Obesity research & clinical practice最新文献

{"title":"Comparison of obesity indices for discriminating hypertension, diabetes, dyslipidemia, and metabolic syndrome according to sex and age groups","authors":"Esther Kim,&nbsp;Su-Min Jeong,&nbsp;Dong Hoon Lee,&nbsp;Leandro F.M. Rezende,&nbsp;Edward L. Giovannucci","doi":"10.1016/j.orcp.2026.06.001","DOIUrl":"10.1016/j.orcp.2026.06.001","url":null,"abstract":"<div><h3>Introduction</h3><div>This study compared the discriminatory performance of seven obesity indices for metabolic diseases by sex and age.</div></div><div><h3>Methods</h3><div>We analyzed data from 8900 Korean adults aged ≥ 20 years using the 2022–2023 Korea National Health and Nutrition Examination Survey. Seven obesity indices (body mass index, waist circumference, waist-to-height ratio, a body shape index, body roundness index, fat mass index, and body fat percentage) were evaluated in relation to hypertension, diabetes, dyslipidemia, and metabolic syndrome. Associations and discriminatory ability were assessed using logistic regression and receiver operating characteristic analyses stratified by sex and age.</div></div><div><h3>Results</h3><div>Central obesity indices, particularly waist-to-height ratio and body roundness index, showed the strongest associations with all metabolic outcomes in both sexes. A body shape index exhibited weaker associations after age adjusted. Discriminatory performance declined with age across all indices, especially after 50 years.</div></div><div><h3>Conclusions</h3><div>Waist-to-height ratio, body roundness index, and waist circumference were superior to body mass index and comparable to fat mass index and body fat percentage in identifying metabolic risk, particularly in younger and middle-aged adults. The reduced discriminatory power in older adults underscores the need for age-sensitive obesity metrics and complementary functional assessments.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 4","pages":"Pages 311-319"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The case to augment healthcare professional training for the treatment of obesity by integrating cognitive dissonance interventions to reduce weight stigma","authors":"Ashley N. Dunford,&nbsp;Janet A. Lydecker,&nbsp;Carolyn Walsh,&nbsp;Kace Boland,&nbsp;Elizabeth W. Cotter","doi":"10.1016/j.orcp.2026.06.003","DOIUrl":"10.1016/j.orcp.2026.06.003","url":null,"abstract":"<div><div>Obesity is associated with risk for chronic health problems and increased mortality. Weight stigma, which entails negative attitudes and behaviors directed at people based solely on their body size, is psychologically harmful and contributes to obesity and obesity-related health problems. Yet, weight stigma is pervasive in society and commonly experienced by patients in healthcare settings, which lowers the quality of patients’ healthcare experiences. Healthcare providers and trainees report feeling underprepared to treat obesity, which may lead to overreliance on weight-management strategies that are not evidence-based and are susceptible to weight stigma, such as fad diets emphasizing unrealistic dietary restriction. In the current manuscript, we discuss current weight stigma interventions with other populations and the rationale for integrating training in evidence-based approaches to treat obesity with weight stigma interventions, specifically cognitive dissonance-based interventions. Current learning theories emphasize empathic perspective-taking, and current methods to reduce weight stigma use social-cognitive theories to raise awareness of stereotypes. However, current methods are insufficient because they create discomfort but fail to alter internalized bias nor advise providers on how to deliver non-stigmatizing, evidence-based obesity interventions. Cognitive dissonance theory posits that resolving tension between beliefs and behaviors will change future behaviors. Cognitive dissonance-based interventions have effectively reduced personal weight stigma and are promising to be similarly effective in reducing weight stigma among healthcare providers. In this manuscript, we highlight how cognitive dissonance theory can help improve interventions to reduce bias and support providers’ efforts treating obesity.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 4","pages":"Pages 261-267"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated glucose disposal rate and triglyceride–glucose index jointly predict mortality in advanced cardiovascular–kidney–metabolic syndrome","authors":"Zhaoqi Yan,&nbsp;Yifeng Xu,&nbsp;Xiufan Du","doi":"10.1016/j.orcp.2026.05.006","DOIUrl":"10.1016/j.orcp.2026.05.006","url":null,"abstract":"<div><h3>Objective</h3><div>Advanced cardiovascular–kidney–metabolic (CKM) syndrome carries substantial mortality risk, yet the independent and joint prognostic roles of insulin resistance–related markers—estimated glucose disposal rate (eGDR) and triglyceride–glucose (TyG) index—remain insufficiently characterized in advanced CKM.</div></div><div><h3>Methods</h3><div>We analyzed 6527 adults with advanced CKM (AHA stages 3–4) from NHANES 1999–2018 with mortality follow-up through 2019. Survey-weighted Cox models with restricted cubic splines and segmented regression evaluated associations and thresholds. Joint-exposure models quantified additive interaction (RERI/AP/SI). Survival-based machine learning was performed to account for follow-up time and censoring, with XGBoost-Cox interpreted using SHAP.</div><div><strong>Results:</strong></div><div>Higher eGDR was linearly associated with lower mortality (per 1-unit increase: all-cause HR 0.80; cardiovascular HR 0.73). TyG showed threshold effects: risk increased steeply above 9.13 (all-cause) and 9.09 (cardiovascular) (above-threshold per 1-unit increase: HR 3.85 and 5.50, respectively). Joint analyses showed the highest risk in the TyG-high/eGDR-low group (all-cause HR 2.20; cardiovascular HR 2.80 vs TyG-low/eGDR Q1), while additive interaction was antagonistic for higher eGDR categories (SI &lt;1), indicating attenuation of TyG-associated excess risk at higher eGDR. The combined eGDR–TyG model improved discrimination (C-index 0.883). XGBoost-Cox showed the best discrimination, and SHAP analysis supported the prognostic importance of age, eGDR, and TyG.</div></div><div><h3>Conclusion</h3><div>In advanced CKM, eGDR is consistently protective, whereas TyG confers additional risks; higher eGDR mitigates TyG-associated risk. Combined eGDR–TyG assessment may improve mortality risk stratification.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 4","pages":"Pages 301-310"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148006292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal obesity as an independent and additive risk factor for sciatica: A population-based cross-sectional study in Taiwan","authors":"Sheng-Hua Wu,&nbsp;I.-Cheng Lu,&nbsp;Yen-Chin Liu,&nbsp;Chi-An Chen,&nbsp;Szu-Chia Chen,&nbsp;Shu-Pin Huang,&nbsp;Jiun-Hung Geng","doi":"10.1016/j.orcp.2026.06.002","DOIUrl":"10.1016/j.orcp.2026.06.002","url":null,"abstract":"<div><h3>Background/Objectives</h3><div>Sciatica from sciatic nerve pathology remains a major public health concern. Individual components of metabolic syndrome (MetS) have been associated with nonspecific lower back pain. Accordingly, this study investigated the association between MetS and sciatica, evaluated the cumulative association according to the number of MetS traits, and identified key contributing factors in a large Taiwanese population.</div></div><div><h3>Methods</h3><div>This cross-sectional analysis included 121,673 adults aged 30–70 years from the Taiwan Biobank. MetS was defined using the modified National Cholesterol Education Program Adult Treatment Panel III criteria for Asian populations. Sciatica was assessed through a standardized self-reported questionnaire. Multivariate logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for sciatica in relation to MetS and its individual components.</div></div><div><h3>Results</h3><div>MetS was associated with a higher prevalence of sciatica after multivariable adjustment (adjusted OR, 1.19; 95% CI, 1.06–1.34). A graded association was observed between the number of MetS components and the prevalence of sciatica, with a significant trend across increasing component burden (adjusted p for trend = 0.001). Among the individual components, abdominal obesity remained significantly associated with sciatica (adjusted OR, 1.42; 95% CI, 1.28–1.57). These findings were consistent across sex-stratified and standardized analyses.</div></div><div><h3>Conclusions</h3><div>MetS, particularly abdominal obesity, was associated with a higher prevalence of sciatica. A trend toward increasing prevalence was observed with a higher number of MetS components. Given the cross-sectional design, causal relationships cannot be inferred. These findings suggest that metabolic health may be related to sciatica burden in the general population.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 4","pages":"Pages 320-326"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148227238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food categorization strategies in adults living with obesity: the role of orthorexia nervosa and food addiction","authors":"Clara Lakritz,&nbsp;Gabrielle Hudon,&nbsp;Jérémie Lafraire,&nbsp;Sylvain Iceta","doi":"10.1016/j.orcp.2026.05.002","DOIUrl":"10.1016/j.orcp.2026.05.002","url":null,"abstract":"<div><h3>Objective</h3><div>Obesity is associated with societal pressure to eat \"healthy\", potentially increasing the risk of orthorexia nervosa (ON), an obsession with healthy eating characterized by food hyperselectivity. This observational study explored ON traits in obesity, focusing on food hyperselectivity and categorization strategies.</div></div><div><h3>Methods</h3><div>A total of 114 participants with obesity (91 women, 20 men, 3 gender-diverse; Age = 44.6 ± 10.5; BMI = 39.6 ± 7.4) were assessed through an online food categorization task and questionnaires, including the Eating Habits Questionnaire, Eating Disorders Examination Questionnaire, Yale Food Addiction Scale, Patient Health Questionnaire-9, and Generalized Anxiety Disorders-7. Quantitative data were analyzed using correlations and regression models.</div></div><div><h3>Results</h3><div>Participants scored high on eating disorders, addictive-like eating behaviors, anxiety, and depression, but not ON traits. However, those with higher ON traits displayed distinct food categorization strategies compared to those with lower ON traits, avoiding categorizing unhealthy foods as healthy. Participants with addictive-like eating behaviors exhibited similar categorization patterns alongside heightened scores for eating disorders, anxiety, and depression.</div></div><div><h3>Conclusion</h3><div>ON traits correlated with risk-averse food evaluation strategies in obesity, emphasizing caution towards \"unhealthy\" foods, potentially exacerbating restrictive eating behaviors. Integrating these insights into psychological or nutritional interventions could improve support by addressing maladaptive food evaluation.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 4","pages":"Pages 293-300"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of sleep duration at 1.5 years with overweight/obesity at 3 years and effect modification by allergic conditions: The Japan Environment and Children’s Study","authors":"Masanobu Kawai,&nbsp;Sachiko Baba,&nbsp;Kanami Tanigawa,&nbsp;Junji Miyazaki,&nbsp;Ryo Kawasaki,&nbsp;Hiroyasu Iso,&nbsp;the Japan Environment and Children's Study Group","doi":"10.1016/j.orcp.2026.04.008","DOIUrl":"10.1016/j.orcp.2026.04.008","url":null,"abstract":"<div><h3>Background</h3><div>Evidence on associations of short sleep duration with obesity is limited and conflicting in toddlers. Additionally, the role of allergic conditions in this association remains elusive although the allergic conditions are known to affect both sleep quality and the development of obesity.</div></div><div><h3>Methods</h3><div>In the current study, we investigated these associations using the Japan Environment and Children’s Study, a nationwide prospective birth cohort. Data from 52,047 term-singleton births born with appropriate-for-gestational age without background disorders were included. Self-administered questionnaires evaluated sleep durations at 1.5 years old completed by caregivers. Overweight/obesity was defined as body mass index (BMI) at or above the 85th percentile at 3 years old.</div></div><div><h3>Results</h3><div>After adjustment for sex, age, mother’s BMI, socioeconomic status, and allergic conditions (asthma, food allergy, and atopic dermatitis), the multivariate odds ratio (95% confidence interval) for overweight/obesity at 3 years old were 0.97 (0.91–1.05), 1.03 (0.96–1.10), and 1.09 (1.00–1.19) for 10.5 or 11 h, 9.5 or 10 h, and ≤ 9 h of nighttime sleep duration, respectively, compared with those with ≥ 11.5 h (p for trend = 0.002). Similar associations were observed for total sleep duration. Food allergy modified the association between nighttime sleep duration and overweight/obesity (p for interaction = 0.02), whereas asthma and atopic dermatitis did not.</div></div><div><h3>Conclusions</h3><div>Our study revealed the associations between short sleep duration and overweight/obesity and its effect modification by food allergy.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 4","pages":"Pages 276-284"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is agreement with the statement “obesity is a disease” helpful or harmful? Insights from a National cross-sectional survey","authors":"Roni Elran-Barak,&nbsp;Lena Sagi-Dain","doi":"10.1016/j.orcp.2026.06.007","DOIUrl":"10.1016/j.orcp.2026.06.007","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate how individuals with different BMI (Body Mass Index) levels respond to the statement “obesity is a disease” in terms of agreement, emotional reactions, and motivation for weight loss.</div></div><div><h3>Methods</h3><div>A cross-sectional online survey was conducted in January 2024 among 597 Israeli adults (43.3<u>+</u>16.7 years old), stratified by weight status (normal weight (n = 200), overweight (n = 200), obesity (n = 197)) and gender (females (50.1%), males (49.9%)). Participants reported their level of agreement with the statement “obesity is a disease” their emotional reactions to this statement, and weight-related motivation. Multivariate analyses examined demographic and psychological predictors of agreement.</div></div><div><h3>Results</h3><div>Overall, 47.6% of participants agreed with the disease framing. Agreement was significantly associated with higher BMI, lower religiosity, and poorer self-rated mental health. However, agreement was not associated with greater motivation to lose weight or perceived control over weight. Participants with obesity endorsed more negative emotional responses, to the statement including worry, frustration, helplessness, and pressure versus those with lower weight-status. Positive emotions such as optimism or confidence were not significantly associated with weight status.</div></div><div><h3>Conclusions</h3><div>Framing obesity as a disease is common and more frequently endorsed by individuals with obesity (versus those with lower weight status), yet it does not appear to enhance motivation for weight loss. This framing is also associated with emotional distress, suggesting that such messaging may unintentionally reinforce internalized stigma. Public health communications should consider these nuanced responses and strive to promote messages that are empathetic, non-stigmatizing, and behaviorally supportive.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 4","pages":"Pages 365-370"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148397294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 receptor agonist therapy before bariatric surgery: Effects on weight loss and body composition in clinical practice","authors":"Sonsoles Gutiérrez-Medina,&nbsp;Isabel Higuera,&nbsp;Gloria Velasco,&nbsp;Isabel Yagüe,&nbsp;Elena Sanchez,&nbsp;Fernando Lapuente,&nbsp;Jose María Lopesino,&nbsp;Javier Escalada,&nbsp;Sonsoles Guadalix,&nbsp;Magdalena de la Higuera","doi":"10.1016/j.orcp.2026.05.007","DOIUrl":"10.1016/j.orcp.2026.05.007","url":null,"abstract":"<div><h3>Introduction</h3><div>The use of anti-obesity medications, particularly including glucagon-like peptide-1 receptor agonists (GLP1-RA), is expanding and increasingly combined with bariatric surgery (BS). However, evidence on their use preoperative and impact on body composition remains limited.</div></div><div><h3>Purpose</h3><div>To compare weight loss and body composition changes in patients undergoing BS with or without prior GLP1-RA treatment.</div></div><div><h3>Patients and methods</h3><div>Retrospective observational study of adults who underwent BS at Clínica Universidad de Navarra (Madrid) between 2017 and 2023.</div></div><div><h3>Results</h3><div>Overall, 86 patients (mean age, 46.6 ± 12 years; 66% women) were included; 80.2% and 19.8% underwent sleeve gastrectomy and gastric bypass, respectively. Preoperative GLP1-RA therapy (63.4% liraglutide and 36.6% semaglutide) was prescribed in 34.8% of patients for a mean of 21.7 ± 15.9 weeks. Adverse events were mild and mostly gastrointestinal symptoms. Patients treated with GLP1-RA achieved greater weight loss preoperatively (5.1% ± 4.9% vs. 2.4% ± 3.7%; p = 0.005) and at 1 month postoperatively (15.4% ± 5.2% vs. 13.0% ± 3.8%; p = 0.03), but not at 6 months. Prior to BS, fat mass was lower in the GLP1-RA group (53.3 kg [95% CI 50.7–56.0] vs. 58.6 kg [95% CI 56.6–60.5]; p = 0.01), whereas no differences in lean mass or body composition were observed at 6 months between the two groups.</div></div><div><h3>Conclusions</h3><div>Preoperative GLP1-RA therapy resulted in greater preoperative weight and fat mass reduction without additional lean mass loss. Larger prospective studies are warranted to define the long-term role of GLP1-RA therapy before BS.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 4","pages":"Pages 358-364"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148033609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable machine learning and incremental prognostic model for all-cause and cardiovascular mortality in obesity with MASLD population: Comorbidity insights from triglyceride-glucose and its obesity-related derivatives","authors":"Limin Nie,&nbsp;Yuanyuan Li,&nbsp;Qun Wang,&nbsp;Yanchao Luo,&nbsp;Jun Zhou,&nbsp;Yuxin Zhang,&nbsp;Rina Du,&nbsp;Lu Liu,&nbsp;Bin Li","doi":"10.1016/j.orcp.2026.06.005","DOIUrl":"10.1016/j.orcp.2026.06.005","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate comorbid correlation and prognostic value of triglyceride-glucose (TyG) and its obesity-related derivatives for all-cause and cardiovascular mortality in the obesity with metabolic dysfunction-associated fatty liver disease (MASLD), and develop incremental predictive model using machine learning and SHapley Additive exPlanations (SHAP) analysis.</div></div><div><h3>Methods</h3><div>4807 adults with obesity and MASLD enrolled from National Health and Nutrition Examination Survey 1999–2018. Kaplan-Meier, Cox regression, and restricted cubic splines (RCS) were used to examine associations. Machine learning and incremental prognostic model were developed to predict mortality, with SHAP interpreting feature importance.</div></div><div><h3>Results</h3><div>Both TyG and TyG-WHtR were associated with all-cause mortality after full adjustment, whereas TyG-WHtR showed a more robust association with cardiovascular mortality. TyG-WHtR showed the strongest association: each 1-unit increase linked to 31.7% and 46.7% higher risk of all-cause and cardiovascular mortality respectively in the fully adjusted model, with RCS showing an S-shaped relationship. Time-varying hazard ratio patterns suggested that the associations of TyG and TyG-WHtR with mortality were stronger in the early follow-up period and attenuated over time. XGBoost performed best with SHAP analysis identified age, fasting plasma glucose (FPG), male as primary factors. The incorporation of TyG and TyG-WHtR into predictive models modestly improved the prediction performance for mortality outcomes.</div></div><div><h3>Conclusions</h3><div>TyG-WHtR showed a stronger time-dependent association with mortality in obesity-MASLD comorbidity, while TyG mainly associated with all-cause mortality. S-shaped curve for TyG-WHtR indicates the critical need for early intervention. Integrating TyG-WHtR into XGBoost prognostic models enhances risk identification, while SHAP values clarify age, FPG, male as key drivers.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 4","pages":"Pages 327-336"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A body shape index is a better predictor of overall and cardiovascular mortality than body mass index: Results from the ENAH study","authors":"Marija Domislović,&nbsp;Andrej Belančić,&nbsp;Jelena Kos,&nbsp;Ana Jelaković,&nbsp;Josipa Josipović,&nbsp;Viktor Domislović,&nbsp;Lana Gellineo,&nbsp;Ivan Brzić,&nbsp;Mirta Abramović Barić,&nbsp;Vesna Matijević,&nbsp;Matea Bilobrk,&nbsp;Lovorka Bilajac,&nbsp;Ivan Pećin,&nbsp;Mihaela Marinović Glavić,&nbsp;Krunoslav Capak,&nbsp;Bojan Jelaković","doi":"10.1016/j.orcp.2026.06.006","DOIUrl":"10.1016/j.orcp.2026.06.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Body mass index (BMI) is commonly used to estimate obesity-related risk, but it does not reflect fat distribution. A Body Shape Index (ABSI), which captures central adiposity independently of BMI, may offer better prognostic value. We compared ABSI and BMI as predictors of all-cause and cardiovascular (CV) mortality in a general rural population.</div></div><div><h3>Methods</h3><div>This prospective analysis included 820 participants from the ENAH (Endemic Nephropathy in Croatia – Epidemiology, Diagnostics and Etiopathogenesis) cohort with complete baseline anthropometric data. BMI and ABSI were calculated at baseline and expressed as z-scores. Participants were followed for a median of 9.7 years. Associations with all-cause mortality, CV mortality, and a composite non-fatal outcome were examined using multivariable Cox regression. Discriminative ability was assessed by receiver operating characteristic analysis.</div></div><div><h3>Results</h3><div>Higher ABSI was independently associated with increased all-cause mortality (hazard ratio per 1-SD increase 1.15, 95% confidence interval 1.01–1.32) and CV mortality (1.27, 1.04–1.55), whereas BMI showed no significant association with either outcome. Mortality risk increased across ABSI tertiles but not BMI tertiles. ABSI demonstrated better discrimination for all-cause and CV mortality than BMI, while neither index predicted non-fatal outcomes.</div></div><div><h3>Conclusion</h3><div>ABSI outperformed BMI in predicting all-cause and CV mortality. Measures of central adiposity such as ABSI may improve mortality risk stratification beyond BMI alone.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 4","pages":"Pages 337-344"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}