.</p><p><strong>Conclusion: </strong>Different dimensions of obesity are all significantly associated with an increased risk of gallstones. These findings highlight the importance of managing obesity, including both overall body weight and abdominal fat, to prevent the occurrence of gallstones.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-13"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Brief Form of the Weight Control/Blame Subscale of the Antifat Attitudes Test.","authors":"Julia Petersen, Bjarne Schmalbach, Elmar Brähler, Oliver Decker, Anja Hilbert","doi":"10.1159/000545380","DOIUrl":"10.1159/000545380","url":null,"abstract":"<p><strong>Introduction: </strong>The Weight Control/Blame (WCB) subscale of the Antifat Attitudes Test (AFAT) measures weight stigma, particularly beliefs linking obesity to personal responsibility, which contributes to discrimination and negative psychological, often reinforced by political ideologies and authoritarian attitudes. This study sought to (1) develop and validate an economic version of the WCB subscale and (2) evaluate associations between weight stigmatizing attitudes, authoritarian beliefs, sexist attitudes, and conspiracy mentality.</p><p><strong>Methods: </strong>A four-item short form of the WCB subscale (WCB-4) was developed using a representative sample of the German population (N = 1,000) and validated on a second sample (N = 2,524). We assessed psychometric properties, convergent, and divergent validity.</p><p><strong>Results: </strong>The four-item solution demonstrated good internal consistency (ω = 0.807) and favorable confirmatory factor analysis results. Weight stigma positively correlated with authoritarian and sexist beliefs, and negatively with depression, anxiety, and body mass index.</p><p><strong>Conclusion: </strong>The WCB-4 is a reliable and valid tool for assessing weight stigma in epidemiological research. It highlighted positive associations with authoritarian beliefs and sexist attitudes, reflecting an interconnected system of biases against marginalized groups. Though a minor correlation was found between conspiracy mentality and authoritarian beliefs, no significant link emerged between conspiracy mentality and weight stigma.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-11"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture Combined with Press Needles Alleviates Simple Obesity via VEGF-C/VEGFR-3/PI3K/AKT Signaling Pathway.","authors":"Minghui Xia, Zhi Yu, Yuhang Wang, Donghua Liu, Yan Wang, Shuang Wu, Bin Xu","doi":"10.1159/000545330","DOIUrl":"10.1159/000545330","url":null,"abstract":"<p><strong>Introduction: </strong>Simple obesity is an increasingly prevalent chronic condition. While electroacupuncture (EA) has demonstrated potential in addressing this issue, its effectiveness may be hindered by insufficient continuous stimulation and challenges related to patient adherence. This study aimed to compare the efficacy of EA alone versus EA combined with press needles in the treatment of simple obesity and to explore the underlying mechanisms contributing to weight loss.</p><p><strong>Methods: </strong>Eighty simple obese patients with a body mass index (BMI) ≥25.0 kg/m2 were divided into two groups: the observation group (treated with EA combined with press needles) and the control group (treated with EA alone). The efficacy of the treatments was evaluated by monitoring obesity indicators. Additionally, obesity rat models were established through a high-fat diet (HFD), and rats were randomly assigned to three groups: obesity control group (no treatment), EA group, and EA combined with press needles group. Treatment outcomes were assessed by monitoring obesity indicators, examining adipose and liver cell morphology using staining techniques, and evaluating intestinal lymphatic vessel function through qRT-PCR, Western blot, and immunofluorescence analyses.</p><p><strong>Results: </strong>The patients in the observation group exhibited significantly lower body weight (BW), BMI, body fat percentage (F%), abdominal circumference (A), waist circumference (WC), as well as serum levels of intestinal lymphatic function-related factors such as VEGF-C, delta-like ligand 4 (DLL4), and adrenomedullin (ADM) compared to the control group. Similarly, compared to EA group, EA combined with press needles significantly decreased obesity indexes, serum intestinal lymphatic function-related factors, and improved lymphatic vessel function in obese rats. Mechanistically, the VEGF-C/VEGFR-3/PI3K/AKT signaling pathway was inhibited by EA combined with press needles intervention.</p><p><strong>Conclusion: </strong>The combined therapy of EA with press needles had shown significantly superior efficacy in treating simple obesity compared to EA treatment alone. It achieved this by modulating the VEGF-C/VEGFR-3/PI3K/AKT signaling pathway, improving lymphatic vessel structure and function, and ultimately inhibiting obesity.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-16"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight-Loss Plateau during Lifestyle Intervention Predicts Treatment Response in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease and Obesity.","authors":"Ling Luo, Junzhao Ye, Ting Zhou, Zhi Dong, Shiting Feng, Wei Wang, Shuyu Zhuo, Bihui Zhong","doi":"10.1159/000543818","DOIUrl":"10.1159/000543818","url":null,"abstract":"<p><strong>Introduction: </strong>Whether the weight-loss plateau and its values differ in obesity with or without metabolic dysfunction-associated steatotic liver disease (MASLD) undergoing continuous lifestyle intervention remains unknown. We aimed to investigate this problem.</p><p><strong>Methods: </strong>This prospective observational cohort study included 305 patients with obesity and MASLD and 103 matched individuals with non-MASLD from January 2015 to April 2023, with a 12-month follow-up to monitor weight changes. Liver biochemistry, liver fat content with magnetic resonance imaging-based proton density fat fraction with Dixon sequence, and liver stiffness measurement via 2D-SWE were assessed at baseline and after 12 months. A validated weight trajectory regression model was applied to estimate the weight-loss plateau.</p><p><strong>Results: </strong>Individuals with MASLD and non-MASLD presented a similar timing of the weight plateau at 6 months, but patients with MASLD experienced less weight loss and maintained their weight plateaus longer compared to those with non-MASLD. Among patients with MASLD, a greater total weight loss (TWL) at 6 months was associated with better treatment response in hepatic steatosis and injury (all p < 0.001). Further multivariate logistic analysis showed that the 6-month TWL was an independent predictor of subsequent improvements in hepatic steatosis (OR: 0.78, 95% CI: 0.72-0.84) and alanine aminotransferase levels (OR: 0.82, 95% CI: 0.76-0.90) at 12 months.</p><p><strong>Conclusion: </strong>Patients with MASLD experienced gradual weight loss followed by a prolonged plateau, with the maximum reduction observed at 6 months. The degree of 6-month weight loss was a valuable prognostic factor for the 12-month hepatic treatment outcomes. Strategies to overcome this plateau are essential for improving long-term treatment efficacy in MASLD.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-14"},"PeriodicalIF":3.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}