Obesity research & clinical practice最新文献_第5页

Effects of duration of high-fat diet on adipocyte hyperplasia in rat epididymis 高脂饮食持续时间对大鼠附睾脂肪细胞增生的影响。

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.orcp.2025.02.001

Zhaoxin Wang , Xiujuan Liu , Lei Sheng , Yuting Xie , Wanyu Feng , Li Yu

{"title":"Effects of duration of high-fat diet on adipocyte hyperplasia in rat epididymis","authors":"Zhaoxin Wang , Xiujuan Liu , Lei Sheng , Yuting Xie , Wanyu Feng , Li Yu","doi":"10.1016/j.orcp.2025.02.001","DOIUrl":"10.1016/j.orcp.2025.02.001","url":null,"abstract":"<div><h3>Background</h3><div>High-fat diet (HFD) contributes to obesity and enhances the expression of mature adipocyte markers. However, the effect of HFD on adipocyte hyperplasia remains controversial. This may be due to variations in the duration of HFD. This study aimed to investigate the effects of different durations of HFD on adipocyte hyperplasia and the expression of mature adipocyte-related markers in obese rats.</div></div><div><h3>Methods</h3><div>We divided 32 Sprague-Dawley rats into four groups: B (standard diet control), H1 (HFD for four weeks), H2 (HFD for eight weeks), and H3 (HFD for 12 weeks). We evaluated the morphological changes in epididymal fat cells, measured serum inflammatory markers using enzyme-linked immunosorbent assay (ELISA) kits, and quantified adipocyte hyperplasia and maturation markers using western blotting.</div></div><div><h3>Results</h3><div>We observed progressive increases in body weight, epididymal fat weight, serum leptin, TNF-α, IL-6, irisin, PPARγ, adiponectin, and FNDC5 protein expression over 8 weeks of HFD. 12 weeks of HFD intervention resulted in significant decreases in irisin, PPARγ, adiponectin, and FNDC5. Concurrently, the expression of perilipin A and ATGL declined with prolonged HFD.</div></div><div><h3>Conclusions</h3><div>Our results suggest that the duration of HFD significantly affects adipocyte ability to undergo hyperplasia in the epididymis of obese rats. Specifically, 4 weeks of HFD did not change the capacity for adipocyte hyperplasia, while 8 weeks of the diet enhanced this capacity. Interestingly, a longer diet duration (12 weeks) led to a decrease in adipocyte hyperplasia.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 1","pages":"Pages 54-62"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of liraglutide on body composition in people living with obesity or overweight: A systematic review 利拉鲁肽对肥胖或超重人群身体成分的影响：系统综述。

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.orcp.2025.01.009

Pedro Henrique Siedschlag Schmidt , Eric Pasqualotto , Henrique Vilar dos Santos , Lis Sodré Nonato de Souza , Bruno Eulálio dos Santos , Matheus Pedrotti Chavez , Rafael Oliva Morgado Ferreira , Alexandre Hohl , Marcelo Fernando Ronsoni , Simone van de Sande-Lee

{"title":"Effects of liraglutide on body composition in people living with obesity or overweight: A systematic review","authors":"Pedro Henrique Siedschlag Schmidt , Eric Pasqualotto , Henrique Vilar dos Santos , Lis Sodré Nonato de Souza , Bruno Eulálio dos Santos , Matheus Pedrotti Chavez , Rafael Oliva Morgado Ferreira , Alexandre Hohl , Marcelo Fernando Ronsoni , Simone van de Sande-Lee","doi":"10.1016/j.orcp.2025.01.009","DOIUrl":"10.1016/j.orcp.2025.01.009","url":null,"abstract":"<div><h3>Aim</h3><div>To evaluate the effect of liraglutide on body composition in people living with obesity or overweight.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in PubMed, Embase, and Cochrane Library databases up to June 10, 2024. Randomized controlled trials (RCTs) comparing liraglutide to placebo and reporting body composition outcomes were included.</div></div><div><h3>Results</h3><div>Data from 15 studies involving 960 participants were analyzed. Liraglutide consistently demonstrated significant reductions in total weight, fat mass, and visceral adipose tissue (VAT) compared to placebo across the included studies. VAT reductions ranged from 12.49 % to 23 %, highlighting liraglutide's effectiveness in targeting visceral fat, a key factor in cardiometabolic risk. Fat mass reductions were also substantial and consistent, reinforcing the efficacy of liraglutide in improving overall body composition. In contrast, lean mass outcomes were more variable, with some studies reporting preservation or even gains in lean mass, while others indicated losses.</div></div><div><h3>Conclusions</h3><div>Liraglutide effectively reduces fat mass and VAT, supporting its use in managing obesity and related cardiometabolic risks. However, the inability to accurately calculate lean and fat mass proportions underscores the need for standardized reporting and availability of individual-level data. Future research should prioritize these elements and include muscle function assessments to better evaluate the clinical impacts of GLP-1 receptor agonists on body composition.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 1","pages":"Pages 11-18"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into diet, psychological distress, and personality traits among patients with lower-extremity lymphedema and overweight/obesity in comparison to patients with lifestyle-induced overweight/obesity and patients with normal body weight 对下肢淋巴水肿和超重/肥胖患者与生活方式引起的超重/肥胖患者和体重正常患者的饮食、心理困扰和人格特征的研究

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.orcp.2025.01.006

Małgorzata Jeziorek , Gabriela Kania , Ivana Stanimirova , Klaudia Konikowska , Andrzej Szuba , Angelika Chachaj

{"title":"Insights into diet, psychological distress, and personality traits among patients with lower-extremity lymphedema and overweight/obesity in comparison to patients with lifestyle-induced overweight/obesity and patients with normal body weight","authors":"Małgorzata Jeziorek , Gabriela Kania , Ivana Stanimirova , Klaudia Konikowska , Andrzej Szuba , Angelika Chachaj","doi":"10.1016/j.orcp.2025.01.006","DOIUrl":"10.1016/j.orcp.2025.01.006","url":null,"abstract":"<div><div>Obesity is a leading cause of cardiovascular diseases. There are significant and mutual associations between lymphatic dysfunction and obesity. This case-control study aimed to compare nutrient intake, depressive symptoms, and Eysenck’s personality traits in patients with lower extremity lymphedema and overweight/obesity (n = 34) in comparison to patients with lifestyle-induced overweight/obesity (n = 30) and patients with normal body weight (n = 30). The study groups were evaluated using the Food Frequency Questionnaire (FFQ), Beck Depression Inventory-II, and Eysenck Personality Questionnaire-Revised (EPQ-R). Surprisingly, the study groups did not differ in any item in the FFQ, including total daily energy value and total intake of macronutrients, vitamins, or minerals. The group with lymphedema and overweight/obesity had higher scores on the depression scale, and the groups with lymphedema and overweight/obesity and lifestyle-induced overweight/obesity differed from the control group in Eysenck’s psychoticism score; however, in all study groups, the scores of this trait were within the normal range. In conclusion, our study suggests that when FFQ is used, the problem of under-reporting of usual dietary intake among patients with lower extremity lymphedema and overweight/obesity, and lifestyle-induced overweight/obesity should be considered.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 1","pages":"Pages 48-53"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Semaglutide: Nonarteritic Anterior Ischemic Optic Neuropathy in the FDA adverse event reporting system – A disproportionality analysis Semaglutide: FDA不良事件报告系统中的非动脉性前缺血性视神经病变-歧化分析。

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.orcp.2025.01.011

Marina Azab , Luca Pasina

{"title":"Semaglutide: Nonarteritic Anterior Ischemic Optic Neuropathy in the FDA adverse event reporting system – A disproportionality analysis","authors":"Marina Azab , Luca Pasina","doi":"10.1016/j.orcp.2025.01.011","DOIUrl":"10.1016/j.orcp.2025.01.011","url":null,"abstract":"<div><div>Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is used for type 2 diabetes (T2D) and approved for obesity by the FDA in 2022 and in Europe in 2023. Its increasing use has raised concerns about access for T2D patients and potential adverse events (AE), such as Nonarteritic Anterior Ischemic Optic Neuropathy (NAION). This study investigates the association between semaglutide and these AE using the FDA Adverse Event Reporting System (FAERS). We conducted a disproportionality analysis using FAERS data. AE were identified using MedDRA Preferred Terms (PTs) and related terms. OpenVigil 2.1 was used for data extraction and analysis. This system is a spontaneous safety surveillance database for drugs. The participants are patients who reported AE related to GLP-1 receptor agonists in the FAERS database from January 1, 2004, to September 30, 2024. Reporting Odds Ratios (ROR) and Proportional Reporting Ratios (PRR) were calculated to assess the association between GLP-1 receptor agonists and the AE. Semaglutide showed a significant ROR and PRR for NAION, suggesting a stronger association compared to other GLP-1 receptor agonists. The findings suggest a disproportionate reporting signal for semaglutide and NAION. The mechanisms behind these associations are not fully understood but may involve effects on the hypothalamus and vascular health. Further research is necessary to confirm these findings ensure the safe use of semaglutide, given the potential risk associated with this rare but severe adverse event.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 1","pages":"Pages 77-79"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of waist circumference measurement site on the cardiometabolic risk factors in Korean adults 韩国成人腰围测量部位对心脏代谢危险因素的影响。

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.orcp.2025.01.007

Yejin Kim , Jennifer L. Kuk , Kyung Hee Park , SoJung Lee

{"title":"Influence of waist circumference measurement site on the cardiometabolic risk factors in Korean adults","authors":"Yejin Kim , Jennifer L. Kuk , Kyung Hee Park , SoJung Lee","doi":"10.1016/j.orcp.2025.01.007","DOIUrl":"10.1016/j.orcp.2025.01.007","url":null,"abstract":"<div><h3>Background</h3><div>Waist circumference (WC) has been recognized as a simple anthropometric measure of abdominal obesity and associated health risk. We compared WC values at five measurement sites, and examined whether measurement sites influence the relationships between WC and cardiometabolic risk in Korean adults.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, participants included 180 men and 176 women (age: 30–60 years, BMI: 18.5–30.0 kg/m<sup>2</sup>) who underwent a regular health examination between 2021 and 2022. WC was measured at the following sites; lowest rib, superior border of the iliac crest, midpoint between the lowest rib and the iliac crest, umbilicus, and narrowest waist. Fasting glucose and lipids, and resting blood pressure were measured after a 10-hour overnight fast. Cardiometabolic risk factors were defined using the modified National Cholesterol Education Program Adult Treatment Panel-III.</div></div><div><h3>Results</h3><div>All WC measures at five sites were highly correlated (<em>P</em> < 0.01) with each other in men (<em>r</em> = 0.933–0.995) and women (<em>r</em> = 0.893–0.990). Differences in absolute mean WC values existed in both men and women. The prevalence of abdominal obesity (men: 17.2 %-34.4 %, women: 5.7 %-40.9 %) and metabolic syndrome (men: 30.6 %-38.9 % women: 13.6 %-22.2 %) varied depending on the measurement site. All five WC sites were similarly associated (<em>P</em> < 0.05) with an increased odd ratio for elevated glucose, elevated triglycerides, low HDL cholesterol and cardiometabolic risk clustering in men, and elevated blood pressure and cardiometabolic risk clustering in women.</div></div><div><h3>Conclusion</h3><div>Although the differences in absolute WC values existed, the associations between WC at each site and cardiometabolic risk were similar in Korean adults.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 1","pages":"Pages 28-33"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin resistance and vigorous physical activity mediates the relationship between waist circumference and metabolic syndrome in Korean children 胰岛素抵抗和剧烈运动介导韩国儿童腰围与代谢综合征的关系。

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.orcp.2025.02.005

Seamon Kang, Mungu Song, Hyunsik Kang

{"title":"Insulin resistance and vigorous physical activity mediates the relationship between waist circumference and metabolic syndrome in Korean children","authors":"Seamon Kang, Mungu Song, Hyunsik Kang","doi":"10.1016/j.orcp.2025.02.005","DOIUrl":"10.1016/j.orcp.2025.02.005","url":null,"abstract":"<div><h3>Background</h3><div>Little is known about how physical activity (PA) and insulin resistance (IR) influence the impact of obesity on metabolic syndrome in pediatric populations.</div></div><div><h3>Objectives</h3><div>This cross-sectional observational study aimed to investigate the mediating effects of PA and IR on the relationship between waist circumference (WC) and continuous metabolic syndrome (cMetS) risk scores in children.</div></div><div><h3>Methods</h3><div>A total of 1008 children aged 7–12 years (535 girls and 473 boys) were recruited from our local elementary schools. PA, body mass index (BMI), WC, and percent body fat were measured. cMetS risk scores were calculated by summing the standardized residuals for mean arterial pressure, triglycerides, fasting blood glucose, and high-density lipoprotein cholesterol.</div></div><div><h3>Results</h3><div>Mediation analysis showed a significant indirect effect of WC on cMetS scores through insulin (β= 0.270, 95 % confidence interval [CI = 0.234–0.306) and vigorous PA (β= 0.007, 95 % CI = 0.001–0.015). The direct effect of WC on cMet scores in the presence of the two mediators was significant (β= 0.193, 95 % CI = 0.040–0.066).</div></div><div><h3>Conclusion</h3><div>Our study findings suggest that while WC is the primary determinant of cMetS scores, fasting insulin and vigorous PA partially mediate the association between the two parameters in this study population.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 1","pages":"Pages 43-47"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating osteopontin as a biomarker of obesity related complications before and after metabolic and bariatric surgery: A systematic review and meta-analysis 评估骨桥蛋白作为代谢和减肥手术前后肥胖相关并发症的生物标志物：一项系统综述和荟萃分析

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.orcp.2025.01.010

Alessio Ardizzone , Rosalba Siracusa , Anna Paola Capra , Rosanna Di Paola , Emanuela Esposito , Salvatore Cuzzocrea , Ramona D’Amico , Daniela Impellizzeri

{"title":"Evaluating osteopontin as a biomarker of obesity related complications before and after metabolic and bariatric surgery: A systematic review and meta-analysis","authors":"Alessio Ardizzone , Rosalba Siracusa , Anna Paola Capra , Rosanna Di Paola , Emanuela Esposito , Salvatore Cuzzocrea , Ramona D’Amico , Daniela Impellizzeri","doi":"10.1016/j.orcp.2025.01.010","DOIUrl":"10.1016/j.orcp.2025.01.010","url":null,"abstract":"<div><h3>Background/Objectives</h3><div>Obesity is a major public health concern, significantly elevating the risk of developing comorbid conditions such as type 2 diabetes mellitus and cardio-vascular diseases, while also shortening life expectancy. Currently, metabolic and bariatric surgery (MBS) is one of the most effective long-term interventions for achieving substantial weight loss, alongside notable improvements in overall quality of life. However, evidence suggests that these procedures may negatively affect bone health, leading to an increased risk of fractures. This systematic review and meta-analysis aim to assess the role of Osteopontin (OPN) as a potential biomarker for predicting both persistent inflammation and bone deterioration following MBS.</div></div><div><h3>Methods</h3><div>A comprehensive search of scientific databases including PubMed (MEDLINE), Embase (OVID), and Web of Science, covering literature up to January 31, 2024, identified 6 studies that met the inclusion criteria for the systematic review. For the meta-analysis, data from 5 studies measuring circulating OPN levels pre- and post-surgery were pooled.</div></div><div><h3>Results</h3><div>The combined analysis revealed a significant increase in OPN levels after MBS compared to baseline (OR: 24.56; 95 % CI: 13.30–35.81; p < 0.0001).</div></div><div><h3>Conclusions</h3><div>These findings suggest that OPN may serve as a valuable biomarker for monitoring inflammation and assessing the risk of bone-related complications in patients following MBS.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 1","pages":"Pages 19-27"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is single anastomosis duodenoileal bypass (SADI) an effective option for conversional surgery following sleeve gastrectomy? A comprehensive review and revised scope of current literature 单吻合术十二指肠油膜旁路（SADI）是袖胃切除术后转换手术的有效选择吗？对当前文献的全面回顾和修订范围。

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.orcp.2025.01.005

Ana Marta Pereira , Sofia S. Pereira , Mariana P. Monteiro , Marta Guimarães

{"title":"Is single anastomosis duodenoileal bypass (SADI) an effective option for conversional surgery following sleeve gastrectomy? A comprehensive review and revised scope of current literature","authors":"Ana Marta Pereira , Sofia S. Pereira , Mariana P. Monteiro , Marta Guimarães","doi":"10.1016/j.orcp.2025.01.005","DOIUrl":"10.1016/j.orcp.2025.01.005","url":null,"abstract":"<div><h3>Background</h3><div>Conversional surgery following sleeve gastrectomy (SG) is required in about 20 % of patients due to suboptimal outcomes. Single anastomosis duodenoileal bypass (SADI) has emerged as an option for such cases, though long-term outcomes remain unclear. This review analyzed available data on SADI as a conversional or second-stage procedure after SG.</div></div><div><h3>Methods</h3><div>A systematic search across PubMed, Web of Science, and Scopus included studies on adult patients who underwent SADI as a conversional or second-stage surgery following SG, with a minimum of 12 months’ follow-up up to July 2024.</div></div><div><h3>Results</h3><div>Nineteen studies involving 867 patients examined weight loss, comorbidity resolution, postoperative complications, and nutritional deficiencies. Results showed a total weight loss (TWL) of 24 % in the first year post-revision, with a trend toward weight stabilization or regain over two years. Maximum TWL (27 %) occurred at 24 months, decreasing to 24 % at 60 months. Average follow-up of 27 months showed remission rates for type 2 diabetes, hypertension, and dyslipidemia at 68 %, 53 %, and 37 %, respectively. Short-term morbidity within 30 days was 8 %, including a 5 % rate of anastomotic leaks or fistulas and a 5 % reoperation rate. Overall mortality was 2 %.</div></div><div><h3>Conclusion</h3><div>In conclusion, SADI shows promise as a safe and effective mid-term conversional surgery after SG with suboptimal results. However, further studies are needed to confirm its long-term safety and effectiveness.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 1","pages":"Pages 1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bariatric surgeons’ views on barriers and enablers to bariatric surgery in Australia and New Zealand: A qualitative content analysis 减肥外科医生对澳大利亚和新西兰减肥手术的障碍和促进因素的看法：定性内容分析。

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2024-11-01 DOI: 10.1016/j.orcp.2024.12.002

Mia Majstorovic , Anna Chur-Hansen , Anne L.J. Burke , Jane M. Andrews

{"title":"Bariatric surgeons’ views on barriers and enablers to bariatric surgery in Australia and New Zealand: A qualitative content analysis","authors":"Mia Majstorovic , Anna Chur-Hansen , Anne L.J. Burke , Jane M. Andrews","doi":"10.1016/j.orcp.2024.12.002","DOIUrl":"10.1016/j.orcp.2024.12.002","url":null,"abstract":"<div><h3>Problem and Aims</h3><div>Bariatric surgery can be an effective treatment for severe obesity, yet publicly-funded access is often limited. Bariatric surgeons contribute to decisions regarding consumer (non)progression to bariatric surgery. Still, little is known about their views on barriers and enablers to bariatric surgery in the Australian and New Zealand context. The current study addresses this knowledge gap.</div></div><div><h3>Methods</h3><div>A qualitative design was utilised. Sixteen bariatric surgeons and registrars from Australia and New Zealand were interviewed about their views on barriers and enablers to bariatric surgery. The data were analysed using qualitative content analysis.</div></div><div><h3>Results</h3><div>Five content categories were derived from the analysis: 1. patient-related factors; 2. healthcare experiences and clinician-related factors; 3. societal beliefs and attitudes towards obesity, bariatric surgery and bariatric surgeons; 4. economic, governmental and institutional factors; and 5. bariatric surgery in the context of other treatments. A perceived lack of focus on obesity and publicly-funded bariatric surgery was apparent throughout the data in the form of descriptions of stigma, clinicians’ disillusionment, patients not being guided and supported, and inadequate regulation and organisation of the field. The role of patients in determining their surgical progression was emphasised.</div></div><div><h3>Conclusions</h3><div>Participants discussed numerous barriers but fewer facilitators to bariatric surgery in Australia and New Zealand. Some of their opinions merit exploration with other bariatric multi-disciplinary team members and patients to understand further how the pre-operative process might be enhanced to support patients’ needs and improve equity.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 6","pages":"Pages 443-449"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High percentage of immune Th1 and Tc1 cells infiltrating visceral adipose tissue in people with obesity 在肥胖人群中，免疫Th1和Tc1细胞浸润内脏脂肪组织的比例很高。

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2024-11-01 DOI: 10.1016/j.orcp.2024.12.006

Pedro Barbosa , Aryane Pinho , André Lázaro , Diogo Paula , José C. Campos , José G. Tralhão , Maria J. Pereira , Artur Paiva , Paula Laranjeira , Eugenia Carvalho

{"title":"High percentage of immune Th1 and Tc1 cells infiltrating visceral adipose tissue in people with obesity","authors":"Pedro Barbosa , Aryane Pinho , André Lázaro , Diogo Paula , José C. Campos , José G. Tralhão , Maria J. Pereira , Artur Paiva , Paula Laranjeira , Eugenia Carvalho","doi":"10.1016/j.orcp.2024.12.006","DOIUrl":"10.1016/j.orcp.2024.12.006","url":null,"abstract":"<div><div>Subcutaneous (SAT) and visceral (VAT) adipose tissue dysfunction during the obesity onset can lead to increased expression of inflammatory molecules, and consequently to immune cell infiltration. The aim was to deeply characterize the T cells, those infiltrating SAT and VAT, compared to peripheral blood (PB), in individuals undergoing bariatric surgery. Forty-two adult individuals were recruited, SAT and VAT samples were collected. T cell characterization was performed by flow cytometry. Results show that T cells infiltrating VAT from people with obesity display higher polarization towards Th1, Tc1 and T1-like CD4<sup>+</sup>CD8<sup>+</sup> T cells, compared to SAT. These cells also display higher percentage of activated cells, and a higher percentage of PD-1-expressing cells. Furthermore, the percentage of Th1/17 and Tc1/17 cells was increased 7–18 months post-surgery. In summary, the phenotype of T cells and their expression of PD-1 within SAT and VAT appear different, especially compared to PB.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 6","pages":"Pages 426-435"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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