Hanwen Ye,Hafiz Muhammad Yasir,Jinbo Hu,Wenjin Luo,Yao Qin,Lina Mao,Zhuo Chen,Xiaoru Zhang,Qifu Li,Xiangjun Chen,Zhihong Wang
{"title":"Abdominal obesity and CKD: A potential mediating role of serum metabolites in the UK Biobank population.","authors":"Hanwen Ye,Hafiz Muhammad Yasir,Jinbo Hu,Wenjin Luo,Yao Qin,Lina Mao,Zhuo Chen,Xiaoru Zhang,Qifu Li,Xiangjun Chen,Zhihong Wang","doi":"10.1016/j.orcp.2024.09.274","DOIUrl":"https://doi.org/10.1016/j.orcp.2024.09.274","url":null,"abstract":"BACKGROUNDIt is generally known that although a connection between abdominal obesity and chronic kidney disease (CKD) is well-established, there is a lack of systematic research investigating the specific roles of serum metabolites, including lipid metabolites, amino acid metabolites, carbohydrate metabolites and inflammatory substances in explaining this associations.METHODSWe included 118,020 general patients with data of serum metabolites from UK Biobank. We defined abdominal obesity and CKD based on waist circumference and ICD-10 criteria. The serum metabolites were assessed by a high-throughput nuclear magnetic resonance (NMR) based metabolic biomarker profiling platform. We conducted mediation analysis by R software and used the proportion of mediation to quantify the mediation effect.RESULTSThis study demonstrated that lipid metabolites played a more important role in mediating the relationship between abdominal obesity and CKD than amino acid metabolites and carbohydrate metabolites. And Glycoprotein Acetyls (GlycA) was the strongest mediator for the correlation between abdominal obesity and CKD, accounting for 26.4 %. And In the mediation analysis stratified by sex, we found that the mediating effects of lipid metabolites were mostly higher in men than in women, while GlycA accounted for the largest proportion of the mediation association in both two groups (31.0 % for women and 19.8 % for men).CONCLUSIONAmong lipid metabolites, amino acid metabolites, carbohydrate metabolites and inflammatory substances, our study showed that infammation marker GlycA was the novel and key mediator for the correlation between abdominal obesity and CKD.","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142259690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Once-weekly semaglutide in heart failure with preserved ejection fraction and obesity: main results from the STEP-HFpEF trial","authors":"","doi":"10.1016/j.orcp.2024.09.084","DOIUrl":"10.1016/j.orcp.2024.09.084","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142328175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The impact of obesity on pregnancy outcomes in women with type 1 and type 2 diabetes across the NSW population","authors":"","doi":"10.1016/j.orcp.2024.09.069","DOIUrl":"10.1016/j.orcp.2024.09.069","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142328177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Integrating health literacy and cultural considerations into a web-based program promoting healthy behaviours in infants","authors":"","doi":"10.1016/j.orcp.2024.09.024","DOIUrl":"10.1016/j.orcp.2024.09.024","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142328225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Barriers to accessing a public hospital multidisciplinary weight management program for women with class 3 obesity","authors":"","doi":"10.1016/j.orcp.2024.09.048","DOIUrl":"10.1016/j.orcp.2024.09.048","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Developing a framework to enable clinical health promotion across the healthcare system in Queensland, Australia.","authors":"","doi":"10.1016/j.orcp.2024.09.035","DOIUrl":"10.1016/j.orcp.2024.09.035","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of nutrition and other health-oriented marketing claims on young adults’ perceptions and hypothetical consumption of alcohol products: an online experiment","authors":"","doi":"10.1016/j.orcp.2024.09.077","DOIUrl":"10.1016/j.orcp.2024.09.077","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142325954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characterising support needs of adolescents with obesity participating in a dietary intervention","authors":"","doi":"10.1016/j.orcp.2024.09.046","DOIUrl":"10.1016/j.orcp.2024.09.046","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Knowledge of obesity-related cancer risk factors via public health messaging and impact on dietary behaviour","authors":"","doi":"10.1016/j.orcp.2024.09.054","DOIUrl":"10.1016/j.orcp.2024.09.054","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cycling between chow and high-fat diet: a longitudinal follow-up of diet-induced obesity","authors":"","doi":"10.1016/j.orcp.2024.09.057","DOIUrl":"10.1016/j.orcp.2024.09.057","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}