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Dynamic Routing of Theta-Frequency Synchrony in the Amygdalo-Hippocampal-Entorhinal Circuit Coordinates Retrieval of Competing Memories.
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-02-01 DOI: 10.1007/s12264-025-01356-w
Jiahua Zheng, Yiqi Sun, Fuhai Wang, Zhongyu Xie, Qianyun Wang, Jian-Ya Peng, Jianguang Ni
{"title":"Dynamic Routing of Theta-Frequency Synchrony in the Amygdalo-Hippocampal-Entorhinal Circuit Coordinates Retrieval of Competing Memories.","authors":"Jiahua Zheng, Yiqi Sun, Fuhai Wang, Zhongyu Xie, Qianyun Wang, Jian-Ya Peng, Jianguang Ni","doi":"10.1007/s12264-025-01356-w","DOIUrl":"https://doi.org/10.1007/s12264-025-01356-w","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histamine H1 Receptor in Medial Septum Cholinergic Circuit: New Hope for Fear-related Disorders?
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-02-01 DOI: 10.1007/s12264-025-01357-9
Kang Liu
{"title":"Histamine H<sub>1</sub> Receptor in Medial Septum Cholinergic Circuit: New Hope for Fear-related Disorders?","authors":"Kang Liu","doi":"10.1007/s12264-025-01357-9","DOIUrl":"https://doi.org/10.1007/s12264-025-01357-9","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-Neuron Reconstruction of the Macaque Primary Motor Cortex Reveals the Diversity of Neuronal Morphology.
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-28 DOI: 10.1007/s12264-025-01352-0
Siyu Li, Yan Shen, Yefei Chen, Zexuan Hong, Lewei Zhang, Lufeng Ding, Chao-Yu Yang, Xiaoyang Qi, Quqing Shen, Yanyang Xiao, Pak-Ming Lau, Zhonghua Lu, Fang Xu, Guo-Qiang Bi
{"title":"Single-Neuron Reconstruction of the Macaque Primary Motor Cortex Reveals the Diversity of Neuronal Morphology.","authors":"Siyu Li, Yan Shen, Yefei Chen, Zexuan Hong, Lewei Zhang, Lufeng Ding, Chao-Yu Yang, Xiaoyang Qi, Quqing Shen, Yanyang Xiao, Pak-Ming Lau, Zhonghua Lu, Fang Xu, Guo-Qiang Bi","doi":"10.1007/s12264-025-01352-0","DOIUrl":"https://doi.org/10.1007/s12264-025-01352-0","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Scorpion Venom Heat-Resistant Peptide is Neuroprotective Against Cerebral Ischemia-Reperfusion Injury in Association with the NMDA-MAPK Pathway.
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-27 DOI: 10.1007/s12264-024-01340-w
Xu-Gang Wang, Dan-Dan Zhu, Na Li, Yue-Lin Huang, Ying-Zi Wang, Ting Zhang, Chen-Mei Wang, Bin Wang, Yan Peng, Bi-Ying Ge, Shao Li, Jie Zhao
{"title":"Correction to: Scorpion Venom Heat-Resistant Peptide is Neuroprotective Against Cerebral Ischemia-Reperfusion Injury in Association with the NMDA-MAPK Pathway.","authors":"Xu-Gang Wang, Dan-Dan Zhu, Na Li, Yue-Lin Huang, Ying-Zi Wang, Ting Zhang, Chen-Mei Wang, Bin Wang, Yan Peng, Bi-Ying Ge, Shao Li, Jie Zhao","doi":"10.1007/s12264-024-01340-w","DOIUrl":"https://doi.org/10.1007/s12264-024-01340-w","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of Pharmacoresistance in Drug-Naïve Temporal Lobe Epilepsy Using Ictal EEGs Based on Convolutional Neural Network.
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-27 DOI: 10.1007/s12264-025-01350-2
Yiwei Gong, Zheng Zhang, Yuanzhi Yang, Shuo Zhang, Ruifeng Zheng, Xin Li, Xiaoyun Qiu, Yang Zheng, Shuang Wang, Wenyu Liu, Fan Fei, Heming Cheng, Yi Wang, Dong Zhou, Kejie Huang, Zhong Chen, Cenglin Xu
{"title":"Prediction of Pharmacoresistance in Drug-Naïve Temporal Lobe Epilepsy Using Ictal EEGs Based on Convolutional Neural Network.","authors":"Yiwei Gong, Zheng Zhang, Yuanzhi Yang, Shuo Zhang, Ruifeng Zheng, Xin Li, Xiaoyun Qiu, Yang Zheng, Shuang Wang, Wenyu Liu, Fan Fei, Heming Cheng, Yi Wang, Dong Zhou, Kejie Huang, Zhong Chen, Cenglin Xu","doi":"10.1007/s12264-025-01350-2","DOIUrl":"https://doi.org/10.1007/s12264-025-01350-2","url":null,"abstract":"<p><p>Approximately 30%-40% of epilepsy patients do not respond well to adequate anti-seizure medications (ASMs), a condition known as pharmacoresistant epilepsy. The management of pharmacoresistant epilepsy remains an intractable issue in the clinic. Its early prediction is important for prevention and diagnosis. However, it still lacks effective predictors and approaches. Here, a classical model of pharmacoresistant temporal lobe epilepsy (TLE) was established to screen pharmacoresistant and pharmaco-responsive individuals by applying phenytoin to amygdaloid-kindled rats. Ictal electroencephalograms (EEGs) recorded before phenytoin treatment were analyzed. Based on ictal EEGs from pharmacoresistant and pharmaco-responsive rats, a convolutional neural network predictive model was constructed to predict pharmacoresistance, and achieved 78% prediction accuracy. We further found the ictal EEGs from pharmacoresistant rats have a lower gamma-band power, which was verified in seizure EEGs from pharmacoresistant TLE patients. Prospectively, therapies targeting the subiculum in those predicted as \"pharmacoresistant\" individual rats significantly reduced the subsequent occurrence of pharmacoresistance. These results demonstrate a new methodology to predict whether TLE individuals become resistant to ASMs in a classic pharmacoresistant TLE model. This may be of translational importance for the precise management of pharmacoresistant TLE.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Paraventricular Hypothalamus: A Sorting Center for Visceral and Somatic Pain.
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-27 DOI: 10.1007/s12264-025-01353-z
Li Sun, Shumin Duan
{"title":"The Paraventricular Hypothalamus: A Sorting Center for Visceral and Somatic Pain.","authors":"Li Sun, Shumin Duan","doi":"10.1007/s12264-025-01353-z","DOIUrl":"https://doi.org/10.1007/s12264-025-01353-z","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Therapeutic Potential of Psychedelics in Chronic Pain Management: A New Frontier in Medicine. 探索致幻剂在慢性疼痛管理中的治疗潜力：医学的新前沿。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-20 DOI: 10.1007/s12264-025-01351-1
Cong Lin, Xue Wang, Xiaohui Wang
{"title":"Exploring the Therapeutic Potential of Psychedelics in Chronic Pain Management: A New Frontier in Medicine.","authors":"Cong Lin, Xue Wang, Xiaohui Wang","doi":"10.1007/s12264-025-01351-1","DOIUrl":"https://doi.org/10.1007/s12264-025-01351-1","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Etiology Link to Brain Function Underlying ADHD Symptoms and its Interaction with Sleep Disturbance: An ABCD Study. ADHD症状与脑功能相关的遗传病因及其与睡眠障碍的相互作用：一项ABCD研究。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-19 DOI: 10.1007/s12264-025-01349-9
Aichen Feng, Dongmei Zhi, Zening Fu, Shan Yu, Na Luo, Vince Calhoun, Jing Sui
{"title":"Genetic Etiology Link to Brain Function Underlying ADHD Symptoms and its Interaction with Sleep Disturbance: An ABCD Study.","authors":"Aichen Feng, Dongmei Zhi, Zening Fu, Shan Yu, Na Luo, Vince Calhoun, Jing Sui","doi":"10.1007/s12264-025-01349-9","DOIUrl":"https://doi.org/10.1007/s12264-025-01349-9","url":null,"abstract":"<p><p>Attention deficit hyperactivity disorder (ADHD), a prevalent neurodevelopmental disorder influenced by both genetic and environmental factors, remains poorly understood regarding how its polygenic risk score (PRS) impacts functional networks and symptomology. This study capitalized on data from 11,430 children in the Adolescent Brain Cognitive Development study to explore the interplay between PRS<sub>ADHD</sub>, brain function, and behavioral problems, along with their interactive effects. The results showed that children with a higher PRS<sub>ADHD</sub> exhibited more severe attention deficits and rule-breaking problems, and experienced sleep disturbances, particularly in initiating and maintaining sleep. We also identified the central executive network, default mode network, and sensory-motor network as the functional networks most associated with PRS and symptoms in ADHD cases, with potential mediating roles. Particularly, the impact of PRS<sub>ADHD</sub> was enhanced in children experiencing heightened sleep disturbances, emphasizing the need for early intervention in sleep issues to potentially mitigate subsequent ADHD symptoms.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role and Mechanisms of Ubiquitin-Proteasome System-Mediated Ferroptosis in Neurological Disorders. 泛素-蛋白酶体系统介导的铁下垂在神经系统疾病中的作用和机制。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-07 DOI: 10.1007/s12264-024-01343-7
Xin Liu, Wei Wang, Qiucheng Nie, Xinjing Liu, Lili Sun, Qiang Ma, Jie Zhang, Yiju Wei
{"title":"The Role and Mechanisms of Ubiquitin-Proteasome System-Mediated Ferroptosis in Neurological Disorders.","authors":"Xin Liu, Wei Wang, Qiucheng Nie, Xinjing Liu, Lili Sun, Qiang Ma, Jie Zhang, Yiju Wei","doi":"10.1007/s12264-024-01343-7","DOIUrl":"https://doi.org/10.1007/s12264-024-01343-7","url":null,"abstract":"<p><p>Ferroptosis is a form of cell death elicited by an imbalance in intracellular iron concentrations, leading to enhanced lipid peroxidation. In neurological disorders, both oxidative stress and mitochondrial damage can contribute to ferroptosis, resulting in nerve cell dysfunction and death. The ubiquitin-proteasome system (UPS) refers to a cellular pathway in which specific proteins are tagged with ubiquitin for recognition and degradation by the proteasome. In neurological conditions, the UPS plays a significant role in regulating ferroptosis. In this review, we outline how the UPS regulates iron metabolism, ferroptosis, and their interplay in neurological diseases. In addition, we discuss the future application of small-molecule inhibitors and identify potential drug targets. Further investigation into the mechanisms of UPS-mediated ferroptosis will provide novel insights and strategies for therapeutic interventions and clinical applications in neurological diseases.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 2 Diabetes Mellitus Exacerbates Pathological Processes of Parkinson's Disease: Insights from Signaling Pathways Mediated by Insulin Receptors. 2型糖尿病加剧帕金森病的病理过程：胰岛素受体介导的信号通路的见解
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-01-04 DOI: 10.1007/s12264-024-01342-8
Shufen Liu, Tingting Liu, Jingwen Li, Jun Hong, Ali A Moosavi-Movahedi, Jianshe Wei
{"title":"Type 2 Diabetes Mellitus Exacerbates Pathological Processes of Parkinson's Disease: Insights from Signaling Pathways Mediated by Insulin Receptors.","authors":"Shufen Liu, Tingting Liu, Jingwen Li, Jun Hong, Ali A Moosavi-Movahedi, Jianshe Wei","doi":"10.1007/s12264-024-01342-8","DOIUrl":"https://doi.org/10.1007/s12264-024-01342-8","url":null,"abstract":"<p><p>Parkinson's disease (PD), a chronic and common neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the dense part of the substantia nigra and abnormal aggregation of alpha-synuclein. Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by chronic insulin resistance and deficiency in insulin secretion. Extensive evidence has confirmed shared pathogenic mechanisms underlying PD and T2DM, such as oxidative stress caused by insulin resistance, mitochondrial dysfunction, inflammation, and disorders of energy metabolism. Conventional drugs for treating T2DM, such as metformin and glucagon-like peptide-1 receptor agonists, affect nerve repair. Even drugs for treating PD, such as levodopa, can affect insulin secretion. This review summarizes the relationship between PD and T2DM and related therapeutic drugs from the perspective of insulin signaling pathways in the brain.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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