Moderate caloric restriction improved body composition and maintains bone quality of rats under hypoestrogenism

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice Pub Date : 2025-03-01 DOI:10.1016/j.orcp.2025.04.002

Rafael Henrique de Oliveira Nascimento, Taciane Maria Melges Pejon, Wladimir Rafael Beck

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引用次数: 0

Abstract

Background

Hypoestrogenism state is associated with weight and adiposity gain, generally impairing bone properties. Caloric restriction (CR) is the main intervention to promote weight loss, however, a chronic severe restriction can lead to bone loss and malnutrition.

Objective

To analyse whether 12 weeks of moderate CR could reduce body mass and adiposity without worsening the bone health of ovariectomized (OVX) rats.

Methods

CR and OVX-CR animals were subject daily to receive a 20 % less amount of food based on the last week's consumption of C and OVX groups. Body mass and food intake were recorded weekly, and spontaneous physical activity (SPA) biweekly. The adipose tissue of subcutaneous (SAT), peritoneal (PTAT), and perigonadal (PGAT) portions was collected to record its mass, and the right femur was collected to determine bone volume (BV), density (BD), mineral density (BMD), and percentage of mineral material (MM).

Results

Ovariectomy increased body mass and food intake (p < 0.001), SAT, PTAT, and PGAT mass (p < 0.01), decreased BV (p < 0.05), BD and BMD (p < 0.01) and MM (p < 0.05), but not affected SPA (p = 0.16). CR decreased body mass, SAT, PTAT, and PGAT mass (p < 0.01) and BMD and MM (p < 0.05), but did not affect BV (p = 0.90), BD (p = 0.24), and SPA (p = 0.25). Therefore, post-hoc data did not demonstrate significant differences in these bone parameters between the OVX and OVX-RC groups (p > 0.05).

Conclusion

12 weeks of 20 % of CR is enough to prevent weight and fat gain in the hypoestrogenism state without causing additional worsening in bone properties.

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适度的热量限制改善了低雌激素大鼠的身体成分并维持了骨质量

背景：低雌激素状态与体重和脂肪增加有关，通常会损害骨骼特性。热量限制（CR）是促进体重减轻的主要干预措施，然而，长期严格限制会导致骨质流失和营养不良。目的分析12周的中度CR能否在不损害去卵巢（OVX）大鼠骨骼健康的情况下降低体重和脂肪。方法scr组和OVX- cr组每天在C组和OVX组的基础上减少20 %的摄取量。每周记录体重和食物摄入量，每两周记录自发身体活动（SPA）。采集皮下（SAT）、腹膜（PTAT）和股骨头周围（PGAT）部分的脂肪组织，记录其质量，采集右侧股骨，测定骨体积（BV）、密度（BD）、矿物质密度（BMD）和矿物物质百分比（MM）。ResultsOvariectomy增加体重和食物摄入量(p & lt; 0.001),坐,PTAT,和PGAT质量(p & lt; 0.01),降低BV (p & lt; 0.05),BD和BMD (p & lt; 0.01)和MM (0.05 p & lt; ),但不影响水疗(p = 0.16)。CR减少体重,坐,PTAT PGAT质量(p & lt; 0.01)和BMD和MM (0.05 p & lt; ),但并不影响BV (p = 0.90),BD (p = 0.24),温泉(p = 0.25)。因此，事后数据显示OVX组和OVX- rc组在这些骨参数上没有显著差异（p >； 0.05）。结论12周20% %的CR足以防止低雌激素状态下的体重和脂肪增加，而不会引起骨骼性能的进一步恶化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity research & clinical practice 医学-内分泌学与代谢

CiteScore

7.10

自引率

0.00%

发文量

审稿时长

49 days

期刊介绍： The aim of Obesity Research & Clinical Practice (ORCP) is to publish high quality clinical and basic research relating to the epidemiology, mechanism, complications and treatment of obesity and the complication of obesity. Studies relating to the Asia Oceania region are particularly welcome, given the increasing burden of obesity in Asia Pacific, compounded by specific regional population-based and genetic issues, and the devastating personal and economic consequences. The journal aims to expose health care practitioners, clinical researchers, basic scientists, epidemiologists, and public health officials in the region to all areas of obesity research and practice. In addition to original research the ORCP publishes reviews, patient reports, short communications, and letters to the editor (including comments on published papers). The proceedings and abstracts of the Annual Meeting of the Asia Oceania Association for the Study of Obesity is published as a supplement each year.