Insulin resistance and vigorous physical activity mediates the relationship between waist circumference and metabolic syndrome in Korean children

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice Pub Date : 2025-01-01 DOI:10.1016/j.orcp.2025.02.005

Seamon Kang, Mungu Song, Hyunsik Kang

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引用次数: 0

Abstract

Background

Little is known about how physical activity (PA) and insulin resistance (IR) influence the impact of obesity on metabolic syndrome in pediatric populations.

Objectives

This cross-sectional observational study aimed to investigate the mediating effects of PA and IR on the relationship between waist circumference (WC) and continuous metabolic syndrome (cMetS) risk scores in children.

Methods

A total of 1008 children aged 7–12 years (535 girls and 473 boys) were recruited from our local elementary schools. PA, body mass index (BMI), WC, and percent body fat were measured. cMetS risk scores were calculated by summing the standardized residuals for mean arterial pressure, triglycerides, fasting blood glucose, and high-density lipoprotein cholesterol.

Results

Mediation analysis showed a significant indirect effect of WC on cMetS scores through insulin (β= 0.270, 95 % confidence interval [CI = 0.234–0.306) and vigorous PA (β= 0.007, 95 % CI = 0.001–0.015). The direct effect of WC on cMet scores in the presence of the two mediators was significant (β= 0.193, 95 % CI = 0.040–0.066).

Conclusion

Our study findings suggest that while WC is the primary determinant of cMetS scores, fasting insulin and vigorous PA partially mediate the association between the two parameters in this study population.

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来源期刊

Obesity research & clinical practice 医学-内分泌学与代谢

CiteScore

7.10

自引率

0.00%

发文量

审稿时长

49 days

期刊介绍： The aim of Obesity Research & Clinical Practice (ORCP) is to publish high quality clinical and basic research relating to the epidemiology, mechanism, complications and treatment of obesity and the complication of obesity. Studies relating to the Asia Oceania region are particularly welcome, given the increasing burden of obesity in Asia Pacific, compounded by specific regional population-based and genetic issues, and the devastating personal and economic consequences. The journal aims to expose health care practitioners, clinical researchers, basic scientists, epidemiologists, and public health officials in the region to all areas of obesity research and practice. In addition to original research the ORCP publishes reviews, patient reports, short communications, and letters to the editor (including comments on published papers). The proceedings and abstracts of the Annual Meeting of the Asia Oceania Association for the Study of Obesity is published as a supplement each year.