Obesity research & clinical practice最新文献

{"title":"Maternal body mass index and risk of post-partum haemorrhage: A population-based study in primiparous women","authors":"Alemayehu Mekonnen,&nbsp;Glyn Teale,&nbsp;Vidanka Vasilevski,&nbsp;Linda Sweet","doi":"10.1016/j.orcp.2026.07.002","DOIUrl":"10.1016/j.orcp.2026.07.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Post-partum haemorrhage (PPH) is a leading cause of maternal morbidity and mortality, yet its relationship with body mass index (BMI) remains unclear.</div></div><div><h3>Aim</h3><div>To examine the association between BMI and PPH among primiparous women in Australia.</div></div><div><h3>Methods</h3><div>A population-based retrospective cohort study was conducted using Victorian Perinatal Data Collection registry (2010─2019). BMI data were available for 311,266 primiparous women. Post-partum haemorrhage was defined using two blood loss thresholds: ≥ 500 mL and ≥ 1000 mL. Logistic regression models were used.</div></div><div><h3>Results</h3><div>The prevalence of overweight and obesity increased from 24.9% to 26.4% and 16.5–18.6%, respectively, while PPH rates rose from 25.5% to 31.5% (≥500 mL) and 2.6–6.4% (≥1000 mL). Women with overweight and obesity had higher odds of PPH compared to women with normal BMI: adjusted odds ratios (AORs) for PPH ≥ 500 mL were 1.11 (95% CI: 1.07–1.13) for overweight and 1.32 (95% CI: 1.29–1.36) for obesity. For PPH ≥ 1000 mL, AORs were 1.10 (95% CI: 1.05–1.15) and 1.30 (95% CI: 1.24–1.37), respectively. Subgroup analysis of vaginal births showed a stronger association between obese BMI and PPH ≥ 1000 mL. For caesarean births, BMI was not significantly associated with PPH ≥ 1000 mL.</div></div><div><h3>Conclusion</h3><div>Higher maternal BMI is significantly associated with PPH, particularly in vaginal births. Rising PPH rates over time align with increasing overweight and obesity prevalence, but cannot be fully explained by BMI alone. Enhanced focus on pre-pregnancy weight management and tailored maternity care could contribute to mitigating these risks and improving maternal health outcomes.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 5","pages":"Pages 418-427"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern \"Evaluation of diagnostic and predictive value of serum adipokines: Leptin, resistin and visfatin in postmenopausal breast cancer\" [Obes Res Clin Pract 10 4 (2016) 442-453].","authors":"","doi":"10.1016/j.orcp.2026.08.003","DOIUrl":"10.1016/j.orcp.2026.08.003","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":" ","pages":"488"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic burden of rare leptin-melanocortin variants in pediatric nonsyndromic obesity: Evidence from a Taiwanese cohort","authors":"Yu-Ming Chang,&nbsp;Daw-Yang Hwang,&nbsp;Yen-Yin Chou,&nbsp;Yu-Wen Pan,&nbsp;Yun-Han Weng,&nbsp;Meng-Che Tsai","doi":"10.1016/j.orcp.2026.07.003","DOIUrl":"10.1016/j.orcp.2026.07.003","url":null,"abstract":"<div><h3>Background</h3><div>Rare and deleterious variants in the leptin-melanocortin pathway can underlie severe childhood obesity, but data from East Asian populations remain limited.</div></div><div><h3>Methods</h3><div>We conducted a single-center prospective observational cohort study of 188 Taiwanese children (4–18 years) with nonsyndromic obesity recruited between Jan 2017 and Dec 2024 for targeted sequencing of 12 leptin-melanocortin genes and compared them with two cohorts from the Taiwan Biobank: 527 normal‑weight adults presumed to have normal weight in childhood and 213 obese adults. We compared carrier proportions and mean variant counts and applied the Optimal Sequence Kernel Association Test (SKAT-O) across groups at the pathway and gene levels for three variant sets: all exonic variants, rare variants, and potentially influential variants (PIVs, defined as rare protein-truncating variants or missense variants with high deleteriousness scores). We also analyzed questionnaire-derived eating behavior scores using SKAT-O within the childhood obesity cohort.</div></div><div><h3>Results</h3><div>Children with obesity carried a higher PIV burden than both normal-weight adults (41.0% vs. 24.1%; p &lt; 0.0001) and obese adults (41.0% vs. 25.8%; p = 0.001); mean PIV counts were also higher. Pathway-level SKAT-O supported enrichment driven by rare variants and PIVs. Gene-level enrichment for <em>LEPR</em> and <em>MAGEL2</em>, and variant-level enrichment for two missense variants, <em>MAGEL2</em> p.Gly285Arg and LEPR p.Asn128Lys, were observed in the childhood obesity group. Analyses of eating‑behavior scores showed nominal signals for exonic variants in <em>MAGEL2</em> and PIVs in <em>SIM1</em>, but neither met the Bonferroni‑corrected threshold.</div></div><div><h3>Conclusions</h3><div>Rare, putatively deleterious leptin-melanocortin variants, particularly in <em>LEPR</em> and <em>MAGEL2</em>, are enriched in Taiwanese children with nonsyndromic obesity, underscoring the value of pathway-focused genetic evaluation in pediatric obesity.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 5","pages":"Pages 401-408"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicenter real-world study on the safety and effectiveness of the glucagon-like peptide-1 receptor agonist (liraglutide) in adolescents with obesity in Taiwan","authors":"Chiao-Fan Chiu,&nbsp;Chu-Kuang Chou,&nbsp;Shu-Wei Hu,&nbsp;Kuo-Chin Huang,&nbsp;Yi-Lei Wu,&nbsp;Hsiang-Fan Wu,&nbsp;Yang-Lin Liu,&nbsp;Yu-Chen Yang,&nbsp;Huey-Ling Chen,&nbsp;Chun-Yan Yeung","doi":"10.1016/j.orcp.2026.09.001","DOIUrl":"10.1016/j.orcp.2026.09.001","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Pediatric obesity is linked to many metabolic complications and has limited treatment options. We evaluated the safety and effectiveness of GLP-1 receptor agonist (liraglutide) in adolescents with obesity in clinical practice in Taiwan.</div></div><div><h3>Methods</h3><div>We conducted a prospective study (NCT06283641) across 14 hospitals and clinics from February 2024 to March 2025 evaluating adolescents receiving liraglutide at baseline, week 13, and week 26. Demographics, and safety and effectiveness outcomes, including incidence proportions of adverse events and adverse drug reactions, and changes in body weight and body mass index, were assessed.</div></div><div><h3>Results</h3><div>Among 41 participants, 22 (53.7%) were male, with mean age (±standard deviation) 13.9 ± 1.8 years, body weight (BW) 88.5 ± 19.3 kg, and body mass index (BMI) 33.4 ± 5.1 kg/m². Nineteen (46.3%) had medical history of hepatic impairment. Mean daily and maximum doses were 1.4 ± 0.5 mg/day and 1.8 ± 0.7 mg/day, respectively, throughout 128.3 ± 56.0 days; 14.4% escalated to 3.0 mg/day. Overall respective incidence proportions of adverse events and adverse drug reactions were 19.5% (8/41; all mild) and 9.8% (4/41; 6 events), respectively. Gastrointestinal events were most frequent, followed by injection site-related events. No treatment discontinuation resulted from intolerance. Mean respective losses in BW, BMI, and BMI standard deviation score at weeks 13 and 26 were −2.7 ± 3.8 kg (<em>p</em> = 0.0003), −1.3 ± 1.4 kg/m² (<em>p</em> &lt; 0.0001), and −0.2 ± 0.2 (<em>p</em> &lt; 0.0001); and −4.4 ± 5.7 kg (<em>p</em> = 0.0015), −1.9 ± 2.1 kg/m² (<em>p</em> = 0.0004), and −0.4 ± 0.3 (<em>p</em> &lt; 0.0001), respectively.</div></div><div><h3>Conclusion</h3><div>In adolescents with obesity in Taiwan, liraglutide at doses below 3.0 mg/day was well-tolerated, and reductions in BW, BMI, and BMI standard deviation score were observed.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 5","pages":"Pages 437-444"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A jejunal adenoma with high-grade dysplasia in the excluded limb 25 years after biliopancreatic diversion: A case report","authors":"Francesco Saverio Papadia,&nbsp;Federica Grillo,&nbsp;Luca Mastracci,&nbsp;Franco De Cian","doi":"10.1016/j.orcp.2026.09.007","DOIUrl":"10.1016/j.orcp.2026.09.007","url":null,"abstract":"<div><div>Biliopancreatic diversion (BPD) creates a biliopancreatic limb that is inaccessible to conventional endoscopic surveillance, and its long-term neoplastic risk is unknown. A woman in her late 40 s presented 25 years after BPD with recurrent protein malnutrition and subocclusive symptoms. Computed tomography showed jejunal intussusception. At surgery, the intussusception was localized to the proximal biliopancreatic limb, 10–20 cm from the ligament of Treitz and remote from the entero-enterostomy. A 2.6-cm tubulovillous adenoma with focal high-grade dysplasia was found at the corresponding site and was completely excised. This appears to be the first reported high-grade dysplastic adenoma in an excluded biliopancreatic limb after BPD. The finding shows that a conventional dysplastic adenoma can arise in this compartment and makes an adenoma-carcinoma pathway biologically plausible, but a single case cannot establish causality, incidence, or risk in other bariatric procedures. Routine imaging surveillance is not supported by current evidence. However, an intussusception remote from the entero-enterostomy, particularly when associated with recurrent obstructive symptoms, warrants evaluation for a structural lead point.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 5","pages":"Pages 483-486"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of treadmill exercise on bone and skeletal muscle in ovariectomized rats through Wnt/β-catenin pathway","authors":"Jinling Wang,&nbsp;Mengmeng Li,&nbsp;Le Changhao,&nbsp;Huali Tang,&nbsp;Yang Liao,&nbsp;Xing Wen,&nbsp;Lizhi Hu,&nbsp;Xiarong Huang,&nbsp;Jun Zhou","doi":"10.1016/j.orcp.2026.08.002","DOIUrl":"10.1016/j.orcp.2026.08.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Physical exercise has been reported positive effects on both bones and muscles simultaneously. The underlying mechanisms remain unclear. This study investigated whether treadmill training can inhabit bone loss and muscle atrophy in ovariectomized (OVX) rats by activating Wnt/β-Catenin pathway.</div></div><div><h3>Materials and methods</h3><div>8-week-old female Sprague-Dawley (SD) rats were randomly divided into three groups (n = 12 per group): Sham group with sham operation, OVX group with bilateral ovariectomy and sham treadmill training, and ET groups with bilateral ovariectomy and 12 weeks treadmill training. Bone mineral density/microarchitecture, level of serum biochemical markers, osteogenesis-related and muscle atrophy markers, and Wnt/β-catenin signaling genes in rat were then analyzed.</div></div><div><h3>Results</h3><div>The 12-week treadmill training intervention showed a significant effect on inhibition of ovariectomy-induced bone loss and muscle atrophy. Further analysis revealed that treadmill training enhanced bone mineral density of the proximal femoral metaphysis, improved the proximal tibia microarchitecture, inhabiting bone marrow adipogenesis, decreased serum TRACP-5b, CTX-I, CK, LDH and MDA levels, and elevated the serum BALP, Irisin, CAT and SOD levels. Furthermore, treadmill training upregulated RUNX2, BMP2 and Osterix, but downregulated PPAR-γ in the bone marrow of OVX rats; it downregulated atrogin1 and MuRF1, but upregulated PAX7, in their skeletal muscle; additionally, it markedly upregulated Wnt3a, LRP5 and β-catenin, but downregulated DKK1 and GSK3β, in both their bone marrow and skeletal muscle tissues.</div></div><div><h3>Conclusion</h3><div>Treadmill training mitigates bone loss and muscle damage associated with estrogen deficiency. The Wnt/β-catenin signaling pathway potentially serves as a common mechanism.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 5","pages":"Pages 469-482"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public–private differences in bariatric surgery care pathways in Australia: Implications for continuity of care","authors":"Sally Badorrek,&nbsp;Janet Franklin,&nbsp;Zhenjun Liao,&nbsp;Christine Madronio,&nbsp;Marijka Batterham,&nbsp;Michael Devadas,&nbsp;Nicholas Williams,&nbsp;Igor Lemech,&nbsp;Kathryn Williams","doi":"10.1016/j.orcp.2026.09.002","DOIUrl":"10.1016/j.orcp.2026.09.002","url":null,"abstract":"<div><h3>Background</h3><div>Australian public–private bariatric surgery comparisons have largely focused on access, safety and clinical outcomes, with less evidence describing provider-specific engagement across the perioperative pathway.</div></div><div><h3>Objectives</h3><div>To compare pre-operative engagement, provider-specific follow-up, attrition and weight outcomes between public and private bariatric surgery pathways in Australia.</div></div><div><h3>Methods</h3><div>This prospective multi-site observational study included adults undergoing bariatric surgery across two public and two private services in New South Wales (2021–2024). Appointment attendance across the perioperative period (12 months pre- to 24 months post-surgery) was analysed. Engagement, attrition and weight outcomes were compared using non-parametric tests, regression analyses and Kaplan–Meier and Cox proportional hazards models.</div></div><div><h3>Results</h3><div>Of 240 participants, 176 (73.3%) underwent private and 64 (26.7%) public surgery. Public patients had higher baseline weight, BMI, multimorbidity and greater socioeconomic disadvantage (all p &lt; 0.001). They engaged longer pre-operatively (21.6 vs 2.7 months) and attended more MDT appointments (14 vs 2; both p &lt; 0.001), with greater exposure to non-surgical doctors, dietitians, nurses, psychologists, and exercise professionals. Post-operatively, public patients attended a median of 12 (IQR 9–18) appointments compared to 7 (IQR 5–10) in the private services (p &lt; 0.001) and remained engaged longer (18.2 vs 14.5 months). Attrition occurred later in public patients but was similar by 24 months. No statistically significant differences in relative weight loss were detected beyond 6 months. Surgical setting (B =4.344, p &lt; 0.001) and anticipated support need (B =2.194, p = 0.035) were independently associated with post-operative attendance.</div></div><div><h3>Conclusion</h3><div>Follow-up engagement appeared to be associated with surgical setting and anticipated support need, while observed weight loss outcomes were broadly similar between sectors. However, baseline differences and observational design preclude conclusions about the comparative effectiveness of the care pathways.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 5","pages":"Pages 428-436"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent body mass index as a strong predictor of pre-pregnancy obesity in Arkansas mothers","authors":"Antonije Lazic,&nbsp;Joseph W. Thompson,&nbsp;Ronald F. Kahn","doi":"10.1016/j.orcp.2026.06.008","DOIUrl":"10.1016/j.orcp.2026.06.008","url":null,"abstract":"<div><div>Maternal obesity is strongly associated with adverse pregnancy outcomes. However, the extent to which adolescent weight status can predict pre-pregnancy obesity and severe obesity among future first-time mothers has not been well explored. This cohort study utilized adolescent body mass index (BMI) assessments linked to birth records for women 20–30 years old to examine this relationship. The population-based study cohort included 27,370 first-time mothers who had a 10th-grade BMI measurement; among this cohort, 18,881 had BMI assessments in 10th, 8th, and 6th grade. Most women who had severe obesity in 10th grade still had severe obesity prior to their first pregnancy (78.2%). Predictive characteristics using 10th-grade weight categories for predicting pre-pregnancy obesity and severe obesity combined achieved an area under the curve (AUC) of 84.2%, with 79.1% accuracy, 74.3% sensitivity, and 81.4% specificity. For pre-pregnancy severe obesity alone, the approach yielded an AUC of 88.1%, accuracy of 86.9%, sensitivity of 65.7%, and specificity of 91.0%. Predictive accuracy declined minimally in earlier grades (8th and 6th). Adolescent weight status demonstrates predictive capacity for pre-pregnancy obesity and severe obesity, even as early as 6th grade. Early risk identification may enable interventions to reduce maternal obesity and improve pregnancy outcomes.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 5","pages":"Pages 396-400"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148369154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fixed-dose, extended-release combination of naltrexone and bupropion reduces craving and body weight: A pooled post hoc analysis","authors":"Robert F. Kushner,&nbsp;Sylvain Iceta,&nbsp;Jena S. Tronieri,&nbsp;Christopher D. Still,&nbsp;Angela Fitch,&nbsp;Caroline M. Apovian","doi":"10.1016/j.orcp.2026.08.001","DOIUrl":"10.1016/j.orcp.2026.08.001","url":null,"abstract":"<div><h3>Background</h3><div>The fixed-dose, extended-release combination of naltrexone and bupropion (NB-ER), approved for obesity treatment, is hypothesized to affect the reward system and reduce food cravings.</div></div><div><h3>Methods</h3><div>A pooled, on-treatment, post hoc analysis was performed on data from 1967 patients who completed a phase 3 trial of NB-ER (NCT00532779, NCT00567255, NCT00456521, NCT00474630). Changes in weight and cravings based on Control of Eating Questionnaire (CoEQ) and Food Craving Inventory (FCI) scores, as well as mood and craving control, were examined for NB-ER vs placebo at weeks 8, 16, 28, and 56.</div></div><div><h3>Results</h3><div>Patients treated with NB-ER (n = 1206) vs placebo (n = 761) experienced greater weight reductions through 56 weeks (−9.5% ± 8.0% vs −2.7% ± 6.9%). Patients treated with NB-ER vs placebo reported larger improvements in estimated treatment differences (ETDs) for craving control (2.68 [95% CI, 0.85, 4.50]), positive mood (1.35 [95% CI, 0.47, 2.23]), and cravings for savory (−1.81 [95% CI, −3.32, −0.30]) per CoEQ scores. Per FCI scores, patients had improvements in ETDs for cravings for high fats (−0.65 [95% CI, −0.98, −0.32]) and fast-food fats (−0.18 [95% CI, −0.39, −0.03]). Change in body weight at week 56 with NB-ER vs placebo did not differ by baseline CoEQ or FCI scores.</div></div><div><h3>Conclusions</h3><div>Patients receiving NB-ER experienced greater improvements in cravings, craving control, mood, and weight vs placebo. NB-ER also led to weight reduction in individuals with both low and high baseline cravings. NB-ER is a suitable treatment option for patients with obesity seeking improvements in body weight, mood, cravings, and craving control.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 5","pages":"Pages 445-450"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very low calorie diet versus conventional energy-restricted diet for weight loss before bariatric surgery. A randomized controlled trial","authors":"Sara Schwartz,&nbsp;Marie Kirk,&nbsp;Tina Østergaard Troelsen,&nbsp;Tobias Stadil,&nbsp;Jens Meldgaard Bruun,&nbsp;Bjørn Richelsen,&nbsp;Steen Bønløkke Pedersen,&nbsp;Sigrid Bjerge Gribsholt","doi":"10.1016/j.orcp.2026.05.009","DOIUrl":"10.1016/j.orcp.2026.05.009","url":null,"abstract":"<div><h3>Background</h3><div>In Denmark, achieving ≥ 8% preoperative weight loss within 6 months is a requirement for bariatric surgery (BS). This weight loss is difficult for many patients, postponing their surgery.</div></div><div><h3>Objectives</h3><div>This study aimed to optimize pre-surgical weight loss strategies for patients referred to BS.</div></div><div><h3>Setting</h3><div>Aarhus University Hospital, Denmark.</div></div><div><h3>Methods</h3><div>In a prospective study, we evaluated the proportion of patients who underwent BS within 6 months after referral as a marker of successful preoperative weight loss. Furthermore, a randomized controlled trial (RCT) with complete follow-up was performed, comparing very low calorie diet (VLCD) to conventional energy-restricted diet regarding the proportion of patients achieving the mandatory weight loss and undergoing BS within 6 months.</div></div><div><h3>Results</h3><div>Our prospective study revealed that 67% underwent BS during the entire study period (median time to surgery 8 months), while only 16% underwent BS within 6 months. In the RCT, 65 patients were assigned to either VLCD or conventional diet. The proportion of patients achieving the target weight loss was 94% in the VLCD group vs. 62% in the control group (p &lt; 0.01), and the proportion that underwent BS within 6 months was 86% vs. 38% (p &lt; 0.01), in the VLCD and control group, respectively. VLCD was well tolerated with no adverse effects on surgery time or postoperative complications.</div></div><div><h3>Conclusion</h3><div>These findings support VLCD as an effective and feasible preoperative intervention to optimize weight loss goals and thereby BS outcomes.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 4","pages":"Pages 352-357"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}