Neuroscience bulletin最新文献

{"title":"Mitochondrial Gating of the Neuronal Warburg-Like Effect in Neurological Diseases.","authors":"Qinshuai Ni, Yifan Wang, Keli Ge, Shenghan Zhang, Yinuo Liu, Litong Han, Yunliang Guo, Yingjuan Liu","doi":"10.1007/s12264-026-01741-z","DOIUrl":"https://doi.org/10.1007/s12264-026-01741-z","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149299240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial Evoked Potentials are Minimally Influenced by Afferent Feedback From Peripheral Muscle Contraction.","authors":"Mancuso Marco, Guerra Andrea, Fabbrini Andrea, Perretti Carlo, Leodori Giorgio, Lorenzo Rocchi","doi":"10.1007/s12264-026-01729-9","DOIUrl":"https://doi.org/10.1007/s12264-026-01729-9","url":null,"abstract":"<p><p>Transcranial magnetic stimulation with electroencephalography (TMS-EEG) investigates cortical reactivity, yet the contribution of sensory feedback from muscle twitches to the recorded signals remains debated. We combined M1 TMS-EEG with electromyography, accelerometry, and peripheral electrical stimulation to dissociate central and peripheral contributions. We compared EEG responses across trials yielding large versus small motor outputs, while peripheral stimulation isolated pure afferent components. Bayesian analysis revealed that larger motor outputs covaried with distinct EEG morphologies uniformly across all time windows-including those too early for peripheral feedback-indicating that spontaneous fluctuations in baseline motor cortex excitability drive both responses. Conversely, isolated muscle contraction produced delayed (> 65 ms), markedly smaller EEG responses with distinct spatiotemporal profiles. We conclude that sensory feedback from muscle twitches contributes minimally to TMS-evoked EEG responses, which instead primarily reflect the baseline excitability state of the stimulated cortex.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149271277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Contributions and Sensorimotor Encoding of PV and FoxP2 Neurons in the External Globus Pallidus during Perceptual Decision-making.","authors":"Xiaotian Pu, Jingyu Ren, Taorong Xie, Kexin Zou, Jingze Xu, Yaping Li, Dechen Liu, Haishan Yao","doi":"10.1007/s12264-026-01739-7","DOIUrl":"https://doi.org/10.1007/s12264-026-01739-7","url":null,"abstract":"<p><p>The external globus pallidus (GPe), the central nucleus of the basal ganglia, comprises diverse cell types, including parvalbumin (PV) and forkhead box protein P2 (FoxP2) neurons. Their roles in movement regulation and sensory processing are well established; however, their contribution to perceptual decision-making remains unclear. Using a Go/No-Go visual task in mice, we found that optogenetic activation of either population impaired performance, whereas PV inhibition, but not FoxP2 inhibition, disrupted behavioral accuracy. Electrophysiological recordings showed that PV and FoxP2 neurons differentially encoded visual stimuli, licking movements, and trial outcomes. FoxP2 inhibition produced minimal changes in the spontaneous firing of substantia nigra pars reticulata (SNr) neurons. PV inhibition altered spontaneous SNr firing and, together with PV activation, altered task-evoked SNr activity, reducing the preference for reward-predicting stimuli in one subpopulation and unrewarded outcomes in another. These findings reveal the distinct roles of GPe PV and FoxP2 neurons in shaping perceptual decisions and modulating basal ganglia output.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149245652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal Resolution for Neurodegenerative Diseases: Linking Proteinopathy, Cellular Vulnerability, and Disease Trajectories.","authors":"Mengyuan Dong, Chunrong Wang, Zhao Chen, Siyu Ding, Linliu Peng, Hong Jiang","doi":"10.1007/s12264-026-01726-y","DOIUrl":"https://doi.org/10.1007/s12264-026-01726-y","url":null,"abstract":"<p><p>Neurodegenerative diseases (NDs) are a heterogeneous group of disorders characterized by selective and progressive degeneration of specific neuronal populations, often accompanied by glial dysfunction. Despite extensive investigation, proposed pathogenic models remain insufficient to fully explain selective vulnerability and stereotyped spatiotemporal patterns of neurodegeneration across diseases. Spatial omics technologies preserve anatomical context and enable interrogation of cell-type composition, molecular heterogeneity, and intercellular interactions within neural systems. In this review, we synthesize current concepts and technological advances in spatial omics and discuss how these approaches are reshaping our understanding of NDs. Spatial omics provides an integrative framework for linking pathological protein aggregation with selective cellular vulnerability, microenvironment-dependent interactions, and disease progression across molecular, cellular, and anatomical scales. We highlight emerging insights into pathology-associated gene modules, neuron-glia interactions, and mechanisms underlying regional vulnerability. Finally, we discuss multimodal data integration and future directions for translating spatially resolved molecular maps into mechanistic understanding.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149245707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroplastin Suppresses Seizures by Downregulating Endophilin A1 to Promote Internalization of GluA1-AMPA Receptors: Therapeutic Implications of Arbutin.","authors":"Sijun Li, Meiling Chen, Shouhuan Zheng, Xing Wei, Lanfeng Sun, Lei Wei, Yuling Lu, Meigang Ma, Yuan Wu","doi":"10.1007/s12264-026-01732-0","DOIUrl":"https://doi.org/10.1007/s12264-026-01732-0","url":null,"abstract":"<p><p>Status epilepticus (SE) is a critical neurological disorder characterized by an imbalance between excitatory and inhibitory neurotransmission. α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) mediate fast excitatory synaptic transmission, whereas internalization of GluA1-containing AMPARs regulates neuronal excitability. Although neuroplastin (Np) modulates neuronal excitability, its role in GluA1-AMPAR internalization in epilepsy remains unclear. Using single-cell transcriptomics, virtual knockout, in vitro and in vivo epilepsy models, patch-clamp, biochemistry, and behavioral tests, we identified Endophilin A1 (EndoA1) as a key target through which Np regulates GluA1 internalization. In epilepsy models, EndoA1 was upregulated, surface GluA1 levels increased, and receptor internalization was reduced. EndoA1 knockdown decreased the amplitude and frequency of miniature excitatory postsynaptic currents (mEPSCs), promoted GluA1 internalization, prolonged seizure latency, and shortened seizure duration. Np overexpression reduced EndoA1 expression, facilitated GluA1 internalization, and suppressed hyperexcitability, whereas EndoA1 knockdown rescued the Np knockdown-induced phenotype. Network pharmacology and molecular docking studies identified arbutin as an EndoA1-targeting compound that reduced hyperexcitability, mEPSC amplitude, and surface GluA1 in a concentration-dependent manner. These findings establish the Np-EndoA1-GluA1 axis as a key epileptic pathway, whereby Np negatively regulates EndoA1 to promote GluA1-AMPAR internalization and suppress excitability. Arbutin, which targets EndoA1, exerts anti-epileptic effects by modulating excitatory transmission.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149245690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theta-Band Temporal Interference Stimulation Modulates Food Reward Prediction Error Encoding in Individuals with Elevated Food Addiction Symptoms.","authors":"Yatong Wen, Mo Wang, Xinwen Dong, Mateusz Gola, Quanying Liu, Yiheng Tu, Yonghui Li","doi":"10.1007/s12264-026-01738-8","DOIUrl":"https://doi.org/10.1007/s12264-026-01738-8","url":null,"abstract":"<p><p>Prediction error (PE) signals support feedback evaluation and adaptive updating, and are closely linked to medial frontal theta dynamics, particularly within dorsal anterior cingulate cortex (dACC)-centered networks. However, evidence linking these oscillatory mechanisms to the modulation of PE encoding remains limited. Here, we tested whether theta-band modulation of a dACC-centered medial frontal network altered trial-level PE encoding during food-reward processing. In a single-blind, sham-controlled pre-post design, individuals with elevated food addiction symptoms performed a food incentive-delay task while undergoing electroencephalographic recordings combined with theta-band temporal interference stimulation. Single-trial analyses revealed that feedback-related negativity (FRN) amplitudes varied as a function of both behavioral and model-derived prediction errors. Critically, theta-band modulation altered FRN-PE coupling, with the effect most pronounced for unfavorable outcomes, whereas anticipatory activity remained unchanged. These findings support the hypothesis that theta-band modulation can alter feedback-related PE encoding within this population and task context.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystatin C and its Role in the Neuro-Glial-Vascular Unit: Implications for Cerebrovascular Diseases and Neurodegeneration.","authors":"Mingchun Li, Zihao Wang, Zifeng Huang, Xihua Guo, Qing Wang, Xiaobo Wei","doi":"10.1007/s12264-026-01730-2","DOIUrl":"https://doi.org/10.1007/s12264-026-01730-2","url":null,"abstract":"<p><p>Cystatin C (CysC) is emerging as a key regulator and intercellular signaling mediator within the neuro-glial-vascular unit (NGVU). This review comprehensively examines its multifaceted roles across NGVU components, detailing mechanisms by which CysC preserves blood-brain barrier integrity, modulates neuroinflammation, and influences pathological protein aggregation. Rather than providing a merely descriptive catalogue, we emphasize its context-dependent nature. In cerebrovascular and neurodegenerative diseases, CysC exhibits functional duality along the neuron-glia axis, either restraining or perpetuating inflammation and proteinopathy depending on cellular context and disease stage. Similarly, along the endothelial-oligodendrocyte precursor cell crosstalk, its coordination of angiogenesis and myelination may shift from protective to detrimental under chronic hypoperfusion. We evaluate its dual utility as a clinical biomarker and therapeutic target, addressing challenges in brain delivery, target selectivity, and safety. This integrative synthesis provides a critical perspective on unresolved controversies and future research priorities regarding CysC in neurological disorders.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative Modeling of Amygdala Subfields and Disease-Specific Vulnerabilities Across Neurological Disorders.","authors":"Chao Zhang, Lu Bai, Dongli Shi, Wenling Li, Liping Ai, Feng Ao, Yalin Bai, Yutong Bai, Haihua Bao, Qing Cai, Jiancang Cao, Li Chai, Feiyan Chen, Feng Chen, Kun Chen, Yaojing Chen, Dan Cheng, James Cole, Zaixu Cui, Hui Dai, Demao Deng, Xiaozhou Du, Yuhui Du, Xujun Duan, Ying Fu, Zheqi Gao, Lubin Gou, Chunjie Guo, Min Guo, Ya Guo, Xuemei Han, Hongjian He, Yang Hou, Basheng Hu, Jianping Hu, Tiantian Hua, Chuchung Huang, Peiyu Huang, Junqiang Lei, Huijie Li, Jianrui Li, Junlin Li, Kexuan Li, Kuncheng Li, Shaowu Li, Xinyu Li, Yang Li, Yao Li, Yongmei Li, Yunfei Li, Peipeng Liang, Haiyan Liao, Lifang Liao, Bingjie Lin, Ching-Po Lin, Jun Liu, Jungang Liu, Weiqi Liu, Ying Liu, Shanshan Lu, Jie Luo, Yuqi Luo, Su Lui, Hailin Ma, Ning Mao, Lanxi Meng, Linghui Meng, Jun Qiu, Juwei Shao, Qin Shen, Yulu Shi, Zhenyu Shu, Decai Tian, Yiheng Tu, Fei Wang, Jiajia Wang, Jinhui Wang, Junkai Wang, Wen Wang, Xiaochun Wang, Yilong Wang, Yinshan Wang, Yong Wang, Zheng Wang, Jinyuan Weng, Feiyun Wu, Ying Wu, Yuankui Wu, Haiyan Wu, Xiaona Xia, Cheng Xu, Jiaheng Xu, Jun Xu, Rui Xu, Ruimeng Yang, Songtao Yin, Xi Yin, Yulong Yin, Rongjun Yu, Zhen Yuan, Feifei Zhang, Hailian Zhang, Jianguo Zhang, Ningnannan Zhang, Renlong Zhang, Tong Zhang, Yaqin Zhang, Zhiqiang Zhang, Zhihua Zhang, Jian Zhao, Lianping Zhao, Xiaohu Zhao, Xinxiang Zhao, Xin Zhao, Xia Zhe, Fuqing Zhou, Jiajia Zhu, Li Zhu, Zhizheng Zhuo, Guoguang Fan, Yinfeng Qian, Jingxuan Wang, Yunyun Duan, Yaou Liu","doi":"10.1007/s12264-026-01735-x","DOIUrl":"https://doi.org/10.1007/s12264-026-01735-x","url":null,"abstract":"<p><p>As an integrative center of the limbic system, the amygdala and its subfields participate in diverse neural functions and demonstrate heterogeneous structural changes in various neurological disorders. In this study, three-dimensional T1-weighted MRI data from 22,258 healthy participants were analyzed using normative modeling to establish normative references for the volumes of the amygdala and its subfields. These models elucidated the developmental and aging curves of the amygdala and identified distinct ages at peak volume across subfields, ranging from 24.6 to 43.7 years. Based on these references, individual centile scores were calculated for 4132 patients with mild cognitive impairment, Alzheimer's disease, Parkinson's disease, cerebral small vessel disease, multiple sclerosis, and neuromyelitis optica spectrum disorder. These centile scores not only captured disease-specific deviation patterns of the amygdala subfields but also demonstrated utility in disease classification. Moreover, the centile scores correlated with clinical measures of cognitive function, emotional state, and motor performance across disorders. These findings suggest that normative references of the amygdala subfields provide insights into cross-disease alteration patterns and offer potential neuroimaging biomarkers to aid differential diagnosis and clinical assessment.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Spatial Confinement Enhances Memory by Selectively Suppressing Rac1-Dependent Forgetting in Drosophila.","authors":"Yufen Liang, Haocheng Xie, Jiaqi Chen, Qiamian Xiao, Kaikai Huang, Jiran Zhou, Zhen Wang, Yu Cui, Jianzhi Zeng, Qian Li","doi":"10.1007/s12264-026-01734-y","DOIUrl":"https://doi.org/10.1007/s12264-026-01734-y","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RIPK1 Links Metabolic Stresses to Inflammatory and Degenerative Pathways in Alzheimer's Disease.","authors":"Xiaoshi Chen, Chengyu Zou","doi":"10.1007/s12264-026-01736-w","DOIUrl":"https://doi.org/10.1007/s12264-026-01736-w","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}