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The Role of Prefrontal and Posterior Parietal Cortex in Generating Multiple Step Saccades.
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-03-11 DOI: 10.1007/s12264-025-01377-5
Wenbo Ma, Zhaohuan Ding, Leixiao Feng, Xiaoli Li, Mingsha Zhang
{"title":"The Role of Prefrontal and Posterior Parietal Cortex in Generating Multiple Step Saccades.","authors":"Wenbo Ma, Zhaohuan Ding, Leixiao Feng, Xiaoli Li, Mingsha Zhang","doi":"10.1007/s12264-025-01377-5","DOIUrl":"https://doi.org/10.1007/s12264-025-01377-5","url":null,"abstract":"<p><p>While multiple step saccades (MSS) are occasionally reported in the healthy population, they are more evident in patients with Parkinson's disease (PD). Therefore, MSS has been suggested as a biological marker for the diagnosis of PD. However, the lack of clarity on the neural mechanism underlying the generation of MSS largely impedes their application in the clinic. We have proposed recently that MSS are triggered by the discrepancy between desired and executed saccades. Accordingly, brain regions involved in saccadic planning and execution might play a role in the generation of MSS. To test this hypothesis, we explored the role of the prefrontal (PFC) and posterior parietal cortex (PPC) in generating MSS by conducting two experiments: electroencephalographic recording and single-pulse transcranial magnetic stimulation in the PFC or PPC of humans while participants were performing a gap saccade task. We found that the PFC and PPC are involved in the generation of MSS.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Model of Traumatic Optic Neuropathy Under Direct Vision Through the Anterior Orbital Approach in Non-human Primates.
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-03-10 DOI: 10.1007/s12264-025-01372-w
Zhi-Qiang Xiao, Xiu Han, Xin Ren, Zeng-Qiang Wang, Si-Qi Chen, Qiao-Feng Zhu, Hai-Yang Cheng, Yin-Tian Li, Dan Liang, Xuan-Wei Liang, Ying Xu, Hui Yang
{"title":"A Novel Model of Traumatic Optic Neuropathy Under Direct Vision Through the Anterior Orbital Approach in Non-human Primates.","authors":"Zhi-Qiang Xiao, Xiu Han, Xin Ren, Zeng-Qiang Wang, Si-Qi Chen, Qiao-Feng Zhu, Hai-Yang Cheng, Yin-Tian Li, Dan Liang, Xuan-Wei Liang, Ying Xu, Hui Yang","doi":"10.1007/s12264-025-01372-w","DOIUrl":"https://doi.org/10.1007/s12264-025-01372-w","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct Hippocampal and Thalamic Inputs to Layer 3 Pyramidal Cells in the Medial Entorhinal Cortex Revealed by Monosynaptic Rabies Tracing.
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-03-10 DOI: 10.1007/s12264-025-01363-x
Ze Chen, Dietmar Schmitz, John J Tukker
{"title":"Direct Hippocampal and Thalamic Inputs to Layer 3 Pyramidal Cells in the Medial Entorhinal Cortex Revealed by Monosynaptic Rabies Tracing.","authors":"Ze Chen, Dietmar Schmitz, John J Tukker","doi":"10.1007/s12264-025-01363-x","DOIUrl":"https://doi.org/10.1007/s12264-025-01363-x","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-33 Knockout Promotes High Mobility Group Box 1 Release from Astrocytes by Acetylation Mediated by P300/CBP-Associated Factor in Experimental Autoimmune Encephalomyelitis.
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-03-10 DOI: 10.1007/s12264-025-01374-8
Yifan Xiao, Liyan Hao, Xinyi Cao, Yibo Zhang, Qingqing Xu, Luyao Qin, Yixuan Zhang, Yangxingzi Wu, Hongyan Zhou, Mengjuan Wu, Mingshan Pi, Qi Xiong, Youhua Yang, Yuran Gui, Wei Liu, Fang Zheng, Xiji Shu, Yiyuan Xia
{"title":"Interleukin-33 Knockout Promotes High Mobility Group Box 1 Release from Astrocytes by Acetylation Mediated by P300/CBP-Associated Factor in Experimental Autoimmune Encephalomyelitis.","authors":"Yifan Xiao, Liyan Hao, Xinyi Cao, Yibo Zhang, Qingqing Xu, Luyao Qin, Yixuan Zhang, Yangxingzi Wu, Hongyan Zhou, Mengjuan Wu, Mingshan Pi, Qi Xiong, Youhua Yang, Yuran Gui, Wei Liu, Fang Zheng, Xiji Shu, Yiyuan Xia","doi":"10.1007/s12264-025-01374-8","DOIUrl":"https://doi.org/10.1007/s12264-025-01374-8","url":null,"abstract":"<p><p>High mobility group box 1 (HMGB1), when released extracellularly, plays a pivotal role in the development of spinal cord synapses and exacerbates autoimmune diseases within the central nervous system. In experimental autoimmune encephalomyelitis (EAE), a condition that models multiple sclerosis, the levels of extracellular HMGB1 and interleukin-33 (IL-33) have been found to be inversely correlated. However, the mechanism by which IL-33 deficiency enhances HMGB1 release during EAE remains elusive. Our study elucidates a potential signaling pathway whereby the absence of IL-33 leads to increased binding of P300/CBP-associated factor with HMGB1 in the nuclei of astrocytes, upregulating HMGB1 acetylation and promoting its release from astrocyte nuclei in the spinal cord of EAE mice. Conversely, the addition of IL-33 counteracts the TNF-α-induced increase in HMGB1 and acetylated HMGB1 levels in primary astrocytes. These findings underscore the potential of IL-33-associated signaling pathways as a therapeutic target for EAE treatment.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain White Matter Changes in Non-demented Individuals with Color Discrimination Deficits and Their Association with Cognitive Impairment: A NODDI Study.
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-03-07 DOI: 10.1007/s12264-025-01373-9
Jiejun Zhang, Peilin Huang, Lin Lin, Yingzhe Cheng, Weipin Weng, Jiahao Zheng, Yixin Sun, Shaofan Jiang, Xiaodong Pan
{"title":"Brain White Matter Changes in Non-demented Individuals with Color Discrimination Deficits and Their Association with Cognitive Impairment: A NODDI Study.","authors":"Jiejun Zhang, Peilin Huang, Lin Lin, Yingzhe Cheng, Weipin Weng, Jiahao Zheng, Yixin Sun, Shaofan Jiang, Xiaodong Pan","doi":"10.1007/s12264-025-01373-9","DOIUrl":"https://doi.org/10.1007/s12264-025-01373-9","url":null,"abstract":"<p><p>Previous studies have found associations between color discrimination deficits and cognitive impairments besides aging. However, investigations into the microstructural pathology of brain white matter (WM) associated with these deficits remain limited. This study aimed to examine the microstructural characteristics of WM in the non-demented population with abnormal color discrimination, utilizing Neurite Orientation Dispersion and Density Imaging (NODDI), and to explore their correlations with cognitive functions and cognition-related plasma biomarkers. The tract-based spatial statistic analysis revealed significant differences in specific brain regions between the abnormal color discrimination group and the healthy controls, characterized by increased isotropic volume fraction and decreased neurite density index and orientation dispersion index. Further analysis of region-of-interest parameters revealed that the isotropic volume fraction in the bilateral anterior thalamic radiation, superior longitudinal fasciculus, cingulum, and forceps minor was significantly correlated with poorer performance on neuropsychological assessments and to varying degrees various cognition-related plasma biomarkers. These findings provide neuroimaging evidence that WM microstructural abnormalities in non-demented individuals with abnormal color discrimination are associated with cognitive dysfunction, potentially serving as early markers for cognitive decline.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Mouse Model Unveils Protein Deficiency in Truncated CDKL5 Mutations.
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-03-05 DOI: 10.1007/s12264-024-01346-4
Xue Feng, Zi-Ai Zhu, Hong-Tao Wang, Hui-Wen Zhou, Ji-Wei Liu, Ya Shen, Yu-Xian Zhang, Zhi-Qi Xiong
{"title":"A Novel Mouse Model Unveils Protein Deficiency in Truncated CDKL5 Mutations.","authors":"Xue Feng, Zi-Ai Zhu, Hong-Tao Wang, Hui-Wen Zhou, Ji-Wei Liu, Ya Shen, Yu-Xian Zhang, Zhi-Qi Xiong","doi":"10.1007/s12264-024-01346-4","DOIUrl":"https://doi.org/10.1007/s12264-024-01346-4","url":null,"abstract":"<p><p>Mutations in the cyclin-dependent kinase-like 5 gene (CDKL5) cause a severe neurodevelopmental disorder, yet the impact of truncating mutations remains unclear. Here, we introduce the Cdkl5<sup>492stop</sup> mouse model, mimicking C-terminal truncating mutations in patients. 492stop/Y mice exhibit altered dendritic spine morphology and spontaneous seizure-like behaviors, alongside other behavioral deficits. After creating cell lines with various Cdkl5 truncating mutations, we found that these mutations are regulated by the nonsense-mediated RNA decay pathway. Most truncating mutations result in CDKL5 protein loss, leading to multiple disease phenotypes, and offering new insights into the pathogenesis of CDKL5 disorder.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Follistatin, A Novel Therapeutic Target for Chronic Pain.
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-03-02 DOI: 10.1007/s12264-025-01369-5
Huimin Nie, Boyi Liu
{"title":"Follistatin, A Novel Therapeutic Target for Chronic Pain.","authors":"Huimin Nie, Boyi Liu","doi":"10.1007/s12264-025-01369-5","DOIUrl":"https://doi.org/10.1007/s12264-025-01369-5","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
YAP Signaling in Glia: Pivotal Roles in Neurological Development, Regeneration and Diseases. 胶质细胞中的 YAP 信号：神经发育、再生和疾病中的关键作用。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-03-01 Epub Date: 2024-11-06 DOI: 10.1007/s12264-024-01308-w
Lin Lin, Yinfeng Yuan, Zhihui Huang, Yongjie Wang
{"title":"YAP Signaling in Glia: Pivotal Roles in Neurological Development, Regeneration and Diseases.","authors":"Lin Lin, Yinfeng Yuan, Zhihui Huang, Yongjie Wang","doi":"10.1007/s12264-024-01308-w","DOIUrl":"10.1007/s12264-024-01308-w","url":null,"abstract":"<p><p>Yes-associated protein (YAP), the key transcriptional co-factor and downstream effector of the Hippo pathway, has emerged as one of the primary regulators of neural as well as glial cells. It has been detected in various glial cell types, including Schwann cells and olfactory ensheathing cells in the peripheral nervous system, as well as radial glial cells, ependymal cells, Bergmann glia, retinal Müller cells, astrocytes, oligodendrocytes, and microglia in the central nervous system. With the development of neuroscience, understanding the functions of YAP in the physiological or pathological processes of glia is advancing. In this review, we aim to summarize the roles and underlying mechanisms of YAP in glia and glia-related neurological diseases in an integrated perspective.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"501-519"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Current State and Future Outlook of PET Tracers for AMPA Receptors. AMPA受体PET示踪剂的研究现状及展望。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-03-01 Epub Date: 2024-12-11 DOI: 10.1007/s12264-024-01332-w
Ling Li, Shenglin Wen, Ji Dai
{"title":"The Current State and Future Outlook of PET Tracers for AMPA Receptors.","authors":"Ling Li, Shenglin Wen, Ji Dai","doi":"10.1007/s12264-024-01332-w","DOIUrl":"10.1007/s12264-024-01332-w","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"531-535"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Scorpion Venom Heat-Resistant Peptide is Neuroprotective Against Cerebral Ischemia-Reperfusion Injury in Association with the NMDA-MAPK Pathway.
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-03-01 DOI: 10.1007/s12264-024-01340-w
Xu-Gang Wang, Dan-Dan Zhu, Na Li, Yue-Lin Huang, Ying-Zi Wang, Ting Zhang, Chen-Mei Wang, Bin Wang, Yan Peng, Bi-Ying Ge, Shao Li, Jie Zhao
{"title":"Correction to: Scorpion Venom Heat-Resistant Peptide is Neuroprotective Against Cerebral Ischemia-Reperfusion Injury in Association with the NMDA-MAPK Pathway.","authors":"Xu-Gang Wang, Dan-Dan Zhu, Na Li, Yue-Lin Huang, Ying-Zi Wang, Ting Zhang, Chen-Mei Wang, Bin Wang, Yan Peng, Bi-Ying Ge, Shao Li, Jie Zhao","doi":"10.1007/s12264-024-01340-w","DOIUrl":"10.1007/s12264-024-01340-w","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"549-550"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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