Obesity Facts最新文献

{"title":"Association of Abdominal Volume Index with Asymptomatic Intracranial Arterial Stenosis in Rural Chinese Adults: A Population-Based Study.","authors":"Qiuting Wang, Xinhao Yang, Zhengyu Yang, Xinyan Hu, Jiehong Yuan, Maoyu Li, Xiaotong Ma, Xiang Wang, Chengxuan Qiu, Qinjian Sun","doi":"10.1159/000543790","DOIUrl":"10.1159/000543790","url":null,"abstract":"<p><strong>Introduction: </strong>The abdominal volume index (AVI), a novel anthropometric index that reflects abdominal obesity, has been related to atherosclerosis. We sought to investigate the association of AVI with the severity and burden of asymptomatic intracranial arterial stenosis (aICAS) in a rural Chinese population.</p><p><strong>Methods: </strong>The population-based cross-sectional study included 1,994 participants who were aged ≥40 years and living in Kongcun Town, Pingyin County, Shandong, and who had no history of clinical stroke or transient ischemic attack. We detected aICAS by combining transcranial Doppler ultrasound with magnetic resonance angiography. We used multiple logistic regression models to investigate the association between AVI and aICAS.</p><p><strong>Results: </strong>Of the 1,994 participants, 146 were diagnosed with aICAS, including 51 with mild aICAS and 95 with moderate-to-severe aICAS. Controlling for confounding factors, a greater AVI was significantly associated with an adjusted odds ratio (OR) (95% confidence interval [CI]) of 1.08 (1.02-1.14) for having aICAS, 1.11 (1.04-1.18) for moderate-to-severe aICAS, and 1.12 (1.01-1.23) for multiple moderate-to-severe aICAS. We detected a statistical interaction of AVI with hypertension on aICAS (p for interaction = 0.011). Stratified analysis by hypertension showed a significantly independent association between AVI and aICAS in participants with hypertension (upper versus lower tertile of AVI: OR = 2.90; 95% CI: 1.65-5.10, p < 0.001) but not in those without hypertension.</p><p><strong>Conclusion: </strong>A greater AVI is independently associated with aICAS, especially among individuals with hypertension. Moreover, AVI may help to identify both the severity and burden of aICAS.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-9"},"PeriodicalIF":3.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Related Arterial Stiffening Is Associated with a Body Shape Index and Lean Body Mass Index: A Retrospective Cohort Study in Healthy Japanese Population.","authors":"Daiji Nagayama, Yasuhiro Watanabe, Kentaro Fujishiro, Kenji Suzuki, Masahiro Ohira, Kohji Shirai, Atsuhito Saiki","doi":"10.1159/000543791","DOIUrl":"10.1159/000543791","url":null,"abstract":"<p><strong>Introduction: </strong>Several anthropometric indices reflecting cardiometabolic risks have been developed, but the relationship of body composition with arterial stiffness remains unclear. We aimed to determine the interaction between age-related anthropometric changes and progression of arterial stiffness.</p><p><strong>Methods: </strong>This research analyzed cross-sectional data (N = 13,672) and 4-year longitudinal data (N = 5,118) obtained from a healthy Japanese population without metabolic disorders. The relationship of age with anthropometric indices comprising estimated lean body mass index (eLBMI), body mass index (BMI), waist circumference (WC), and a body shape index (ABSI) was examined. The mediating effects of the indices on the association between age and arterial stiffness assessed by cardio-ankle vascular index (CAVI) were analyzed.</p><p><strong>Results: </strong>Unlike BMI and WC, ABSI (Rs = 0.284) and CAVI (Rs = 0.733) showed a positive linear relationship with aging in stratified analyses. Especially in the middle-older age groups, eLBMI showed a declining trend with aging. An increase in ABSI was associated with a decrease in eLBMI, whereas increase in BMI or WC was related to increased eLBMI. In cross-sectional analyses, age was associated with CAVI, partially mediated by ABSI or eLBMI after adjusting confounders. Baseline CAVI correlated negatively with 4-year change in (Δ)eLBMI (Rs = -0.120 in men, -0.161 in women). ΔCAVI correlated negatively with ΔeLBMI (Rs = -0.031).</p><p><strong>Conclusion: </strong>ABSI is a modifiable index that well reflects age-related changes in arterial stiffness and body composition including lean body mass. Since arterial stiffening may cause skeletal muscle loss, potentially creating a vicious cycle, prioritizing CAVI and anthropometric indices in clinical practice may be a useful strategy.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-12"},"PeriodicalIF":3.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher Visceral and Lower Peripheral Adiposity Characterize Fat Distribution and Insulin Resistance in Asian Indian Women with Polycystic Ovary Syndrome in Mauritius.","authors":"Vinaysing Ramessur, Sadhna Hunma, Noorjehan Joonas, Bibi Nasreen Ramessur, Yves Schutz, Jean-Pierre Montani, Abdul Dulloo","doi":"10.1159/000543332","DOIUrl":"10.1159/000543332","url":null,"abstract":"<p><strong>Introduction: </strong>There are controversies about whether women with polycystic ovary syndrome (PCOS) show a disproportionately higher visceral adiposity, and its relevance to their higher cardiometabolic risks. We investigated in women of Asian Indian descent in Mauritius, a population inherently prone to abdominal obesity, whether those with PCOS will show a more adverse cardiometabolic risk profile that could be explained by abnormalities in fat distribution.</p><p><strong>Methods: </strong>Young women newly diagnosed with PCOS (n = 25) were compared with a reference control cohort (n = 139) for the following measurements made after an overnight fast: body mass index (BMI), waist circumference (WC), body composition by dual-energy X-ray absorptiometry, and blood pressure and blood assays for glycemic (glucose, HbA1c, and insulin) and lipid (triglycerides and cholesterols) profiles.</p><p><strong>Results: </strong>Women with PCOS showed, on average, higher BMI, WC, fat mass and lean mass (p < 0.01) than controls, but linear regression analyses indicate that for the same BMI (or same WC), the two groups showed no significant differences in fat mass and lean mass. By contrast, linear regression plots indicate that for the same total fat mass, women with PCOS showed higher trunk, android, and visceral fat (p < 0.01); no difference in abdominal subcutaneous fat; and lower peripheral (gynoid or limb) fat (p < 0.05). Furthermore, women with PCOS showed higher fasting plasma insulin, insulin resistance (HOMA-IR) index, and lower insulin sensitivity index (QUICKI) (all p < 0.001), which were completely or markedly abolished after adjusting for visceral fat or central-to-peripheral fat ratios.</p><p><strong>Conclusion: </strong>In Mauritius, young women of Asian Indian descent with PCOS show altered fat distribution characterized by a disproportionately higher visceral (hazardous) adiposity in parallel to lower peripheral (protective) adiposity, which together explain their exacerbated state of hyperinsulinemia and insulin resistance.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-12"},"PeriodicalIF":3.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased Quality of Life in Patients Who Desire Body Contouring Surgery after Bariatric Metabolic Surgery: A Multicenter Longitudinal Analysis.","authors":"Phillip J Dijkhorst, Robin A Debi, Claire E E de Vries, Dennis J S Makarawung, Aebele B Mink van der Molen, Steve M M de Castro, Ruben N van Veen","doi":"10.1159/000543632","DOIUrl":"10.1159/000543632","url":null,"abstract":"<p><strong>Introduction: </strong>Excess skin after bariatric metabolic surgery may negatively impact quality of life (QoL). Nevertheless, not every eligible patient undergoes body contouring surgery (BCS), which may be explained by differences in QoL. The objective of this study was to assess the differences in QoL between patients with and without a desire for BCS after bariatric metabolic surgery and to identify predictive factors that contribute to this desire.</p><p><strong>Methods: </strong>Patients completed the BODY-Q and a question regarding any desire for BCS, 6 months and yearly after bariatric metabolic surgery. BODY-Q outcomes were compared between patients with and without a desire for BCS and corrected for excess skin.</p><p><strong>Results: </strong>A total of 380 patients who completed 3 years of follow-up were included. Of these patients, 69.5% desired BCS. Patients who did not desire BCS demonstrated significantly higher QoL scores across all domains at every follow-up moment compared to patients who desired BCS (except physical functioning at 3 years). These associations were largely explained by the amount and burden of excess skin. Younger age was the only significant predictor for desiring BCS when correcting for excess skin.</p><p><strong>Conclusion: </strong>Patients with a desire for BCS demonstrated significantly lower QoL compared to patients without a desire due to a high burden of excess skin, which emphasizes the need for effective treatments aiming to improve QoL such as BCS.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-9"},"PeriodicalIF":3.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram for Predicting Suboptimal Weight Loss at Three Years after Roux-en-Y Gastric Bypass Surgery in Chinese Patients with Obesity and Type 2 Diabetes.","authors":"Yiming Si, Hongwei Zhang, Xiaodong Han, Weijie Liu, Yinfang Tu, Xiaojing Ma, Haoyong Yu, Yuqian Bao","doi":"10.1159/000542923","DOIUrl":"https://doi.org/10.1159/000542923","url":null,"abstract":"<p><strong>Introduction: </strong>Strategies to address suboptimal weight loss after Roux-en-Y gastric bypass (RYGB) can be developed if at-risk patients are identified in advance. This study aimed to build a pre-surgery prediction nomogram for early prediction of insufficient weight loss (IWL) or weight regain (WR) after bariatric surgery in Chinese patients.</p><p><strong>Methods: </strong>In this retrospective study, 187 patients with obesity and type 2 diabetes who underwent laparoscopic RYGB were followed yearly for 3 years. Suboptimal weight loss included IWL and WR. IWL was defined as a total weight loss percentage of <25% at 1 year postoperatively, and WR was defined as a maximum weight loss percentage of >20% at 3 years postoperatively. Multivariate logistic regression was performed to identify independent predictors and to establish a nomogram to predict the occurrence of suboptimal weight loss.</p><p><strong>Results: </strong>Multivariate logistic regression revealed that male sex (OR 4.268, 95% CI: 1.413-12.890), body mass index (OR 0.816, 95% CI: 0.705-0.946), and glycated hemoglobin (OR 1.493, 95% CI: 1.049-2.126) were independent predictors of IWL/WR. The AUC value of the nomogram constructed from the above three factors was 0.781. The Hosmer-Lemeshow test showed that the model had a good fit (p = 0.143). The calibration curve of the nomogram is close to an ideal diagonal line. Furthermore, the decision curve analysis demonstrated the good net benefits of the model.</p><p><strong>Conclusions: </strong>A nomogram based on pre-surgery factors was developed to predict postoperative IWL/WR. This provides a convenient and useful tool for predicting suboptimal weight loss before surgery.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-12"},"PeriodicalIF":3.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortisol Secretion in Obesity Revisited: Lower Basal Serum and Salivary Cortisol with Diminished Cortisol Response to the Low Dose ACTH Challenge.","authors":"Yael Sofer, Esther Osher, Wiessam Abu Ahmad, Yona Greenman, Yaffa Moshe, Sigal Shaklai, Marianna Yaron, Merav Serebro, Karen Tordjman, Naftali Stern","doi":"10.1159/000543449","DOIUrl":"10.1159/000543449","url":null,"abstract":"<p><strong>Introduction: </strong>Some clinical resemblance may exist between obesity, particularly abdominal obesity, and Cushing's syndrome. This has stimulated ongoing interest in the role of cortisol's secretion pattern, control, and metabolism in obesity.</p><p><strong>Goals: </strong>The aim of the study was to investigate whether basal and stimulated levels of cortisol differ between healthy people with obesity and individuals with normal weight.</p><p><strong>Methods: </strong>Total, free, and salivary cortisol was tested at baseline state and after 1 μg ACTH stimulation in 60 healthy subjects with obesity and 54 healthy lean controls.</p><p><strong>Results: </strong>Baseline total cortisol was lower in subjects with obesity compared to lean controls (347 [265-452] nmol/L vs. 422 [328-493] nmol/L, respectively; p < 0.05). Similarly, basal salivary cortisol was significantly lower in subjects with obesity (7.5 [5.2-9.7] nmol/L vs. 10.7 [7.5-17.6] nmol/L; p < 0.05). Upon challenge with ACTH, total peak serum and salivary peak cortisol responses were significantly lower in people with obesity than in lean subjects (665.16 ± 151.8 vs. 728.64 ± 124.2 nmol/L; p < 0.05 and 31.66 [19-38.64] vs. 40.05 [31.46-46.64] nmol/L; p < 0.05, respectively). Additionally, baseline total cortisol and salivary cortisol were inversely related to BMI (r = -0.24, r = -0.27; p < 0.05 for both) and waist circumference (r = -0.27, r = -0.34; p < 0.05 for both).</p><p><strong>Conclusion: </strong>Baseline as well as peak stimulated total serum and salivary cortisol were significantly lower in subjects with obesity. It thus appears that obesity is not associated with enhanced basal or ACTH-stimulated cortisol.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-9"},"PeriodicalIF":3.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Depression 3 Years before and 3 Years after Obesity Surgery: Sex-Stratified Case-Control Study Using German Health Insurance Claims Data between 2009 and 2015.","authors":"Jelena Epping, Astrid Müller, Lieselotte Mond, Martina de Zwaan","doi":"10.1159/000543407","DOIUrl":"https://doi.org/10.1159/000543407","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity shows significant association with depression, elevating morbidity burden. Obesity surgery (OS) has been proven as an effective therapy, reducing weight as well as depression prevalence rates, though the latter decrease appears to be unstable over time. For a better interpretation of the time trend, data on depression prevalence in OS patients for the period before the surgery are needed. Furthermore, sex-stratified analyses can reveal potentials for improvements in mental health care in OS patients.</p><p><strong>Methods: </strong>Claims data from a German statutory health insurance provider were used for the estimation of depression prevalence in patients who underwent obesity surgery in 2012 (n = 340) and controls with (CGO) and without a diagnosis of obesity (CG; n = 1,700 each). The controls were matched to OS patients regarding sex, age, and insurance type. Sex-stratified depression prevalence was calculated between 2009 and 2015.</p><p><strong>Results: </strong>Overall, depression rates were higher in women than in men and increased from 2009 to 2015. Depression prevalence rates differed significantly between female OS patients and controls in every year analyzed, e.g., in 2012: 39.4% in OS (95% CI: 33.4%-45.5%) vs. 19.8% in CGO (17.6%-22.0%) and 15.4% in CG (13.4%-17.4%). In men, no significant differences between OS patients and controls could be observed at any time. After OS, depression prevalence rates dropped in women, then gradually increased until 2015. Also, in male OS patients, depression prevalence decreased in the year after OS and increased in the following years. In both sexes, the prevalence rates in 2015 did not significantly differ from the rates in 2012 (year of OS).</p><p><strong>Conclusions: </strong>We found a decrease in depression prevalence rates in the first year after OS in both sexes, followed by an increase in the subsequent 2 years. OS appears to have a short-term effect on the prevalence rates of depression followed by a subsequent increase paralleling the increase over time found in the non-OS control groups. Due to the sex-stratified approach, differential results in the comparison of depression prevalence between OS patients and controls became apparent. Depression prevalence was significantly increased 3 years before and after OS compared to controls in women, but not in men. Measures to perpetuate the decrease in depression prevalence rates after OS should be implemented during post-operative treatment.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-9"},"PeriodicalIF":3.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Body Mass Index during the COVID-19 Pandemic among Indonesian Adolescents: The Role of Sex, Urban Area, Baseline BMI, and Appetitive Traits.","authors":"Eveline Sarintohe, William J Burk, Jacqueline M Vink, Junilla K Larsen","doi":"10.1159/000543078","DOIUrl":"10.1159/000543078","url":null,"abstract":"<p><strong>Introduction: </strong>Little is known about how the COVID-19 situation affected weight development among Indonesian adolescents. This longitudinal study examined whether, and for whom, the COVID-19 situation affected weight outcomes over time among adolescents from private schools and higher socio-economic positions in Indonesia, where being overweight is a rather prevalent characteristic. This study specifically examined whether appetitive traits (i.e., emotional overeating, food responsiveness) as well as baseline zBMI, sex, and urban area could explain changes in zBMI.</p><p><strong>Methods: </strong>At baseline, 411 adolescents from 5 private schools in Indonesia (53.3% males, Mage = 12.02 years, SD = 0.45) filled out questionnaires on appetitive traits and background characteristics. In addition, their height and weight were measured. Of these, 336 adolescents (81.8%) also participated at follow-up. At follow-up, height and weight were measured or reported. We used linear regression to analyze the association between predictors and interactions with zBMI.</p><p><strong>Results: </strong>The results showed a significant decrease in zBMI over time, with a lower average zBMI during COVID-19 compared to before COVID-19. Female adolescents and adolescents with higher baseline zBMI values particularly tended to show this zBMI decreasing pattern. We did not find statistically significant main effects of baseline emotional overeating, food responsiveness, and urban area or any interactions.</p><p><strong>Conclusions: </strong>Indonesian adolescents appeared to decrease in terms of zBMI during COVID-19, particularly females and adolescents with higher pre-COVID-19 zBMI. Our findings suggest that (culturally-specific) contextual changes (i.e., less exposure to the Indonesian food environment at schools and more exposure to the home environment) might have a beneficial impact in terms of preventing overweight among Indonesian adolescents, particularly among those being more vulnerable (i.e., having higher baseline zBMI).</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-9"},"PeriodicalIF":3.9,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annual Health Expenditures by Body Mass Index Categories and the Economic Impact of Obesity in Türkiye: A Retrospective Modeling Study.","authors":"Ergun Oksuz, Simten Malhan, Halil Alis, Dilek GogasYavuz, Tarkan Karakan, Mehmet Sargin, Alper Sonmez, Lale Tokgozoglu, Batu Gurser, Esra Safak Yilmaz, Volkan Demirhan Yumuk","doi":"10.1159/000542821","DOIUrl":"10.1159/000542821","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity is considered not only a public health issue on a global scale but also a disease adversely affecting the world economies. Economic impact of overweight and obesity has not yet been investigated in Türkiye at a national level. This study aimed to investigate the impact of obesity on healthcare costs in Türkiye and to estimate the overall national economic burden of obesity.</p><p><strong>Methods: </strong>The study was based on a cross-sectional analysis of retrospectively pooled data from 2009 to 2014 payer claims data and 2014-2019 Türkiye Health Survey (THS). In the first step, obesity-related annual per person overall health expenditures in adults with obesity were calculated and calculations were also made in subgroups of payer and healthcare categories. In the second step, using the developed model, the national economic disease burden of adult obesity was estimated, along with the projections for the estimated expenditures over the next 30 years. Economic values were adjusted according to US dollar values of 2021 purchasing power parities (PPPs) (PPP 1.0 = 2.782 TRY).</p><p><strong>Results: </strong>The annual healthcare costs were significantly higher in individuals with obesity than in those with normal body mass index (BMI) (odds ratio 1.243; 95% confidence interval: 1.206-1.281), and the cost increment was positively correlated with higher BMI (by 117% in class I obesity vs. 169% in class III obesity, p < 0.001). In the year 2021, obesity-related direct and indirect costs in adults were estimated to be PPP 27.4 billion and 39.5 billion, respectively. The total economic burden was estimated to be PPP 66.9 billion, which is equivalent to 2.6% of gross national product. Direct medical cost of obesity corresponds to 8.4% of total health expenditure in Türkiye.</p><p><strong>Conclusions: </strong>Obesity is both an individual and social health problem, which emphasizes the potential role of a range of stakeholders, besides the health sector, in addressing this problem. The indirect costs comprise the key cost driver of the total national cost of obesity, which forms the rationale for population-wide policy interventions toward prevention or reduction of obesity.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-18"},"PeriodicalIF":3.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum ferritin with total and regional fat measured by dual-energy X-ray absorptiometry in a nationally representative survey.","authors":"Yuan Chen, Chao Wang, Yanyan Xiao, Tian Hu, Xuerong Yang, Guohua Mu, Hao Lu, Junfei Xu, Chi Chen","doi":"10.1159/000542896","DOIUrl":"https://doi.org/10.1159/000542896","url":null,"abstract":"<p><strong>Introduction: </strong>Fat distribution is a stronger predictor for cardiometabolic morbidity and mortality. We aimed to investigate the association of elevated iron stores, measured as serum ferritin levels, with total and regional body fat.</p><p><strong>Methods: </strong>Data from 2,646 adults from the National Health and Nutrition Examination Survey 2017-2018 was analyzed. Dual-energy X-ray absorptiometry was used to measure overall and regional body fat. The fat mass index (FMI) was calculated by dividing the fat mass (kg) by the square of body height (m²). The leg fat mass to trunk fat mass ratio (LTR) was used to assess the relative distribution of leg fat compared to trunk fat.</p><p><strong>Results: </strong>Medians (IQR) of serum ferritin levels were 0.168 μg/mL (0.104-0.269) for men and 0.053 μg/mL (0.026-0.102) for women. After adjusting for sociodemographic, lifestyle, and metabolic factors, serum ferritin showed a significant positive association with total FMI (β=2.662) and trunk FMI (β=0.983), and a negative association with leg FMI (β=-0.324) and LTR (β=-0.160) in men. In women, serum ferritin showed a significant positive association with total FMI (β=4.658), trunk FMI (β=2.085), and negative association with LTR (β=-0.312). Significant positive trends were observed for serum ferritin with total and trunk FMI in men and women, using the lowest serum ferritin quartile as the reference group. Additionally, significant negative trends were observed for serum ferritin with leg FMI and LTR in men. The mediation analysis revealed that C-reactive protein mediated 16.4% and 22.6% of the potential effects of serum ferritin on trunk FMI in men and women, respectively.</p><p><strong>Conclusion: </strong>Higher ferritin levels were associated with greater total and trunk fat but lower leg fat. Further prospective and mechanistic studies are warranted to confirm the study results.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-16"},"PeriodicalIF":3.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}