Obesity research & clinical practice最新文献

{"title":"Investigating genetic variants in early-onset obesity through exome sequencing: A retrospective cohort study","authors":"Deyun Liu,&nbsp;Yuxiang Liu,&nbsp;Chen yu Lu,&nbsp;Qian Wang,&nbsp;Yingying Bao,&nbsp;Yue Yu,&nbsp;Qiang Wang,&nbsp;Wu Peng","doi":"10.1016/j.orcp.2024.12.001","DOIUrl":"10.1016/j.orcp.2024.12.001","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to examine clinical data and analyze exome sequencing (ES) findings in children diagnosed with early-onset obesity.</div></div><div><h3>Methods</h3><div>We screened children presenting with severe (body mass index-standard deviation score &gt;3) and early-onset (&lt;7 years) obesity using ES. Participants were categorized into either the \"no variant identified\" group or the \"variant identified\" group, facilitating the exploration of correlations between clinical-demographic characteristics and genetic mutations linked to early-onset obesity. The functional implications of identified variants were assessed through in silico analyses.</div></div><div><h3>Results</h3><div>Of the patients, 32 (35.5 %) possessed one or more mutations in pathways associated with obesity, all of which were heterozygous and patients with more than two obesity-associated variants were more obese. This cohort included 29 novel mutations distinct to our study population, 7 previously reported pathogenic variants, two instances of uniparental disomy, and one mitochondrial hotspot mutation. Variants in the SH2B1 gene emerged as a prevalent genetic determinant of obesity within our group, accounting for 16.6 % of cases. Statistical evaluations showed no significant differences in demographic attributes between the two groups.</div></div><div><h3>Conclusion</h3><div>Exome sequencing proves to be an instrumental approach for uncovering new variants and broadening the spectrum of mutations in early-onset obesity among children. Concurrently, further functional studies, both in vitro and in vivo, are crucial to elucidate the contributions of these variants to obesity's pathogenesis.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 6","pages":"Pages 417-425"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained effects after a multidisciplinary lifestyle modification program for children with excess weight and children affected with obesity","authors":"Tung-En Chien ,&nbsp;Pei-Shan Chen ,&nbsp;Kai-Chi Chang ,&nbsp;Chien-Ting Hsu ,&nbsp;Hsi-Wen Huang ,&nbsp;Shu-Mei Tsai ,&nbsp;Yen-Tsz Chen ,&nbsp;Chih-Hsuan Chang ,&nbsp;Hui-Ru Yang ,&nbsp;Yi-Ching Tung ,&nbsp;Huey-Ling Chen","doi":"10.1016/j.orcp.2025.01.001","DOIUrl":"10.1016/j.orcp.2025.01.001","url":null,"abstract":"<div><h3>Background</h3><div>Lifestyle modification (LM) is the mainstay in the management of obese children. This study aimed to investigate the long-term effects of a pediatric cohort participating in a hospital-based LM program.</div></div><div><h3>Methods</h3><div>Overweight/obese children and adolescents who visited a multidisciplinary LM program “The Health and Vitality Clinic” were included. Data on weight and height were collected at 6, 12, and 18 months following the initial visit. The changes in body mass index (BMI) and BMI z-score were analyzed.</div></div><div><h3>Results</h3><div>A total of 120 participants aged 5–18 years who visited the clinic were included. Sixty-one subjects who completed &gt; 1 months (up to a maximum of 5 months) of the LM program constituted the LM group, while those who visited the clinic once were characterized as hospital-control (HC) group. There was a significant reduction in BMI at 6 and 12 months in the LM group, and at 6 months in the HC group, with a greater reduction observed in the LM group at 6 and 12 months (-1.05 ± 1.46 vs. −0.42 ± 1.21, <em>p</em> = 0.027; −0.87 ± 1.46 vs. −0.14 ± 1.43, <em>p</em> = 0.038, res<em>p</em>ectively). Both groups showed a downward trend in BMI z-score at 6, 12, and 18 months, with the LM group showing a greater reduction at the 6 months (-0.33 ± 0.28 vs. −0.22 ± 0.18, <em>p</em> = 0.019). BMI decline was more pronounced in adolescents than in children, showing variations in weight gains based on age.</div></div><div><h3>Conclusions</h3><div>The study demonstrated lasting effects in BMI and BMI z-score following the completion of the LM program.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 6","pages":"Pages 450-456"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity in the US: Exploring the paradox of increasing obesity rates alongside growing physical activity","authors":"Yoshiyasu Takefuji","doi":"10.1016/j.orcp.2024.12.004","DOIUrl":"10.1016/j.orcp.2024.12.004","url":null,"abstract":"<div><div>The study analyzes a CDC dataset on US adult obesity and physical activity from 2011 to 2022. Despite rising obesity rates and insufficient fruit consumption, physical activity levels are increasing and overweight rates are slightly declining. The role of ultra-processed food intake, price sensitivity, early eating habits, and stress in obesity is highlighted. The findings suggest a complex obesity epidemic, indicating the need for multifaceted solutions such as regulating ultra-processed foods, improving access to healthy foods, and promoting healthy eating habits from childhood.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 6","pages":"Pages 465-468"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of a healthy lifestyle index with anthropometric indices and obesity in Hong Kong Chinese women: Evidence from the MECH-HK cohort study","authors":"Yunyang Deng ,&nbsp;Tongyu Ma ,&nbsp;Fei Wan Ngai ,&nbsp;Harry Haoxiang Wang ,&nbsp;Lin Yang ,&nbsp;Qi Sun ,&nbsp;Yao Jie Xie","doi":"10.1016/j.orcp.2025.01.003","DOIUrl":"10.1016/j.orcp.2025.01.003","url":null,"abstract":"<div><h3>Aim</h3><div>This cross-sectional study aimed to examine the associations of a healthy lifestyle index (HLI) with several anthropometric indices and obesity among Hong Kong Chinese women.</div></div><div><h3>Subjects/Methods</h3><div>A total of 3174 women (56.16 ± 8.43 years) were included. The HLI consisted of diet, physical activity, sedentary time, sleep duration, skipping breakfast, smoking, and alcohol. Each factor was scored as 0 (unhealthy) or 1 (healthy). The overall HLI was the sum of these points, ranging from 0 (the least healthy) to 7 (healthiest). Percent body fat (PBF), body fat mass (BFM), fat free mass (FFM), waist circumference (WC), waist-to-hip ratio (WHR), height, and weight were measured using the InBody 270 device.</div></div><div><h3>Results</h3><div>The number of women with 0–2, 3, 4, 5, 6–7-point HLI groups were 551, 759, 954, 645, and 265, respectively. As HLI increased, most anthropometric indices declined while FFM increased. The adjusted βs (95 % confidence intervals (95 % CIs)) for PBF (%), BFM (kg), WC (cm), WHR, height (cm), weight (kg), BMI (kg/m^2), and FFM (kg) were −0.653 (-0.829, −0.476), −0.582 (-0.751, −0.414), −0.719 (-0.971, −0.467), −0.005 (-0.006, −0.004), −0.181 (-0.347, −0.015), −0.602 (-0.850, −0.355), −0.188 (-0.282, −0.095), and 0.339 (0.213, 0.465), respectively. Additionally, compared to the 0–2-point group, the odds ratios (95 % CIs) of the 6–7-point groups were 0.54 (0.38–0.75) for central obesity and 0.55 (0.37–0.82) for general obesity.</div></div><div><h3>Conclusions</h3><div>HLI was inversely associated with PBF, BFM, WC, WHR, height, weight, BMI, central obesity, and general obesity, but was positively associated with FFM.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 6","pages":"Pages 401-408"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal, birth, and postnatal mediators of maternal education level and children affected with obesity at five years","authors":"Olivera Djuric ,&nbsp;Laura Bonvicini ,&nbsp;Serena Broccoli ,&nbsp;Marta Ottone ,&nbsp;Anna Maria Davoli ,&nbsp;Elena Ferrari ,&nbsp;Costantino Panza ,&nbsp;Maddalena Marchesi ,&nbsp;Francesca Bontempo ,&nbsp;Paolo Giorgi Rossi","doi":"10.1016/j.orcp.2025.01.004","DOIUrl":"10.1016/j.orcp.2025.01.004","url":null,"abstract":"<div><h3>Objective</h3><div>To establish which prenatal, birth, and postnatal characteristics mediate the association between maternal educational level and having a child with obesity at five years.</div></div><div><h3>Study design</h3><div>This is a sub analysis of a longitudinal study nested in the BMInForma (Bambini Molto In Forma) program. BMInForma is an ongoing public health multilevel intervention started in 2013 to prevent childhood obesity.</div></div><div><h3>Methods</h3><div>A cohort of 4835 children born from 1.7.2010 to 31.12.2011 and who received well-health visit at three and five years of age in Reggio Emilia, Italy were included in the study. Maternal and child anthropometric and lifestyle data were linked with routinely collected birth data. A series of simple and multiple mediation analyses were performed.</div></div><div><h3>Results</h3><div>There were 232 (4.8 %) children with obesity at five year visit. Low maternal educational level was significantly associated with children's obesity at 5 years of age (Odds ratio for the total effect 1.8, 95 %CI 1.4 – 2.5), and with almost all prenatal, birth, postnatal and 3-years-old behaviors. Pre-pregnancy overweight and obesity (OW/OB) and hours in front of TV at three years were two significant mediators that explained 32 % of the total effect of maternal educational level on children with obesity at five years of age (Odds ratio for the indirect effect 1.17, 95 %CI 1.10 – 1.24). Nine percent of this effect was evinced through LGA and gestational diabetes (Odds ratio for the indirect effect 1.07, 95 %CI 1.01 – 1.13).</div></div><div><h3>Conclusions</h3><div>Pre-pregnancy OW/OB was the most important mediator of the effect of maternal educational level on childhood obesity at five years. Interventions are needed to increase awareness of unhealthy behaviors in early pregnancy.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 6","pages":"Pages 409-416"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of miR-21–5p in children with obesity and its predictive value for metabolic syndrome","authors":"Qiuping Zhu ,&nbsp;Jiayao Fu ,&nbsp;Li Hong ,&nbsp;Li Liu ,&nbsp;Shiyu Yang","doi":"10.1016/j.orcp.2024.12.005","DOIUrl":"10.1016/j.orcp.2024.12.005","url":null,"abstract":"<div><h3>Background</h3><div>microRNAs (miRNAs) could mediate the glucose and lipid metabolism progress in metabolic syndrome (MetS).</div></div><div><h3>Objectives</h3><div>To analyze the value of miRNA (miR)-21–5p for MetS diagnosis in children with obesity. Function of miR-21–5p has been explored by the prediction of target genes and functional and pathway enrichment analysis.</div></div><div><h3>Methods</h3><div>Relative miR-21–5p level was examined by qRT-PCR. Predictive value of miR-21–5p for MetS was assessed by ROC curve. miRBase, TargetScan, and miRWalk databases were used to screen the target genes of miR-21–5p. GO and KEGG were operated to analyze the function of candidate genes of miR-21–5p.</div></div><div><h3>Results</h3><div>Overexpressed miR-21–5p was discovered in MetS children (<em>P</em> &lt; 0.001). High miR-21–5p level could predict MetS patients from children with obesity. Serum miR-21–5p level was closely related to BMI (r = 0.631, <em>P</em> &lt; 0.001), FBG (r = 0.341, <em>P</em> &lt; 0.001), Fasting Insulin (r = 0.438, <em>P</em> &lt; 0.001), TG (r = 0.662, <em>P</em> &lt; 0.001), SBP (r = 0.432, <em>P</em> &lt; 0.001), DBP (r = 0.524, <em>P</em> &lt; 0.001), and HDL-C (r = -0.201, <em>P</em> &lt; 0.001). High miR-21–5p level could predict MetS patients from children with obesity (AUC= 0.827, sensitivity= 0.750, specificity=0.806, cutoff value= 1.0293, <em>P</em> &lt; 0.001). Venn diagram found 83 intersection genes among 3 databases. GO and KEGG analyses indicated that candidate genes of miR-21–5p were mainly correlated with Axon guidance, FoxO signaling pathway, cytokine-cytokine receptor interaction, and insulin resistance pathways.</div></div><div><h3>Conclusion</h3><div>Blood miR-21–5p was elevated in MetS children, and could predict MetS subjects from children with obesity. miR-21–5p could regulate the MetS development via FoxO signaling pathway and insulin resistance pathways.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 6","pages":"Pages 436-442"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics affecting weight loss in an East Asian population receiving semaglutide: A STEP 6 subgroup analysis","authors":"Takashi Kadowaki ,&nbsp;Sang Yeoup Lee ,&nbsp;Wataru Ogawa ,&nbsp;Tomoyuki Nishida ,&nbsp;Maria Overvad ,&nbsp;Kazuyuki Tobe ,&nbsp;Toshimasa Yamauchi ,&nbsp;Soo Lim ,&nbsp;for the STEP 6 investigators","doi":"10.1016/j.orcp.2025.01.002","DOIUrl":"10.1016/j.orcp.2025.01.002","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the effects of semaglutide versus placebo on body weight (BW) by subgroups of baseline characteristics.</div></div><div><h3>Methods</h3><div>In STEP 6, Japanese and Korean adults with overweight or obesity were randomized to subcutaneous semaglutide 2.4 mg, semaglutide 1.7 mg, or placebo for 68 weeks. A subset of Japanese participants with type 2 diabetes (T2D) was also included. In this <em>post-hoc</em> analysis, change from baseline in BW (%) was assessed by subgroups of baseline characteristics including baseline BW, body mass index, age, sex, glycemic status, dyslipidemia, and hypertension.</div></div><div><h3>Results</h3><div>Of 401 participants (148 female and 253 male) included, the estimated mean change in BW was clinically relevant across all subgroups for semaglutide 2.4 mg, ranging from –9.40 % to –16.42 %. Estimated treatment differences also favored both semaglutide doses versus placebo. Significant treatment-by-subgroup interactions were observed for sex with semaglutide 1.7 mg and 2.4 mg versus placebo at week 68 (<em>p</em> = 0.0008 and <em>p</em> = 0.0005, respectively). Significant treatment-by-subgroup interactions were also observed for presence of T2D and dyslipidemia at baseline, for semaglutide 2.4 mg versus placebo only (<em>p</em> = 0.0381 and <em>p</em> = 0.0181, respectively).</div></div><div><h3>Conclusions</h3><div>Semaglutide reduces BW in a wide demographic of people with a range of weight-related comorbidities in an East Asian population.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 6","pages":"Pages 457-464"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of nutrition and other health-oriented marketing claims on young adults’ perceptions and hypothetical consumption of alcohol products: an online experiment","authors":"Ashleigh Haynes ,&nbsp;Zenobia Talati ,&nbsp;Danica Keric ,&nbsp;Julia Stafford ,&nbsp;Ainslie Sartori ,&nbsp;Gael Myers ,&nbsp;Jane Martin ,&nbsp;Alison McAleese ,&nbsp;Tahnee McCausland ,&nbsp;Melanie Wakefield ,&nbsp;Helen Dixon ⁎,","doi":"10.1016/j.orcp.2024.09.077","DOIUrl":"10.1016/j.orcp.2024.09.077","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 5","pages":"Page S33"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142325954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of obesity-related cancer risk factors via public health messaging and impact on dietary behaviour","authors":"Belinda Morley ⁎, ,&nbsp;Rebecca Godwin ,&nbsp;Elizaveta Ilchenko","doi":"10.1016/j.orcp.2024.09.054","DOIUrl":"10.1016/j.orcp.2024.09.054","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 5","pages":"Page S23"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide improves cardiovascular outcomes in patients with high risk for metabolic dysfunction-associated steatohepatitis – a subgroup analysis from the SELECT trial","authors":"Melissa Leung ⁎, ,&nbsp;Sebastian M Meyhöfer ,&nbsp;Bertrand Cariou ,&nbsp;Cintia Cercato ,&nbsp;Helen M Colhoun ,&nbsp;Anne Katrine Duun-Henriksen ,&nbsp;Iris Kliers ,&nbsp;Abraham M Lincoff ,&nbsp;Ildiko Lingvay ,&nbsp;Michelle T Long ,&nbsp;Philip Newsome ,&nbsp;Stephen J Nicholls ,&nbsp;Maria De Los Angeles Quiroga Pelaez ,&nbsp;Ferruccio Santini ,&nbsp;Arun J Sanyal ,&nbsp;Steven E Kahn","doi":"10.1016/j.orcp.2024.09.021","DOIUrl":"10.1016/j.orcp.2024.09.021","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"18 5","pages":"Page S9"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}