Neuroscience bulletin最新文献

Liquid-Liquid Phase Separation in Hereditary Hearing Loss. 遗传性听力损失的液-液相分离。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-09 DOI: 10.1007/s12264-025-01446-9

Kefan Tao, Yanjun Zong, Xiaozhou Liu, Xinyu Shi, Zhengdong Zhao, Yu Sun

引用次数: 0

A Comparative Analysis of Subtyping Methodologies on Cross-sectional sMRI Data. 横断面sMRI数据分型方法的比较分析。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-09 DOI: 10.1007/s12264-025-01462-9

Shirui Zhang, Baitong Zhang, Kun Zhao, Zhuangzhuang Li, Pan Wang, Dawei Wang, Chengyuan Song, Jie Lu, Zengqiang Zhang, Hongxiang Yao, Tong Han, Chunshui Yu, Bo Zhou, Ying Han, Xi Zhang, Pindong Chen, Yong Liu

引用次数: 0

Viewing Psychiatric Disorders Through Viruses: Simple Architecture, Burgeoning Implications. 通过病毒观察精神疾病：简单的结构，迅速发展的影响。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-07 DOI: 10.1007/s12264-025-01443-y

Lingzhuo Kong, Boqing Zhu, Yifan Zhuang, Jianbo Lai, Shaohua Hu

{"title":"Viewing Psychiatric Disorders Through Viruses: Simple Architecture, Burgeoning Implications.","authors":"Lingzhuo Kong, Boqing Zhu, Yifan Zhuang, Jianbo Lai, Shaohua Hu","doi":"10.1007/s12264-025-01443-y","DOIUrl":"https://doi.org/10.1007/s12264-025-01443-y","url":null,"abstract":"A growing interest in the comprehensive pathogenic mechanisms of psychiatric disorders from the perspective of the microbiome has been witnessed in recent decades; the intrinsic link between microbiota and brain function through the microbiota-gut-brain axis or other pathways has gradually been realized. However, little research has focused on viruses-entities characterized by smaller dimensions, simpler structures, greater diversity, and more intricate interactions with their surrounding milieu compared to bacteria. To date, alterations in several populations of bacteriophages and viruses have been documented in both mouse models and patients with psychiatric disorders, including schizophrenia, major depressive disorder, autism spectrum disorder, and Alzheimer's disease, accompanied by metabolic disruptions that may directly or indirectly impact brain function. In addition, eukaryotic virus infection-mediated brain dysfunction provides insights into the psychiatric pathology involving viruses. Efforts towards virus-based diagnostic and therapeutic approaches have primarily been documented. However, limitations due to the lack of large-scale cohort studies, reliability, clinical applicability, and the unclear role of viruses in microbiota interactions pose a challenge for future studies. Nevertheless, it is conceivable that investigations into viruses herald a new era in the field of precise psychiatry.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Driver of Parkinson's Disease: FAM171A2 Facilitates α-Synuclein Uptake and Spread. 帕金森病的新驱动因素：FAM171A2促进α-突触核蛋白的摄取和扩散

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-06 DOI: 10.1007/s12264-025-01449-6

Qiuhan Wang, Tao Qiu, Yiying Hu, Tianbai Li

引用次数: 0

GPR37L1 in Spinal Astrocytes: A Potential Target for Neuropathic Pain Management. 脊髓星形胶质细胞中的GPR37L1：神经性疼痛治疗的潜在靶点。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-04 DOI: 10.1007/s12264-025-01447-8

Jingyang Xu, Yufeng Chen, Lerong Chen, Boyi Liu

引用次数: 0

Astrocyte-Derived CXCL10 Induces Neuronal Tau Hyperphosphorylation and Cognitive Impairments in Sepsis. 星形胶质细胞衍生的CXCL10在败血症中诱导神经元Tau过度磷酸化和认知障碍。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-02 DOI: 10.1007/s12264-025-01445-w

Cuiping Guo, Hang Ruan, Wensheng Li, Yi Liu, Abdoul Razak Yacoubou Mahaman, Qian Guo, You Zhou, Rong Liu, Jianzhi Wang, Chenliang Zhou, Xiaochuan Wang, Shusheng Li

{"title":"Astrocyte-Derived CXCL10 Induces Neuronal Tau Hyperphosphorylation and Cognitive Impairments in Sepsis.","authors":"Cuiping Guo, Hang Ruan, Wensheng Li, Yi Liu, Abdoul Razak Yacoubou Mahaman, Qian Guo, You Zhou, Rong Liu, Jianzhi Wang, Chenliang Zhou, Xiaochuan Wang, Shusheng Li","doi":"10.1007/s12264-025-01445-w","DOIUrl":"https://doi.org/10.1007/s12264-025-01445-w","url":null,"abstract":"Sepsis-associated encephalopathy (SAE) is a severe neurological syndrome marked by widespread brain dysfunctions due to sepsis, yet the underlying mechanisms remain elusive. The current study, using a Lipopolysaccharide (LPS)-induced septic rat model, revealed the hyperphosphorylation of tau and cognitive impairments, accompanied by the release of inflammatory cytokines and activation of glial cells in the hippocampal dentate gyrus region of septic rats. Proteomic and bioinformatic analyses identified C-X-C motif chemokine ligand 10(CXCL10) as a central regulator of neuroinflammation. LPS triggered CXCL10 secretion in astrocytes, and astrocyte-conditioned medium from LPS-treated astrocytes induced tau hyperphosphorylation and synaptic deficits. Recombinant CXCL10 recapitulated these effects in vitro and in vivo. Blocking CXCL10-CXCR3 interaction reversed tau phosphorylation, synaptic impairment, and cognitive decline. Mechanistically, CXCL10-CXCR3 interaction activated CaMKII, driving tau hyperphosphorylation, while CaMKII inhibition restored synaptic protein levels. These findings establish CXCL10 as a key driver of tau pathology in SAE and suggest CXCL10-CXCR3 as a therapeutic target for sepsis-induced cognitive impairments.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 5-HT Descending Facilitation System Contributes to the Disinhibition of Spinal PKCγ Neurons and Neuropathic Allodynia via 5-HT_2C Receptors. 5-羟色胺下降促进系统通过5-羟色胺受体参与脊髓pkc - γ神经元和神经性异常性疼痛的解除抑制。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-01 Epub Date: 2025-03-16 DOI: 10.1007/s12264-025-01383-7

Xiao Zhang, Xiao-Lan He, Zhen-Hua Jiang, Jing Qi, Chen-Chen Huang, Jian-Shuai Zhao, Nan Gu, Yan Lu, Qun Wang

{"title":"The 5-HT Descending Facilitation System Contributes to the Disinhibition of Spinal PKCγ Neurons and Neuropathic Allodynia via 5-HT2C Receptors.","authors":"Xiao Zhang, Xiao-Lan He, Zhen-Hua Jiang, Jing Qi, Chen-Chen Huang, Jian-Shuai Zhao, Nan Gu, Yan Lu, Qun Wang","doi":"10.1007/s12264-025-01383-7","DOIUrl":"10.1007/s12264-025-01383-7","url":null,"abstract":"Neuropathic pain, often featuring allodynia, imposes significant physical and psychological burdens on patients, with limited treatments due to unclear central mechanisms. Addressing this challenge remains a crucial unsolved issue in pain medicine. Our previous study, using protein kinase C gamma (PKCγ)-tdTomato mice, highlights the spinal feedforward inhibitory circuit involving PKCγ neurons in gating neuropathic allodynia. However, the regulatory mechanisms governing this circuit necessitate further elucidation. We used diverse transgenic mice and advanced techniques to uncover the regulatory role of the descending serotonin (5-HT) facilitation system on spinal PKCγ neurons. Our findings revealed that 5-HT neurons from the rostral ventromedial medulla hyperpolarize spinal inhibitory interneurons via 5-HT2C receptors, disinhibiting the feedforward inhibitory circuit involving PKCγ neurons and exacerbating allodynia. Inhibiting spinal 5-HT2C receptors restored the feedforward inhibitory circuit, effectively preventing neuropathic allodynia. These insights offer promising therapeutic targets for neuropathic allodynia management, emphasizing the potential of spinal 5-HT2C receptors as a novel avenue for intervention.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1161-1180"},"PeriodicalIF":5.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oligodendrocyte Precursor Cell-Specific HMGB1 Knockout Reduces Immune Cell Infiltration and Demyelination in Experimental Autoimmune Encephalomyelitis Models. 实验性自身免疫性脑脊髓炎模型中少突胶质前细胞特异性HMGB1敲除减少免疫细胞浸润和脱髓鞘

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-01 Epub Date: 2025-03-20 DOI: 10.1007/s12264-025-01381-9

Gyuree Kim, JiHye Seo, Bokyung Kim, Young-Ho Park, Hong Jun Lee, Fuzheng Guo, Dong-Seok Lee

{"title":"Oligodendrocyte Precursor Cell-Specific HMGB1 Knockout Reduces Immune Cell Infiltration and Demyelination in Experimental Autoimmune Encephalomyelitis Models.","authors":"Gyuree Kim, JiHye Seo, Bokyung Kim, Young-Ho Park, Hong Jun Lee, Fuzheng Guo, Dong-Seok Lee","doi":"10.1007/s12264-025-01381-9","DOIUrl":"10.1007/s12264-025-01381-9","url":null,"abstract":"Infiltration and activation of peripheral immune cells are critical in the progression of multiple sclerosis and its experimental animal model, experimental autoimmune encephalomyelitis (EAE). This study investigates the role of high mobility group box 1 (HMGB1) in oligodendrocyte precursor cells (OPCs) in modulating pathogenic T cells infiltrating the central nervous system through the blood-brain barrier (BBB) by using OPC-specific HMGB1 knockout (KO) mice. We found that HMGB1 released from OPCs promotes BBB disruption, subsequently allowing increased immune cell infiltration. The migration of CD4+ T cells isolated from EAE-induced mice was enhanced when co-cultured with OPCs compared to oligodendrocytes (OLs). OPC-specific HMGB1 KO mice exhibited lower BBB permeability and reduced immune cell infiltration into the CNS, leading to less damage to the myelin sheath and mitigated EAE progression. CD4+ T cell migration was also reduced when co-cultured with HMGB1 knock-out OPCs. Our findings reveal that HMGB1 secretion from OPCs is crucial for regulating immune cell infiltration and provides insights into the immunomodulatory function of OPCs in autoimmune diseases.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1145-1160"},"PeriodicalIF":5.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Strategies for Cognitive Enhancement via Noninvasive Neuromodulation. 通过无创神经调节增强认知的新策略。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-01 Epub Date: 2025-04-21 DOI: 10.1007/s12264-025-01394-4

Hongwei Li, Kun Zhao, Yong Liu

引用次数: 0

Targeting 5-HT to Alleviate Dose-Limiting Neurotoxicity in Nab-Paclitaxel-Based Chemotherapy. 靶向5-HT减轻nab -紫杉醇化疗的剂量限制性神经毒性。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-01 Epub Date: 2025-05-14 DOI: 10.1007/s12264-025-01398-0

Shuangyue Pan, Yu Cai, Ronghui Liu, Shuting Jiang, Hongyang Zhao, Jiahong Jiang, Zhen Lin, Qian Liu, Hongrui Lu, Shuhui Liang, Weijiao Fan, Xiaochen Chen, Yejing Wu, Fangqian Wang, Zheling Chen, Ronggui Hu, Liu Yang

{"title":"Targeting 5-HT to Alleviate Dose-Limiting Neurotoxicity in Nab-Paclitaxel-Based Chemotherapy.","authors":"Shuangyue Pan, Yu Cai, Ronghui Liu, Shuting Jiang, Hongyang Zhao, Jiahong Jiang, Zhen Lin, Qian Liu, Hongrui Lu, Shuhui Liang, Weijiao Fan, Xiaochen Chen, Yejing Wu, Fangqian Wang, Zheling Chen, Ronggui Hu, Liu Yang","doi":"10.1007/s12264-025-01398-0","DOIUrl":"10.1007/s12264-025-01398-0","url":null,"abstract":"Chemotherapy-induced peripheral neurotoxicity (CIPN) is a severe dose-limiting adverse event of chemotherapy. Presently, the mechanism underlying the induction of CIPN remains unclear, and no effective treatment is available. In this study, through metabolomics analyses, we found that nab-paclitaxel therapy markedly increased serum serotonin [5-hydroxtryptamine (5-HT)] levels in both cancer patients and mice compared to the respective controls. Furthermore, nab-paclitaxel-treated enterochromaffin (EC) cells showed increased 5-HT synthesis, and serotonin-treated Schwann cells showed damage, as indicated by the activation of CREB3L3/MMP3/FAS signaling. Venlafaxine, an inhibitor of serotonin and norepinephrine reuptake, was found to protect against nerve injury by suppressing the activation of CREB3L3/MMP3/FAS signaling in Schwann cells. Remarkably, venlafaxine was found to significantly alleviate nab-paclitaxel-induced CIPN in patients without affecting the clinical efficacy of chemotherapy. In summary, our study reveals that EC cell-derived 5-HT plays a critical role in nab-paclitaxel-related neurotoxic lesions, and venlafaxine co-administration represents a novel approach to treating chronic cumulative neurotoxicity commonly reported in nab-paclitaxel-based chemotherapy.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1229-1245"},"PeriodicalIF":5.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0