Obesity research & clinical practice最新文献

{"title":"Re: “Attention to food in adolescents with obesity: No evidence for increased attentional engagement or reduced attentional disengagement”","authors":"Elif Akçay","doi":"10.1016/j.orcp.2025.12.008","DOIUrl":"10.1016/j.orcp.2025.12.008","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Page 80"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary fiber intake and visceral fat volume: A cross-sectional study based on NHANES 2011–2018","authors":"Jiancheng Bo ,&nbsp;Mingyue Yang ,&nbsp;Qingchao Ru ,&nbsp;Xin Guo","doi":"10.1016/j.orcp.2026.01.003","DOIUrl":"10.1016/j.orcp.2026.01.003","url":null,"abstract":"<div><h3>Background</h3><div>Excessive visceral adipose tissue (VAT) is a key driver of metabolic diseases, yet modifiable dietary strategies for VAT reduction remain underexplored.</div></div><div><h3>Objective</h3><div>This cross-sectional study examined the association between dietary fiber intake and visceral fat volume in U.S. adults.</div></div><div><h3>Methods</h3><div>Using 2011–2018 NHANES data from 9111 adults aged 20–59 years, dietary fiber intake was assessed via two 24-hour recalls, and VAT volume was measured by DXA. Weighted gamma regression models adjusted for age, sex, BMI, and lifestyle factors evaluated dose-response relationships.</div></div><div><h3>Results</h3><div>Higher fiber intake was inversely associated with VAT volume (<em>P</em> for trend &lt;0.001). Compared to the lowest intake group (&lt;15 g/day), adjusted VAT reductions were 4.1 % (95 % CI: 2.3–5.9 %), 7.6 % (4.4–10.6 %), and 6.8 % (2.8–10.6 %) for 15–25, 25–35, and &gt; 35 g/day groups, respectively. Restricted cubic splines confirmed linearity (<em>P</em> = 0.67), with stronger effects in females. Sensitivity analyses excluding extreme intake values (&gt;60 g/day) validated robustness.</div></div><div><h3>Conclusion</h3><div>Increased dietary fiber intake is associated with lower visceral adiposity, suggesting a potential strategy for mitigating metabolic risk in U.S. adults.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"20 1","pages":"Pages 13-20"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145990167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dalmatian hypertensive patients and arterial stiffness study (DALMA-HARES): Blood pressure control, body composition, and lifestyle adherence in a mediterranean population","authors":"Josipa Radić ,&nbsp;Hana Đogaš ,&nbsp;Marijana Vučković ,&nbsp;Andrea Gelemanović ,&nbsp;Mislav Radić","doi":"10.1016/j.orcp.2025.11.004","DOIUrl":"10.1016/j.orcp.2025.11.004","url":null,"abstract":"<div><h3>Background</h3><div>Croatia has high arterial hypertension (AH) and obesity rates, yet comprehensive data on the hypertensive Croatian population are lacking. This study investigated blood pressure control using 24-hour ambulatory blood pressure monitoring (24 h-ABPM) and overall characteristics of Dalmatian hypertensive patients.</div></div><div><h3>Methods</h3><div>This cross-sectional study enrolled 646 participants from an Outpatient Clinic for Arterial Hypertension who were prescribed antihypertensive medication or had confirmed AH by 24 h-ABPM. Participants completed the Morisky Medication Adherence Score and Mediterranean Diet Serving Score questionnaires, underwent body composition measurement, and 24 h-ABPM assessment. Medical records were reviewed.</div></div><div><h3>Results</h3><div>Participants had a median BMI of 28.6 kg/m² (IQR=6.6), with 38 % overweight and 39 % obese. Only 7 % adhered to Mediterranean diet (MeDi) recommendations and 50 % demonstrated high medication adherence. Sex-specific patterns emerged: men showed higher peripheral systolic and diastolic BP (p = 0.039, p = 0.001) and greater rates of unregulated diastolic and combined systolic-diastolic hypertension (p = 0.011), while women exhibited higher heart rate and augmentation index with more isolated systolic BP elevation (all p &lt; 0.001 to p = 0.011).</div></div><div><h3>Conclusions</h3><div>The Dalmatian hypertensive population is characterized by high obesity prevalence (77 %), poor medication adherence (50 %), and low Mediterranean diet adherence (7 %). These findings suggest that integrating routine assessment of medication adherence, dietary patterns, and body composition with 24 h-ABPM may improve hypertension control and reduce cardiovascular complications in this high-risk population.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 6","pages":"Pages 503-510"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term weight loss outcomes in older adults treated with obesity pharmacotherapy","authors":"Sarah Schmitz,&nbsp;Mohammad I. Bhatti,&nbsp;Tariq Chukir,&nbsp;Ampadi Karan,&nbsp;Zoe Verzani,&nbsp;Debra D’Angelo,&nbsp;Louis J. Aronne,&nbsp;Alpana P. Shukla","doi":"10.1016/j.orcp.2025.11.002","DOIUrl":"10.1016/j.orcp.2025.11.002","url":null,"abstract":"<div><h3>Objective</h3><div>Data on long-term outcomes with obesity pharmacotherapy in older adults is limited. This study evaluates the long-term effectiveness and tolerability of combination therapy, including FDA approved and off-label obesity pharmacotherapy, over a mean follow-up duration of 4.4 years in adults 65 years or older compared to younger adults.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of 428 adults aged 18–75 years with overweight or obesity who initiated obesity pharmacotherapy at an academic weight management center between 2014 and 2016. Of these, 75 were 65 years or older. Data were manually extracted from electronic medical records.</div></div><div><h3>Results</h3><div>Weight loss was similar between older and younger cohorts (-11.5 % ± 8.7 vs. −10.1 % ± 10.9, p = 0.243) at a mean follow-up of 4.4 years. A greater proportion of older adults achieved ≥ 5 % weight loss (81 % vs. 69 %, p = 0.027); rates of ≥ 10 %, ≥ 15 %, and ≥ 20 % weight loss were comparable. Obesity pharmacotherapy discontinuation rate due to side effects was similar between groups. Among individuals with prediabetes, the incidence of type 2 diabetes (T2D) progression was 10.7 % in older adults and 4.8 % in younger adults.</div></div><div><h3>Conclusions</h3><div>Older adults maintained clinically significant long-term weight loss with obesity pharmacotherapy, comparable to younger adults, with improvements in metabolic markers.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 6","pages":"Pages 532-535"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145506061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic fat deposition in intestinal wall caused the increase of L cell pyroptosis mainly through local hypoxia","authors":"Yimeng Liu ,&nbsp;Huihui Wu ,&nbsp;Qianwen Ma ,&nbsp;Zhijin Lu ,&nbsp;Pu Zhao ,&nbsp;Xiaoyu Li ,&nbsp;Meiyan Li ,&nbsp;Jie Wen","doi":"10.1016/j.orcp.2025.12.002","DOIUrl":"10.1016/j.orcp.2025.12.002","url":null,"abstract":"<div><h3>Purpose</h3><div><span>L</span>-cell dysfunction occurs in people with obesity, characterized by alterations in glucagon-like peptide-1 (GLP-1) secretion.The mechanism of <span>L</span>-cell dysfunction in obesity is not clear. This study was to reveal the mechanisms of GLP-1 secretion change of intestinal L cells in an obesity state.</div></div><div><h3>Methods</h3><div>The metabolic variables such as the body weight, fasting blood glucose, and blood lipids, GLP-1 secretion, local fat infiltration, hypoxia of the ileum in male mice fed with a high-fat diet (HFD, 60 % kcal from fat) and caloric-restriction diet (CRD, calories were 50 % of HFD group) were investigated. On this basis, intestinal <span>L</span>-cell line GLUTag cells were incubated in vitro under the environment of hypoxia or inflammation to investigate their function changes.</div></div><div><h3>Results</h3><div>The body weight, fasting blood glucose, blood lipids and pro-inffammatories levels of the HFD mice were increased after 2 weeks of feeding. At 6 weeks, the existence of local hypoxia was detected. It appeared simultaneously with the decrease of GLP-1 secretion and <span>L</span>-cell number in ileum.</div><div>In GLUTag cells cultured under hypoxia conditions, expressions of pyrogenic products gasdermin D and IL-18 were increased, cell proliferation activity was inhibited, the overall number was decreased.</div></div><div><h3>Conclusion</h3><div>Ectopic fat deposition of the intestinal wall caused by obesity mainly leads to an exacerbatiion of L cell pyroptosis through local hypoxia.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 6","pages":"Pages 477-489"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of referral, initial assessment, and logistical factors on dropout at an adult weight management service: A semi structured interview study","authors":"Jordan D. Everitt ,&nbsp;Enzo M. Battista-Dowds ,&nbsp;Daniel Heggs ,&nbsp;Amanda LM Squire","doi":"10.1016/j.orcp.2025.10.007","DOIUrl":"10.1016/j.orcp.2025.10.007","url":null,"abstract":"<div><h3>Background</h3><div>Patient retention is crucial to the effectiveness of weight management services; however, high dropout rates are a significant limitation. This study aimed to explore the influence of referral, initial assessment and logistical factors on dropout and retention within an NHS weight management service.</div></div><div><h3>Methods</h3><div>This qualitative study employed semi-structured interviews with 37 patients from an NHS weight management service. Interviews were conducted either face-to-face or via telephone, focusing on the impact of referral processes, initial consultations, intervention selection, and logistical factors on early-stage retention. Interviews were recorded, transcribed verbatim, and analysed thematically.</div></div><div><h3>Results</h3><div>Referrers to the weight management service reportedly had limited knowledge of the service and what it involved, and several participants expressed a desire for more detailed information at referral, which might better shape patient expectations and provide an opportunity for an informed and considered decision about engaging. Initial assessment was perceived as a critical opportunity to influence motivation, though experiences were mixed, and some viewed the appointment as perfunctory and system-focused, as opposed to person centred. Participants reported a desire for explorative discussions to align treatment options with individual needs and preferences. While most participants were satisfied with appointment scheduling and locations, travel-related issues and competing commitments emerged as barriers for a minority.</div></div><div><h3>Conclusion</h3><div>Early engagement stages, particularly referral and initial assessment, are pivotal in shaping patient expectations and a key opportunity to positively influence patient motivation. Participant feedback offers valuable insights for refining service delivery, which could improve retention outcomes in weight management services.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 6","pages":"Pages 526-531"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145409761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging trends and hotspots of the link between gut probiotics and obesity from 2000 to 2024: A bibliometric analysis","authors":"Xiwei Li ,&nbsp;Mengping Wang ,&nbsp;Zhen Zhang ,&nbsp;Jingxin Zhou ,&nbsp;Yufan Xie ,&nbsp;Bin Luo ,&nbsp;Xiaoping Yu ,&nbsp;Yanfeng Zhu ,&nbsp;Peiling Cai","doi":"10.1016/j.orcp.2025.12.001","DOIUrl":"10.1016/j.orcp.2025.12.001","url":null,"abstract":"<div><h3>Background</h3><div>In recent decades, the global prevalence of obesity has surged, intricately linked to hypertension, stroke, type 2 diabetes, cardiovascular diseases, and cancer. However, there has been a lack of bibliometric analysis on the connection between gut probiotics and obesity.</div></div><div><h3>Methods</h3><div>Articles concerning gut probiotics and obesity from 1900 to 2024 were sourced from the Science Citation Index - Expanded of Web of Science Core Collection. Tools such as Microsoft Excel 2019, CiteSpace, VOSviewer, and R packages were employed to visualize publication trends and hotspots in this field.</div></div><div><h3>Results</h3><div>The bibliometric analysis showed that between 2000 and 2024, a total of 4604 research papers and reviews were published across 62 countries/regions. China and China Agricultural University ranked first in terms of total papers published in the past 25 years. Author Cani, Patrice D. had the highest number of publications and citations. The intersection of Nutrition &amp; Dietetics, Food Science &amp; Technology, and Microbiology formed the core knowledge network. Journals like “Nutrients,” “Food &amp; Function,” and “Frontiers in Microbiology” were central to publications. Notably, “stress” and “protects” emerged as hot topics.</div></div><div><h3>Conclusion</h3><div>This study comprehensively reviews 25 - year research on obesity and gut probiotics. Probiotics are crucial for obesity prevention and treatment through multiple mechanisms. Their impacts on obesity - related diseases remain a key research area.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 6","pages":"Pages 457-476"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and early evaluation of OPTIMAP: A digitally enabled nurse-led multidisciplinary pathway for care of people with severe obesity in a Public Australian Health Network","authors":"Matthew Y. Lim ,&nbsp;Katie Belobrajdic ,&nbsp;Melanie Mallee ,&nbsp;Marni A. Nenke ,&nbsp;Melissa Carapetis ,&nbsp;David Jesudason ,&nbsp;Shalvin Prasad ,&nbsp;Adam J. Nelson ,&nbsp;Leonie Heilbronn ,&nbsp;Elena Dicus ,&nbsp;Gary Wittert ,&nbsp;Emily J. Meyer","doi":"10.1016/j.orcp.2025.12.004","DOIUrl":"10.1016/j.orcp.2025.12.004","url":null,"abstract":"<div><div>Public obesity services in Australia face significant challenges including long wait times, fragmented care pathways, limited clinical capacity, and high administrative burden. To address these barriers, the Central Adelaide Local Health Network (CALHN) Metabolic and Bariatric Clinic (CMBC) team developed OPTIMAP (Online Pathway from Triage to Individualised Metabolic Action Plan), a digitally enabled, nurse-led model of care designed to streamline triage, enhance patient activation, and improve multidisciplinary coordination for patients with complex obesity. We outline the development process of OPTIMAP and report early outcomes from the restructured CALHN CMBC.</div><div>OPTIMAP was designed in partnership with clinicians, nursing leaders, CALHN Digital, Digivate Health, and the Personify Care platform. The pathway incorporates a digitally delivered active waitlist comprising comprehensive baseline assessment, modular obesity and obesity-related comorbidity education, behavioural tasks, red-flag monitoring, automated general practitioner communication, appointment reminders and confirmation tools. Clinician dashboards provide real-time visibility of patient progress, engagement, and risk indicators, enabling efficient preparation for personalised care.</div><div>During the first three months post-implementation, clinic capacity increased by 138 % from a pre-implementation mean of 78 appointments per month to 171 appointments per month. Failure-to-attend rates decreased by 31 %, and clinician administrative burden reduced substantially, with direct clinical care time increasing from 29 % to 52 %. Digital engagement was high, with 82 % of patients completing the baseline assessment and over 2800 educational activities completed. Patient and clinician feedback was overwhelmingly positive.</div><div>OPTIMAP represents a scalable method for integrating digital tools and nurse-led coordination to improve obesity-care efficiency and patient preparedness within public health systems.</div></div>","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 6","pages":"Pages 544-548"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Understanding the benefits and psychological burdens of using continuous glucose monitoring for lifestyle change: A mixed-methods cross-sectional study” [Obes Res Clin Pract 19 (5) (2025) 417–426]","authors":"Kelli M. Richardson,&nbsp;Michelle R. Jospe,&nbsp;Jessie Somerville,&nbsp;Julia Felrice,&nbsp;Susan M. Schembre","doi":"10.1016/j.orcp.2025.11.001","DOIUrl":"10.1016/j.orcp.2025.11.001","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 6","pages":"Page 550"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Considerations on the association between body fat percentage and Vitamin D deficiency","authors":"Jiawen Wu ,&nbsp;Yuhan Lou","doi":"10.1016/j.orcp.2025.12.003","DOIUrl":"10.1016/j.orcp.2025.12.003","url":null,"abstract":"","PeriodicalId":19408,"journal":{"name":"Obesity research & clinical practice","volume":"19 6","pages":"Page 549"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}