Neuroscience bulletin最新文献_第4页

Neural Network Mechanisms Underlying General Anesthesia: Cortical and Subcortical Nuclei. 全身麻醉的神经网络机制：皮层和皮层下神经核

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-01 Epub Date: 2024-08-21 DOI: 10.1007/s12264-024-01286-z

Yue Hu, Yun Wang, Lingjing Zhang, Mengqiang Luo, Yingwei Wang

引用次数: 0

A Novel Real-time Phase Prediction Network in EEG Rhythm.

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-29 DOI: 10.1007/s12264-024-01321-z

Hao Liu, Zihui Qi, Yihang Wang, Zhengyi Yang, Lingzhong Fan, Nianming Zuo, Tianzi Jiang

引用次数: 0

Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-28 DOI: 10.1007/s12264-024-01323-x

Zhuoran Ma, Yan Xu, Piaopiao Lian, Yi Wu, Ke Liu, Zhaoyuan Zhang, Zhicheng Tang, Xiaoman Yang, Xuebing Cao

{"title":"Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.","authors":"Zhuoran Ma, Yan Xu, Piaopiao Lian, Yi Wu, Ke Liu, Zhaoyuan Zhang, Zhicheng Tang, Xiaoman Yang, Xuebing Cao","doi":"10.1007/s12264-024-01323-x","DOIUrl":"https://doi.org/10.1007/s12264-024-01323-x","url":null,"abstract":"Depression (Dep) is one of the most common concomitant symptoms of Parkinson's disease (PD), but there is a lack of detailed pathologic evidence for the occurrence of PD-Dep. Currently, the management of symptoms from both conditions using conventional pharmacological interventions remains a formidable task. In this study, we found impaired activation of extracellular signal-related kinase (ERK), reduced levels of transcription and translation, and decreased expression of brain-derived neurotrophic factor (BDNF) in the medial prefrontal cortex (mPFC) of PD-Dep rats. We demonstrated that the abnormal phosphorylation of α-synuclein (pS129) induced tropomyosin-related kinase receptor type B (TrkB) retention at the neuronal cell membrane, leading to BDNF/TrkB signaling dysfunction. We chose SEW2871 as an ameliorator to upregulate ERK phosphorylation. The results showed that PD-Dep rats exhibited improvement in behavioral manifestations of PD and depression. In addition, a reduction in pS129 was accompanied by a restoration of the function of the BDNF/ERK signaling loop in the mPFC of PD-Dep rats.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associative Learning-Induced Synaptic Potentiation at the Two Major Hippocampal CA1 Inputs for Cued Memory Acquisition. 联想学习诱导海马 CA1 两大输入端突触电位增强，促进诱导记忆的获得

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-27 DOI: 10.1007/s12264-024-01327-7

Bing-Ying Wang, Bo Wang, Bo Cao, Ling-Ling Gu, Jiayu Chen, Hua He, Zheng Zhao, Fujun Chen, Zhiru Wang

{"title":"Associative Learning-Induced Synaptic Potentiation at the Two Major Hippocampal CA1 Inputs for Cued Memory Acquisition.","authors":"Bing-Ying Wang, Bo Wang, Bo Cao, Ling-Ling Gu, Jiayu Chen, Hua He, Zheng Zhao, Fujun Chen, Zhiru Wang","doi":"10.1007/s12264-024-01327-7","DOIUrl":"https://doi.org/10.1007/s12264-024-01327-7","url":null,"abstract":"Learning-associated functional plasticity at hippocampal synapses remains largely unexplored. Here, in a single session of reward-based trace conditioning, we examine learning-induced synaptic plasticity in the dorsal CA1 hippocampus (dCA1). Local field-potential recording combined with selective optogenetic inhibition first revealed an increase of dCA1 synaptic responses to the conditioned stimulus (CS) induced during conditioning at both Schaffer collaterals to the stratum radiatum (Rad) and temporoammonic input to the lacunosum moleculare (LMol). At these dCA1 inputs, synaptic potentiation of CS-responding excitatory synapses was further demonstrated by locally blocking NMDA receptors during conditioning and whole-cell recording sensory-evoked synaptic responses in dCA1 neurons from naive animals. An overall similar time course of the induction of synaptic potentiation was found in the Rad and LMol by multiple-site recording; this emerged later and saturated earlier than conditioned behavioral responses. Our experiments demonstrate a cued memory-associated dCA1 synaptic plasticity induced at both Schaffer collaterals and temporoammonic pathways.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ventral Hippocampal CA1 GADD45B Regulates Susceptibility to Social Stress by Influencing NMDA Receptor-Mediated Synaptic Plasticity. 腹侧海马CA1 GADD45B通过影响NMDA受体介导的突触可塑性调节对社会压力的易感性

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-27 DOI: 10.1007/s12264-024-01325-9

Mengbing Huang, Jian Bao, Xiaoqing Tao, Yifan Niu, Kaiwei Li, Ji Wang, Xiaokang Gong, Rong Yang, Yuran Gui, Hongyan Zhou, Yiyuan Xia, Youhua Yang, Binlian Sun, Wei Liu, Xiji Shu

{"title":"Ventral Hippocampal CA1 GADD45B Regulates Susceptibility to Social Stress by Influencing NMDA Receptor-Mediated Synaptic Plasticity.","authors":"Mengbing Huang, Jian Bao, Xiaoqing Tao, Yifan Niu, Kaiwei Li, Ji Wang, Xiaokang Gong, Rong Yang, Yuran Gui, Hongyan Zhou, Yiyuan Xia, Youhua Yang, Binlian Sun, Wei Liu, Xiji Shu","doi":"10.1007/s12264-024-01325-9","DOIUrl":"https://doi.org/10.1007/s12264-024-01325-9","url":null,"abstract":"Growth arrest DNA damage-inducible protein 45 β (GADD45B) has been reported to be a regulatory factor for active DNA demethylation and is implicated in the modulation of synaptic plasticity and chronic stress-related psychopathological processes. However, its precise role and mechanism of action in stress susceptibility remain elusive. In this study, we found a significant reduction in GADD45B expression specifically in the ventral, but not the dorsal hippocampal CA1 (dCA1) of stress-susceptible mice. Furthermore, we demonstrated that GADD45B negatively regulates susceptibility to social stress and NMDA receptor-dependent long-term potentiation (LTP) in the ventral hippocampal CA1 (vCA1). Importantly, through pharmacological inhibition using the NMDA receptor antagonist MK801, we provided further evidence supporting the hypothesis that GADD45B potentially modulates susceptibility to social stress by influencing NMDA receptor-mediated LTP. Collectively, these results suggested that modulation of NMDA receptor-mediated synaptic plasticity is a pivotal mechanism underlying the regulation of susceptibility to social stress by GADD45B.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of Centromedial Amygdala GABAergic Neurons Produces Hypotension in Mice. 激活中央区杏仁核 GABA 能神经元可导致小鼠低血压

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-25 DOI: 10.1007/s12264-024-01317-9

Xiaoyi Wang, Ziteng Yue, Luo Shi, Wei He, Liuqi Shao, Yuhang Liu, Jinye Zhang, Shangyu Bi, Tianjiao Deng, Fang Yuan, Sheng Wang

{"title":"Activation of Centromedial Amygdala GABAergic Neurons Produces Hypotension in Mice.","authors":"Xiaoyi Wang, Ziteng Yue, Luo Shi, Wei He, Liuqi Shao, Yuhang Liu, Jinye Zhang, Shangyu Bi, Tianjiao Deng, Fang Yuan, Sheng Wang","doi":"10.1007/s12264-024-01317-9","DOIUrl":"https://doi.org/10.1007/s12264-024-01317-9","url":null,"abstract":"The central amygdala (CeA) is a crucial modulator of emotional, behavioral, and autonomic functions, including cardiovascular responses. Despite its importance, the specific circuit by which the CeA modulates blood pressure remains insufficiently explored. Our investigations demonstrate that photostimulation of GABAergic neurons in the centromedial amygdala (CeMGABA), as opposed to those in the centrolateral amygdala (CeL), produces a depressor response in both anesthetized and freely-moving mice. In addition, activation of CeMGABA axonal terminals projecting to the nucleus tractus solitarius (NTS) significantly reduces blood pressure. These CeMGABA neurons form synaptic connections with NTS neurons, allowing for the modulation of cardiovascular responses by influencing the caudal or rostral ventrolateral medulla. Furthermore, CeMGABA neurons targeting the NTS receive dense inputs from the CeL. Consequently, stimulation of CeMGABA neurons elicits hypotension through the CeM-NTS circuit, offering deeper insights into the cardiovascular responses associated with emotions and behaviors.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Method for Detecting Depression in Adolescence Based on an Affective Brain-Computer Interface and Resting-State Electroencephalogram Signals. 基于情感脑机接口和静息状态脑电信号的青少年抑郁症检测方法。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-20 DOI: 10.1007/s12264-024-01319-7

Zijing Guan, Xiaofei Zhang, Weichen Huang, Kendi Li, Di Chen, Weiming Li, Jiaqi Sun, Lei Chen, Yimiao Mao, Huijun Sun, Xiongzi Tang, Liping Cao, Yuanqing Li

{"title":"A Method for Detecting Depression in Adolescence Based on an Affective Brain-Computer Interface and Resting-State Electroencephalogram Signals.","authors":"Zijing Guan, Xiaofei Zhang, Weichen Huang, Kendi Li, Di Chen, Weiming Li, Jiaqi Sun, Lei Chen, Yimiao Mao, Huijun Sun, Xiongzi Tang, Liping Cao, Yuanqing Li","doi":"10.1007/s12264-024-01319-7","DOIUrl":"https://doi.org/10.1007/s12264-024-01319-7","url":null,"abstract":"Depression is increasingly prevalent among adolescents and can profoundly impact their lives. However, the early detection of depression is often hindered by the time-consuming diagnostic process and the absence of objective biomarkers. In this study, we propose a novel approach for depression detection based on an affective brain-computer interface (aBCI) and the resting-state electroencephalogram (EEG). By fusing EEG features associated with both emotional and resting states, our method captures comprehensive depression-related information. The final depression detection model, derived through decision fusion with multiple independent models, further enhances detection efficacy. Our experiments involved 40 adolescents with depression and 40 matched controls. The proposed model achieved an accuracy of 86.54% on cross-validation and 88.20% on the independent test set, demonstrating the efficiency of multimodal fusion. In addition, further analysis revealed distinct brain activity patterns between the two groups across different modalities. These findings hold promise for new directions in depression detection and intervention.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IsoVISoR: Towards 3D Mesoscale Brain Mapping of Large Mammals at Isotropic Sub-micron Resolution. IsoVISoR：以各向同性亚微米分辨率绘制大型哺乳动物的三维中尺度脑图。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-16 DOI: 10.1007/s12264-024-01316-w

Chao-Yu Yang, Yan Shen, Xiaoyang Qi, Lufeng Ding, Yanyang Xiao, Qingyuan Zhu, Hao Wang, Cheng Xu, Pak-Ming Lau, Pengcheng Zhou, Fang Xu, Guo-Qiang Bi

引用次数: 0

YAP Signaling in Glia: Pivotal Roles in Neurological Development, Regeneration and Diseases. 胶质细胞中的 YAP 信号：神经发育、再生和疾病中的关键作用。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-06 DOI: 10.1007/s12264-024-01308-w

Lin Lin, Yinfeng Yuan, Zhihui Huang, Yongjie Wang

引用次数: 0

Vascular Ossification in the Developing Brain: A Case Study of Pediatric Sturge Weber Syndrome. 发育中大脑的血管骨化：小儿斯特格-韦伯综合征病例研究》。