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YAP Signaling in Glia: Pivotal Roles in Neurological Development, Regeneration and Diseases. 胶质细胞中的 YAP 信号：神经发育、再生和疾病中的关键作用。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-06 DOI: 10.1007/s12264-024-01308-w
Lin Lin, Yinfeng Yuan, Zhihui Huang, Yongjie Wang
{"title":"YAP Signaling in Glia: Pivotal Roles in Neurological Development, Regeneration and Diseases.","authors":"Lin Lin, Yinfeng Yuan, Zhihui Huang, Yongjie Wang","doi":"10.1007/s12264-024-01308-w","DOIUrl":"https://doi.org/10.1007/s12264-024-01308-w","url":null,"abstract":"<p><p>Yes-associated protein (YAP), the key transcriptional co-factor and downstream effector of the Hippo pathway, has emerged as one of the primary regulators of neural as well as glial cells. It has been detected in various glial cell types, including Schwann cells and olfactory ensheathing cells in the peripheral nervous system, as well as radial glial cells, ependymal cells, Bergmann glia, retinal Müller cells, astrocytes, oligodendrocytes, and microglia in the central nervous system. With the development of neuroscience, understanding the functions of YAP in the physiological or pathological processes of glia is advancing. In this review, we aim to summarize the roles and underlying mechanisms of YAP in glia and glia-related neurological diseases in an integrated perspective.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sonic Hedgehog Mediates High Frequency-Dependent Deep Brain Stimulation for the Correction of Motor Deficits in a Parkinson's Disease Model. 音速刺猬介导高频依赖性深部脑刺激以纠正帕金森病模型的运动障碍
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-06 DOI: 10.1007/s12264-024-01306-y
Hui Zhang, Yujuan Su, Zhongwei Qu, Chunkui Zhang, Shaorong Ma, Xia Li, Yizheng Wang
{"title":"Sonic Hedgehog Mediates High Frequency-Dependent Deep Brain Stimulation for the Correction of Motor Deficits in a Parkinson's Disease Model.","authors":"Hui Zhang, Yujuan Su, Zhongwei Qu, Chunkui Zhang, Shaorong Ma, Xia Li, Yizheng Wang","doi":"10.1007/s12264-024-01306-y","DOIUrl":"https://doi.org/10.1007/s12264-024-01306-y","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular Ossification in the Developing Brain: A Case Study of Pediatric Sturge Weber Syndrome. 发育中大脑的血管骨化：小儿斯特格-韦伯综合征病例研究》。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-06 DOI: 10.1007/s12264-024-01311-1
Ranxi Chen, Shuhui Xie, Jin Gao, Shuli Zhang, Xiaobin Zhang, Yi Yao, Gengxiu Zheng, Fengpeng Wang, Zili Liu, Xuefeng Shen
{"title":"Vascular Ossification in the Developing Brain: A Case Study of Pediatric Sturge Weber Syndrome.","authors":"Ranxi Chen, Shuhui Xie, Jin Gao, Shuli Zhang, Xiaobin Zhang, Yi Yao, Gengxiu Zheng, Fengpeng Wang, Zili Liu, Xuefeng Shen","doi":"10.1007/s12264-024-01311-1","DOIUrl":"https://doi.org/10.1007/s12264-024-01311-1","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurodegenerative Diseases: What Can Be Learned from Toothed Whales? 神经退行性疾病：从齿鲸身上能学到什么？
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-01 DOI: 10.1007/s12264-024-01310-2
Simona Sacchini
{"title":"Neurodegenerative Diseases: What Can Be Learned from Toothed Whales?","authors":"Simona Sacchini","doi":"10.1007/s12264-024-01310-2","DOIUrl":"https://doi.org/10.1007/s12264-024-01310-2","url":null,"abstract":"<p><p>Neurodegeneration involves a wide range of neuropathological alterations affecting the integrity, physiology, and architecture of neural cells. Many studies have demonstrated neurodegeneration in different animals. In the case of Alzheimer's disease (AD), spontaneous animal models should display two neurohistopathological hallmarks: the deposition of β-amyloid and the arrangement of neurofibrillary tangles. However, no natural animal models that fulfill these conditions have been reported and most research into AD has been performed using transgenic rodents. Recent studies have also demonstrated that toothed whales - homeothermic, long-lived, top predatory marine mammals - show neuropathological signs of AD-like pathology. The neuropathological hallmarks in these cetaceans could help to better understand their endangered health as well as neurodegenerative diseases in humans. This systematic review analyzes all the literature published to date on this trending topic and the proposed causes for neurodegeneration in these iconic marine mammals are approached in the context of One Health/Planetary Health and translational medicine.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional Connectivity Encodes Sound Locations by Lateralization Angles. 功能连接通过侧化角度编码声音位置
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-10-29 DOI: 10.1007/s12264-024-01312-0
Renjie Tong, Shaoyi Su, Ying Liang, Chunlin Li, Liwei Sun, Xu Zhang
{"title":"Functional Connectivity Encodes Sound Locations by Lateralization Angles.","authors":"Renjie Tong, Shaoyi Su, Ying Liang, Chunlin Li, Liwei Sun, Xu Zhang","doi":"10.1007/s12264-024-01312-0","DOIUrl":"https://doi.org/10.1007/s12264-024-01312-0","url":null,"abstract":"<p><p>The ability to localize sound sources rapidly allows human beings to efficiently understand the surrounding environment. Previous studies have suggested that there is an auditory \"where\" pathway in the cortex for processing sound locations. The neural activation in regions along this pathway encodes sound locations by opponent hemifield coding, in which each unilateral region is activated by sounds coming from the contralateral hemifield. However, it is still unclear how these regions interact with each other to form a unified representation of the auditory space. In the present study, we investigated whether functional connectivity in the auditory \"where\" pathway encoded sound locations during passive listening. Participants underwent functional magnetic resonance imaging while passively listening to sounds from five distinct horizontal locations (-90°, -45°, 0°, 45°, 90°). We were able to decode sound locations from the functional connectivity patterns of the \"where\" pathway. Furthermore, we found that such neural representation of sound locations was primarily based on the coding of sound lateralization angles to the frontal midline. In addition, whole-brain analysis indicated that functional connectivity between occipital regions and the primary auditory cortex also encoded sound locations by lateralization angles. Overall, our results reveal a lateralization-angle-based representation of sound locations encoded by functional connectivity patterns, which could add on the activation-based opponent hemifield coding to provide a more precise representation of the auditory space.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VTA is the Key to Pain Resilience in Empathic Behavior. VTA是移情行为中疼痛复原力的关键
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-10-28 DOI: 10.1007/s12264-024-01313-z
Xue-Qing Wu, Yi-La Ding, Yu Du, Zhong Chen, Bei Tan
{"title":"VTA is the Key to Pain Resilience in Empathic Behavior.","authors":"Xue-Qing Wu, Yi-La Ding, Yu Du, Zhong Chen, Bei Tan","doi":"10.1007/s12264-024-01313-z","DOIUrl":"https://doi.org/10.1007/s12264-024-01313-z","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Postnatal Pharmacological Intervention Rescues the Disruption of Developmental Connectivity in MAO-A KO Mice. 产后早期药物干预可挽救 MAO-A KO 小鼠发育连通性的破坏
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-10-24 DOI: 10.1007/s12264-024-01304-0
Qian Xue, Hanpeng Xu, Muye Zhu, Bin Qian, Lei Gao, Lin Gou, Houri Hintiryan, Jean C Shih, Hong-Wei Dong
{"title":"Early Postnatal Pharmacological Intervention Rescues the Disruption of Developmental Connectivity in MAO-A KO Mice.","authors":"Qian Xue, Hanpeng Xu, Muye Zhu, Bin Qian, Lei Gao, Lin Gou, Houri Hintiryan, Jean C Shih, Hong-Wei Dong","doi":"10.1007/s12264-024-01304-0","DOIUrl":"https://doi.org/10.1007/s12264-024-01304-0","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Right Frontal Gamma Transcranial Alternating Current Stimulation Modulates Optimism Biases. 右额叶伽马经颅交流电刺激可调节乐观偏差
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-10-19 DOI: 10.1007/s12264-024-01307-x
Ziqing Yao, Jinwen Wei, Gan Huang, Linling Li, Zhen Liang, Li Zhang, Haiyan Wu, Tifei Yuan, Zhiguo Zhang, Xiaoqing Hu
{"title":"Right Frontal Gamma Transcranial Alternating Current Stimulation Modulates Optimism Biases.","authors":"Ziqing Yao, Jinwen Wei, Gan Huang, Linling Li, Zhen Liang, Li Zhang, Haiyan Wu, Tifei Yuan, Zhiguo Zhang, Xiaoqing Hu","doi":"10.1007/s12264-024-01307-x","DOIUrl":"https://doi.org/10.1007/s12264-024-01307-x","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tracing from Periphery to Cortex: Application of Herpes Simplex Virus to Somatosensory Neural Networks. 从外周追踪到皮层：单纯疱疹病毒在体感神经网络中的应用。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-10-16 DOI: 10.1007/s12264-024-01309-9
Yan Chen, Qin Chen, Yuran Song, Huadong Wang, Xinyu Hu, Kaikai Wang, Xuanyuan Wu, Fuqiang Xu, Lan Bao, Xu Zhang
{"title":"Tracing from Periphery to Cortex: Application of Herpes Simplex Virus to Somatosensory Neural Networks.","authors":"Yan Chen, Qin Chen, Yuran Song, Huadong Wang, Xinyu Hu, Kaikai Wang, Xuanyuan Wu, Fuqiang Xu, Lan Bao, Xu Zhang","doi":"10.1007/s12264-024-01309-9","DOIUrl":"https://doi.org/10.1007/s12264-024-01309-9","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loss of TET Activity in the Postnatal Mouse Brain Perturbs Synaptic Gene Expression and Impairs Cognitive Function. 出生后小鼠大脑中 TET 活性的丧失会干扰突触基因表达并损害认知功能
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-10-12 DOI: 10.1007/s12264-024-01302-2
Ji-Wei Liu, Ze-Qiang Zhang, Zhi-Chuan Zhu, Kui Li, Qiwu Xu, Jing Zhang, Xue-Wen Cheng, Han Li, Ying Sun, Ji-Jun Wang, Lu-Lu Hu, Zhi-Qi Xiong, Yongchuan Zhu
{"title":"Loss of TET Activity in the Postnatal Mouse Brain Perturbs Synaptic Gene Expression and Impairs Cognitive Function.","authors":"Ji-Wei Liu, Ze-Qiang Zhang, Zhi-Chuan Zhu, Kui Li, Qiwu Xu, Jing Zhang, Xue-Wen Cheng, Han Li, Ying Sun, Ji-Jun Wang, Lu-Lu Hu, Zhi-Qi Xiong, Yongchuan Zhu","doi":"10.1007/s12264-024-01302-2","DOIUrl":"https://doi.org/10.1007/s12264-024-01302-2","url":null,"abstract":"<p><p>Conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) by ten-eleven translocation (TET) family proteins leads to the accumulation of 5hmC in the central nervous system; however, the role of 5hmC in the postnatal brain and how its levels and target genes are regulated by TETs remain elusive. We have generated mice that lack all three Tet genes specifically in postnatal excitatory neurons. These mice exhibit significantly reduced 5hmC levels, altered dendritic spine morphology within brain regions crucial for cognition, and substantially impaired spatial and associative memories. Transcriptome profiling combined with epigenetic mapping reveals that a subset of genes, which display changes in both 5hmC/5mC levels and expression patterns, are involved in synapse-related functions. Our findings provide insight into the role of postnatally accumulated 5hmC in the mouse brain and underscore the impact of 5hmC modification on the expression of genes essential for synapse development and function.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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