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Postprandial Symptoms in a Mixed-Meal-Test after Bariatric Surgery: Clinical Experience and a Critical Review of Dumping Syndrome Definition and Management. 减肥手术后混合餐测试中的餐后症状--临床经验以及对倾倒综合征定义和管理的批判性回顾。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2024-10-15 DOI: 10.1159/000541780
Azat Samigullin, Julia Weihrauch, Mirko Otto, Andrea Rech, Sandra Buchenberger, Michael Morcos, Per M Humpert
{"title":"Postprandial Symptoms in a Mixed-Meal-Test after Bariatric Surgery: Clinical Experience and a Critical Review of Dumping Syndrome Definition and Management.","authors":"Azat Samigullin, Julia Weihrauch, Mirko Otto, Andrea Rech, Sandra Buchenberger, Michael Morcos, Per M Humpert","doi":"10.1159/000541780","DOIUrl":"10.1159/000541780","url":null,"abstract":"<p><strong>Introduction: </strong>Despite recent attempts to reach a consensus on the diagnostic criteria and treatment of dumping syndrome (DS) after bariatric surgery, many questions about the clinical applicability and significance of standardized provocation tests remain unanswered. The objective of this study was to retrospectively evaluate a mixed-meal-test (MMT) based on general nutritional recommendations after bariatric surgery and its clinical value in diagnosing DS.</p><p><strong>Methods: </strong>The MMT contained 15.5 g of protein, 10 g of fat, 20.7 g of carbohydrates, and 3.1 g of dietary fiber, totaling 241 kcal. Symptoms based on the Sigstad Score, along with blood sugar, hematocrit, pulse rate, and blood pressure, were collected as primary readouts. The analysis included 58 MMTs from 56 patients who reported postprandial symptoms indicative of DS and were referred to the clinic by surgeons or general practitioners.</p><p><strong>Results: </strong>Although all individuals reported significant symptoms at home, the MMT showed a positive symptom score (Sigstad Score ≥7) in only 16 cases (28%). Neither a heart rate increase >10 BPM nor the 3% hematocrit increase suggested as cut-offs for early DS by the consensus paper were associated with the Sigstad Score or individually reported symptoms. None of the participants had a postprandial glucose decrease below 50 mg/dL; one fell below 60 mg/dL and 14 fell below 70 mg/dL. A blood glucose decrease below 70 mg/dL was not associated with symptoms.</p><p><strong>Conclusion: </strong>The MMT showed that only a minority of patients reported classical DS symptoms under controlled conditions. Changes in hematocrit, heart rate, and blood sugar decrease below 70 mg/dL did not help to predict symptoms in the individuals studied. The data, in the context of existing evidence, suggest that provocation tests have little value in clinical practice and that DS as a clinical entity after bariatric surgery should be reevaluated.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"31-38"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Characteristics of Sarcopenia in Nonalcoholic Fatty Liver Disease: A Systemic Scoping Review. 非酒精性脂肪肝患者 "肌少症 "的临床特征:系统性范围界定综述
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2024-10-16 DOI: 10.1159/000541650
Tingdan Ye, Ke Mi, Lin Zhu, Jonathan Li, Calvin Q Pan
{"title":"Clinical Characteristics of Sarcopenia in Nonalcoholic Fatty Liver Disease: A Systemic Scoping Review.","authors":"Tingdan Ye, Ke Mi, Lin Zhu, Jonathan Li, Calvin Q Pan","doi":"10.1159/000541650","DOIUrl":"10.1159/000541650","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic scoping review aimed to synthesize existing research findings on the clinical manifestations in patients with nonalcoholic fatty liver disease (NAFLD) and sarcopenia.</p><p><strong>Methods: </strong>Adhering to scoping review guidelines, we comprehensively searched five databases for literature on sarcopenia's clinical manifestations in NAFLD patients from December 2013 to December 2023, meticulously compiling and synthesizing the findings.</p><p><strong>Results: </strong>A total of 312 articles were identified, with 9 studies included in the final review. Of these, 90% were cross-sectional investigations, with 70% from Asian cohorts. Comparative analysis between patients solely afflicted with NAFLD and those additionally experiencing sarcopenia revealed discernible trends. Individuals with both conditions tended to be older, have a higher body mass index, and show a higher prevalence among females, underscoring the influence of unhealthy lifestyles and obesity. Furthermore, comorbidities like metabolic syndrome, hypertension, and diabetes have been implicated in sarcopenia manifestation among NAFLD patients. Nonetheless, the lack of standardized diagnostic criteria and patterns poses an ongoing clinical challenge for this subgroup.</p><p><strong>Conclusions: </strong>Our review highlights distinct clinical characteristics evident in NAFLD patients with sarcopenia. However, comprehensive investigations remain scarce, impeding accurate early detection and intervention. Future research should prioritize bridging these gaps and fostering enhanced clinical management strategies.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"72-85"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Abdominal Volume Index with Asymptomatic Intracranial Arterial Stenosis in Rural Chinese Adults: A Population-Based Study. 中国农村成人腹容积指数与无症状颅内动脉狭窄的相关性:一项基于人群的研究。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.1159/000543790
Qiuting Wang, Xinhao Yang, Zhengyu Yang, Xinyan Hu, Jiehong Yuan, Maoyu Li, Xiaotong Ma, Xiang Wang, Chengxuan Qiu, Qinjian Sun
{"title":"Association of Abdominal Volume Index with Asymptomatic Intracranial Arterial Stenosis in Rural Chinese Adults: A Population-Based Study.","authors":"Qiuting Wang, Xinhao Yang, Zhengyu Yang, Xinyan Hu, Jiehong Yuan, Maoyu Li, Xiaotong Ma, Xiang Wang, Chengxuan Qiu, Qinjian Sun","doi":"10.1159/000543790","DOIUrl":"10.1159/000543790","url":null,"abstract":"<p><strong>Introduction: </strong>The abdominal volume index (AVI), a novel anthropometric index that reflects abdominal obesity, has been related to atherosclerosis. We sought to investigate the association of AVI with the severity and burden of asymptomatic intracranial arterial stenosis (aICAS) in a rural Chinese population.</p><p><strong>Methods: </strong>The population-based cross-sectional study included 1,994 participants who were aged ≥40 years and living in Kongcun Town, Pingyin County, Shandong, and who had no history of clinical stroke or transient ischemic attack. We detected aICAS by combining transcranial Doppler ultrasound with magnetic resonance angiography. We used multiple logistic regression models to investigate the association between AVI and aICAS.</p><p><strong>Results: </strong>Of the 1,994 participants, 146 were diagnosed with aICAS, including 51 with mild aICAS and 95 with moderate-to-severe aICAS. Controlling for confounding factors, a greater AVI was significantly associated with an adjusted odds ratio (OR) (95% confidence interval [CI]) of 1.08 (1.02-1.14) for having aICAS, 1.11 (1.04-1.18) for moderate-to-severe aICAS, and 1.12 (1.01-1.23) for multiple moderate-to-severe aICAS. We detected a statistical interaction of AVI with hypertension on aICAS (p for interaction = 0.011). Stratified analysis by hypertension showed a significantly independent association between AVI and aICAS in participants with hypertension (upper versus lower tertile of AVI: OR = 2.90; 95% CI: 1.65-5.10, p < 0.001) but not in those without hypertension.</p><p><strong>Conclusion: </strong>A greater AVI is independently associated with aICAS, especially among individuals with hypertension. Moreover, AVI may help to identify both the severity and burden of aICAS.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"260-268"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
32nd European Congress on Obesity (ECO 2025) - LATE BREAKING ABSTRACTS. 第32届欧洲肥胖大会(ECO 2025) -最新摘要。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2025-05-28 DOI: 10.1159/000545968
{"title":"32nd European Congress on Obesity (ECO 2025) - LATE BREAKING ABSTRACTS.","authors":"","doi":"10.1159/000545968","DOIUrl":"10.1159/000545968","url":null,"abstract":"<p><p>n/a.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"657-829"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Food and Health Literacy in Patients Awaiting Metabolic-Bariatric Surgery. 等待代谢减重手术患者的饮食与健康知识。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2024-10-03 DOI: 10.1159/000541408
Anne Jacobs, Leontien M G Nijland, Ingrid H M Steenhuis, Ruben N van Veen, Ronald S L Liem, Hanno Pijl, Lies Ter Beek, Rob A E M Tollenaar, Valerie M Monpellier
{"title":"Food and Health Literacy in Patients Awaiting Metabolic-Bariatric Surgery.","authors":"Anne Jacobs, Leontien M G Nijland, Ingrid H M Steenhuis, Ruben N van Veen, Ronald S L Liem, Hanno Pijl, Lies Ter Beek, Rob A E M Tollenaar, Valerie M Monpellier","doi":"10.1159/000541408","DOIUrl":"10.1159/000541408","url":null,"abstract":"<p><strong>Introduction: </strong>Specialized lifestyle programmes for patients undergoing metabolic-bariatric surgery (MBS) are provided to facilitate adjustment and adherence to a healthy lifestyle after surgery. However, pre-programme food and health literacy in MBS patients is often unknown. In the general population, approximately three-quarters of people exhibit sufficient health literacy. This study aimed to examine food and health literacy of patients awaiting MBS and to identify patient-specific factors associated with these literacies.</p><p><strong>Methods: </strong>Patients awaiting MBS completed questionnaires on food literacy (Self-Perceived Food Literacy scale) and health literacy (European Health Literacy Survey Questionnaire-16) at the start of a preoperative lifestyle programme. Linear and logistic regression analyses were used to identify associations between multiple variables and preoperative food and health literacy.</p><p><strong>Results: </strong>Among 216 patients, the preoperative mean food literacy score was 3.49 ± 0.44, on a five-point scale. Furthermore, 96.3% of patients showed sufficient health literacy, with scores of 13 or more out of 16. Patients with sufficient health literacy had higher food literacy scores (β 0.508; 95% CI: 0.208-0.809, p < 0.001).</p><p><strong>Conclusion: </strong>This study among people living with obesity awaiting MBS suggests that food literacy is comparable, and health literacy is higher than in the general population. These findings emphasize the complexity of the aetiology of obesity due to factors that extend beyond food and health literacy.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-9"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of the 40-Item and 24-Item Short Version of the Person-Centred Obesity Care Instrument for Patients Living with Obesity. 验证针对肥胖症患者的 40 项以人为中心的肥胖症护理(PCOC)工具和 24 项简易版。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2024-09-24 DOI: 10.1159/000541499
Paige I Crompvoets, Anna Petra Nieboer, Elisabeth F C van Rossum, Jane M Cramm
{"title":"Validation of the 40-Item and 24-Item Short Version of the Person-Centred Obesity Care Instrument for Patients Living with Obesity.","authors":"Paige I Crompvoets, Anna Petra Nieboer, Elisabeth F C van Rossum, Jane M Cramm","doi":"10.1159/000541499","DOIUrl":"10.1159/000541499","url":null,"abstract":"<p><strong>Introduction: </strong>Person-centred care (PCC) may hold promise for improved healthcare experiences and outcomes among patients living with obesity. A validated instrument to assess the delivery of PCC to patients living with obesity is, however, currently lacking. This study aimed to validate such an instrument. In this article, we describe the development and psychometric testing of the 40-item and 24-item short version of the Person-Centred Obesity Care (PCOC) instrument.</p><p><strong>Methods: </strong>A total of 590 individuals living with obesity (BMI 33.4 ± 3.9) from a representative Dutch sample completed the 49-item PCOC instrument measuring the eight dimensions of PCC (patient preferences, physical comfort, coordination of care, emotional support, access to care, continuity and transition, information and education, and family and friends), and two measures of satisfaction with care. We performed confirmatory factor analyses to verify the factor structure of the instrument and examined its reliability and validity.</p><p><strong>Results: </strong>Fit indicators of the first model with all 49 items showed that the model left room for improvement (comparative fit index [CFI] <0.90). A 40-item version was obtained with satisfactory-to-good fit (standardized root mean square residual [SRMR] = 0.05, root mean square error of approximation [RMSEA] = 0.06, CFI = 0.90). The instrument demonstrated good reliability, and the relationship between the PCOC and two indicators of satisfaction with care supported the validity of the scale. Shortening the instrument only further improved the fit indicators, resulting in the development of a 24-item short version (SRMR = 0.04, RMSEA = 0.05, CFI = 0.96), with similar results in terms of reliability and validity.</p><p><strong>Conclusion: </strong>The 40-item PCOC instrument and the 24-item short version showed to be reliable and valid instruments for the assessment of PCC among patients living with obesity. Based on the results, the 40 and 24-item PCOC are promising tools that can be used by clinicians and researchers to explore PCC delivery for patients living with obesity.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"10-20"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum. 勘误表。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2025-04-04 DOI: 10.1159/000544896
{"title":"Erratum.","authors":"","doi":"10.1159/000544896","DOIUrl":"10.1159/000544896","url":null,"abstract":"","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"319-320"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decreased Quality of Life in Patients Who Desire Body Contouring Surgery after Bariatric Metabolic Surgery: A Multicenter Longitudinal Analysis. 减肥代谢手术后希望进行身体轮廓手术的患者生活质量下降:一项多中心纵向分析。
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2025-01-22 DOI: 10.1159/000543632
Phillip J Dijkhorst, Robin A Debi, Claire E E de Vries, Dennis J S Makarawung, Aebele B Mink van der Molen, Steve M M de Castro, Ruben N van Veen
{"title":"Decreased Quality of Life in Patients Who Desire Body Contouring Surgery after Bariatric Metabolic Surgery: A Multicenter Longitudinal Analysis.","authors":"Phillip J Dijkhorst, Robin A Debi, Claire E E de Vries, Dennis J S Makarawung, Aebele B Mink van der Molen, Steve M M de Castro, Ruben N van Veen","doi":"10.1159/000543632","DOIUrl":"10.1159/000543632","url":null,"abstract":"<p><strong>Introduction: </strong>Excess skin after bariatric metabolic surgery may negatively impact quality of life (QoL). Nevertheless, not every eligible patient undergoes body contouring surgery (BCS), which may be explained by differences in QoL. The objective of this study was to assess the differences in QoL between patients with and without a desire for BCS after bariatric metabolic surgery and to identify predictive factors that contribute to this desire.</p><p><strong>Methods: </strong>Patients completed the BODY-Q and a question regarding any desire for BCS, 6 months and yearly after bariatric metabolic surgery. BODY-Q outcomes were compared between patients with and without a desire for BCS and corrected for excess skin.</p><p><strong>Results: </strong>A total of 380 patients who completed 3 years of follow-up were included. Of these patients, 69.5% desired BCS. Patients who did not desire BCS demonstrated significantly higher QoL scores across all domains at every follow-up moment compared to patients who desired BCS (except physical functioning at 3 years). These associations were largely explained by the amount and burden of excess skin. Younger age was the only significant predictor for desiring BCS when correcting for excess skin.</p><p><strong>Conclusion: </strong>Patients with a desire for BCS demonstrated significantly lower QoL compared to patients without a desire due to a high burden of excess skin, which emphasizes the need for effective treatments aiming to improve QoL such as BCS.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"287-295"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electroacupuncture Combined with Press Needles Alleviates Simple Obesity via VEGF-C/VEGFR-3/PI3K/AKT Signaling Pathway. 电针联合压针通过VEGF-C/VEGFR-3/PI3K/AKT信号通路缓解单纯性肥胖
IF 4.7 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2025-03-19 DOI: 10.1159/000545330
Bin Xu, Minghui Xia, Zhi Yu, Yuhang Wang, Donghua Liu, Yan Wang, Shuang Wu, Bin Xu
{"title":"Electroacupuncture Combined with Press Needles Alleviates Simple Obesity via VEGF-C/VEGFR-3/PI3K/AKT Signaling Pathway.","authors":"Bin Xu, Minghui Xia, Zhi Yu, Yuhang Wang, Donghua Liu, Yan Wang, Shuang Wu, Bin Xu","doi":"10.1159/000545330","DOIUrl":"10.1159/000545330","url":null,"abstract":"<p><p><p>Introduction: Simple obesity is an increasingly prevalent chronic condition. While electroacupuncture (EA) has demonstrated potential in addressing this issue, its effectiveness may be hindered by insufficient continuous stimulation and challenges related to patient adherence. This study aimed to compare the efficacy of EA alone versus EA combined with press needles in the treatment of simple obesity and to explore the underlying mechanisms contributing to weight loss.</p><p><strong>Methods: </strong>Eighty simple obese patients with a body mass index (BMI) ≥25.0 kg/m2 were divided into two groups: the observation group (treated with EA combined with press needles) and the control group (treated with EA alone). The efficacy of the treatments was evaluated by monitoring obesity indicators. Additionally, obesity rat models were established through a high-fat diet (HFD), and rats were randomly assigned to three groups: obesity control group (no treatment), EA group, and EA combined with press needles group. Treatment outcomes were assessed by monitoring obesity indicators, examining adipose and liver cell morphology using staining techniques, and evaluating intestinal lymphatic vessel function through qRT-PCR, Western blot, and immunofluorescence analyses.</p><p><strong>Results: </strong>The patients in the observation group exhibited significantly lower body weight (BW), BMI, body fat percentage (F%), abdominal circumference (A), waist circumference (WC), as well as serum levels of intestinal lymphatic function-related factors such as VEGF-C, delta-like ligand 4 (DLL4), and adrenomedullin (ADM) compared to the control group. Similarly, compared to EA group, EA combined with press needles significantly decreased obesity indexes, serum intestinal lymphatic function-related factors, and improved lymphatic vessel function in obese rats. Mechanistically, the VEGF-C/VEGFR-3/PI3K/AKT signaling pathway was inhibited by EA combined with press needles intervention.</p><p><strong>Conclusion: </strong>The combined therapy of EA with press needles had shown significantly superior efficacy in treating simple obesity compared to EA treatment alone. It achieved this by modulating the VEGF-C/VEGFR-3/PI3K/AKT signaling pathway, improving lymphatic vessel structure and function, and ultimately inhibiting obesity. </p>.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"348-363"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Depression 3 Years before and 3 Years after Obesity Surgery: Sex-Stratified Case-Control Study Using German Health Insurance Claims Data between 2009 and 2015. 肥胖手术前后3年的抑郁症患病率:2009年至2015年德国健康保险索赔数据的性别分层病例对照研究
IF 3.9 3区 医学
Obesity Facts Pub Date : 2025-01-01 Epub Date: 2025-01-06 DOI: 10.1159/000543407
Jelena Epping, Astrid Müller, Lieselotte Mond, Martina de Zwaan
{"title":"Prevalence of Depression 3 Years before and 3 Years after Obesity Surgery: Sex-Stratified Case-Control Study Using German Health Insurance Claims Data between 2009 and 2015.","authors":"Jelena Epping, Astrid Müller, Lieselotte Mond, Martina de Zwaan","doi":"10.1159/000543407","DOIUrl":"10.1159/000543407","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity shows significant association with depression, elevating morbidity burden. Obesity surgery (OS) has been proven as an effective therapy, reducing weight as well as depression prevalence rates, though the latter decrease appears to be unstable over time. For a better interpretation of the time trend, data on depression prevalence in OS patients for the period before the surgery are needed. Furthermore, sex-stratified analyses can reveal potentials for improvements in mental health care in OS patients.</p><p><strong>Methods: </strong>Claims data from a German statutory health insurance provider were used for the estimation of depression prevalence in patients who underwent obesity surgery in 2012 (n = 340) and controls with (CGO) and without a diagnosis of obesity (CG; n = 1,700 each). The controls were matched to OS patients regarding sex, age, and insurance type. Sex-stratified depression prevalence was calculated between 2009 and 2015.</p><p><strong>Results: </strong>Overall, depression rates were higher in women than in men and increased from 2009 to 2015. Depression prevalence rates differed significantly between female OS patients and controls in every year analyzed, e.g., in 2012: 39.4% in OS (95% CI: 33.4%-45.5%) vs. 19.8% in CGO (17.6%-22.0%) and 15.4% in CG (13.4%-17.4%). In men, no significant differences between OS patients and controls could be observed at any time. After OS, depression prevalence rates dropped in women, then gradually increased until 2015. Also, in male OS patients, depression prevalence decreased in the year after OS and increased in the following years. In both sexes, the prevalence rates in 2015 did not significantly differ from the rates in 2012 (year of OS).</p><p><strong>Conclusions: </strong>We found a decrease in depression prevalence rates in the first year after OS in both sexes, followed by an increase in the subsequent 2 years. OS appears to have a short-term effect on the prevalence rates of depression followed by a subsequent increase paralleling the increase over time found in the non-OS control groups. Due to the sex-stratified approach, differential results in the comparison of depression prevalence between OS patients and controls became apparent. Depression prevalence was significantly increased 3 years before and after OS compared to controls in women, but not in men. Measures to perpetuate the decrease in depression prevalence rates after OS should be implemented during post-operative treatment.</p>","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"227-235"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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