Evaluating osteopontin as a biomarker of obesity related complications before and after metabolic and bariatric surgery: A systematic review and meta-analysis

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice Pub Date : 2025-01-01 DOI:10.1016/j.orcp.2025.01.010

Alessio Ardizzone , Rosalba Siracusa , Anna Paola Capra , Rosanna Di Paola , Emanuela Esposito , Salvatore Cuzzocrea , Ramona D’Amico , Daniela Impellizzeri

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引用次数: 0

Abstract

Background/Objectives

Obesity is a major public health concern, significantly elevating the risk of developing comorbid conditions such as type 2 diabetes mellitus and cardio-vascular diseases, while also shortening life expectancy. Currently, metabolic and bariatric surgery (MBS) is one of the most effective long-term interventions for achieving substantial weight loss, alongside notable improvements in overall quality of life. However, evidence suggests that these procedures may negatively affect bone health, leading to an increased risk of fractures. This systematic review and meta-analysis aim to assess the role of Osteopontin (OPN) as a potential biomarker for predicting both persistent inflammation and bone deterioration following MBS.

Methods

A comprehensive search of scientific databases including PubMed (MEDLINE), Embase (OVID), and Web of Science, covering literature up to January 31, 2024, identified 6 studies that met the inclusion criteria for the systematic review. For the meta-analysis, data from 5 studies measuring circulating OPN levels pre- and post-surgery were pooled.

Results

The combined analysis revealed a significant increase in OPN levels after MBS compared to baseline (OR: 24.56; 95 % CI: 13.30–35.81; p < 0.0001).

Conclusions

These findings suggest that OPN may serve as a valuable biomarker for monitoring inflammation and assessing the risk of bone-related complications in patients following MBS.

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评估骨桥蛋白作为代谢和减肥手术前后肥胖相关并发症的生物标志物：一项系统综述和荟萃分析

背景/目的：肥胖是一个主要的公共卫生问题，它显著增加了发生合并症的风险，如2型糖尿病和心血管疾病，同时也缩短了预期寿命。目前，代谢和减肥手术（MBS）是实现大幅度减肥和显著改善整体生活质量的最有效的长期干预措施之一。然而，有证据表明，这些手术可能会对骨骼健康产生负面影响，导致骨折的风险增加。本系统综述和荟萃分析旨在评估骨桥蛋白（OPN）作为预测MBS后持续炎症和骨退化的潜在生物标志物的作用。方法：综合检索PubMed （MEDLINE）、Embase （OVID）、Web of Science等科学数据库，检索截止到2024年1月31日的文献，确定6项符合系统评价纳入标准的研究。在荟萃分析中，我们收集了5项研究中测量手术前后循环OPN水平的数据。结果：综合分析显示，与基线相比，MBS后OPN水平显著增加(OR: 24.56；95 % ci: 13.30-35.81；P < 0.0001)。结论：这些发现表明，OPN可能作为一种有价值的生物标志物，用于监测MBS患者的炎症和评估骨相关并发症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity research & clinical practice 医学-内分泌学与代谢

CiteScore

7.10

自引率

0.00%

发文量

审稿时长

49 days

期刊介绍： The aim of Obesity Research & Clinical Practice (ORCP) is to publish high quality clinical and basic research relating to the epidemiology, mechanism, complications and treatment of obesity and the complication of obesity. Studies relating to the Asia Oceania region are particularly welcome, given the increasing burden of obesity in Asia Pacific, compounded by specific regional population-based and genetic issues, and the devastating personal and economic consequences. The journal aims to expose health care practitioners, clinical researchers, basic scientists, epidemiologists, and public health officials in the region to all areas of obesity research and practice. In addition to original research the ORCP publishes reviews, patient reports, short communications, and letters to the editor (including comments on published papers). The proceedings and abstracts of the Annual Meeting of the Asia Oceania Association for the Study of Obesity is published as a supplement each year.