Obesity Facts最新文献

{"title":"In vitro Modeling of Adipogenesis Using Mesenchymal Stem Cells from Subcutaneous Adipose Tissue to Explore the Cellular and Molecular Mechanisms Underlying Pediatric Obesity and Obesogenic Memory.","authors":"Marko Dardi, Clarissa Berardo, Gloria Pelizzo, Maxime Bonnet, Francesca Destro, Gerson Capelo, Michele Ceresola, Alessia Lai, Stephana Carelli, Gianvincenzo Zuccotti, Valeria Calcaterra","doi":"10.1159/ofa/adzag003","DOIUrl":"10.1159/ofa/adzag003","url":null,"abstract":"<p><strong>Introduction: </strong>Pediatric obesity is associated with early metabolic complications and increased risk of persistent obesity in adulthood. Beyond fat accumulation, obesity may induce long-lasting molecular alterations in adipose tissue, described as \"obesogenic memory.\" However, whether such intrinsic alterations are already present in pediatric adipose progenitor cells remains poorly understood. This study aimed to develop an in vitro model of adipogenesis using pediatric adipose-derived mesenchymal stem cells (hMSCs) and to investigate whether obesity is associated with intrinsic metabolic reprogramming of adipose progenitors.</p><p><strong>Methods: </strong>hMSCs were isolated from periumbilical subcutaneous adipose tissue obtained from pediatric subjects with normal weight (NW), overweight (OW), and obesity (OB). Cells were expanded and induced to undergo adipogenic differentiation for up to 14 days using defined adipogenic media. Differentiation was evaluated through morphological analysis, lipid accumulation (BODIPY staining), gene expression profiling by RT-qPCR, and protein analysis by Western blot.</p><p><strong>Results: </strong>Two differentiation protocols efficiently induced adipocyte maturation without cytotoxicity. hMSCs derived from NW and OB subjects showed comparable adipogenic differentiation capacity, with similar lipid droplet accumulation and expression of canonical adipogenic markers, including C/EBPα, PPARγ, and FABP4. Despite this comparable differentiation efficiency, OB-derived adipocytes exhibited altered transcriptional regulation of genes involved in lipid metabolism, including pathways associated with lipogenesis, lipolysis, and fatty acid β-oxidation. Protein analyses further revealed dysregulated expression of key metabolic regulators such as SCD1, SREBP1, PNPLA2, and FADS1, suggesting altered lipid-metabolic programming.</p><p><strong>Conclusions: </strong>Pediatric obesity does not impair adipogenic differentiation but is associated with intrinsic metabolic alterations in adipose progenitor cells. These findings suggest the hypothesis of the presence of obesogenic memory in adipose tissue that may contribute to long-term metabolic dysfunction.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1"},"PeriodicalIF":4.1,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13688390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosing Obesity in Korean Children Using BMI and Body Fat Percentage: Differences in Growth and Body Composition.","authors":"Jihun Kim, Seo Jung Kim, Junghwan Suh, Dohyun Chun","doi":"10.1159/000553145","DOIUrl":"10.1159/000553145","url":null,"abstract":"<p><strong>Introduction: </strong>We examined how obesity classifications based on body mass index (BMI) vs. body fat percentage (BFP) differentially characterize growth and body composition among Korean children, and to identify discordant phenotypes missed by BMI alone.</p><p><strong>Methods: </strong>Children aged 7-12 were classified into 5 obesity groups and a control group: BMI Obesity (BMI > +2 SDS; n = 15,719), BFP Obesity (BFP > +2 SDS; n = 8,142), BMI- and BFP Obesity (n = 5,022), BMI-Only Obesity (BMI > +2 SDS with normal BFP; n = 10,157), BFP-Only Obesity (BFP > +2 SDS with normal BMI; n = 3,120), and controls (BMI and BFP between 2 and +2 SDS; n = 423,745). Height, weight, BMI, BFP, body fat mass (BFM), BFM index (BFMI), skeletal muscle mass index (SMMI), and waist-to-hip ratio (WHR) were compared across groups and ages.</p><p><strong>Results: </strong>Children classified as BMI Obesity were taller and had higher SMMI, whereas those with BFP Obesity showed lower height and higher BFMI and BFP. These contrasts became more pronounced with age. At ages 11-12, many boys meeting BMI criteria did not meet BFP criteria, consistent with age-related increases in lean mass. In contrast, BFP-Only Obesity was more common in girls, indicating adiposity not captured by BMI. WHR distinguished children with obesity from children without obesity but did not differentiate BMI- and BFP-defined obesity.</p><p><strong>Conclusion: </strong>BMI-based and BFP-based definitions identify distinct obesity phenotypes in late childhood. Reliance on BMI alone may lead to misclassification, particularly during early pubertal growth.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-11"},"PeriodicalIF":4.1,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The BARIAlink Global Collaborative Platform: Just Another Educative Tool or a Pioneering Evolution in the Treatment of Metabolic and Obesity-Related Disease?","authors":"Ala Wafa, Jacques Himpens, Antonio Torres, Chetan Parmar, Bruno Dillemans","doi":"10.1159/ofa/adzag001","DOIUrl":"10.1159/ofa/adzag001","url":null,"abstract":"","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1"},"PeriodicalIF":4.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep-Disordered Breathing and Decreased Bone Mineral Density: Masking Effects of Body Mass Index.","authors":"Wiaam Y Elkhatib, Virend K Somers, Prachi Singh, Jan Bukartyk, Joshua M Bock, Sreeja Sompalli, Soumya Vungarala, Alexandria B Danyluk, Abel Romero-Corral, Naima Covassin","doi":"10.1159/000552188","DOIUrl":"10.1159/000552188","url":null,"abstract":"<p><strong>Introduction: </strong>The relationship between sleep-disordered breathing (SDB), bone mineral density (BMD), and risk of osteoporosis is unclear. Obesity, a condition often comorbid with SDB, has been associated with high BMD, yet its impact on bone health remains controversial. The purpose of this study was to evaluate the implications of obesity in the relationship between SDB and BMD.</p><p><strong>Methods: </strong>A total of 225 adults aged 20-65 years were enrolled in this study. Participants were nonsmokers, free of major cardiovascular diseases, and not receiving treatment for SDB. Participants completed overnight polysomnography and whole-body dual-energy X-ray absorptiometry (DEXA) scans. SDB was defined as apnea-hypopnea index of ≥5 events/hour. Total body BMD (g/cm2), T scores, and Z scores were obtained from DEXA scans. Height and weight measures were collected for computation of body mass index (BMI, kg/m2). Multivariable linear regression analysis was conducted to test the association between SDB and BMD metrics and the contribution of relevant covariates.</p><p><strong>Results: </strong>Participants with SDB (n = 74, 32.9% of the sample) had higher total-body BMD (p = 0.003), T score (p = 0.017), and Z score (p = 0.011) compared to non-SDB controls. In multivariable models adjusted for demographic characteristics, SDB was not significantly associated with total-body bone measures. However, when including BMI, significant inverse relationships between SDB and total body BMD (p = 0.046), T score (p = 0.049), and Z score (p = 0.049) became apparent. Such associations persisted after controlling for lifestyle, clinical and sleep variables (fully adjusted models, total BMD, p = 0.036; T score, p = 0.037; Z score, p = 0.034). In sensitivity analysis, there were no associations between SDB and bone measures in models adjusted for body fat in lieu of BMI.</p><p><strong>Conclusion: </strong>An inverse, albeit modest, association between SDB and BMD exists, and this relationship emerges when considering BMI but not body fat. Hence, our data suggest that elevated body mass rather than adiposity may mask the negative association between SDB and bone health, thus possibly explaining prior conflicting evidence. Longitudinal investigations corroborating these findings and evaluating their implications for osteoporosis risk in patients with SDB are needed.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-11"},"PeriodicalIF":4.1,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13498330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endotypic Trait Responses to 12-Month Tirzepatide Treatment for an Obese Patient with Obstructive Sleep Apnea: A Case Report.","authors":"Yen Hsu, Wan-Ju Cheng, Eysteinn Finnsson, Jón S Ágústsson, Liang-Wen Hang","doi":"10.1159/000553125","DOIUrl":"10.1159/000553125","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity is a major risk factor for obstructive sleep apnea (OSA), and weight loss induced by glucagon-like peptide-1 (GLP-1) receptor agonists has been associated with reductions in the apnea-hypopnea index (AHI).</p><p><strong>Case presentation: </strong>We report a 35-year-old obese man with severe OSA who received tirzepatide for 12 months during the SURMOUNT-OSA trial. His body mass index decreased from 31.0 to 24.9 kg/m2, and AHI decreased from 54.8 to 4.4 events/h. Endotypic traits demonstrated improved upper airway patency, increased compensatory pharyngeal muscle responsiveness, reduced loop gain, and a lower arousal threshold, accompanied by paradoxically longer event duration.</p><p><strong>Conclusion: </strong>This case suggests that tirzepatide improves OSA through weight loss as well as favorable shifts in airway physiology and ventilatory control. GLP-1-based therapy may represent a promising treatment for obesity-related OSA, warranting further mechanistic studies.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-4"},"PeriodicalIF":4.1,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Inflammation in Obesity and the Cardiovascular-Kidney-Metabolic Syndrome Spectrum: A Narrative Review.","authors":"Afsaneh Noormandi, Heiko Bugger, Faisal Aziz, Zvonko Milicevic, Dirk von Lewinski, Bernhard Ludvik, Verena Parzer, Andreas Zirlik, Thomas R Pieber, Hans Peter Dimai, Harald Sourij","doi":"10.1159/000553324","DOIUrl":"10.1159/000553324","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular-kidney-metabolic (CKM) syndrome refers to a multi-systemic condition with established pathophysiological connections between obesity, diabetes mellitus, chronic kidney disease, and cardiovascular disease. Chronic low-grade inflammation has been recognized as a common pathophysiological theme linking metabolic dysfunction to multisystem damage of the heart, kidneys, and vasculature. The aim of this narrative review was to summarize the major pharmacologic strategies that target inflammatory pathways in obesity and across the CKM disease spectrum, including metabolic therapies with indirect anti-inflammatory effects and targeted immunomodulatory agents.</p><p><strong>Summary: </strong>New therapies have markedly changed the obesity and the CKM treatment paradigms, with evidence that currently available metabolic medications confer cardiovascular and renal benefits in addition to glycemic control or weight improvement. Nutrient-stimulated hormone therapies and sodium-glucose cotransporter-2 inhibitors (SGLT2i) work synergistically to positively modulate systemic inflammation while maintaining cardiovascular health and cardiometabolic function throughout therapy. Additionally, emerging clinical data for direct anti-inflammatory treatments, such as interleukin-1β/interleukin-6 inhibition and low-dose colchicine, have established inflammation as a modifiable cardiovascular risk factor. Furthermore, therapies that target the liver, such as resmetirom, fibroblast growth factor-21 (FGF21) analogs, and peroxisome proliferator-activated receptors agonists, have highlighted the role of the liver-adipose axis in metabolic inflammation and CKM progression.</p><p><strong>Key messages: </strong>Together, both metabolic and direct anti-inflammatory therapies represent the most recent evolution of a combined approach to treating metabolic dysfunction and inflammation. This type of approach has the potential to revolutionize the prevention and treatment of CKM across the spectrum of diseases and usher in personalized medicine for obesity-related cardiometabolic diseases. However, further studies are needed to determine when these therapies should be initiated, which patients are most likely to benefit, and whether combination approaches can alter disease progression beyond the current standard of care.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-25"},"PeriodicalIF":4.1,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148339441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing Weight Stigma in Healthcare Settings Using an Obesity Checklist: A Mixed-Method Development Study.","authors":"Giang T Nguyen, Jade H Thorne, Stephanie Goodlet, Lisa Davies, Emilie Combet Aspray, Dimitris Papamargaritis, Alexander Dimitri Miras, Sarah Le Brocq, Suzy Cooke, Jill Harland, Nicola Heslehurst","doi":"10.1159/000552921","DOIUrl":"10.1159/000552921","url":null,"abstract":"<p><strong>Introduction: </strong>Experiencing weight stigma negatively impacts health yet remains present in healthcare environments. Hospital environments must be inclusive for people living with obesity (PLwO). The aim of this study was to develop and refine a checklist to increase obesity inclusivity in UK National Health Service (UK NHS) hospital environments, with input from healthcare professionals (HCPs), researchers, PLwO, and their carers and family members (C/FM).</p><p><strong>Methods: </strong>This study used a sequential mixed-methods approach. Phase 1 used a converging coding matrix to integrate existing checklists and reviewed language for inclusivity. In phase 2, HCPs, researchers, PLwO, and C/FM were recruited from professional and patient networks to provide feedback on the integrated checklist using a mixed-methods survey (February-March 2025) and qualitative semi-structured interviews (May-July 2025). Descriptive statistics and deductive and inductive framework analyses were used to identify patterns in the data to inform refinement of the checklist and implementation recommendations (Phase 3).</p><p><strong>Results: </strong>Searches identified five checklists, which were integrated, resulting in categories for reading materials, furniture, equipment, and access and infrastructure. Sixty-nine participants completed the survey, and eighteen were interviewed. Overall, participants considered the checklist comprehensive. Integration of the qualitative survey and interview data resulted in four themes: (1) recommendations and thoughts about checklist components; (2) wording, language, images, and structure; (3) patient impact and care experiences; (4) implementation barriers and support. Primary implementation barriers related to funding, space, outdated infrastructure, and deep-rooted weight bias. Management buy-in, training, education, endorsement, and accreditation schemes were considered facilitators. Twenty recommendations were developed to support hospitals with implementation.</p><p><strong>Conclusion: </strong>Findings indicate that a clear, practical, and inclusive checklist could support hospitals in reducing weight stigma and improving care experiences for PLwO. The collaboratively developed and refined checklist offers a practical tool for hospitals to use. However, support will be required for effective and complete implementation.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-15"},"PeriodicalIF":4.1,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Bariatric Surgery Motivation Questionnaire: A Validated Tool for Preoperative Assessment in Persian Population.","authors":"Hastimansooreh Ansar, Razieh Salehian, Mohammad Eslami, Ali Kabir","doi":"10.1159/000552922","DOIUrl":"10.1159/000552922","url":null,"abstract":"<p><strong>Introduction: </strong>Bariatric surgery represents a highly effective intervention for individuals with severe obesity, yet the preoperative motivational factors influencing adherence and long-term outcomes remain insufficiently explored, particularly in the context of mental health. This study aimed to develop and validate a culturally tailored questionnaire to assess preoperative motivations among bariatric surgery candidates, thereby enhancing personalized care.</p><p><strong>Methods: </strong>A mixed-methods study conducted from 2017 to 2019 at Rasool-e-Akram Hospital, Tehran, Iran, enrolled 448 adults with severe obesity (BMI ≥40 kg/m2 or ≥35 kg/m2 with at least one comorbidity). Semi-structured interviews (n = 200) generated an initial 158-item pool, which was refined into a 94-item pilot questionnaire (n = 100) and subsequently a final 30-item version (n = 148). The validation process encompassed evaluations of content validity (via content validity Ratio [CVR] and Content Validity Index [CVI]), construct validity (through Exploratory Factor Analysis [EFA]), reliability (using Cronbach's alpha), and convergent/divergent validity (employing the Treatment Self-Regulation Questionnaire [TSRQ] and Patient Health Questionnaire-9 [PHQ-9]).</p><p><strong>Results: </strong>The 30-item Bariatric Surgery Motivation Questionnaire encompasses four domains: Health (8 items), Physical Discomfort (4 items), Psychosocial Factors (12 items), and Attitudes Toward Surgery (6 items). EFA confirmed the factorial structure, accounting for 63.4% of variance (KMO = 0.739, p < 0.001). Content validity was strong (S-CVI/Ave = 0.87; CVR >0.49). Overall reliability was satisfactory (α = 0.813), with domain-specific alphas ranging from 0.312 to 0.807. Convergent validity with TSRQ (r = 0.78, p < 0.001) and divergent validity with PHQ-9 (r = -0.02, p = 0.032) were supported.</p><p><strong>Conclusion: </strong>The Bariatric Surgery Motivation Questionnaire is a potentially valid and reliable instrument for evaluating preoperative motivations among bariatric surgery candidates. It provides clinicians with a practical means to identify motivational factors that may affect surgical outcomes. Further refinement of domains with lower reliability and validation in larger multicenter samples could enhance its clinical utility.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-9"},"PeriodicalIF":4.1,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline and Follow-Up Association between Adiposity and Renal Function: Data from the ILERVAS Cohort.","authors":"Aitziber Izarra, Marcelino Bermúdez-López, José Manuel Valdivielso, María José Soler, Reinald Pamplona, Gerard Torres, Dídac Mauricio, Eva Castro-Boqué, Elvira Fernández, Marta Hernández, Rafael Simó, Cristina Hernández, Albert Lecube","doi":"10.1159/000552362","DOIUrl":"10.1159/000552362","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity is multifactorial and increasingly prevalent disease associated with chronic kidney disease (CKD). While cross-sectional studies support a link between adiposity and renal dysfunction, the long-term impact of total body fat on kidney function remains unclear. This study aims to evaluate the association between baseline adiposity, assessed by body mass index (BMI) and total body fat percentage, and renal function parameters, and to determine whether adiposity predicts CKD outcomes over 4 years in individuals without diabetes at low-to-moderate cardiovascular risk.</p><p><strong>Methods: </strong>This retrospective, multicenter study included 8,153 participants from the ILERVAS project in Lleida, Spain. Adiposity was measured using BMI and estimated body fat percentage (CUN-BAE formula). Renal function was evaluated by estimated glomerular filtration rate (eGFR) and albumin-to-creatinine ratio (ACR). A subset of 3,222 individuals was reevaluated after 4 years. Multivariable regression models and ROC analysis were performed to explore associations and predictive performance.</p><p><strong>Results: </strong>CKD prevalence was 15.1%, higher in individuals with obesity (17.2%) than in those with overweight (13.7%) or normal weight (13.9%, p < 0.001). Body fat percentage showed a stronger inverse correlation with eGFR than BMI and was independently associated with eGFR decline. Baseline body fat percentage and its increase over time were associated with eGFR decline. Neither adiposity measure independently predicted CKD presence nor albuminuria.</p><p><strong>Conclusions: </strong>Higher total body fat is associated with impaired renal function and its progression over time, independently of traditional CKD risk factors. These findings support incorporating body fat assessment in CKD prevention beyond BMI-based strategies.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-11"},"PeriodicalIF":4.1,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13412413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of an Intensive Lifestyle Camp on Anthropometry and Quality of Life in Vulnerable Children: A 3-Year Follow-Up of a Nonrandomized Clinical Trial.","authors":"Dorthe Dalstrup Pauls, Loa Clausen, Lea Brader, Kajsa Järvholm, Henrik Støvring, Jens Meldgaard Bruun","doi":"10.1159/000552702","DOIUrl":"10.1159/000552702","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of overweight and obesity in children and adolescents continues to rise, and there is a lack of long-term follow-up to clarify health and well-being trajectories into adolescence and adulthood. This study investigated anthropometry and quality of life (QoL) trajectories in 7-14-year-old vulnerable children 3 years after attending a lifestyle camp.</p><p><strong>Methods: </strong>Vulnerable children referred to a 10-week multicomponent lifestyle camp due to overweight or obesity, and/or psychosocial issues were enrolled. Anthropometry was assessed using bioelectric impedance and QoL using the Pediatric Quality of Life Inventory. Mixed-effects models were performed to assess longitudinal changes in anthropometry and QoL and explore if improvements achieved during the lifestyle intervention predicted long-term outcomes.</p><p><strong>Results: </strong>In total, 222 participants (12.3 ± 1.4 years) were included, of which 126 (56%) participated in the 3-year follow-up (15.4 ± 1.3 years). Of those, 91 (72%) had anthropometry assessed, and the majority (83%) of participants were still living with overweight/obesity. Body mass index standard deviation score (BMI-SDS) was lower at 3 years (2.00 standard deviation [SD] ± 1.1) compared to baseline (2.48 SD ± 0.9). QoL remained higher at the 3-year follow-up compared to before the intervention. Compared to end-of-treatment, girls had an increase in BMI-SDS (0.37 SD [95% CI 0.26; 0.48]) and body fat (5.62% [95% CI 4.36; 6.88]) at the 3-year follow-up, while boys had a decrease in body fat (-2.25% [95% CI -3.87; -0.62]) but no change in BMI-SDS. Overall, QoL decreased (total QoL -8.33 [95% CI -10.73; -5.94]) during the post-intervention phase.</p><p><strong>Conclusion: </strong>The lifestyle camp, a child-centered intensive short-term multicomponent intervention focused on well-being, peer interaction, and social belonging, may be a promising treatment strategy for improving health and well-being long-term in vulnerable children, although the improvements attenuate across time. Future research should explore the potential to rethink treatment strategies and investigate whether continuous long-term support may help sustain improvements further throughout adolescence.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-12"},"PeriodicalIF":4.1,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13327717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}