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The Medial Prefrontal Cortex-Basolateral Amygdala Circuit Mediates Anxiety in Shank3 InsG3680 Knock-in Mice. 内侧前额叶皮层-基底外侧杏仁核环路介导 Shank3 InsG3680 基因敲入小鼠的焦虑情绪
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-08-29 DOI: 10.1007/s12264-024-01280-5
Jiabin Feng, Xiaojun Wang, Meidie Pan, Chen-Xi Li, Zhe Zhang, Meng Sun, Tailin Liao, Ziyi Wang, Jianhong Luo, Lei Shi, Yu-Jing Chen, Hai-Feng Li, Junyu Xu
{"title":"The Medial Prefrontal Cortex-Basolateral Amygdala Circuit Mediates Anxiety in Shank3 InsG3680 Knock-in Mice.","authors":"Jiabin Feng, Xiaojun Wang, Meidie Pan, Chen-Xi Li, Zhe Zhang, Meng Sun, Tailin Liao, Ziyi Wang, Jianhong Luo, Lei Shi, Yu-Jing Chen, Hai-Feng Li, Junyu Xu","doi":"10.1007/s12264-024-01280-5","DOIUrl":"10.1007/s12264-024-01280-5","url":null,"abstract":"<p><p>Anxiety disorder is a major symptom of autism spectrum disorder (ASD) with a comorbidity rate of ~40%. However, the neural mechanisms of the emergence of anxiety in ASD remain unclear. In our study, we found that hyperactivity of basolateral amygdala (BLA) pyramidal neurons (PNs) in Shank3 InsG3680 knock-in (InsG3680<sup>+/+</sup>) mice is involved in the development of anxiety. Electrophysiological results also showed increased excitatory input and decreased inhibitory input in BLA PNs. Chemogenetic inhibition of the excitability of PNs in the BLA rescued the anxiety phenotype of InsG3680<sup>+/+</sup> mice. Further study found that the diminished control of the BLA by medial prefrontal cortex (mPFC) and optogenetic activation of the mPFC-BLA pathway also had a rescue effect, which increased the feedforward inhibition of the BLA. Taken together, our results suggest that hyperactivity of the BLA and alteration of the mPFC-BLA circuitry are involved in anxiety in InsG3680<sup>+/+</sup> mice.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"77-92"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SARS-CoV-2 Inhibits Exo-Endocytosis and Enhances Short-Term Depression at a Central Synapse. SARS-CoV-2抑制中枢突触的外吞作用并增强其短期抑制作用
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-08-31 DOI: 10.1007/s12264-024-01293-0
Jiawei Hu, Yuhan Zhang, Qingzhuo Liu, Jiaqi Hu, Yichen Ru, Lu Zhang, Lixin Xie, Lei Xue
{"title":"SARS-CoV-2 Inhibits Exo-Endocytosis and Enhances Short-Term Depression at a Central Synapse.","authors":"Jiawei Hu, Yuhan Zhang, Qingzhuo Liu, Jiaqi Hu, Yichen Ru, Lu Zhang, Lixin Xie, Lei Xue","doi":"10.1007/s12264-024-01293-0","DOIUrl":"10.1007/s12264-024-01293-0","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"165-171"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Physiology to Pathology of Astrocytes: Highlighting Their Potential as Therapeutic Targets for CNS Injury. 星形胶质细胞从生理学到病理学：突显其作为中枢神经系统损伤治疗靶点的潜力。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-07-30 DOI: 10.1007/s12264-024-01258-3
Yimin Yuan, Hong Liu, Ziwei Dai, Cheng He, Shangyao Qin, Zhida Su
{"title":"From Physiology to Pathology of Astrocytes: Highlighting Their Potential as Therapeutic Targets for CNS Injury.","authors":"Yimin Yuan, Hong Liu, Ziwei Dai, Cheng He, Shangyao Qin, Zhida Su","doi":"10.1007/s12264-024-01258-3","DOIUrl":"10.1007/s12264-024-01258-3","url":null,"abstract":"<p><p>In the mammalian central nervous system (CNS), astrocytes are the ubiquitous glial cells that have complex morphological and molecular characteristics. These fascinating cells play essential neurosupportive and homeostatic roles in the healthy CNS and undergo morphological, molecular, and functional changes to adopt so-called 'reactive' states in response to CNS injury or disease. In recent years, interest in astrocyte research has increased dramatically and some new biological features and roles of astrocytes in physiological and pathological conditions have been discovered thanks to technological advances. Here, we will review and discuss the well-established and emerging astroglial biology and functions, with emphasis on their potential as therapeutic targets for CNS injury, including traumatic and ischemic injury. This review article will highlight the importance of astrocytes in the neuropathological process and repair of CNS injury.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"131-154"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dentate Gyrus Morphogenesis is Regulated by an Autism Risk Gene Trio Function in Granule Cells. 齿状回形态发生受颗粒细胞中自闭症风险基因三联体功能的调控
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-06-22 DOI: 10.1007/s12264-024-01241-y
Mengwen Sun, Weizhen Xue, Hu Meng, Xiaoxuan Sun, Tianlan Lu, Weihua Yue, Lifang Wang, Dai Zhang, Jun Li
{"title":"Dentate Gyrus Morphogenesis is Regulated by an Autism Risk Gene Trio Function in Granule Cells.","authors":"Mengwen Sun, Weizhen Xue, Hu Meng, Xiaoxuan Sun, Tianlan Lu, Weihua Yue, Lifang Wang, Dai Zhang, Jun Li","doi":"10.1007/s12264-024-01241-y","DOIUrl":"10.1007/s12264-024-01241-y","url":null,"abstract":"<p><p>Autism Spectrum Disorders (ASDs) are reported as a group of neurodevelopmental disorders. The structural changes of brain regions including the hippocampus were widely reported in autistic patients and mouse models with dysfunction of ASD risk genes, but the underlying mechanisms are not fully understood. Here, we report that deletion of Trio, a high-susceptibility gene of ASDs, causes a postnatal dentate gyrus (DG) hypoplasia with a zigzagged suprapyramidal blade, and the Trio-deficient mice display autism-like behaviors. The impaired morphogenesis of DG is mainly caused by disturbing the postnatal distribution of postmitotic granule cells (GCs), which further results in a migration deficit of neural progenitors. Furthermore, we reveal that Trio plays different roles in various excitatory neural cells by spatial transcriptomic sequencing, especially the role of regulating the migration of postmitotic GCs. In summary, our findings provide evidence of cellular mechanisms that Trio is involved in postnatal DG morphogenesis.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1-15"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Transcranial Magnetic Stimulation Comfort: The Role of Electrical Stimulation in Pain Reduction. 提高经颅磁刺激的舒适度：电刺激在减轻疼痛中的作用。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-08-23 DOI: 10.1007/s12264-024-01283-2
Zihui Qi, Zhengyi Yang, Hao Liu, Lingzhong Fan, Nianming Zuo, Tianzi Jiang
{"title":"Enhancing Transcranial Magnetic Stimulation Comfort: The Role of Electrical Stimulation in Pain Reduction.","authors":"Zihui Qi, Zhengyi Yang, Hao Liu, Lingzhong Fan, Nianming Zuo, Tianzi Jiang","doi":"10.1007/s12264-024-01283-2","DOIUrl":"10.1007/s12264-024-01283-2","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"155-158"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational Modeling of the Prefrontal-Cingulate Cortex to Investigate the Role of Coupling Relationships for Balancing Emotion and Cognition. 前额叶-扣带回皮层的计算建模，研究耦合关系在平衡情绪和认知方面的作用。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-06-13 DOI: 10.1007/s12264-024-01246-7
Jinzhao Wei, Licong Li, Jiayi Zhang, Erdong Shi, Jianli Yang, Xiuling Liu
{"title":"Computational Modeling of the Prefrontal-Cingulate Cortex to Investigate the Role of Coupling Relationships for Balancing Emotion and Cognition.","authors":"Jinzhao Wei, Licong Li, Jiayi Zhang, Erdong Shi, Jianli Yang, Xiuling Liu","doi":"10.1007/s12264-024-01246-7","DOIUrl":"10.1007/s12264-024-01246-7","url":null,"abstract":"<p><p>Within the prefrontal-cingulate cortex, abnormalities in coupling between neuronal networks can disturb the emotion-cognition interactions, contributing to the development of mental disorders such as depression. Despite this understanding, the neural circuit mechanisms underlying this phenomenon remain elusive. In this study, we present a biophysical computational model encompassing three crucial regions, including the dorsolateral prefrontal cortex, subgenual anterior cingulate cortex, and ventromedial prefrontal cortex. The objective is to investigate the role of coupling relationships within the prefrontal-cingulate cortex networks in balancing emotions and cognitive processes. The numerical results confirm that coupled weights play a crucial role in the balance of emotional cognitive networks. Furthermore, our model predicts the pathogenic mechanism of depression resulting from abnormalities in the subgenual cortex, and network functionality was restored through intervention in the dorsolateral prefrontal cortex. This study utilizes computational modeling techniques to provide an insight explanation for the diagnosis and treatment of depression.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"33-45"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Intravenous Anesthetics for Neuro: Protection or Toxicity? 静脉麻醉剂对神经系统的作用：保护还是毒性？
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-08-17 DOI: 10.1007/s12264-024-01265-4
Kaixin Wang, Yafeng Wang, Tianhao Zhang, Bingcheng Chang, Daan Fu, Xiangdong Chen
{"title":"The Role of Intravenous Anesthetics for Neuro: Protection or Toxicity?","authors":"Kaixin Wang, Yafeng Wang, Tianhao Zhang, Bingcheng Chang, Daan Fu, Xiangdong Chen","doi":"10.1007/s12264-024-01265-4","DOIUrl":"10.1007/s12264-024-01265-4","url":null,"abstract":"<p><p>The primary intravenous anesthetics employed in clinical practice encompass dexmedetomidine (Dex), propofol, ketamine, etomidate, midazolam, and remimazolam. Apart from their established sedative, analgesic, and anxiolytic properties, an increasing body of research has uncovered neuroprotective effects of intravenous anesthetics in various animal and cellular models, as well as in clinical studies. However, there also exists conflicting evidence pointing to the potential neurotoxic effects of these intravenous anesthetics. The role of intravenous anesthetics for neuro on both sides of protection or toxicity has been rarely summarized. Considering the mentioned above, this work aims to offer a comprehensive understanding of the underlying mechanisms involved both in the central nerve system (CNS) and the peripheral nerve system (PNS) and provide valuable insights into the potential safety and risk associated with the clinical use of intravenous anesthetics.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"107-130"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-dimensional Heterogeneity and Intrinsic Plasticity of the Projection from the Cerebellar Interposed Nucleus to the Ventral Tegmental Area. 小脑间隔核向被盖区投射的三维异质性和内在可塑性
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-08-20 DOI: 10.1007/s12264-024-01285-0
Chen Wang, Si-Yu Wang, Kuang-Yi Ma, Zhao-Xiang Wang, Fang-Xiao Xu, Zhi-Ying Wu, Yan Gu, Wei Chen, Ying Shen, Li-Da Su, Lin Zhou
{"title":"Three-dimensional Heterogeneity and Intrinsic Plasticity of the Projection from the Cerebellar Interposed Nucleus to the Ventral Tegmental Area.","authors":"Chen Wang, Si-Yu Wang, Kuang-Yi Ma, Zhao-Xiang Wang, Fang-Xiao Xu, Zhi-Ying Wu, Yan Gu, Wei Chen, Ying Shen, Li-Da Su, Lin Zhou","doi":"10.1007/s12264-024-01285-0","DOIUrl":"10.1007/s12264-024-01285-0","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"159-164"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurotensin Modulates Emotional Valence Assignment in the Basolateral Amygdala Through Neuromodulator Gain. 神经紧张素通过神经调节剂增益调节杏仁核基底外侧的情绪价值分配
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-07-26 DOI: 10.1007/s12264-024-01269-0
Maimaitishalijiang Abudureheman, Yu-Hao Xiao, Li-Zang Zeng, Hong-Yan Geng
{"title":"Neurotensin Modulates Emotional Valence Assignment in the Basolateral Amygdala Through Neuromodulator Gain.","authors":"Maimaitishalijiang Abudureheman, Yu-Hao Xiao, Li-Zang Zeng, Hong-Yan Geng","doi":"10.1007/s12264-024-01269-0","DOIUrl":"10.1007/s12264-024-01269-0","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"177-180"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141766891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Now You See Me": A Neural Pathway Independent of the Amygdala Responsible for Fear and Anxiety. "现在你看到我了一条独立于杏仁核的神经通路，负责恐惧和焦虑。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-08-23 DOI: 10.1007/s12264-024-01287-y
Xiaojie Zhang, Cenglin Xu, Zhong Chen
{"title":"\"Now You See Me\": A Neural Pathway Independent of the Amygdala Responsible for Fear and Anxiety.","authors":"Xiaojie Zhang, Cenglin Xu, Zhong Chen","doi":"10.1007/s12264-024-01287-y","DOIUrl":"10.1007/s12264-024-01287-y","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"186-188"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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