Obesity research & clinical practice最新文献

{"title":"Prenatal, birth, and postnatal mediators of maternal education level and children affected with obesity at five years","authors":"Olivera Djuric ,&nbsp;Laura Bonvicini ,&nbsp;Serena Broccoli ,&nbsp;Marta Ottone ,&nbsp;Anna Maria Davoli ,&nbsp;Elena Ferrari ,&nbsp;Costantino Panza ,&nbsp;Maddalena Marchesi ,&nbsp;Francesca Bontempo ,&nbsp;Paolo Giorgi Rossi","doi":"10.1016/j.orcp.2025.01.004","DOIUrl":"10.1016/j.orcp.2025.01.004","url":null,"abstract":"<div><h3>Objective</h3><div>To establish which prenatal, birth, and postnatal characteristics mediate the association between maternal educational level and having a child with obesity at five years.</div></div><div><h3>Study design</h3><div>This is a sub analysis of a longitudinal study nested in the BMInForma (Bambini Molto In Forma) program. BMInForma is an ongoing public health multilevel intervention started in 2013 to prevent childhood obesity.</div></div><div><h3>Methods</h3><div>A cohort of 4835 children born from 1.7.2010 to 31.12.2011 and who received well-health visit at three and five years of age in Reggio Emilia, Italy were included in the study. Maternal and child anthropometric and lifestyle data were linked with routinely collected birth data. A series of simple and multiple mediation analyses were performed.</div></div><div><h3>Results</h3><div>There were 232 (4.8 %) children with obesity at five year visit. Low maternal educational level was significantly associated with children's obesity at 5 years of age (Odds ratio for the total effect 1.8, 95 %CI 1.4 – 2.5), and with almost all prenatal, birth, postnatal and 3-years-old behaviors. Pre-pregnancy overweight and obesity (OW/OB) and hours in front of TV at three years were two significant mediators that explained 32 % of the total effect of maternal educational level on children with obesity at five years of age (Odds ratio for the indirect effect 1.17, 95 %CI 1.10 – 1.24). Nine percent of this effect was evinced through LGA and gestational diabetes (Odds ratio for the indirect effect 1.07, 95 %CI 1.01 – 1.13).</div></div><div><h3>Conclusions</h3><div>Pre-pregnancy OW/OB was the most important mediator of the effect of maternal educational level on childhood obesity at five years. Interventions are needed to increase awareness of unhealthy behaviors in early pregnancy.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 6","pages":"Pages 409-416"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of miR-21–5p in children with obesity and its predictive value for metabolic syndrome","authors":"Qiuping Zhu ,&nbsp;Jiayao Fu ,&nbsp;Li Hong ,&nbsp;Li Liu ,&nbsp;Shiyu Yang","doi":"10.1016/j.orcp.2024.12.005","DOIUrl":"10.1016/j.orcp.2024.12.005","url":null,"abstract":"<div><h3>Background</h3><div>microRNAs (miRNAs) could mediate the glucose and lipid metabolism progress in metabolic syndrome (MetS).</div></div><div><h3>Objectives</h3><div>To analyze the value of miRNA (miR)-21–5p for MetS diagnosis in children with obesity. Function of miR-21–5p has been explored by the prediction of target genes and functional and pathway enrichment analysis.</div></div><div><h3>Methods</h3><div>Relative miR-21–5p level was examined by qRT-PCR. Predictive value of miR-21–5p for MetS was assessed by ROC curve. miRBase, TargetScan, and miRWalk databases were used to screen the target genes of miR-21–5p. GO and KEGG were operated to analyze the function of candidate genes of miR-21–5p.</div></div><div><h3>Results</h3><div>Overexpressed miR-21–5p was discovered in MetS children (<em>P</em> &lt; 0.001). High miR-21–5p level could predict MetS patients from children with obesity. Serum miR-21–5p level was closely related to BMI (r = 0.631, <em>P</em> &lt; 0.001), FBG (r = 0.341, <em>P</em> &lt; 0.001), Fasting Insulin (r = 0.438, <em>P</em> &lt; 0.001), TG (r = 0.662, <em>P</em> &lt; 0.001), SBP (r = 0.432, <em>P</em> &lt; 0.001), DBP (r = 0.524, <em>P</em> &lt; 0.001), and HDL-C (r = -0.201, <em>P</em> &lt; 0.001). High miR-21–5p level could predict MetS patients from children with obesity (AUC= 0.827, sensitivity= 0.750, specificity=0.806, cutoff value= 1.0293, <em>P</em> &lt; 0.001). Venn diagram found 83 intersection genes among 3 databases. GO and KEGG analyses indicated that candidate genes of miR-21–5p were mainly correlated with Axon guidance, FoxO signaling pathway, cytokine-cytokine receptor interaction, and insulin resistance pathways.</div></div><div><h3>Conclusion</h3><div>Blood miR-21–5p was elevated in MetS children, and could predict MetS subjects from children with obesity. miR-21–5p could regulate the MetS development via FoxO signaling pathway and insulin resistance pathways.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 6","pages":"Pages 436-442"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics affecting weight loss in an East Asian population receiving semaglutide: A STEP 6 subgroup analysis","authors":"Takashi Kadowaki ,&nbsp;Sang Yeoup Lee ,&nbsp;Wataru Ogawa ,&nbsp;Tomoyuki Nishida ,&nbsp;Maria Overvad ,&nbsp;Kazuyuki Tobe ,&nbsp;Toshimasa Yamauchi ,&nbsp;Soo Lim ,&nbsp;for the STEP 6 investigators","doi":"10.1016/j.orcp.2025.01.002","DOIUrl":"10.1016/j.orcp.2025.01.002","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the effects of semaglutide versus placebo on body weight (BW) by subgroups of baseline characteristics.</div></div><div><h3>Methods</h3><div>In STEP 6, Japanese and Korean adults with overweight or obesity were randomized to subcutaneous semaglutide 2.4 mg, semaglutide 1.7 mg, or placebo for 68 weeks. A subset of Japanese participants with type 2 diabetes (T2D) was also included. In this <em>post-hoc</em> analysis, change from baseline in BW (%) was assessed by subgroups of baseline characteristics including baseline BW, body mass index, age, sex, glycemic status, dyslipidemia, and hypertension.</div></div><div><h3>Results</h3><div>Of 401 participants (148 female and 253 male) included, the estimated mean change in BW was clinically relevant across all subgroups for semaglutide 2.4 mg, ranging from –9.40 % to –16.42 %. Estimated treatment differences also favored both semaglutide doses versus placebo. Significant treatment-by-subgroup interactions were observed for sex with semaglutide 1.7 mg and 2.4 mg versus placebo at week 68 (<em>p</em> = 0.0008 and <em>p</em> = 0.0005, respectively). Significant treatment-by-subgroup interactions were also observed for presence of T2D and dyslipidemia at baseline, for semaglutide 2.4 mg versus placebo only (<em>p</em> = 0.0381 and <em>p</em> = 0.0181, respectively).</div></div><div><h3>Conclusions</h3><div>Semaglutide reduces BW in a wide demographic of people with a range of weight-related comorbidities in an East Asian population.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 6","pages":"Pages 457-464"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of nutrition and other health-oriented marketing claims on young adults’ perceptions and hypothetical consumption of alcohol products: an online experiment","authors":"Ashleigh Haynes ,&nbsp;Zenobia Talati ,&nbsp;Danica Keric ,&nbsp;Julia Stafford ,&nbsp;Ainslie Sartori ,&nbsp;Gael Myers ,&nbsp;Jane Martin ,&nbsp;Alison McAleese ,&nbsp;Tahnee McCausland ,&nbsp;Melanie Wakefield ,&nbsp;Helen Dixon ⁎,","doi":"10.1016/j.orcp.2024.09.077","DOIUrl":"10.1016/j.orcp.2024.09.077","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 5","pages":"Page S33"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142325954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of obesity-related cancer risk factors via public health messaging and impact on dietary behaviour","authors":"Belinda Morley ⁎, ,&nbsp;Rebecca Godwin ,&nbsp;Elizaveta Ilchenko","doi":"10.1016/j.orcp.2024.09.054","DOIUrl":"10.1016/j.orcp.2024.09.054","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 5","pages":"Page S23"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide improves cardiovascular outcomes in patients with high risk for metabolic dysfunction-associated steatohepatitis – a subgroup analysis from the SELECT trial","authors":"Melissa Leung ⁎, ,&nbsp;Sebastian M Meyhöfer ,&nbsp;Bertrand Cariou ,&nbsp;Cintia Cercato ,&nbsp;Helen M Colhoun ,&nbsp;Anne Katrine Duun-Henriksen ,&nbsp;Iris Kliers ,&nbsp;Abraham M Lincoff ,&nbsp;Ildiko Lingvay ,&nbsp;Michelle T Long ,&nbsp;Philip Newsome ,&nbsp;Stephen J Nicholls ,&nbsp;Maria De Los Angeles Quiroga Pelaez ,&nbsp;Ferruccio Santini ,&nbsp;Arun J Sanyal ,&nbsp;Steven E Kahn","doi":"10.1016/j.orcp.2024.09.021","DOIUrl":"10.1016/j.orcp.2024.09.021","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 5","pages":"Page S9"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Once-weekly semaglutide in heart failure with preserved ejection fraction and obesity: main results from the STEP-HFpEF trial","authors":"Andrew Sindone ⁎, ,&nbsp;Mikhail Kosiborod ,&nbsp;Steen Z Abildstrøm ,&nbsp;Barry A Borlaug ,&nbsp;Javed Butler ,&nbsp;Søren Rasmussen ,&nbsp;Melanie J Davies ,&nbsp;G. Kees Hovingh ,&nbsp;Dalane W Kitzman ,&nbsp;Marie L Lindegaard ,&nbsp;Daniél Vega Møller ,&nbsp;Sanjiv J Shah ,&nbsp;Marianne Bach Treppendahl ,&nbsp;Subodh Verma ,&nbsp;Mark C Petrie","doi":"10.1016/j.orcp.2024.09.084","DOIUrl":"10.1016/j.orcp.2024.09.084","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 5","pages":"Pages S36-S37"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142328175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of obesity on pregnancy outcomes in women with type 1 and type 2 diabetes across the NSW population","authors":"Xavier XR Rickard ⁎, ,&nbsp;Matilda ML Longfield ,&nbsp;Sarah SG Glastras","doi":"10.1016/j.orcp.2024.09.069","DOIUrl":"10.1016/j.orcp.2024.09.069","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 5","pages":"Pages S29-S30"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142328177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating health literacy and cultural considerations into a web-based program promoting healthy behaviours in infants","authors":"Danielle Jawad ⁎, ,&nbsp;Li Ming Wen ,&nbsp;Louise Baur ,&nbsp;Chris Rissel ,&nbsp;Seema Mihrshahi ,&nbsp;Sarah Taki","doi":"10.1016/j.orcp.2024.09.024","DOIUrl":"10.1016/j.orcp.2024.09.024","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 5","pages":"Pages S10-S11"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142328225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cycling between chow and high-fat diet: a longitudinal follow-up of diet-induced obesity","authors":"Nhan Ho Trong Pham ⁎, ,&nbsp;Mahek Thanki ,&nbsp;Ehsan Alvandi ,&nbsp;Wilson Wong ,&nbsp;Mugdha Joglekar ,&nbsp;Anandwardhan Hardikar","doi":"10.1016/j.orcp.2024.09.057","DOIUrl":"10.1016/j.orcp.2024.09.057","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 5","pages":"Page S24"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}