{"title":"前/前和合成抗生素是否会影响超重和肥胖儿童和青少年的心血管危险因素？随机对照试验的分级系统评价和荟萃分析。","authors":"Yunduo Wu, Jun Zhang, Xiaoshuai Wang, Shoulin Li","doi":"10.1016/j.orcp.2025.08.010","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gut microbiota modulation has been proposed as a potential intervention for managing obesity. This meta-analysis aimed to evaluate the effects of prebiotic/probiotic/synbiotic supplementation on cardiometabolic risk factors in obese pediatrics.</p><p><strong>Methods: </strong>A systematic search was conducted up to January 2025. Randomized controlled trials (RCTs) evaluating biotics in children and adolescents with overweight/obesity were included. The outcomes were weight, body mass index (BMI), BMI-z score, fasting blood sugar (FBS), homeostatic model assessment for insulin resistance (HOMA-IR), insulin, hemoglobin A1C (HbA1c), total cholesterol (TC), triglycerides (TG), low- and high- density lipoprotein-cholesterol (LDL-C and HDL-C). Data were pooled using a random-effects model.</p><p><strong>Results: </strong>Meta-analysis showed no significant effect of prebiotic/probiotic/synbiotic supplementation on weight (WMD = -0.25 kg; 95 % CI: -1.96, 1.47), BMI (WMD = -0.18 kg/m²; 95 % CI: -0.66, 0.29), BMI-z score (WMD = -0.02 unit; 95 % CI: -0.12, 0.05), FBS (WMD = -0.27 mg/dl; 95 % CI: -1.11, 0.57), insulin (WMD = 0.70 μIU/mL; 95 % CI: -1.18, 2.59), HOMA-IR (WMD = 0.24 unit; 95 % CI: -0.28, 0.75), TG (WMD = -0.73 mg/dl; 95 % CI: -7.11-8.57), TC (WMD = 0.99 mg/dl; 95 % CI: -4.24-2.25), LDL-C (WMD = 0.24 mg/dl; 95 % CI: -3.65-3.18), and HDL-C (WMD = -1.04 mg/dl; 95 % CI: -3.18-1.05). However, a significant reduction in FBS was shown with probiotics (P < 0.001). Sensitivity analysis revealed a significant decrease in BW, FBS, and HDL-C (P < 0.05).</p><p><strong>Conclusion: </strong>Prebiotic/probiotic/synbiotic supplementation cannot improve cardiometabolic risk factors in overweight and obese children.</p>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Can pre-/pro and synbiotics affect cardiovascular risk factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized controlled trials.\",\"authors\":\"Yunduo Wu, Jun Zhang, Xiaoshuai Wang, Shoulin Li\",\"doi\":\"10.1016/j.orcp.2025.08.010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Gut microbiota modulation has been proposed as a potential intervention for managing obesity. This meta-analysis aimed to evaluate the effects of prebiotic/probiotic/synbiotic supplementation on cardiometabolic risk factors in obese pediatrics.</p><p><strong>Methods: </strong>A systematic search was conducted up to January 2025. Randomized controlled trials (RCTs) evaluating biotics in children and adolescents with overweight/obesity were included. The outcomes were weight, body mass index (BMI), BMI-z score, fasting blood sugar (FBS), homeostatic model assessment for insulin resistance (HOMA-IR), insulin, hemoglobin A1C (HbA1c), total cholesterol (TC), triglycerides (TG), low- and high- density lipoprotein-cholesterol (LDL-C and HDL-C). Data were pooled using a random-effects model.</p><p><strong>Results: </strong>Meta-analysis showed no significant effect of prebiotic/probiotic/synbiotic supplementation on weight (WMD = -0.25 kg; 95 % CI: -1.96, 1.47), BMI (WMD = -0.18 kg/m²; 95 % CI: -0.66, 0.29), BMI-z score (WMD = -0.02 unit; 95 % CI: -0.12, 0.05), FBS (WMD = -0.27 mg/dl; 95 % CI: -1.11, 0.57), insulin (WMD = 0.70 μIU/mL; 95 % CI: -1.18, 2.59), HOMA-IR (WMD = 0.24 unit; 95 % CI: -0.28, 0.75), TG (WMD = -0.73 mg/dl; 95 % CI: -7.11-8.57), TC (WMD = 0.99 mg/dl; 95 % CI: -4.24-2.25), LDL-C (WMD = 0.24 mg/dl; 95 % CI: -3.65-3.18), and HDL-C (WMD = -1.04 mg/dl; 95 % CI: -3.18-1.05). However, a significant reduction in FBS was shown with probiotics (P < 0.001). Sensitivity analysis revealed a significant decrease in BW, FBS, and HDL-C (P < 0.05).</p><p><strong>Conclusion: </strong>Prebiotic/probiotic/synbiotic supplementation cannot improve cardiometabolic risk factors in overweight and obese children.</p>\",\"PeriodicalId\":19408,\"journal\":{\"name\":\"Obesity research & clinical practice\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obesity research & clinical practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.orcp.2025.08.010\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity research & clinical practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.orcp.2025.08.010","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Can pre-/pro and synbiotics affect cardiovascular risk factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized controlled trials.
Background: Gut microbiota modulation has been proposed as a potential intervention for managing obesity. This meta-analysis aimed to evaluate the effects of prebiotic/probiotic/synbiotic supplementation on cardiometabolic risk factors in obese pediatrics.
Methods: A systematic search was conducted up to January 2025. Randomized controlled trials (RCTs) evaluating biotics in children and adolescents with overweight/obesity were included. The outcomes were weight, body mass index (BMI), BMI-z score, fasting blood sugar (FBS), homeostatic model assessment for insulin resistance (HOMA-IR), insulin, hemoglobin A1C (HbA1c), total cholesterol (TC), triglycerides (TG), low- and high- density lipoprotein-cholesterol (LDL-C and HDL-C). Data were pooled using a random-effects model.
期刊介绍：
The aim of Obesity Research & Clinical Practice (ORCP) is to publish high quality clinical and basic research relating to the epidemiology, mechanism, complications and treatment of obesity and the complication of obesity. Studies relating to the Asia Oceania region are particularly welcome, given the increasing burden of obesity in Asia Pacific, compounded by specific regional population-based and genetic issues, and the devastating personal and economic consequences. The journal aims to expose health care practitioners, clinical researchers, basic scientists, epidemiologists, and public health officials in the region to all areas of obesity research and practice. In addition to original research the ORCP publishes reviews, patient reports, short communications, and letters to the editor (including comments on published papers). The proceedings and abstracts of the Annual Meeting of the Asia Oceania Association for the Study of Obesity is published as a supplement each year.
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