Neuroscience bulletin最新文献_第4页

Anterior Cingulate Cortex Contributes to the Hyperlocomotion under Nitrogen Narcosis. 前扣带回皮层有助于氮麻醉下的过度运动

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2024-08-19 DOI: 10.1007/s12264-024-01278-z

Bin Peng, Xiao-Bo Wu, Zhi-Jun Zhang, De-Li Cao, Lin-Xia Zhao, Hao Wu, Yong-Jing Gao

{"title":"Anterior Cingulate Cortex Contributes to the Hyperlocomotion under Nitrogen Narcosis.","authors":"Bin Peng, Xiao-Bo Wu, Zhi-Jun Zhang, De-Li Cao, Lin-Xia Zhao, Hao Wu, Yong-Jing Gao","doi":"10.1007/s12264-024-01278-z","DOIUrl":"10.1007/s12264-024-01278-z","url":null,"abstract":"Nitrogen narcosis is a neurological syndrome that manifests when humans or animals encounter hyperbaric nitrogen, resulting in a range of motor, emotional, and cognitive abnormalities. The anterior cingulate cortex (ACC) is known for its significant involvement in regulating motivation, cognition, and action. However, its specific contribution to nitrogen narcosis-induced hyperlocomotion and the underlying mechanisms remain poorly understood. Here we report that exposure to hyperbaric nitrogen notably increased the locomotor activity of mice in a pressure-dependent manner. Concurrently, this exposure induced heightened activation among neurons in both the ACC and dorsal medial striatum (DMS). Notably, chemogenetic inhibition of ACC neurons effectively suppressed hyperlocomotion. Conversely, chemogenetic excitation lowered the hyperbaric pressure threshold required to induce hyperlocomotion. Moreover, both chemogenetic inhibition and genetic ablation of activity-dependent neurons within the ACC reduced the hyperlocomotion. Further investigation revealed that ACC neurons project to the DMS, and chemogenetic inhibition of ACC-DMS projections resulted in a reduction in hyperlocomotion. Finally, nitrogen narcosis led to an increase in local field potentials in the theta frequency band and a decrease in the alpha frequency band in both the ACC and DMS. These results collectively suggest that excitatory neurons within the ACC, along with their projections to the DMS, play a pivotal role in regulating the hyperlocomotion induced by exposure to hyperbaric nitrogen.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"775-789"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents. 更正：用于啮齿动物情境依赖认知研究的虚拟现实平台。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 DOI: 10.1007/s12264-025-01382-8

Xue-Tong Qu, Jin-Ni Wu, Yunqing Wen, Long Chen, Shi-Lei Lv, Li Liu, Li-Jie Zhan, Tian-Yi Liu, Hua He, Yu Liu, Chun Xu

引用次数: 0

A Novel Mouse Model Unveils Protein Deficiency in Truncated CDKL5 Mutations. 一种新的小鼠模型揭示了CDKL5突变缺失中的蛋白质缺陷。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-03-05 DOI: 10.1007/s12264-024-01346-4

Xue Feng, Zi-Ai Zhu, Hong-Tao Wang, Hui-Wen Zhou, Ji-Wei Liu, Ya Shen, Yu-Xian Zhang, Zhi-Qi Xiong

引用次数: 0

Mapping Brain-Wide Neural Activity of Murine Attentional Processing in the Five-Choice Serial Reaction Time Task. 五选择系列反应时间任务中小鼠注意加工的全脑神经活动映射。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-03-22 DOI: 10.1007/s12264-025-01380-w

Yin Yue, Youming Tan, Pin Yang, Shu Zhang, Hongzhen Pan, Yiran Lang, Zengqiang Yuan

{"title":"Mapping Brain-Wide Neural Activity of Murine Attentional Processing in the Five-Choice Serial Reaction Time Task.","authors":"Yin Yue, Youming Tan, Pin Yang, Shu Zhang, Hongzhen Pan, Yiran Lang, Zengqiang Yuan","doi":"10.1007/s12264-025-01380-w","DOIUrl":"10.1007/s12264-025-01380-w","url":null,"abstract":"Attention is the cornerstone of effective functioning in a complex and information-rich world. While the neural activity of attention has been extensively studied in the cortex, the brain-wide neural activity patterns are largely unknown. In this study, we conducted a comprehensive analysis of neural activity across the mouse brain during attentional processing using EEG and c-Fos staining, utilizing hierarchical clustering and c-Fos-based functional network analysis to evaluate the c-Fos activation patterns. Our findings reveal that a wide range of brain regions are activated, notably in the high-order cortex, thalamus, and brain stem regions involved in advanced cognition and arousal regulation, with the central lateral nucleus of the thalamus as a strong hub, suggesting the crucial role of the thalamus in attention control. These results provide valuable insights into the neural network mechanisms underlying attention, offering a foundation for formulating functional hypotheses and conducting circuit-level testing.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"741-758"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zona Incerta: A Bridge for Infant-Mother Interaction. 空间：母婴互动的桥梁。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-02-08 DOI: 10.1007/s12264-025-01361-z

Yawen Huang, Jun Wang, Na Liu, Han Xu

引用次数: 0

Activation of Centromedial Amygdala GABAergic Neurons Produces Hypotension in Mice. 激活中央区杏仁核 GABA 能神经元可导致小鼠低血压

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2024-11-25 DOI: 10.1007/s12264-024-01317-9

Xiaoyi Wang, Ziteng Yue, Luo Shi, Wei He, Liuqi Shao, Yuhang Liu, Jinye Zhang, Shangyu Bi, Tianjiao Deng, Fang Yuan, Sheng Wang

{"title":"Activation of Centromedial Amygdala GABAergic Neurons Produces Hypotension in Mice.","authors":"Xiaoyi Wang, Ziteng Yue, Luo Shi, Wei He, Liuqi Shao, Yuhang Liu, Jinye Zhang, Shangyu Bi, Tianjiao Deng, Fang Yuan, Sheng Wang","doi":"10.1007/s12264-024-01317-9","DOIUrl":"10.1007/s12264-024-01317-9","url":null,"abstract":"The central amygdala (CeA) is a crucial modulator of emotional, behavioral, and autonomic functions, including cardiovascular responses. Despite its importance, the specific circuit by which the CeA modulates blood pressure remains insufficiently explored. Our investigations demonstrate that photostimulation of GABAergic neurons in the centromedial amygdala (CeMGABA), as opposed to those in the centrolateral amygdala (CeL), produces a depressor response in both anesthetized and freely-moving mice. In addition, activation of CeMGABA axonal terminals projecting to the nucleus tractus solitarius (NTS) significantly reduces blood pressure. These CeMGABA neurons form synaptic connections with NTS neurons, allowing for the modulation of cardiovascular responses by influencing the caudal or rostral ventrolateral medulla. Furthermore, CeMGABA neurons targeting the NTS receive dense inputs from the CeL. Consequently, stimulation of CeMGABA neurons elicits hypotension through the CeM-NTS circuit, offering deeper insights into the cardiovascular responses associated with emotions and behaviors.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"759-774"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-invasive Modulation of Deep Brain Nuclei by Temporal Interference Stimulation. 颞叶干扰刺激对脑深部核的无创调节。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-02-08 DOI: 10.1007/s12264-025-01359-7

Long Li, Hao Bai, Linyan Wu, Liang Zheng, Liang Huang, Yang Li, Wenlong Zhang, Jue Wang, Shunnan Ge, Yan Qu, Tian Liu

引用次数: 0

"CATCH ME IF YOU CAN": Unlocking the Hidden Key in Obesity Intervention via the Vagus-Jejunum Axis. “如果你能抓住我”：通过迷走-空肠轴解开肥胖干预的隐藏钥匙。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-03-01 DOI: 10.1007/s12264-025-01368-6

Shuo Zhang, Lingyu Xu, Yila Ding, Cenglin Xu

引用次数: 0

Embracing Internal States: A Review of Optimization of Repetitive Transcranial Magnetic Stimulation for Treating Depression. 拥抱内在状态：重复经颅磁刺激治疗抑郁症的优化研究综述。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-02-20 DOI: 10.1007/s12264-024-01347-3

Tingting Wu, Qiuxuan Yu, Ximei Zhu, Yinjiao Li, Mingyue Zhang, Jiahui Deng, Lin Lu

引用次数: 0

Prediction of Pharmacoresistance in Drug-Naïve Temporal Lobe Epilepsy Using Ictal EEGs Based on Convolutional Neural Network. 基于卷积神经网络的癫痫发作脑电图预测Drug-Naïve颞叶癫痫患者药物耐药。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-01-27 DOI: 10.1007/s12264-025-01350-2

Yiwei Gong, Zheng Zhang, Yuanzhi Yang, Shuo Zhang, Ruifeng Zheng, Xin Li, Xiaoyun Qiu, Yang Zheng, Shuang Wang, Wenyu Liu, Fan Fei, Heming Cheng, Yi Wang, Dong Zhou, Kejie Huang, Zhong Chen, Cenglin Xu

{"title":"Prediction of Pharmacoresistance in Drug-Naïve Temporal Lobe Epilepsy Using Ictal EEGs Based on Convolutional Neural Network.","authors":"Yiwei Gong, Zheng Zhang, Yuanzhi Yang, Shuo Zhang, Ruifeng Zheng, Xin Li, Xiaoyun Qiu, Yang Zheng, Shuang Wang, Wenyu Liu, Fan Fei, Heming Cheng, Yi Wang, Dong Zhou, Kejie Huang, Zhong Chen, Cenglin Xu","doi":"10.1007/s12264-025-01350-2","DOIUrl":"10.1007/s12264-025-01350-2","url":null,"abstract":"Approximately 30%-40% of epilepsy patients do not respond well to adequate anti-seizure medications (ASMs), a condition known as pharmacoresistant epilepsy. The management of pharmacoresistant epilepsy remains an intractable issue in the clinic. Its early prediction is important for prevention and diagnosis. However, it still lacks effective predictors and approaches. Here, a classical model of pharmacoresistant temporal lobe epilepsy (TLE) was established to screen pharmacoresistant and pharmaco-responsive individuals by applying phenytoin to amygdaloid-kindled rats. Ictal electroencephalograms (EEGs) recorded before phenytoin treatment were analyzed. Based on ictal EEGs from pharmacoresistant and pharmaco-responsive rats, a convolutional neural network predictive model was constructed to predict pharmacoresistance, and achieved 78% prediction accuracy. We further found the ictal EEGs from pharmacoresistant rats have a lower gamma-band power, which was verified in seizure EEGs from pharmacoresistant TLE patients. Prospectively, therapies targeting the subiculum in those predicted as \"pharmacoresistant\" individual rats significantly reduced the subsequent occurrence of pharmacoresistance. These results demonstrate a new methodology to predict whether TLE individuals become resistant to ASMs in a classic pharmacoresistant TLE model. This may be of translational importance for the precise management of pharmacoresistant TLE.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"790-804"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0