The impact of paternal body mass index on semen parameters and assisted reproductive outcomes in couples undergoing IVF/ICSI-ET treatment.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice Pub Date : 2025-08-30 DOI:10.1016/j.orcp.2025.08.007

Jing Yi Han, Chen Yang, Bing Nan Ren, Pei Xin Li, Ran Shen, Wei Zheng, Ruo Wen Zu, Yi Xuan Yan, Yue Yang, Man Yu Hu, Yi Chun Guan

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引用次数: 0

Abstract

Purpose: To investigate the impact of paternal body mass index (BMI) on semen parameters and assisted reproductive outcomes in couples undergoing their first IVF/ICSI-ET cycle.

Materials and methods: This retrospective study included 7618 couples undergoing IVF/ICSI-ET for maternal tubal/pelvic factors from 2017 to 2023. Paternal BMI was classified according to WHO criteria: normal weight (n = 3433), overweight (n = 3248), and obese (n = 937). Semen quality, embryological outcomes (utilizable/high-quality embryos, blastocysts), and ART outcomes (pregnancy, singleton live birth) were compared. ANOVA, chi-square tests, and multivariate regression were used; subgroup analyses were conducted for IVF and ICSI-ET.

Results: Normal sperm morphology was higher in the normal weight group (5.32 ± 4.92 %) vs. overweight (4.85 ± 3.53 %) and obese (4.79 ± 4.93 %) (P < 0.001). Utilizable embryo rate was higher in the normal weight group (84.22 ± 19.29 %) than in the overweight group (82.98 ± 20.20 %) (P = 0.018). The utilizable blastocyst rate was also higher vs. obese group (29.60 ± 22.61 % vs. 26.93 ± 21.87 %; P = 0.004). Clinical pregnancy rates were 59.2 %, 56.6 %, and 55.5 % in the normal, overweight, and obese groups, respectively (P = 0.037). ICSI subgroup showed limited ART differences except higher birthweight in the obese group (P = 0.003).

Conclusions: Men with normal BMI demonstrated better sperm morphology, embryo utilization, and pregnancy rates. These findings underscore the importance of assessing paternal BMI in ART and support integrating paternal weight management into preconception care.

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父亲体重指数对接受IVF/ICSI-ET治疗的夫妇精液参数和辅助生殖结果的影响

目的：探讨父亲体重指数（BMI）对首次IVF/ICSI-ET周期夫妇精液参数及辅助生殖结局的影响。材料和方法：本回顾性研究纳入2017年至2023年因母体输卵管/盆腔因素接受IVF/ICSI-ET治疗的7618对夫妇。根据WHO标准将父亲BMI分为正常体重（n = 3433）、超重（n = 3248）和肥胖（n = 937）。比较精液质量、胚胎学结局（可利用/高质量胚胎、囊胚）和抗逆转录病毒治疗结局（妊娠、单胎活产）。采用方差分析、卡方检验和多元回归分析；对IVF和ICSI-ET进行亚组分析。结果：正常体重组精子形态正常（5.32 ±4.92 %）高于超重组（4.85±3.53 %）和肥胖组（4.79±4.93 %）(P结论：BMI正常的男性精子形态、胚胎利用率和妊娠率较好。这些发现强调了评估父亲体重指数在抗逆转录病毒治疗中的重要性，并支持将父亲体重管理纳入孕前护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity research & clinical practice 医学-内分泌学与代谢

CiteScore

7.10

自引率

0.00%

发文量

审稿时长

49 days

期刊介绍： The aim of Obesity Research & Clinical Practice (ORCP) is to publish high quality clinical and basic research relating to the epidemiology, mechanism, complications and treatment of obesity and the complication of obesity. Studies relating to the Asia Oceania region are particularly welcome, given the increasing burden of obesity in Asia Pacific, compounded by specific regional population-based and genetic issues, and the devastating personal and economic consequences. The journal aims to expose health care practitioners, clinical researchers, basic scientists, epidemiologists, and public health officials in the region to all areas of obesity research and practice. In addition to original research the ORCP publishes reviews, patient reports, short communications, and letters to the editor (including comments on published papers). The proceedings and abstracts of the Annual Meeting of the Asia Oceania Association for the Study of Obesity is published as a supplement each year.