Obesity research & clinical practice最新文献

{"title":"Appetite regulation following energy restriction with almond-enriched vs. nut-free diets - a randomised controlled trial","authors":"Sharayah Carter ,&nbsp;Alison M. Hill ,&nbsp;Jonathan D. Buckley ,&nbsp;Sze-Yen Tan ,&nbsp;Geraint B. Rogers ,&nbsp;Alison M. Coates","doi":"10.1016/j.orcp.2026.04.001","DOIUrl":"10.1016/j.orcp.2026.04.001","url":null,"abstract":"<div><div>This study assessed the impact of almonds (AL) or carbohydrate-rich snack bars (SB) on appetite and energy intake. Participants (25–65 yrs, BMI 27.5–34.9 kg/m²) were randomised to consume AL (n = 68) or SB (n = 72) during weight loss (WL) and weight maintenance (WM) diets. Fasting and postprandial appetite hormones and subjective appetite ratings (over 120 min) were measured at baseline (BL), after WL and after WM. Buffet meal energy intake was recorded at 150 min.</div><div>Fasting ghrelin decreased in AL and increased in SB (group x time, p = 0.011), while leptin had a greater increase in AL versus SB post-WM (group x time, p = 0.001). Fasting glucagon and pancreatic polypeptide (PP) were consistently higher in AL compared to SB at each time point (group, p &lt; 0.001). Fasting cholecystokinin (CCK), glucagon and leptin decreased (p &lt; 0.001), while glucose-dependent insulinotropic polypeptide (GIP) (p = 0.004), glucagon-like peptide-1 (GLP-1), PP, peptide YY (PYY), and subjective hunger (p &lt; 0.001) increased over time for all participants,</div><div>Postprandial AUCs were consistently higher in AL than SB for glucagon and PP (p &lt; 0.001), and GIP and GLP-1 (p &lt; 0.05). Over time CCK and leptin AUCs decreased (WL −11% and −2%, WM −9% and −2%, p &lt; 0.05), GIP and subjective hunger AUC increased over time (WL +17%,WM +12%, p &lt; 0.05). Total and discretionary buffet energy intake declined over time (WL −16%, WM −25%,p &lt; 0.05).</div><div>Both groups experienced increased subjective hunger post-WL but demonstrated reduced energy intake at the buffet, suggesting effective behavioural adaptations. AL led to more favourable hormonal changes than SB, highlighting its potential appetite-regulating benefits in long-term WM strategies.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 3","pages":"Pages 244-251"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity, body adiposity, and intracranial aneurysms: A narrative review of clinical evidence beyond body mass index","authors":"Luca Ruggeri ,&nbsp;Rita Lipani ,&nbsp;Giuliano Cassataro ,&nbsp;Valentina Paternò ,&nbsp;Nicola Sinatra ,&nbsp;Caterina Carollo ,&nbsp;Giuseppe Cuttone ,&nbsp;Riccardo Polosa ,&nbsp;Pietro Ferrara ,&nbsp;Giulio Geraci","doi":"10.1016/j.orcp.2026.05.005","DOIUrl":"10.1016/j.orcp.2026.05.005","url":null,"abstract":"<div><div>Intracranial aneurysms are a prevalent cerebrovascular condition and a leading cause of aneurysmal subarachnoid hemorrhage (aSAH). Beyond established risk factors, increasing attention has been focused on metabolic conditions that may modulate vascular inflammation and endothelial function. In this context, obesity has been proposed as potential modifiers of intracranial aneurysm vulnerability. However, clinical evidence remains inconsistent and, in some cases, counterintuitive. Most studies rely on body mass index (BMI) as a proxy for adiposity. Across population-based cohorts and clinical series, BMI has not consistently emerged as an independent risk factor for aneurysm formation or rupture after adjustment for major confounders. Conversely, several studies have reported inverse associations between higher BMI and the risk of aSAH or post-hemorrhagic mortality, findings that have contributed to the concept of an “obesity paradox.” Nevertheless, these associations vary widely by study design, population characteristics, and clinical endpoints, and do not show a consistent linear response pattern. Interpretation of these findings is limited by substantial methodological constraints. BMI does not reflect body composition, fat distribution, or the biological activity of adipose tissue, and may instead capture overall health status or nutritional reserve. Overall, current clinical evidence does not support a consistent or independent role of BMI-defined obesity in intracranial aneurysm risk or prognosis. Reported inverse associations should be interpreted with caution, as they may reflect methodological constraints rather than true biological effects. Future research should incorporate direct and biologically meaningful measures of adiposity to better clarify the relationship between metabolic factors and aneurysm disease.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 3","pages":"Pages 176-184"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“I don't know if medical interventions help obesity”: Perspectives from patients with obesity and the general public on obesity awareness","authors":"Lucas Schreurs ,&nbsp;Hanne Vandevelde ,&nbsp;Melike Köckü ,&nbsp;Zeyneb Achaoui ,&nbsp;Shahad Al-Magdy ,&nbsp;Martijn Schoneveld ,&nbsp;Jonas De Rop ,&nbsp;Inge Gies ,&nbsp;Bart Van der Schueren ,&nbsp;Diederik De Cock","doi":"10.1016/j.orcp.2026.04.006","DOIUrl":"10.1016/j.orcp.2026.04.006","url":null,"abstract":"<div><h3>Objectives</h3><div>Improving public perceptions of obesity may be crucial for preventing the disease and enhancing its management in people with obesity (PwO). This study aimed to examine perceptions concerning obesity among PwO and the general public.</div></div><div><h3>Methods</h3><div>In this cross-sectional qualitative study, consecutive patients visiting the obesity clinic of the University Hospitals of Brussels between December 2023 and May 2024 were invited to participate. Members of the general public (BMI &lt; 25 kg/m²) were recruited at 3 Belgian train stations (Gent, Brussel, Jette). Participants were interviewed, and data were analysed thematically.</div></div><div><h3>Results</h3><div>Thirty PwO and 24 individuals of the general public were interviewed. This study revealed contrasting views on whether obesity should be classified as a disease between patients and the general public. Participants who opposed the recognition of obesity as a disease emphasized personal responsibility as the central factor and advocated for lifestyle changes as the sole form of treatment and management. In contrast, individuals recognizing obesity as a disease underscored the role of biological factors as critical contributors to its development. They emphasized the necessity of a multidisciplinary treatment approach and noted that current behavioural treatments are sometimes insufficient.</div></div><div><h3>Conclusion</h3><div>Limited differences in obesity-related perceptions between patients living with obesity and the general public were noted. In both populations, perceptions of obesity as a disease varied considerably, underscoring persistent knowledge gaps, even in PwO, highlighting the need for public health strategies that emphasize the biological foundations of obesity and the importance of multidisciplinary care approaches, including pharmacotherapy, in its effective management.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 3","pages":"Pages 252-260"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgG N-glycosylation in the causal associations between adiposity, tobacco use, and the risk of cardiovascular diseases: A mediation Mendelian randomization study","authors":"Qing Wang ,&nbsp;Pengcheng Liu ,&nbsp;Xiangli Chen ,&nbsp;Shanshan Zhang ,&nbsp;Qian Shen ,&nbsp;Siyue Wang ,&nbsp;Huan Liu ,&nbsp;Chenhui Zhang ,&nbsp;Cong Zhang ,&nbsp;Ying Qu ,&nbsp;Rong Zhong ,&nbsp;Lei Liu","doi":"10.1016/j.orcp.2026.04.007","DOIUrl":"10.1016/j.orcp.2026.04.007","url":null,"abstract":"<div><h3>Background</h3><div>Despite interest in the health effects of IgG N-glycosylation, the mediating role of IgG N-glycosylation in the effects of adiposity and tobacco use on cardiovascular diseases (CVDs) has not been systematically studied.</div></div><div><h3>Objective</h3><div>This study aimed to investigate the causal effects of adiposity and tobacco use on CVDs and the potential mediating role of 23 traits of IgG N-glycosylation using Mendelian randomization (MR).</div></div><div><h3>Methods</h3><div>Summary statistics from GWAS were used. Two-sample MR assessed the causal links between adiposity, tobacco use, and CVDs, while two-step MR examined whether IgG N-glycosylation traits mediate these associations. Random-effects inverse-variance weighted analyses, along with MR-Egger, weighted median, simple, and weighted model approaches, were conducted.</div></div><div><h3>Results</h3><div>We observed genetically predicted body mass index (OR = 1.48, 95% CI: 1.40, 1.56), fat mass index (OR = 1.68, 95% CI: 1.37, 2.06), fat-free mass index (OR = 1.55, 95% CI: 1.27, 1.89), lifetime smoking index (OR = 1.75, 95% CI: 1.43, 2.14), and smoking initiation (OR = 1.15, 95% CI: 1.06, 1.25) were positively associated with CVDs. Moreover, IGP5 mediated 5.4% of the effect of BMI on pulmonary embolism, whereas IGP7 mediated 2.8% of the effect of BMI on coronary artery disease.</div></div><div><h3>Conclusion</h3><div>Our findings illustrated the causal associations of adiposity and tobacco use with CVDs, with IgG N-glycosylation traits potentially acting as mediators, and thereby highlighting possible mechanistic targets for further investigation.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 3","pages":"Pages 194-202"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147932230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuity of care after bariatric surgery in Australia: Perspectives of general practitioners and patients","authors":"Sally Badorrek ,&nbsp;Janet Franklin ,&nbsp;Michael Devadas ,&nbsp;Laura Conway ,&nbsp;Katherine Smith ,&nbsp;Rachel Russell ,&nbsp;Supreet Saluja ,&nbsp;Kate McBride ,&nbsp;Kathryn Williams","doi":"10.1016/j.orcp.2026.03.003","DOIUrl":"10.1016/j.orcp.2026.03.003","url":null,"abstract":"<div><h3>Aims</h3><div>To explore General Practitioner (GP) and patient perspectives on contemporary post-bariatric surgery care in Australia across metropolitan and regional settings and public and private surgical pathways.</div></div><div><h3>Methods</h3><div>This qualitative study used semi-structured interviews with 16 GPs and 19 adults who had undergone sleeve gastrectomy or gastric bypass ≥ 12 months previously. Participants were purposively sampled across metropolitan and regional locations, and public and private surgery settings. Interviews were conducted virtually, transcribed verbatim, and analysed inductively using reflexive thematic analysis. Coding density and participant characteristics were descriptively examined to explore variation by geography and funding sector.</div></div><div><h3>Results</h3><div>Six themes were identified: medical care and continuity, healthcare setting constraints, patient-level determinants, navigating surgery outcomes, support, and weight stigma and sensitive communications. GPs emphasised system-level challenges, including inadequate information from surgeons, workload pressures, and the need for stigma-sensitive communication. Patients highlighted inconsistent medical care and access to multidisciplinary services, variable confidence in GP-led follow-up and unmet support needs. GP perspectives were consistent across geographical settings, whereas patient experiences differed by location and surgery funding sector, with greater barriers reported by regional and public patients. Clear handover documentation and structured follow-up were consistently described by GPs and patients as facilitating more coordinated and satisfactory care.</div></div><div><h3>Conclusions</h3><div>Post-bariatric surgery care in Australia remains fragmented, with persistent gaps in continuity, multidisciplinary access, and support. Strengthening shared-care frameworks through consistent surgical handover, structured lifelong follow-up, and targeted education for both GPs and patients, would improve care coordination and long-term outcomes.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 3","pages":"Pages 232-243"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective audit of weight loss and health outcomes following bariatric surgery at a tertiary public hospital","authors":"Joanna Perin Lee ,&nbsp;Ahmed Bahamdan ,&nbsp;Janet Franklin ,&nbsp;David Martin ,&nbsp;Craig Taylor ,&nbsp;David Joseph ,&nbsp;Philip Le Page ,&nbsp;Samantha L. Hocking ,&nbsp;Tania P. Markovic","doi":"10.1016/j.orcp.2026.05.003","DOIUrl":"10.1016/j.orcp.2026.05.003","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess longterm weight and comorbidity outcomes following bariatric surgery at a publicly funded obesity service.</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Setting and Participants</h3><div>Cohort of 203 individuals who underwent bariatric surgery between 1 October 2009 and 1 June 2024 were followed for 1–10 years postoperatively. Major obesity-related comorbidities assessed included type 2 diabetes mellitus (T2DM), dyslipidaemia, hypertension, obstructive sleep apnoea (OSA), arthritis and arthralgia, and depression and anxiety.</div></div><div><h3>Main outcome measures</h3><div>Percentage change in weight over time and change in prevalence of obesity-related comorbidities.</div></div><div><h3>Results</h3><div>At baseline the mean age was 50.4 years (SD, 11 years), mean weight 134.6 kg (SD, 30.3 kg), mean BMI 49.3 kg/m² (SD, 9.5 kg/m²) and 59.6% (n = 121) of the cohort had ≥ three of the six comorbidities. Maximal weight loss occurred at 18-months post-surgery with a mean 26.6% (SD, 9.8%) weight reduction. Data were available for 45% (n = 73/162) at 5 years and 38% (n = 19/50) of the cohort at 10 years, with mean weight loss of 23% and 21.9%, respectively. Compared to baseline, at 5 years there was a significant reduction in the proportion of the cohort with T2DM (-13.2%, p &lt; 0.001), OSA (-11.4%, p &lt; 0.001), hypertension (-10.4%, p &lt; 0.002) and dyslipidaemia (-9.2%, p &lt; 0.003), but there was no change in the proportion with anxiety, depression, arthritis or arthralgia.</div></div><div><h3>Conclusions</h3><div>Bariatric surgery in a publicly funded service was shown to have long-term efficacy, with weight loss maintained to 10 years follow-up and a reduction in the incidence of four major obesity-related comorbidities after 5 years.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 3","pages":"Pages 222-231"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are new obesity medications fueling eating and body image disorders?","authors":"Jônatas Oliveira","doi":"10.1016/j.orcp.2026.01.004","DOIUrl":"10.1016/j.orcp.2026.01.004","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 2","pages":"Pages 83-85"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of postpartum weight retention: A hospital-based longitudinal observational study in India","authors":"Divjyot Kaur ,&nbsp;Anita Malhotra ,&nbsp;Piyush Ranjan ,&nbsp;Archana Kumari ,&nbsp;Hem Chandra Sati ,&nbsp;Nikita Madan ,&nbsp;Gauri Shanker Kaloiya ,&nbsp;Amandeep Singh ,&nbsp;Prayas Sethi ,&nbsp;Upendra Baitha","doi":"10.1016/j.orcp.2026.01.007","DOIUrl":"10.1016/j.orcp.2026.01.007","url":null,"abstract":"<div><h3>Background and aims</h3><div>Postpartum weight retention (PPWR) is a critical public health concern linked to long-term obesity and metabolic disorders. This study aimed to identify predictors of PPWR at 6-months among overweight and obese postpartum women in India.</div></div><div><h3>Methods</h3><div>A longitudinal observational study was conducted on 210 postpartum women at a tertiary care hospital. PPWR was defined as the difference of ≥ 5.0 kg between pre-pregnancy and 6-months postpartum. Predictor variables included socio-demographic, obstetric, anthropometric, and lifestyle-related factors. Multiple logistic regression was employed to determine associations.</div></div><div><h3>Results</h3><div>The mean age of participants was 29.4 ± 4.1 years, and mean PPWR was 6.0 ± 4.3 kg. Overall, 55.2 % retained <u>&gt;</u> 5.0 kg at 6-months postpartum. Significant predictors included socioeconomic status (Upper/Upper middle class: AOR 2.784; Lower middle: AOR 4.077), gestational weight gain (AOR 3.667), pre-pregnancy BMI (AOR 0.599), and BMI at 3-months (Obese I: AOR 6.746; Obese II: AOR 67.128). Among dietary factors, inadequate energy intake at 3-months (AOR 2.600), high energy from carbohydrates (AOR 3.317) and fats (AOR 12.463) at 3-months and decline in protein energy contribution from baseline to endline (AOR 1.293) were associated with increased risk. A reduction in visible fat intake during the study period showed a protective effect (AOR 0.938).</div></div><div><h3>Conclusion</h3><div>PPWR is influenced by socioeconomic, anthropometric, and dietary factors. Regular screening, gestational weight monitoring, and balanced macronutrient intake in the early postpartum phase may help mitigate PPWR risk.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 2","pages":"Pages 111-118"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are breast screening recall rates associated with body mass index? Analysis of data from a population-based screening program","authors":"Ross Marriott ,&nbsp;Sarah Pirikahu ,&nbsp;Gareth Porter ,&nbsp;Emmeline Lee ,&nbsp;Elizabeth Wylie ,&nbsp;Jennifer Stone","doi":"10.1016/j.orcp.2026.02.003","DOIUrl":"10.1016/j.orcp.2026.02.003","url":null,"abstract":"<div><h3>Background</h3><div>Increased body mass index (BMI) is associated with increased risk of post-menopausal breast cancer, but little is known about its association with other key screening outcomes. This study investigates the association between BMI and the likelihood of being recalled after routine screening mammography.</div></div><div><h3>Methods</h3><div>To describe the associations between recall rates (crude and age-standardized) and BMI, descriptive statistics were estimated from screening events from clients attending the population-based BreastScreen Western Australia program. For those recalled, multivariable logistic regression models were fitted to investigate the association between BMI and invasive breast cancer and ductal carcinoma in situ (DCIS).</div></div><div><h3>Results</h3><div>The probability of being recalled following mammographic screening was non-linearly associated with BMI and differed by screening round (P_interaction=0.019). Women screening for the first time had lower odds of being recalled if they had very low BMI (&lt;18.5 kg/m²) or very high BMI (&gt;35 kg/m²), compared to those with normal BMI. For women who had screened previously, the odds of being recalled were also lower for those with very low BMI. Among those recalled, women with higher BMI had higher odds of being diagnosed with invasive breast cancer, but not DCIS, relative to those with normal BMI.</div></div><div><h3>Conclusion</h3><div>The decision to recall following mammographic screening may be influenced by prior screening information, which may help explain inconsistent non-linear associations between BMI and recall rates between first time and subsequent screeners. Once recalled, high odds of detection within women with obesity are indicative of increased specificity of mammography to detect cancers.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 2","pages":"Pages 155-163"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147308554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient experience of improvements in physical activity and movement after gastric bypass","authors":"Jeff Wennerlund ,&nbsp;Karin Strigård ,&nbsp;Magnus Sundbom ,&nbsp;Anette Edin-Liljegren","doi":"10.1016/j.orcp.2026.03.002","DOIUrl":"10.1016/j.orcp.2026.03.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Physical activity is an important part of accomplishing and maintaining weight loss. As far as the improvement in associated disease is concerned, the effects of Metabolic Bariatric Surgery (MBS) are well known, but the effects on physical activity and ability to perform everyday activities are less obvious. This study explores how weight loss after Roux-en-Y gastric bypass (RYGB) improves physical activity and movement, and how this impacts everyday life.</div></div><div><h3>Method</h3><div>Semi-structured interviews were held with patients 1–3 years after RYGB. Audio recordings were transcribed verbatim, and the texts were condensed in steps and abstracted with an inductive approach using Qualitative Content Analysis.</div></div><div><h3>Results</h3><div>15 individuals, 12 women and 3 men, median age 36 years (26−73), and median body mass index (BMI) 28 (range 22–45), were interviewed until information power was reached.</div><div>The overall theme <em><strong>“New Life and Freedom”</strong></em> was the result of the analysis process. This was derived from two sub-themes: 1. <em>Discovery of Having Higher Physical Capacity</em>, including the categories Higher Capacity for Physical Activity, No More Limitations, Daily Tasks Are Less Strenuous, and Bodily Change is an Achievement; and 2. <em>Physical Activity is More Rewarding</em>, including the categories Increased Motivation and Initiative, Increased Social Participation, Better Wellbeing, and More Energy.</div></div><div><h3>Conclusion</h3><div>After MBS, patients describe they have gained a new life and freedom thanks to greater ease of participating in physical activities. Patients should be encouraged to continue increased physical activity during follow-up.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 2","pages":"Pages 142-147"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}