Obesity research & clinical practice最新文献

{"title":"Effectiveness of a kindergarten-based obesity prevention intervention to reduce risk of overweight at school entry","authors":"Mette Fogh ,&nbsp;Rasmus Møller Jørgensen ,&nbsp;Henrik Støvring ,&nbsp;Gunnar Toft ,&nbsp;Helle Terkildsen Maindal ,&nbsp;Jens Meldgaard Bruun ,&nbsp;Jane Nautrup Østergaard","doi":"10.1016/j.orcp.2025.12.011","DOIUrl":"10.1016/j.orcp.2025.12.011","url":null,"abstract":"<div><h3>Background</h3><div>Accelerated weight gain from two to six years of age is associated with overweight and obesity in adolescence. Kindergartens may play an important role in shaping early healthy behaviors, making this setting ideal for interventions aiming at preventing childhood obesity.</div></div><div><h3>Objectives</h3><div>To examine the effectiveness of a kindergarten-based obesity prevention intervention on Body-Mass-Index (BMI) z-score and risk of overweight at school entry.</div></div><div><h3>Methods</h3><div>A kindergarten-based obesity prevention intervention group (n = 1755) was compared to a usual care group (n = 750). The intervention consisted of two workshops focusing on developing activities to promote healthy behaviors, delivered to kindergarten staff and parents. The children's weight and height were measured once during mandatory school health examination between ages five to seven years. Socioeconomic data were obtained from national registers. Group differences in BMI z-score and risk of overweight were analyzed, adjusted for socioeconomic data.</div></div><div><h3>Results</h3><div>No significant differences were found in BMI z-score (mean difference: 0.03, 95 % Confidence Interval (CI): −0.06, 0.12) or risk of overweight (risk ratio: 0.96, 95 % CI: 0.78, 1.19) between the groups. However, children with lower parental education showed a trend toward lower BMI z-score in the intervention group compared to the usual care group (P = 0.09).</div></div><div><h3>Conclusion</h3><div>While the kindergarten-based obesity prevention intervention showed no overall effect on BMI z-score or overweight risk at the population level, children from families with lower parental education levels may have more benefit of the intervention.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 52-58"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern “Evaluation of diagnostic and predictive value of serum adipokines: Leptin, resistin and visfatin in postmenopausal breast cancer” [Obes Res Clin Pract 10 4 (2016) 442–453]","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 5","pages":"Page 488"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of internalised weight stigma and engagement with weight-inclusive approaches to health on experienced weight stigma and psychosocial health: A cross-sectional analysis of Australian community adults","authors":"Hugh Bidstrup ,&nbsp;Leah Brennan ,&nbsp;Leah Kaufmann ,&nbsp;Alexandra Phillips ,&nbsp;Xochitl de la Piedad Garcia","doi":"10.1016/j.orcp.2025.12.006","DOIUrl":"10.1016/j.orcp.2025.12.006","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the relationship between weight stigma and psychosocial health, and to characterise the extent to which individuals are engaged with weight inclusive (i.e., weight neutral, “non-diet”) approaches to health. First, we aimed to (1) estimate whether internalised weight stigma mediated the relationship between experienced weight stigma and psychosocial health and (2) understand the role that awareness, engagement, and endorsement (AEE) of non-diet approaches to health might have in affecting this mediation. All methods were pre-registered (see osf.io/uwf7n).</div></div><div><h3>Methods</h3><div>Participants (<em>n</em> = 418; <em>M</em>_Age = 36.8, <em>SD</em> = 12.5; <em>M</em>_BMI = 29.5, <em>SD</em> = 6.8) completed an online survey on measures including non-diet AEE, weight stigma, and psychosocial health.</div></div><div><h3>Results</h3><div>Consistent with hypotheses, weight stigma was positively correlated with adverse psychosocial health. Internalised weight stigma mediated the relationship between experienced weight stigma and all 16 psychosocial health correlates measured, including psychological distress, disordered eating, and intuitive eating (controlling for BMI). AEE of non-diet approaches was associated with external forms of weight stigma, but not internal, self-directed weight stigma (partially supporting hypothesis). Contrary to hypotheses, there were few consistent relationships between non-diet AEE and psychosocial health correlates, and AEE of non-diet approaches to health did not moderate the hypothesised mediation effect.</div></div><div><h3>Conclusion</h3><div>We found that internalised weight stigma mediated experienced weight stigmas’ effects, and that weight stigma was consistently related to adverse psychosocial health. However, the results were mixed for non-diet AEE. At the bivariate level, there was some indication of non-diet AEE’s importance, but not at the level of our hypothesised moderating effect.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 59-67"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Development and early evaluation of OPTIMAP: A digitally enabled nurse-led multidisciplinary pathway for care of people with severe obesity in a Public Australian Health Network” [Obesity Research & Clinical Practice, 19(6), 2025, 544–548]","authors":"Matthew Y. Lim ,&nbsp;Katie Belobrajdic ,&nbsp;Melani Mallee ,&nbsp;Marni A. Nenke ,&nbsp;Melissa Carapetis ,&nbsp;David Jesudason ,&nbsp;Shalvin Prasad ,&nbsp;Adam J. Nelson ,&nbsp;Leonie Heilbronn ,&nbsp;Elena Dicus ,&nbsp;Gary Wittert ,&nbsp;Emily J. Meyer","doi":"10.1016/j.orcp.2025.12.007","DOIUrl":"10.1016/j.orcp.2025.12.007","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Page 81"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incoming co-editor-in-chief statement","authors":"Leonie Heilbronn","doi":"10.1016/j.orcp.2026.01.006","DOIUrl":"10.1016/j.orcp.2026.01.006","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Page 1"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146147424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between small vessel disease and persons with overweight and obesity: A study using peak width of skeletonized mean diffusivity","authors":"Kang Min Park ,&nbsp;Jin-Hong Wi ,&nbsp;Bong Soo Park ,&nbsp;Jinseung Kim","doi":"10.1016/j.orcp.2026.01.001","DOIUrl":"10.1016/j.orcp.2026.01.001","url":null,"abstract":"<div><h3>Background</h3><div>Obesity and overweight are established contributors to cerebrovascular disease, including small vessel disease (SVD). Peak width of skeletonized mean diffusivity (PSMD), a diffusion tensor imaging-based marker, sensitively detects white matter microstructural changes linked to SVD. However, the relationship between body mass index (BMI) and PSMD remains unclear.</div></div><div><h3>Methods</h3><div>We analyzed data from 62 neurologically and medically healthy adults who underwent brain magnetic resonance imaging with diffusion tensor imaging. Participants were recruited as normal controls and categorized by World Health Organization Asia-Pacific BMI criteria. PSMD values were compared across BMI groups. Spearman correlation and age-adjusted residual analyses assessed associations between BMI and PSMD.</div></div><div><h3>Results</h3><div>PSMD showed a significant positive correlation with BMI (ρ = 0.42, p = 0.0007), which remained after adjusting for age (ρ = 0.38, p = 0.0021). Overweight individuals (BMI 23.0–24.9 kg/m²) exhibited significantly higher PSMD values than normal-weight participants (BMI 18.5–22.9 kg/m²), both before and after adjustment. When overweight and obese participants (BMI ≥ 23.0 kg/m²) were combined, this group also demonstrated elevated PSMD. The association with obesity (BMI ≥ 25.0 kg/m²) was present but attenuated after age adjustment.</div></div><div><h3>Conclusions</h3><div>This study is the first to demonstrate a significant association between higher BMI and PSMD, even at overweight levels in Asian populations. These findings suggest that excess body weight is linked to early microstructural white matter changes consistent with SVD, and PSMD may serve as a useful imaging biomarker for obesity-related cerebral microvascular damage.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 35-42"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal and tissue-specific changes in iron homeostasis and mitochondrial metabolism of leptin-deficient obese mice: an integrated view","authors":"Ana Paula Oliveira Ferreira ,&nbsp;Kaique Alves de Araujo ,&nbsp;Jessica Monteiro Volejnik Pino ,&nbsp;Tamirez Villas Boas Petrucci ,&nbsp;Marcio Henrique Mello da Luz ,&nbsp;Gabriel Orefice de Souza ,&nbsp;Isaias Glezer ,&nbsp;Jose Donato Jr ,&nbsp;Kil Sun Lee","doi":"10.1016/j.orcp.2025.12.012","DOIUrl":"10.1016/j.orcp.2025.12.012","url":null,"abstract":"<div><div>Obesity is frequently accompanied by metabolic dysfunction and micronutrient imbalances, including iron. Despite the critical role of iron in metabolic regulation, the tissue-specific effects of iron dysregulation remain unclear. In this study, we used leptin-deficient ob/ob mice to investigate whether iron homeostasis is altered during obesity progression and contributes to organ-specific metabolic adaptations. We measured serum metabolites, tissue iron and relative expression levels of proteins involved in iron homeostasis and key metabolic pathways across multiple organs of ob/ob mice at 3 and 5 months of age (3OB and 5OB), and their respective lean controls (3LC and 5LC). Multivariate analysis revealed that changes in hepatic proteins related to glycemic control and ferritin levels were key factors distinguishing obese mice from lean controls, regardless of age. In contrast, mitochondrial proteins and ferritin in adipose and hippocampal tissues better explained the variance between 3OB and 5OB groups, suggesting that the adipose tissue and hippocampus undergo continuous remodeling during obesity progression. Tissue iron and ferritin levels showed moderate to strong correlations with several key metabolic enzymes, especially with mitochondrial proteins. In linear regressions between tissue ferritin and either cytochrome c oxidase or ATP synthase, these two mitochondrial proteins exhibited opposite angular coefficients across all evaluated tissues. Additionally, 3OB and 5OB mice displayed opposite patterns in adipose tissue and hippocampus, indicating that these proteins play key roles in time- and tissue-specific metabolic adaptation during obesity progression. These findings suggest that local iron dynamics can contribute to metabolic dysfunction in obesity and consequent comorbidities.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 21-28"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of the MetS-IR and SPISE indices for identifying insulin resistance in Mexican children","authors":"Edmundo Gutiérrez-Rosas ,&nbsp;Marco A. Morales-Pérez ,&nbsp;Mayra Cristina Torres-Castañeda ,&nbsp;Lorena Lizárraga-Paulín ,&nbsp;Rita A. Gómez-Díaz ,&nbsp;Adriana L. Valdez-González ,&nbsp;Niels H. Wacher","doi":"10.1016/j.orcp.2026.01.005","DOIUrl":"10.1016/j.orcp.2026.01.005","url":null,"abstract":"<div><h3>Aims</h3><div>To evaluate the utility of MetS-IR and SPISE indices for identifying insulin resistance in Mexican children and adolescents.</div></div><div><h3>Materials and methods</h3><div>A cross-sectional study was conducted using clinical and biochemical records from 934 children aged 8–17 years. Insulin resistance was defined as a HOMA-IR value above the 85th percentile (3.37) of a healthy reference subgroup. MetS-IR and SPISE were calculated using BMI, triglycerides, HDL-C, and glucose. ROC curves were used to evaluate diagnostic performance. Logistic regression models adjusted for age and sex were developed to obtain adjusted AUC values.</div></div><div><h3>Results</h3><div>Of the total sample, 55 % were classified as having insulin resistance. Both indices showed high discriminative capacity: AUC was 0.894 for MetS-IR (cutoff 35.966) and 0.895 for SPISE (cutoff 6.594). After adjusting for age and sex, both AUCs increased slightly to 0.899. Sensitivities and specificities exceeded 80 %, and positive likelihood ratios were close to 5.</div></div><div><h3>Conclusions</h3><div>MetS-IR and SPISE are accurate and low-cost tools for identifying insulin resistance in Mexican pediatric population. These findings support the utility of context-specific cutoff points and highlight the potential of these indices for early screening in primary care settings.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 29-34"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body composition, hepatic fat, metabolic, and safety outcomes of Tesamorelin, a GHRH analogue, in HIV-associated lipodystrophy: A meta-analysis of randomized controlled trials","authors":"Ahmed Samy Badran ,&nbsp;Abdulrhman Helal ,&nbsp;Karim Samir Shata ,&nbsp;Hazem Ayesh","doi":"10.1016/j.orcp.2026.01.002","DOIUrl":"10.1016/j.orcp.2026.01.002","url":null,"abstract":"<div><h3>Background</h3><div>HIV-associated lipodystrophy leads to visceral fat accumulation, metabolic complications, body image concerns, medication non-adherence, and increased cardiovascular risks. We thought to assess the effects of Tesamorelin, a synthetic growth hormone–releasing hormone analogue, that has been proposed as a targeted therapy.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Embase, Scopus, Web of Science, and CENTRAL through July 2025 for randomized controlled trials (RCTs) evaluating Tesamorelin versus placebo in adults with HIV. Random-effects meta-analysis was applied. Outcomes included changes in body composition, hepatic and metabolic parameters, hormonal markers, and adverse events. Risk of bias was assessed with RoB 2.0, and certainty of evidence with GRADE.</div></div><div><h3>Results</h3><div>Five RCTs evaluating Tesamorelin were included in the analysis. Tesamorelin was associated with significant reduction in visceral adipose tissue (MD=-27.71 cm², 95 % CI [-38.37, −17.06]; P &lt; 0.001), trunk fat (MD=-1.18 kg, 95 % CI [-1.40, −0.96]; P &lt; 0.001), limb fat (MD=-0.22 kg, 95 % CI [-0.35, −0.08]; P = 0.001), hepatic fat percentage (MD=-4.28 %, 95 % CI [-6.31, −2.24]; P &lt; 0.001), and waist circumference (MD=-1.61 cm, 95 % CI [-2.28, −0.95]; P &lt; 0.001). A significant increase in lean body mass was observed (MD=1.42 kg, 95 % CI [1.13, 1.71]; P &lt; 0.001). However, no significant reductions in subcutaneous adipose tissue or BMI were observed. Tesamorelin showed no significant change in CD4 + T-cell counts. Tesamorelin was associated with adverse events, including arthralgia, myalgia, paresthesia, and injection-site reactions like erythema.</div></div><div><h3>Conclusion</h3><div>Tesamorelin improves body composition, hepatic fat, lean body mass, and IGF-1 levels in HIV-associated lipodystrophy, without serious side effects or perturbation of glucose.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 2-12"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145990154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: “Attention to food in adolescents with obesity: No evidence for increased attentional engagement or reduced attentional disengagement”","authors":"Elif Akçay","doi":"10.1016/j.orcp.2025.12.008","DOIUrl":"10.1016/j.orcp.2025.12.008","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Page 80"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}