Neuroscience bulletin最新文献

Physical Activity and Depressive Mood Share the Structural Connectivity Between Motor and Reward Networks. 体育活动和抑郁情绪在运动和奖励网络之间共享结构连接。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-10-01 DOI: 10.1007/s12264-025-01501-5

Shiqi Di, Na Luo, Weiyang Shi, Zhengyi Yang, Jing Sui, Rongtao Jiang, Yue Cui, Zongchang Du, Jiaqi Zhang, Yawei Ma, Haiyan Wang, Congying Chu, Yuejia Zhong, Wen Li, Yuheng Lu, Hao Yan, Jinmin Liao, Dai Zhang, Vince Calhoun, Ming Song, Tianzi Jiang

{"title":"Physical Activity and Depressive Mood Share the Structural Connectivity Between Motor and Reward Networks.","authors":"Shiqi Di, Na Luo, Weiyang Shi, Zhengyi Yang, Jing Sui, Rongtao Jiang, Yue Cui, Zongchang Du, Jiaqi Zhang, Yawei Ma, Haiyan Wang, Congying Chu, Yuejia Zhong, Wen Li, Yuheng Lu, Hao Yan, Jinmin Liao, Dai Zhang, Vince Calhoun, Ming Song, Tianzi Jiang","doi":"10.1007/s12264-025-01501-5","DOIUrl":"https://doi.org/10.1007/s12264-025-01501-5","url":null,"abstract":"In various studies, exercise has been revealed to have a positive effect on alleviating depressive symptoms. However, the neural basis behind this phenomenon remains unknown, as well as its underlying biological mechanism. In this study, we used a large neuroimaging cohort [n = 1,027, major depressive disorder (MDD)/healthy controls (HCs) = 492/535] from the UK Biobank to identify structural connectivity (SC) patterns simultaneously linked with physical activity and depression, as well as the biological interpretation. An SC pattern linked with exercise was identified to be both significantly correlated with depressive mood and group discrimination between MDDs and HCs, primarily located between the motor-related regions and reward-related regions. This pattern was associated with multiple neurotransmitter receptors, such as serotonin and GABA receptors, and enriched in pathways like synaptic signaling and the astrocyte cell type. The SC pattern and genetic results were also replicated in another independent MDD dataset (n = 3,496) and present commonalities with bipolar disorder (n = 81). Overall, these findings not only initially identified a reproducible shared SC pattern between physical activity and depressive mood, but also elucidated the underlying biological mechanisms, which enhance our understanding of how exercise helps alleviate depression and may inform the development of novel neuromodulation targets.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular Diversity Underpins Cortical Organization and Disease Vulnerability in the Human Brain. 细胞多样性是人脑皮层组织和疾病易感性的基础。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-09-29 DOI: 10.1007/s12264-025-01512-2

Yafeng Zhan, Cirong Liu

{"title":"Cellular Diversity Underpins Cortical Organization and Disease Vulnerability in the Human Brain.","authors":"Yafeng Zhan, Cirong Liu","doi":"10.1007/s12264-025-01512-2","DOIUrl":"https://doi.org/10.1007/s12264-025-01512-2","url":null,"abstract":"The cellular organization of the human brain fundamentally shapes its structure, function, and vulnerability to psychiatric disorders. However, the specific cellular contributions to laminar architecture and disease susceptibility remain elusive. Here, we estimated the distribution of molecularly defined cell types across cortical regions by integrating human single-nucleus RNA sequencing data with the Allen Human Brain Atlas microarray data. The cellular distribution profiles delineated three major cortical classes: sensory/motor, anterior association, and posterior association, each characterized by distinct cell-type enrichments. The dominant neuronal subtypes within each class exhibited specific laminar preferences that matched the variations in laminar thickness, as quantified using the BigBrain 3D histological atlas. Specifically, granular layer excitatory and parvalbumin-positive interneurons dominated sensory regions, while supragranular and infragranular neuronal subtypes enriched association cortices. Finally, by linking cell-type distributions to cortical shrinkage patterns in autism spectrum disorder, major depressive disorder, and schizophrenia, we identified cell-type-specific contributions to each disorder through predictive modeling. These findings illuminate the crucial role of cellular organization in shaping cortical structure and function, providing new insights into the cellular underpinnings of psychiatric disorders.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

α-Synuclein Pathology from Kidney to Brain in Parkinson's Disease. 帕金森病从肾到脑的α-突触核蛋白病理。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-09-24 DOI: 10.1007/s12264-025-01516-y

Yihang Han, Yanjuan Wang, Yunnan Lu, Chunming Xie, Di Wu

引用次数: 0

Effects of Stress Coping Styles and Social Defeat on Zebrafish Behaviour and Brain Transcriptomics. 应激应对方式和社交失败对斑马鱼行为和脑转录组学的影响。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-09-22 DOI: 10.1007/s12264-025-01506-0

Pavla Hubená, Lisa Benrejdal, David Brodin, Johanna Axling, Oly Sen Sarma, Peter Bergman, Svante Winberg

引用次数: 0

Long-Term Monochromatic Light Exposure Does Not Alter Modular Chromatic Representation in the Visual Cortex of Rhesus Monkeys. 长期单色光照射不会改变恒河猴视觉皮层的模色表征。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-09-20 DOI: 10.1007/s12264-025-01510-4

Wenqing Zhu, Ye Liu, Xiaoxiao Chen, Liling Qian, Wei Wang, Leilei Zou, Yiliang Lu, Rui Liu

{"title":"Long-Term Monochromatic Light Exposure Does Not Alter Modular Chromatic Representation in the Visual Cortex of Rhesus Monkeys.","authors":"Wenqing Zhu, Ye Liu, Xiaoxiao Chen, Liling Qian, Wei Wang, Leilei Zou, Yiliang Lu, Rui Liu","doi":"10.1007/s12264-025-01510-4","DOIUrl":"https://doi.org/10.1007/s12264-025-01510-4","url":null,"abstract":"Long-term exposure to monochromatic light during early life has been shown to significantly impact the development of myopia. However, its effect on color processing in the visual cortex remains unclear. In this study, we investigated the effects of different lighting conditions on the functional organization of color representation in the visual cortical areas V1, V2, and V4 of rhesus monkeys raised under long-wave and short-wave monochromatic illumination for four years. Using cytochrome oxidase staining and intrinsic signal optical imaging, we found that the sizes, densities, and response strengths of cortical color domains in V1, V2, and V4 were consistent across illumination conditions. In addition, the cortical distances between specific hue response patches did not significantly differ among the groups. These findings suggested that long-term monochromatic illumination does not alter the spatial organization or functional properties of color domains in the visual cortex of rhesus monkeys. This research provides new insights into the resilience of the visual system's chromatic representation despite altered lighting conditions in early life.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Transmission of Alpha-Synuclein from the Gastrointestinal Tract to the Substantia Nigra along the Vagal Afferent Pathway. α -突触核蛋白沿迷走神经传入通路从胃肠道到黑质的潜在传递。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-09-20 DOI: 10.1007/s12264-025-01509-x

Fan Han, Meiqiu Liu, Qian Jiao, Xixun Du, Chunling Yan, Xi Chen, Hong Jiang

引用次数: 0

Role of Microglial Dysfunction in Parkinson's Disease: From Multifactorial Causes to Neurodegeneration. 小胶质细胞功能障碍在帕金森病中的作用：从多因素病因到神经退行性变。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-09-19 DOI: 10.1007/s12264-025-01505-1

Yuxiang Xu, Tingting Han, Yue Wu, Haixuan Liu, Keyuan Hou, Zhaowu An, Yongjie Li, Chaoyang Zhu, Song Wang, Jianshe Wei

{"title":"Role of Microglial Dysfunction in Parkinson's Disease: From Multifactorial Causes to Neurodegeneration.","authors":"Yuxiang Xu, Tingting Han, Yue Wu, Haixuan Liu, Keyuan Hou, Zhaowu An, Yongjie Li, Chaoyang Zhu, Song Wang, Jianshe Wei","doi":"10.1007/s12264-025-01505-1","DOIUrl":"https://doi.org/10.1007/s12264-025-01505-1","url":null,"abstract":"Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons, and its prevalence is increasing, alongside global population aging. Neuroinflammation has been widely recognized as a pivotal contributor to PD pathogenesis, particularly owing to the dual role of microglia in this process. This review systematically identifies the multiple factors regulating microglial function and phenotype, thereby driving PD initiation and progression. Furthermore, aging, a major risk factor for PD, and its profound effects on microglial state and functional dynamics are discussed. Notably, microglial hyperactivation is shown to establish a self-perpetuating cycle of \"inflammation-damage-reinflammation\" through the excessive release of pro-inflammatory cytokines and chemokines, which exacerbates neuronal degeneration. Lastly, the potential therapeutic strategies targeting microglial dysfunction, including interventions against the senescence-associated secretory phenotype and the modulation of microglial activity, are summarized. By elucidating how multifactorial alterations in microglial states influence PD pathology, this review provides novel insights and directions for advancing therapeutic research in PD.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SHANK3 Deficiency in AgRP Neurons Inhibits Diet-Induced Obesity by Activating p38α. AgRP神经元SHANK3缺陷通过激活p38α抑制饮食性肥胖

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-09-19 DOI: 10.1007/s12264-025-01493-2

Shanshan Wu, Yixiao Liang, Yang Xu, Yueping Ge, Jing Wang, Lu Wang, Xinchen Jin, Huidong Zhan, Li Peng, Ling Gao, Jiajun Zhao, Zhao He

{"title":"SHANK3 Deficiency in AgRP Neurons Inhibits Diet-Induced Obesity by Activating p38α.","authors":"Shanshan Wu, Yixiao Liang, Yang Xu, Yueping Ge, Jing Wang, Lu Wang, Xinchen Jin, Huidong Zhan, Li Peng, Ling Gao, Jiajun Zhao, Zhao He","doi":"10.1007/s12264-025-01493-2","DOIUrl":"https://doi.org/10.1007/s12264-025-01493-2","url":null,"abstract":"Children with autism often exhibit abnormalities in body weight, but the underlying mechanism remains unclear. SH3 and multiple ankyrin repeat domains protein 3 (SHANK3), a scaffold protein of the postsynaptic density, has been reported to be associated with autism. This study aimed to investigate whether and how SHANK3 influences body weight in the hypothalamic neuronal regulation of energy homeostasis. Adeno-associated viruses 9 (AAV9) carrying CMV-Cre and Agrp-Cre were stereotactically injected to restore SHANK3 expression in the arcuate nucleus (ARC) and agouti-related peptide (AgRP) neurons, respectively. Agrp-Cre mice were injected with AAV9-p38αflox/flox to overexpress p38α. Activated p38α was generated by mutating both D176A and F327S in p38α. Inactivated p38α was constructed by mutating both T180A and Y182F in p38α. Metabolic analysis, immunoblotting, histological analysis, the glucose tolerance test, the insulin tolerance test, and body fat mass analysis were applied to investigate the underlying mechanisms by which SHANK3 regulates body weight. We reveal that SHANK3 regulates body weight via the p38α signaling pathway in the AgRP neurons of the hypothalamus. Shank3 knockout (Shank3-/-) mice exhibit resistance to diet-induced obesity. Shank3 re-expression in the ARC or AgRP neurons increases body weight in Shank3 knock-in mice with an inverted allele (SKO). Overexpression or activation of p38α in AgRP neurons elicits resistance to diet-induced obesity. Inactivated p38α in AgRP neurons abolished the resistance to diet-induced obesity due to SHANK3 deficiency. Our findings suggest that the SHANK3-p38α siganling pathway in AgRP neurons regulates body weight balance in autism, revealing a promising therapeutic target for obesity in children with autism.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial GATAD1 Exacerbates Blood-brain Barrier Dysfunction in Ischemic Stroke through Caveolae-mediated Transcytosis. 内皮GATAD1通过小泡介导的胞吞作用加重缺血性卒中血脑屏障功能障碍。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-09-18 DOI: 10.1007/s12264-025-01507-z

Lizhen Fan, Hui Liu, Shanshan Li, Lingling Li, Zhi Zhang, Pinyi Liu, Haiyan Yang, Shengnan Xia, Xiang Cao, Chun Wang, Yun Xu

{"title":"Endothelial GATAD1 Exacerbates Blood-brain Barrier Dysfunction in Ischemic Stroke through Caveolae-mediated Transcytosis.","authors":"Lizhen Fan, Hui Liu, Shanshan Li, Lingling Li, Zhi Zhang, Pinyi Liu, Haiyan Yang, Shengnan Xia, Xiang Cao, Chun Wang, Yun Xu","doi":"10.1007/s12264-025-01507-z","DOIUrl":"https://doi.org/10.1007/s12264-025-01507-z","url":null,"abstract":"Blood-brain barrier (BBB) dysfunction represents a critical pathological manifestation in exacerbating ischemic stroke, contributing to neuronal death, edema formation, and unfavorable clinical outcomes. GATA zinc finger domain-containing 1 (GATAD1) is recognized as a critical transcription factor in cardiac development and cardiovascular disease. However, the role of GATAD1 in regulating BBB function and ischemic stroke remains elusive. Here, we found that GATAD1 was upregulated in cerebral endothelial cells (ECs) following ischemic stroke in mice. EC-specific Gatad1 deficiency demonstrated remarkable neuroprotection, manifested by reduced infarct volumes, ameliorated BBB dysfunction, and improved neurological outcomes following experimental stroke. Mechanistic investigations revealed that GATAD1 was involved in regulating CD36 expression, thereby modulating caveolae-mediated transcytosis in cerebral ECs. These findings established GATAD1 as a novel regulator of BBB permeability and a potential therapeutic target for ischemic stroke intervention.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrophysiological Characterization of Murine Vestibular Efferent Neurons and Modulation by Acute Peripheral Vestibular Deprivation. 小鼠前庭传出神经元的电生理特征及急性前庭外周剥夺的调节。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-09-18 DOI: 10.1007/s12264-025-01502-4

Jinyu Wang, Mengfan Xu, Lei Zhang, Wenjie Liu, Siyue Wang, Liqin Wang, Ning Cong, Geng-Lin Li, Jing Wang

{"title":"Electrophysiological Characterization of Murine Vestibular Efferent Neurons and Modulation by Acute Peripheral Vestibular Deprivation.","authors":"Jinyu Wang, Mengfan Xu, Lei Zhang, Wenjie Liu, Siyue Wang, Liqin Wang, Ning Cong, Geng-Lin Li, Jing Wang","doi":"10.1007/s12264-025-01502-4","DOIUrl":"https://doi.org/10.1007/s12264-025-01502-4","url":null,"abstract":"Vestibular efferent neurons in the brainstem provide direct cholinergic innervation to peripheral vestibular organs, thereby modulating their sensory responsiveness. In this study, a genetically targeted mouse model with choline acetyltransferase-driven fluorescent labeling enabled the precise localization of these neurons to the dorsolateral region of the genu of the facial nerve. Whole-cell patch-clamp recordings in acute brainstem slices revealed that virtually all neurons exhibited spontaneous action potential firing, with marked heterogeneity in discharge patterns and after-hyperpolarization kinetics. Prominent A-type potassium currents were identified and found to be differentially regulated by acetylcholine and calcitonin gene-related peptide. Acute unilateral vestibular deprivation induced a bilateral enhancement of spontaneous firing, indicating sensitivity to altered sensory input. These findings define the intrinsic electrophysiological properties and neuromodulatory mechanisms of vestibular efferent neurons, providing mechanistic insight into their roles in both physiological regulation and adaptive plasticity within the vestibular system.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0