Obesity research & clinical practice最新文献

{"title":"Evaluation of the hepatic and subcutaneous adipose tissue effects of triiodothyronine treatment in an animal model of metabolic syndrome","authors":"Marta Borges-Canha ,&nbsp;Ana Rita Leite ,&nbsp;Glória Conceição ,&nbsp;Catarina Vale ,&nbsp;Madalena Von-Hafe ,&nbsp;Diana Martins ,&nbsp;Daniela Miranda-Silva ,&nbsp;Cláudia Sousa-Mendes ,&nbsp;Joana Chaves ,&nbsp;Inês Mariana Lourenço ,&nbsp;Carmen Grijota-Martínez ,&nbsp;Soledad Bárez-López ,&nbsp;Isabel M. Miranda ,&nbsp;Adelino Leite-Moreira ,&nbsp;Inês Falcão-Pires ,&nbsp;João Sérgio Neves","doi":"10.1016/j.orcp.2025.04.001","DOIUrl":"10.1016/j.orcp.2025.04.001","url":null,"abstract":"<div><h3>Background and aims</h3><div>Metabolic dysfunction associated steatotic liver disease (MASLD) is a metabolic liver disease and thyroid hormones (TH) may decrease liver fat and extra-hepatic fat content. We aimed to evaluate the effects of high and low dose triiodothyronine (T3) in liver and subcutaneous adipose tissue (sAT) in an animal model of Metabolic Syndrome (MS).</div></div><div><h3>Methods and results</h3><div>Four groups were evaluated: 1) ZSF1 Lean (Lean-Ctrl, n = 8); 2) ZSF1 obese (rat model of MS with MASLD, MetS, n = 13); 3) ZSF1 obese supplemented with high-dose of T3 (MetS-hT3, n = 5); and 4) ZSF1 obese supplemented with a low-dose of T3 (MetS-lT3, n = 8).</div><div>Treatment with both doses of T3 decreased body weight, liver weight and perirenal fat. High-dose T3 treatment normalized the increased expression of COL3A1 in MetS group. Histologically, lipid hepatic burden in treated groups was significantly reduced. Adipocytes and adipocytes’ fibrosis areas were significantly reduced by the treatment with T3. MetS-hT3 had an increased risk of arrhythmias and sudden death.</div></div><div><h3>Conclusion</h3><div>Treatment with T3 improves steatosis and fibrosis at the liver and sAT in animals with MS. High doses of T3 may not be safe due to the risk of cardiac events. Our results support new therapeutic strategies for MASLD focused on the modulation of TH.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 2","pages":"Pages 115-121"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight stigma toward pregnant patients: An experimental study of medical students","authors":"Alicia Niemann,&nbsp;Lara J. LaCaille,&nbsp;Rebecca L. Emery Tavernier","doi":"10.1016/j.orcp.2025.02.008","DOIUrl":"10.1016/j.orcp.2025.02.008","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the presence of implicit and explicit weight bias among a sample of medical students.</div></div><div><h3>Methods</h3><div>Using a between-subjects experimental design, medical students (<em>N</em> = 100; Age_<em>M</em> = 25.83 ± 2.76), were randomly assigned to read a vignette about a pregnant patient with a lower body mass index (BMI; 23 kg/m²) or a higher BMI (33 kg/m²). Participants then completed questionnaires related to perceptions and liking of the patient, and explicit attitudes about people who have larger bodies (i.e., BMIs ≥ 30 kg/m²).</div></div><div><h3>Results</h3><div>There were no significant differences between vignettes, suggesting that implicit bias against pregnant patients with higher versus lower BMIs was not identified. However, weight stigmatizing attitudes were associated with medical student BMI, such that medical students with higher BMIs expressed more positive attitudes for patients with BMIs ≥ 30 kg/m² than medical students with lower BMIs.</div></div><div><h3>Conclusions</h3><div>These findings indicate that implicit weight bias towards pregnant patients in medical students is low, particularly among medical students with higher weight, which may represent a shift in societal attitudes towards patients with larger bodies.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 2","pages":"Pages 175-177"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions to prevent or treat obesity in adult Indigenous Australians: A systematic review","authors":"Nick S.R. Lan ,&nbsp;Josephine Ford ,&nbsp;Lionel Gregory ,&nbsp;Glynis Jones ,&nbsp;Girish Dwivedi ,&nbsp;Bu B. Yeap","doi":"10.1016/j.orcp.2025.04.003","DOIUrl":"10.1016/j.orcp.2025.04.003","url":null,"abstract":"<div><h3>Background</h3><div>Aboriginal and Torres Strait Islander (Indigenous) Australians experience a disproportionately higher prevalence of obesity compared with non-Indigenous Australians. We aimed to describe existing research into lifestyle, pharmacological or surgical interventions for preventing or treating obesity in Indigenous Australians.</div></div><div><h3>Methods</h3><div>A systematic review of published and grey literature was performed. Medline, Embase, Emcare (on the OVID platform), Web of Science and website searches were conducted to April 2024. Observational and randomised studies of adult Indigenous Australians were included if an intervention was implemented to prevent and/or treat obesity and post-intervention results were reported. The PRISMA systematic review reporting methods was used to collate data.</div></div><div><h3>Results</h3><div>Of 1019 records screened, 17 were included; most described educational initiatives or lifestyle programs for improving diet and exercise. There were no reports of pharmacotherapies for weight management. The effect of lifestyle programs on weight reduction was modest (∼2–4 kg after 4–12 months). There were five reports on short-term (12 week) structured exercise programs. Two non-randomised studies of structured exercise showed reduction in weight in the highest weight groups whilst the two randomised trials showed ∼2 kg weight reduction compared with control. One observational study described mean ∼26 kg weight reduction at two years after laparoscopic adjustable gastric banding in 26 Indigenous Australians.</div></div><div><h3>Conclusions</h3><div>Community-based lifestyle interventions to manage excess weight can be successfully conducted in Indigenous Australians, but with generally limited efficacy. Providing background community-based lifestyle programs may facilitate the conduct of randomised trials of newer, effective anti-obesity pharmacotherapy in this high priority population.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 2","pages":"Pages 85-93"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderate caloric restriction improved body composition and maintains bone quality of rats under hypoestrogenism","authors":"Rafael Henrique de Oliveira Nascimento,&nbsp;Taciane Maria Melges Pejon,&nbsp;Wladimir Rafael Beck","doi":"10.1016/j.orcp.2025.04.002","DOIUrl":"10.1016/j.orcp.2025.04.002","url":null,"abstract":"<div><h3>Background</h3><div>Hypoestrogenism state is associated with weight and adiposity gain, generally impairing bone properties. Caloric restriction (CR) is the main intervention to promote weight loss, however, a chronic severe restriction can lead to bone loss and malnutrition.</div></div><div><h3>Objective</h3><div>To analyse whether 12 weeks of moderate CR could reduce body mass and adiposity without worsening the bone health of ovariectomized (OVX) rats.</div></div><div><h3>Methods</h3><div>CR and OVX-CR animals were subject daily to receive a 20 % less amount of food based on the last week's consumption of C and OVX groups. Body mass and food intake were recorded weekly, and spontaneous physical activity (SPA) biweekly. The adipose tissue of subcutaneous (SAT), peritoneal (PTAT), and perigonadal (PGAT) portions was collected to record its mass, and the right femur was collected to determine bone volume (BV), density (BD), mineral density (BMD), and percentage of mineral material (MM).</div></div><div><h3>Results</h3><div>Ovariectomy increased body mass and food intake (p &lt; 0.001), SAT, PTAT, and PGAT mass (p &lt; 0.01), decreased BV (p &lt; 0.05), BD and BMD (p &lt; 0.01) and MM (p &lt; 0.05), but not affected SPA (p = 0.16). CR decreased body mass, SAT, PTAT, and PGAT mass (p &lt; 0.01) and BMD and MM (p &lt; 0.05), but did not affect BV (p = 0.90), BD (p = 0.24), and SPA (p = 0.25). Therefore, post-hoc data did not demonstrate significant differences in these bone parameters between the OVX and OVX-RC groups (p &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>12 weeks of 20 % of CR is enough to prevent weight and fat gain in the hypoestrogenism state without causing additional worsening in bone properties.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 2","pages":"Pages 163-170"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skipping breakfast and nutrient density: Influence on obesity, blood pressure, glucose, and cholesterol in elementary school students","authors":"Hanbit Mun ,&nbsp;Sang Woo Oh","doi":"10.1016/j.orcp.2025.02.009","DOIUrl":"10.1016/j.orcp.2025.02.009","url":null,"abstract":"<div><h3>Background</h3><div>Skipping breakfast is a public health issue affecting childhood obesity worldwide. However, how skipping breakfast adversely affects metabolic health in children has not been investigated comprehensively. This study investigated the associations between breakfast skipping, obesity, and cardiometabolic risk in elementary school students and identified its association with nutritional patterns.</div></div><div><h3>Methods</h3><div>Data on 3590 elementary school students were obtained from the Korea National Health and Nutrition Examination Survey (2013–2020). Participants self-reported weekly breakfast frequency, and dietary nutrient intake was assessed using a 24-h recall survey. The associations of breakfast frequency with obesity, cardiometabolic risk factors, and nutrient density were analyzed using a survey multivariate linear regression analysis.</div></div><div><h3>Results</h3><div>The lowest breakfast frequency group (0–2 times/week) had a higher mean body mass index (estimated mean differences; 0.80 kg/m², 95 % confidence interval (CI) 0.30–1.31) and waist circumference (2.20 cm, 0.83–3.57) than the highest frequency group (5–7 times/week). Additionally, they had higher systolic blood pressure (1.68 mmHg, 0.12–3.24), diastolic blood pressure (2.24 mmHg, 1.09–3.39), fasting glucose (1.58 mg/dL, 0.40–2.75) than the highest breakfast group. Furthermore, this group had higher percentages of energy from fat (1.96 %, 0.90–3.02), sodium density (10.29 mg/100 kcal, 0.75–19.82) and Na/K ratio (0.25 mmol/mmol, 0.11–0.40) than the highest frequency group, despite lower caloric intake.</div></div><div><h3>Conclusions</h3><div>Elementary school students who skipped breakfast had higher obesity and cardiometabolic risk factors. These associations might be assumed from dietary nutrient patterns characterized by higher fat and sodium density despite lower daily caloric consumption.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 2","pages":"Pages 94-100"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disproportionality analysis on semaglutide and nonarteritic anterior ischemic optic neuropathy in the FDA adverse event reporting system: An emerging pharmacovigilance signal?","authors":"Angela Procacci,&nbsp;Elisabetta Poluzzi,&nbsp;Fabrizio De Ponti,&nbsp;Emanuel Raschi","doi":"10.1016/j.orcp.2025.03.001","DOIUrl":"10.1016/j.orcp.2025.03.001","url":null,"abstract":"<div><h3>Background and aim</h3><div>On January 17th 2025, the European Medicines Agency started a review on semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy (NAION); we gained insight into this potential association by appraising post-marketing reporting.</div></div><div><h3>Methods</h3><div>We queried the FDA Adverse Event Reporting System (up to December 2024) to retrieve cases of NAION reported with GLP-1 receptor agonists. Disproportionality analysis was performed by calculating the Reporting Odds Ratio (ROR) with 95 % confidence Interval (CI). Signal of Disproportionate Reporting (SDR) was defined by a lower limit of the 95 %CI&gt; 1. To account for potential confounding by indication and channeling bias, active-comparator restricted design and disproportionality by therapeutic area were performed by comparing semaglutide vs other antidiabetic/antiobesity drugs, including SGLT2-inhibitors.</div></div><div><h3>Results</h3><div>96 NAION cases were retrieved (83 to semaglutide), peaking 53 in last 3 months (18 from Denmark), with a median time to onset of 186 days. An SDR emerged only for semaglutide (ROR=17.57; 95 %CI=13.93–21.90), and remained significant across comparators and therapeutic indications.</div></div><div><h3>Conclusions</h3><div>Notwithstanding limitations, including inability to infer causality, the consistency of disproportionality against a wide range of confounders together with other observational evidence raised the hypothesis of a safety signal, especially from Denmark. The exponential reporting trend calls for urgent clarification of drug-, patient- and Country-related risk factors.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 2","pages":"Pages 178-180"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vertical sleeve gastrectomy improves social behaviors in obese, male mice","authors":"Anne-Marie Neumann,&nbsp;Cathleen Geißler,&nbsp;Randy Seeley,&nbsp;Henriette Kirchner,&nbsp;Henrik Oster","doi":"10.1016/j.orcp.2025.02.003","DOIUrl":"10.1016/j.orcp.2025.02.003","url":null,"abstract":"<div><div>Bariatric surgery is an effective intervention to treat excess weight and deteriorated metabolic health. A majority of patients further benefit from improvements of mental health and the psychosocial state. However, given the complex interplay of factors affecting sociability in humans, the corresponding effects of the surgery remain unclear. In this study, we investigated the effects of vertical sleeve gastrectomy (VSG) on sociability and social interaction in male, obese mice. Results showed an increase in time spent in the social chamber 9 and 30-35 days post-surgery as well as increased interaction with a subject at 9 days post-surgery. The initial enhancement in social behavior was associated with rapid weight loss, but long-term effects persisted beyond this phase when weight was largely recovered. The findings suggest that VSG positively influences sociability, potentially through mechanisms involving the HPA axis, as previously reported. This study provides new insights into the psychosocial benefits of bariatric surgery.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 1","pages":"Pages 80-83"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of intermittently scanned continuous glucose monitoring on body weight and glycemic variability in individuals with overweight and impaired glucose tolerance or mild diabetes: A pilot randomized controlled trial","authors":"Seiji Nishikage ,&nbsp;Yasushi Nakagawa ,&nbsp;Yushi Hirota ,&nbsp;Kai Yoshimura ,&nbsp;Mariko Ueda ,&nbsp;Akane Yamamoto ,&nbsp;Tomofumi Takayoshi ,&nbsp;Atsuko Matsuoka ,&nbsp;Michiko Takahashi ,&nbsp;Akihiko Takeda ,&nbsp;Kazuki Yokota ,&nbsp;Tomoaki Nakamura ,&nbsp;Kazuhiko Sakaguchi ,&nbsp;Wataru Ogawa","doi":"10.1016/j.orcp.2025.01.008","DOIUrl":"10.1016/j.orcp.2025.01.008","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effect of visualizing blood glucose variability by intermittently scanned continuous glucose monitoring (isCGM) on weight reduction in overweight individuals with impaired glucose tolerance (IGT) or mild type 2 diabetes mellitus (T2DM).</div></div><div><h3>Materials and methods</h3><div>Forty overweight (BMI, ≥25 kg/m2) individuals with IGT or T2DM (drug naïve; HbA1c, ≤7.0 %) were included in this 24-week randomized controlled trial. Participants were randomly assigned to the control group (diet and exercise therapy) or the isCGM group (diet and exercise therapy plus isCGM). The primary endpoint was the change in body weight during the 24-week intervention period.</div></div><div><h3>Results</h3><div>One participant in the isCGM group withdrew consent. We therefore analyzed 19 individuals in the isCGM group and 20 in the control group. Baseline BMI was significantly higher in the isCGM group (35.2 ± 5.7 kg/m²) compared to the control group (31.6 ± 6.8 kg/m²). Weight change in the isCGM and control groups (–1.8 and –2.2 kg) did not differ. However, the change in coefficient of variation (–0.9 and 2.9 %) of sensor glucose differed significantly between the two groups. isCGM scan frequency was positively correlated with time above range (TAR) during the first month, positively correlated with the change in protein intake, and negatively correlated with that in TAR.</div></div><div><h3>Conclusion</h3><div>While isCGM use in overweight individuals with IGT or mild T2DM did not reduce body weight, it might have influence dietary behavior. The negative correlation between scan frequency and TAR, and the positive correlation between scan frequency and protein intake suggest that self-awareness of glucose fluctuations contributed to behavioral change.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 1","pages":"Pages 70-76"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional and behavioral problems associated with food addiction in children and adolescents with obesity","authors":"Hye-Ji An ,&nbsp;Sarah Woo ,&nbsp;Hyun Jung Lim ,&nbsp;Yoon Myung Kim ,&nbsp;Kyung Hee Park","doi":"10.1016/j.orcp.2025.02.002","DOIUrl":"10.1016/j.orcp.2025.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>This observational study investigated the association between food addiction (FA) and emotional and behavioral problems in children and adolescents with obesity.</div></div><div><h3>Method</h3><div>This study enrolled 224 children and adolescents with body mass index (BMI) above the 85th percentile (mean age: 11.37). Along with anthropometric measurements, various psychosocial characteristics such as the Youth Self Report (YSR), self-esteem scale, and family function were investigated through questionnaires. Using the Yale Food Addiction Scale for Children (YFAS-C), all participants were divided into the FA and non-FA groups.</div></div><div><h3>Results</h3><div>The FA group had a higher BMI z-score, lower self-esteem scale score, and lower family function than the non-FA group. The FA group showed significantly higher YSR subscale T-scores, including total problems, internalization, and externalization, and a higher proportion of participants in the borderline and clinical group on the YSR total problems and problem behavior syndrome scales. Linear regression analysis showed that the YFAS-C symptom count score was independently associated with higher total YSR problems (β=0.036, 95 % CI [0.014, 0.059]) and externalizing t-scores (β=0.042, 95 % CI [0.020, 0.064]), and tended to be associated with internalizing t-scores (β=0.021, 95 % CI [-0.0004, 0.042]).</div></div><div><h3>Conclusions</h3><div>FA was significantly associated with emotional and behavioral problems in children and adolescents with obesity. Therefore, understanding FA in children and adolescents is important for the prevention and treatment of obesity and psychosocial difficulties.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 1","pages":"Pages 34-42"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tackling suboptimal clinical response after metabolic bariatric surgery: Impact of tirzepatide on weight loss and body composition","authors":"Fabian Stoll ,&nbsp;Tobias Kantowski ,&nbsp;Jonas Laaser ,&nbsp;Ulrike Kloiber ,&nbsp;Gabriel Plitzko ,&nbsp;Oliver Mann ,&nbsp;Jens Aberle ,&nbsp;Anne Lautenbach","doi":"10.1016/j.orcp.2025.02.004","DOIUrl":"10.1016/j.orcp.2025.02.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Insufficient weight loss (IWL) or weight regain (WR) after metabolic bariatric surgery remains a challenge in obesity management. Therefore, this study aimed to retrospectively evaluate the impact of adjunctive tirzepatide therapy over 6 months following sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB).</div></div><div><h3>Methods</h3><div>Post-bariatric patients without type 2 diabetes with IWL or WR (n = 21) were analyzed. Key outcomes included changes in weight, BMI, waist circumference, body composition, basal metabolism, metabolic markers, and inflammatory markers. Subgroup analyses assessed differences based on sex, surgery type, and classification as IWL or WR. Linear regression was performed to identify predictors of weight loss outcomes.</div></div><div><h3>Results</h3><div>At 6 months, mean total weight loss was 12.0 % ± 3.4 % (p &lt; 0.001), with significant reductions in BMI, waist circumference, body fat percentage, and HbA1c. Basal metabolism declined proportionally with weight loss. Weight loss ≥ 5 % occurred in 100.0 % of patients, ≥ 10 % in 76.5 %, and ≥ 15 % in 23.5 %. Basal metabolism differences between RYGB and SG patients converged by 6 months. Male and female patients showed comparable weight loss and metabolic adaptation. IWL patients experienced less fat-free mass loss at 3 months compared to WR (p &lt; 0.05). Baseline BMI nadir, prior weight regain, body composition, and chronic inflammation were significant predictors of weight loss outcomes.</div></div><div><h3>Discussion</h3><div>Tirzepatide treatment significantly enhances weight loss and metabolic health in post-bariatric patients, regardless of surgery type or sex. Differences in fat-free mass loss highlight the need for tailored interventions in IWL and WR groups. Baseline factors, including inflammation and body composition, may help predict treatment success.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 1","pages":"Pages 63-69"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}