Neuroscience bulletin最新文献

Fat on Fire: Disrupted Microglial Lipid Metabolism as a Driver of Anesthetic Neurotoxicity. 燃烧的脂肪：破坏小胶质脂质代谢作为麻醉神经毒性的驱动因素。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2026-04-28 DOI: 10.1007/s12264-026-01623-4

Yu-Jie Mou, Hai-Yue Tu, Yi-Chan Wang, Shao-Yong Song, Hua-Yue Liu, Dong Wang, Jun-Chao Wu, Xiao-Wen Meng, Zheng-Hong Qin, Fu-Hai Ji

引用次数: 0

ErbB4 in the Dorsolateral Prefrontal Cortex is Required for Sensory Gating and Working Memory in Monkey. 猴背外侧前额叶皮层ErbB4在感觉门控和工作记忆中是必需的。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2026-04-28 DOI: 10.1007/s12264-026-01626-1

Minzhe Yang, Yingying Han, Hongfei Zhang, Chaolin Ma, Lin Mei, Baoming Li

引用次数: 0

Imaging Genomics Across Primate Species: Advancing Understanding of Neurological and Psychiatric Disorders. 跨灵长类物种的成像基因组学：推进对神经和精神疾病的理解。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2026-04-28 DOI: 10.1007/s12264-026-01627-0

Tingting Bo, Yichun Huang, Yong Lu, Yang Song, Jiangtao Zhang, Jianmin Zhang, Heqiu Wang, Zheng Wang

{"title":"Imaging Genomics Across Primate Species: Advancing Understanding of Neurological and Psychiatric Disorders.","authors":"Tingting Bo, Yichun Huang, Yong Lu, Yang Song, Jiangtao Zhang, Jianmin Zhang, Heqiu Wang, Zheng Wang","doi":"10.1007/s12264-026-01627-0","DOIUrl":"https://doi.org/10.1007/s12264-026-01627-0","url":null,"abstract":"This review delves into brain imaging genomics, an interdisciplinary field merging brain imaging, genomics, and additional biomarkers with clinical data. The primary aim is to uncover new insights into the brain's phenotypic, genetic, and molecular characteristics. We emphasize recent advances in genome-wide association studies and transcriptome-wide association studies, especially their integration with MRI-derived phenotypes in humans. These studies are crucial for understanding how various factors influence brain structure and function in normal and pathological states. Furthermore, this review highlights imaging transcriptomics progress in non-human primates, essential for elucidating brain organization and improving animal models evolutionarily to bridge gaps in understanding human disorders. We conclude that brain imaging genomics is set to transform research in neurological and psychiatric disorders, owing to its holistic approach that merges advanced genetic analysis with detailed imaging, will deepen our understanding of the brain, and usher in a new epoch in brain imaging research.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Theoretical Evolution of Social Memory and the Core Contribution of the Medial Prefrontal Cortex. 社会记忆的理论演化及内侧前额叶皮层的核心作用。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2026-04-28 DOI: 10.1007/s12264-026-01625-2

Tianyu Li, Xiaohui Zhang

引用次数: 0

Cholesterol in Myelin: Supply Routes, Pathological Consequences, Biophysical Governance, and Future Frontiers. 髓磷脂中的胆固醇：供应途径，病理后果，生物物理治理和未来前沿。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2026-04-25 DOI: 10.1007/s12264-026-01629-y

Xinyu Zhu, Fan Zhang, Jian Wang, Guannan Wang, Jiajia Wang

引用次数: 0

Epigenetic Tuning of TSC: A Metabolic Master Switch for Human Neocortical Expansion. TSC的表观遗传调控：人类新皮质扩展的代谢主开关。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2026-04-12 DOI: 10.1007/s12264-026-01628-z

Jun-Wei Cao, Yinghui Fu

引用次数: 0

Engineered Alzheimer Organoids Validate the Link Between Intracellular and Soluble p-Tau Biomarkers and Highlight the Contribution of Astrocytic Tau. 工程阿尔茨海默病类器官验证细胞内和可溶性p-Tau生物标志物之间的联系，并强调星形细胞Tau的贡献。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2026-04-11 DOI: 10.1007/s12264-026-01615-4

Ru Zhang, Xiaoxu Dong, Gang Pei, Shichao Huang

{"title":"Engineered Alzheimer Organoids Validate the Link Between Intracellular and Soluble p-Tau Biomarkers and Highlight the Contribution of Astrocytic Tau.","authors":"Ru Zhang, Xiaoxu Dong, Gang Pei, Shichao Huang","doi":"10.1007/s12264-026-01615-4","DOIUrl":"https://doi.org/10.1007/s12264-026-01615-4","url":null,"abstract":"Soluble phosphorylated tau has become a key biomarker for Alzheimer's disease pathology, yet further mechanistic studies are needed beyond observational investigations to clarify the relationship between soluble p-tau species and intracellular tau pathology. Here, we utilized chimeric human cerebral organoids (chCOs) to generate a series of organoids in which the endogenous MAPT gene was CRISPR/Cas9 edited in different cell types to create phosphorylation-deficient mutants at the AD-associated sites. We found that the APPswe mutation increased tau phosphorylation in both neurons and astrocytes. Notably, astrocyte-specific phosphorylation-deficient mutations of tau in organoids reduced soluble p-tau181 and p-tau217 levels, as detected by single-molecule array. These findings indicate that astrocytic tau plays a substantial role in contributing to the pool of extracellular phosphorylated tau and suggest it may be an overlooked source of AD biomarkers. Moreover, our engineered chCOs offer a versatile platform for exploring how cell-type-specific pathologies correlate with changes in biomarker profiles.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Fgr-STAT3 Mediated Autophagy Inhibition in the Spinal Cord Alleviates Neuropathic Pain in Rats. 靶向Fgr-STAT3介导的脊髓自噬抑制减轻大鼠神经性疼痛。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2026-04-09 DOI: 10.1007/s12264-026-01616-3

Liqiong He, Yu Zhang, Chunguang Yang, Zhifeng Huang, Kailu Zou, Qingwei Deng, Jianxi Zhang, Malijiang Mulati, Bei Sun, Qulian Guo, Changsheng Huang

{"title":"Targeting Fgr-STAT3 Mediated Autophagy Inhibition in the Spinal Cord Alleviates Neuropathic Pain in Rats.","authors":"Liqiong He, Yu Zhang, Chunguang Yang, Zhifeng Huang, Kailu Zou, Qingwei Deng, Jianxi Zhang, Malijiang Mulati, Bei Sun, Qulian Guo, Changsheng Huang","doi":"10.1007/s12264-026-01616-3","DOIUrl":"https://doi.org/10.1007/s12264-026-01616-3","url":null,"abstract":"The effective treatment of neuropathic pain continues to be a major clinical hurdle, largely because its pathogenic mechanisms are incompletely defined. This study identifies Fgr kinase as a central player in governing autophagy within spinal microglia during the development of neuropathic pain. Using a rat model of chronic constriction injury (CCI), we found that damage to peripheral nerves causes a prolonged increase in Fgr expression specifically in microglia of the spinal dorsal horn (SDH). Genetic interventions and behavioral analyses demonstrated that Fgr overexpression induced pain symptoms, whereas Fgr knockdown alleviated pain hypersensitivity. Mechanistically, Fgr directly phosphorylated STAT3, promoting its nuclear translocation and suppressing autophagic flux, evidenced by reduced LC3-II/LC3-I ratio, accumulated SQSTM1, and diminished autophagosomes. Pharmacological inhibition of Fgr by intrathecal TL02-59 (10 μg/kg) restored autophagy, attenuated STAT3 activation, and reversed CCI-induced neuropathic pain behaviors. These findings position the Fgr-STAT3 axis as a tractable target to normalize microglial autophagy and alleviate neuropathic pain.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Life Cycle and Circadian Rhythms in Central Resident Immunity and Neuropsychiatric Pathology. 中枢居民免疫和神经精神病理学的生命周期和昼夜节律。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2026-04-06 DOI: 10.1007/s12264-026-01612-7

Zhixin Lim, Ha Linh Nguyen, Yuanyuan Zeng, Qigngyue Qu, Yan Le, Ming Sun, Xiaoyu Wang, Hong Zhu, Yuchen Qian, Saboor Saeed, Huaizhi Wang, Dazhong Rong, Yueming Wang, Xuhong Zhang, Shaohua Hu

{"title":"Life Cycle and Circadian Rhythms in Central Resident Immunity and Neuropsychiatric Pathology.","authors":"Zhixin Lim, Ha Linh Nguyen, Yuanyuan Zeng, Qigngyue Qu, Yan Le, Ming Sun, Xiaoyu Wang, Hong Zhu, Yuchen Qian, Saboor Saeed, Huaizhi Wang, Dazhong Rong, Yueming Wang, Xuhong Zhang, Shaohua Hu","doi":"10.1007/s12264-026-01612-7","DOIUrl":"https://doi.org/10.1007/s12264-026-01612-7","url":null,"abstract":"The central resident immune system, commonly known as the glial system, comprises various glial cells that play a critical role in neuropsychiatric disorders. However, a systematic review exploring the relationships between the life cycles and daily rhythms of these immune cells and the pathological features of neuropsychiatric disorders is lacking. These immune cells exhibit unique developmental origins and circadian characteristics, resulting in rhythmic variations in functions such as phagocytosis, immune clearance, neurogenesis, and neurotransmitter recycling. These properties are crucial for understanding the pathological mechanisms underlying developmental disorders like major depressive disorder, autism spectrum disorder, and schizophrenia, as well as age-related conditions such as Alzheimer's and Parkinson's diseases. The daily rhythms of these immune cells correlate with diurnal variations in emotion, cognition, and motor function, involving shared processes like oxidative stress and neuroinflammation. This article systematically reviews the composition, life cycle changes, and circadian characteristics of central immune cells, highlighting their roles in neuropsychiatric diseases.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the "Glycolysis-Lactate-Lactylation" Axis: A Novel Target in Ischemic Cerebrovascular Disease. 揭示“糖酵解-乳酸-乳酸化”轴：缺血性脑血管病的新靶点。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2026-04-06 DOI: 10.1007/s12264-026-01622-5

Yi Xie, Mengmeng Dai, Rui Liu, Ying Li, Hao Yan, Jiacheng Li, Xuantong Liu, Zhiyuan Yu, Shabei Xu, Wei Wang, Xiang Luo

{"title":"Unveiling the \"Glycolysis-Lactate-Lactylation\" Axis: A Novel Target in Ischemic Cerebrovascular Disease.","authors":"Yi Xie, Mengmeng Dai, Rui Liu, Ying Li, Hao Yan, Jiacheng Li, Xuantong Liu, Zhiyuan Yu, Shabei Xu, Wei Wang, Xiang Luo","doi":"10.1007/s12264-026-01622-5","DOIUrl":"https://doi.org/10.1007/s12264-026-01622-5","url":null,"abstract":"Ischemic cerebrovascular disease involves complex interactions between metabolic reprogramming and epigenetic regulation. Recent studies indicate that enhanced glycolysis and lactate accumulation under hypoxic conditions not only maintain cell viability by supplying energy but also participate in disease regulation through lactylation. Lactylation regulates gene expression, immune polarization, metabolic enzyme activity, and angiogenesis through epigenetic remodeling. In ischemic cerebrovascular disease, lactylation exerts dual roles: on one hand, it can induce neuronal death, exacerbate neuroinflammation, and form a vicious metabolic cycle; on the other hand, it can influence immune cell function and gene expression, thereby exerting neuroprotective effects. Accordingly, targeting lactate metabolism or lactylation-modifying enzymes holds considerable therapeutic potential. Nevertheless, the spatiotemporal regulation, synergistic effects, and broader physiopathological implications of lactylation warrant further in-depth investigation. This review systematically summarizes the role of the \"glycolysis-lactate-lactylation\" axis in the pathogenesis of ischemic cerebrovascular disease, and discusses its potential as a therapeutic target.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0