Obesity research & clinical practice最新文献

Questioning the role of food addiction in pediatric obesity: Comment on An et al. (2025).

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-03-28 DOI: 10.1016/j.orcp.2025.03.004

Jônatas de Oliveira

{"title":"Questioning the role of food addiction in pediatric obesity: Comment on An et al. (2025).","authors":"Jônatas de Oliveira","doi":"10.1016/j.orcp.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.orcp.2025.03.004","url":null,"abstract":"The study by An et al. (2025) [1] investigated the association between food addiction (FA), obesity, and emotional and behavioral problems in Korean children and adolescents with overweight or obesity. While FA was linked to higher BMI, lower self-esteem, and increased emotional difficulties, critical methodological limitations challenge the clinical relevance of these findings. Cross-sectional designs require careful control of confounding variables, yet essential factors such as genetic predispositions, socioeconomic status, food environment, and family dynamics were not fully addressed. Additionally, behavioral traits like food neophobia, shown by Dos Anjos et al. (2021) [9] to influence unhealthy eating patterns in children, and neurodevelopmental conditions, such as ADHD and autism spectrum disorder, frequently co-occur with disordered eating behaviors and may confound FA classifications. Recent data from Nyholmer et al. (2024) [15] further highlight the overlap between restrictive eating profiles and psychiatric comorbidities, underscoring the need for comprehensive assessment. The study's lack of dietary pattern analysis, particularly concerning ultra-processed food intake, and absence of age-stratified reliability in dietary reporting limit its interpretability. Future research should integrate neurodevelopmental and psychiatric evaluations to clarify whether FA reflects a distinct clinical entity or broader emotional and behavioral dysregulation within pediatric obesity. Without this, the application of FA as an isolated construct remains questionable.","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the letter to editor entitled "Questioning the role of food addiction in pediatric obesity: Comment on An et al. (2025)".

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-03-26 DOI: 10.1016/j.orcp.2025.03.005

Hye-Ji An

引用次数: 0

Disproportionality analysis on semaglutide and nonarteritic anterior ischemic optic neuropathy in the FDA adverse event reporting system: An emerging pharmacovigilance signal?

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-03-24 DOI: 10.1016/j.orcp.2025.03.001

Angela Procacci, Elisabetta Poluzzi, Fabrizio De Ponti, Emanuel Raschi

{"title":"Disproportionality analysis on semaglutide and nonarteritic anterior ischemic optic neuropathy in the FDA adverse event reporting system: An emerging pharmacovigilance signal?","authors":"Angela Procacci, Elisabetta Poluzzi, Fabrizio De Ponti, Emanuel Raschi","doi":"10.1016/j.orcp.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.orcp.2025.03.001","url":null,"abstract":"Background and aim: On January 17th 2025, the European Medicines Agency started a review on semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy (NAION); we gained insight into this potential association by appraising post-marketing reporting.Methods: We queried the FDA Adverse Event Reporting System (up to December 2024) to retrieve cases of NAION reported with GLP-1 receptor agonists. Disproportionality analysis was performed by calculating the Reporting Odds Ratio (ROR) with 95 % confidence Interval (CI). Signal of Disproportionate Reporting (SDR) was defined by a lower limit of the 95 %CI> 1. To account for potential confounding by indication and channeling bias, active-comparator restricted design and disproportionality by therapeutic area were performed by comparing semaglutide vs other antidiabetic/antiobesity drugs, including SGLT2-inhibitors.Results: 96 NAION cases were retrieved (83 to semaglutide), peaking 53 in last 3 months (18 from Denmark), with a median time to onset of 186 days. An SDR emerged only for semaglutide (ROR=17.57; 95 %CI=13.93-21.90), and remained significant across comparators and therapeutic indications.Conclusions: Notwithstanding limitations, including inability to infer causality, the consistency of disproportionality against a wide range of confounders together with other observational evidence raised the hypothesis of a safety signal, especially from Denmark. The exponential reporting trend calls for urgent clarification of drug-, patient- and Country-related risk factors.","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attention to food in adolescents with obesity: No evidence for increased attentional engagement or reduced attentional disengagement.

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-03-21 DOI: 10.1016/j.orcp.2025.03.002

Nienke C Jonker, Thomas A de Lang, Caroline Braet, Peter J de Jong

{"title":"Attention to food in adolescents with obesity: No evidence for increased attentional engagement or reduced attentional disengagement.","authors":"Nienke C Jonker, Thomas A de Lang, Caroline Braet, Peter J de Jong","doi":"10.1016/j.orcp.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.orcp.2025.03.002","url":null,"abstract":"Objective: This study examined differences in attentional engagement and disengagement bias regarding visual food stimuli between adolescents with a healthy weight versus adolescents with obesity.Method: Participants were adolescents aged 12- 23, with obesity (n = 51, adjusted BMI [(actual BMI/Percentile 50 of BMI for age and gender) × 100]) between 143 % and 313 %, and with a healthy weight (n = 51), adjusted BMI between 75 % and 129 %. Attentional bias (AB) was indexed by the Attentional Response to Distal vs. Proximal Emotional Information (ARDPEI) task.Results: Unexpectedly, results showed moderately strong evidence that individuals with obesity did not show more attentional engagement to food cues than individuals with a healthy weight, and moderately strong evidence that individuals with obesity did not show more difficulty in disengaging from food cues than individuals with a healthy weight.Conclusions: Findings provide no evidence to support the view that in adolescents AB to food cues plays a role in obesity. One conclusion could be that AB to food cues does not play a role in obesity. Yet, future studies should examine whether this might be different for adults or when satiety is well-controlled.","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skipping breakfast and nutrient density: Influence on obesity, blood pressure, glucose, and cholesterol in elementary school students. 不吃早餐与营养密度：对小学生肥胖、血压、血糖和胆固醇的影响。

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-03-07 DOI: 10.1016/j.orcp.2025.02.009

Hanbit Mun, Sang Woo Oh

{"title":"Skipping breakfast and nutrient density: Influence on obesity, blood pressure, glucose, and cholesterol in elementary school students.","authors":"Hanbit Mun, Sang Woo Oh","doi":"10.1016/j.orcp.2025.02.009","DOIUrl":"https://doi.org/10.1016/j.orcp.2025.02.009","url":null,"abstract":"Background: Skipping breakfast is a public health issue affecting childhood obesity worldwide. However, how skipping breakfast adversely affects metabolic health in children has not been investigated comprehensively. This study investigated the associations between breakfast skipping, obesity, and cardiometabolic risk in elementary school students and identified its association with nutritional patterns.Methods: Data on 3590 elementary school students were obtained from the Korea National Health and Nutrition Examination Survey (2013-2020). Participants self-reported weekly breakfast frequency, and dietary nutrient intake was assessed using a 24-h recall survey. The associations of breakfast frequency with obesity, cardiometabolic risk factors, and nutrient density were analyzed using a survey multivariate linear regression analysis.Results: The lowest breakfast frequency group (0-2 times/week) had a higher mean body mass index (estimated mean differences; 0.80 kg/m2, 95 % confidence interval (CI) 0.30-1.31) and waist circumference (2.20 cm, 0.83-3.57) than the highest frequency group (5-7 times/week). Additionally, they had higher systolic blood pressure (1.68 mmHg, 0.12-3.24), diastolic blood pressure (2.24 mmHg, 1.09-3.39), fasting glucose (1.58 mg/dL, 0.40-2.75) than the highest breakfast group. Furthermore, this group had higher percentages of energy from fat (1.96 %, 0.90-3.02), sodium density (10.29 mg/100 kcal, 0.75-19.82) and Na/K ratio (0.25 mmol/mmol, 0.11-0.40) than the highest frequency group, despite lower caloric intake.Conclusions: Elementary school students who skipped breakfast had higher obesity and cardiometabolic risk factors. These associations might be assumed from dietary nutrient patterns characterized by higher fat and sodium density despite lower daily caloric consumption.","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weight stigma toward pregnant patients: An experimental study of medical students.

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-03-06 DOI: 10.1016/j.orcp.2025.02.008

Alicia Niemann, Lara J LaCaille, Rebecca L Emery Tavernier

{"title":"Weight stigma toward pregnant patients: An experimental study of medical students.","authors":"Alicia Niemann, Lara J LaCaille, Rebecca L Emery Tavernier","doi":"10.1016/j.orcp.2025.02.008","DOIUrl":"https://doi.org/10.1016/j.orcp.2025.02.008","url":null,"abstract":"Objective: To investigate the presence of implicit and explicit weight bias among a sample of medical students.Methods: Using a between-subjects experimental design, medical students (N = 100; AgeM = 25.83 ± 2.76), were randomly assigned to read a vignette about a pregnant patient with a lower body mass index (BMI; 23 kg/m2) or a higher BMI (33 kg/m2). Participants then completed questionnaires related to perceptions and liking of the patient, and explicit attitudes about people who have larger bodies (i.e., BMIs ≥ 30 kg/m2).Results: There were no significant differences between vignettes, suggesting that implicit bias against pregnant patients with higher versus lower BMIs was not identified. However, weight stigmatizing attitudes were associated with medical student BMI, such that medical students with higher BMIs expressed more positive attitudes for patients with BMIs ≥ 30 kg/m2 than medical students with lower BMIs.Conclusions: These findings indicate that implicit weight bias towards pregnant patients in medical students is low, particularly among medical students with higher weight, which may represent a shift in societal attitudes towards patients with larger bodies.","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of 3 G rice on plasma glucose, insulin, and gastrointestinal hormones in patients with obesity or type 2 diabetes: A non-randomized experimental study.

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-03-03 DOI: 10.1016/j.orcp.2025.02.010

Chartchai Chaichana, Pornpoj Pramyothin, Witcha Treesuwan, Preechaya Jangtawee, Ahthit Yindeengam, Saroch Kaewmanee, Apichart Vanavichit, Rungroj Krittayaphong

{"title":"Impact of 3 G rice on plasma glucose, insulin, and gastrointestinal hormones in patients with obesity or type 2 diabetes: A non-randomized experimental study.","authors":"Chartchai Chaichana, Pornpoj Pramyothin, Witcha Treesuwan, Preechaya Jangtawee, Ahthit Yindeengam, Saroch Kaewmanee, Apichart Vanavichit, Rungroj Krittayaphong","doi":"10.1016/j.orcp.2025.02.010","DOIUrl":"https://doi.org/10.1016/j.orcp.2025.02.010","url":null,"abstract":"Objective: To evaluate the effects of a novel grain variety 3 G rice compared to traditional white rice on postprandial glycemia, insulinemia, and gastrointestinal hormones in individuals with obesity and type 2 diabetes (T2D).Methods: A non-randomized experimental study was conducted with 20 participants with obesity (without diabetes) and 20 patients with T2D. Each participant consumed meals containing 50 g of carbohydrates from either 3 G rice or white rice. Plasma glucose, insulin, and gastrointestinal hormone levels were measured at baseline and intervals up to 120 min post-consumption.Results: Among participants with obesity, plasma glucose levels were significantly lower at 90 and 120 after 3 G compared to white rice (0.52 ± 0.04 vs. 2.58 ± 0.37 mmol/L, p < 0.001 at 90 min and 0.06 ± 0.02 vs. 1.47 ± 0.26 mmol/L, p = 0.003 at 120 min). In contrast, plasma insulin levels were markedly higher following 3 G rice consumption at 90-120 min (p = 0.003). Gastrointestinal hormones were significantly elevated after 3 G rice intake compared to white rice, with GLP-1 levels showing sustained increases from 60 to 120 min (p = 0.019). In T2D patients, 3 G rice consumption led to a modest reduction in plasma glucose at 120 min (5.15 ± 0.49 mmol/L for white rice vs. 3.57 ± 0.35 mmol/L for 3 G rice, p = 0.0262) without significant effect on other parameters.Conclusion: 3 G rice significantly improved postprandial glycemic control and enhanced gastrointestinal hormone responses in individuals with obesity. These findings highlight the promise of 3 G rice as a dietary intervention for managing postprandial glycemia and insulin sensitivity.","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weight gain following an employer-based randomized trial evaluating the treatment of obesity with and without anti-obesity medication.

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-03-02 DOI: 10.1016/j.orcp.2025.02.006

Noura Nachawi, Marcio L Griebeler, Huijun Xiao, James Bena, Kevin M Pantalone, Bartolome Burguera

{"title":"Weight gain following an employer-based randomized trial evaluating the treatment of obesity with and without anti-obesity medication.","authors":"Noura Nachawi, Marcio L Griebeler, Huijun Xiao, James Bena, Kevin M Pantalone, Bartolome Burguera","doi":"10.1016/j.orcp.2025.02.006","DOIUrl":"https://doi.org/10.1016/j.orcp.2025.02.006","url":null,"abstract":"Background: A pragmatic randomized controlled trial (RCT) reported superior weight loss when anti-obesity medications (AOMs) were added to a 1-year employer-based weight management program (WMP+Rx) compared to WMP alone. Evidence regarding sustainability of weight loss, upon trial completion, is lacking. This report aims to evaluate weight loss sustainability upon completion of the RCT.Methods: This retrospective, observational report, analyzed data from subjects post-completion of the previous RCT. The main outcome was the mean change in body weight from baseline (end visit of the previous RCT) to 24 months.Results: Of 199 subjects included in the RCT, 185 subjects who had pre-trial (prior to the previous RCT) and baseline weight (end visit of the previous RCT) were included in this report. Both groups; [WMP+Rx; 97 subjects, (52.4 %)] and [WMP; 88 subjects (47.6 %)] demonstrated an increase in mean body weight during the observational follow-up period; 5.2 % (95 % CI: 3.4 %, 7 %) and 6.3 % (95 % CI: 4.5 %, 8.1 %) for the WMP+Rx and 1.3 % (95 % CI: -0.6 %, 3.1 %) and 2.1 % (95 % CI: 0.3 %, 4 %) for the WMP, at 12 and 24 months, respectively. Higher percentages of individuals who gained of > 5 % of baseline weight was observed in the WMP+Rx vs WMP group; (47 %) vs (28 %) [odds ratio OR 3.16 (95 % CI: 1.19, 8.37), (P = 0.02)] and (51 %) vs (39 %) [OR 2.85 (95 %CI: 0.93,8.74), (P = 0.067)], at 12 and 24 months, respectively.Conclusions: Weight loss achieved with WMP with or without AOMs was not maintained at 12 and 24 months. Chronic obesity management is needed for sustainable outcomes.","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between obesity and prevalence of significant regurgitant valvular heart disease over time: A cohort study.

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-02-28 DOI: 10.1016/j.orcp.2025.02.007

Damian Craiem, Juan Moukarzel, Mariano E Casciaro, Valentina Stipechi, Eduardo Guevara

{"title":"Association between obesity and prevalence of significant regurgitant valvular heart disease over time: A cohort study.","authors":"Damian Craiem, Juan Moukarzel, Mariano E Casciaro, Valentina Stipechi, Eduardo Guevara","doi":"10.1016/j.orcp.2025.02.007","DOIUrl":"https://doi.org/10.1016/j.orcp.2025.02.007","url":null,"abstract":"Background: The association between valvular heart disease and obesity is poorly documented. The present study evaluated the prevalence and worsening over time of valvular regurgitation by obesity category.Methods: This cohort study included 11385 patients who underwent two echocardiographic examinations at least 1 year apart. Mitral, tricuspid, and aortic regurgitation were graded at the first and last visits. Regurgitation worsening was defined as those going from non/trace to moderate/severe or from moderate to severe. Frequency and worsening of regurgitant valvular heart disease were evaluated across body mass index (BMI) categories and adjusted for age, sex, follow-up time, and significant regurgitation at first exam.Results: Patients aged 63 ± 15 years old at the last visit (43 % women, 29 % with obesity, median follow-up time of 3 years [interquartile range 2-6]). Valve regurgitation was more common in patients without obesity than in those with obesity across all age groups. The prevalence of mitral, tricuspid and aortic valve regurgitations at the last visit diminished for increased BMI categories: 24 %, 19 %, 16 % and 14 % for patients with normal weight, overweight, obesity and severe obesity, respectively (p < 0.001). The regurgitation worsening observed in any valve followed a similar trend: 14 %, 11 %, 9 % and 8 %, respectively (p < 0.001). These inverse associations with BMI remained significant after adjustments for cofactors.Conclusions: Obesity was associated with lower valvular regurgitation prevalence and worsening that persisted in the mitral and tricuspid valves after adjusting for confounders and excluding patients changing weight over time, suggesting the existence of an obesity paradox in valvular heart diseases.","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vertical sleeve gastrectomy improves social behaviors in obese, male mice

IF 2.5 4区医学

Obesity research & clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.orcp.2025.02.003

Anne-Marie Neumann, Cathleen Geißler, Randy Seeley, Henriette Kirchner, Henrik Oster

引用次数: 0